LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Putative 40S ribosomal protein S18

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative 40S ribosomal protein S18
Gene product:
40S ribosomal protein S18, putative
Species:
Leishmania braziliensis
UniProt:
A4HNV2_LEIBR
TriTrypDb:
LbrM.35.1060 , LBRM2903_350016300
Length:
153

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 24
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 20
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005840 ribosome 5 12
GO:0032991 protein-containing complex 1 14
GO:0043226 organelle 2 12
GO:0043228 non-membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043232 intracellular non-membrane-bounded organelle 4 12
GO:0110165 cellular anatomical entity 1 14
GO:1990904 ribonucleoprotein complex 2 14
GO:0005737 cytoplasm 2 2
GO:0005829 cytosol 2 2
GO:0015935 small ribosomal subunit 4 2
GO:0031974 membrane-enclosed lumen 2 2
GO:0031981 nuclear lumen 5 2
GO:0043233 organelle lumen 3 2
GO:0044391 ribosomal subunit 3 2
GO:0070013 intracellular organelle lumen 4 2

Expansion

Sequence features

A4HNV2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNV2

Function

Biological processes
Term Name Level Count
GO:0006412 translation 4 14
GO:0006518 peptide metabolic process 4 14
GO:0006807 nitrogen compound metabolic process 2 14
GO:0008152 metabolic process 1 14
GO:0009058 biosynthetic process 2 14
GO:0009059 macromolecule biosynthetic process 4 14
GO:0009987 cellular process 1 14
GO:0019538 protein metabolic process 3 14
GO:0034641 cellular nitrogen compound metabolic process 3 14
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 14
GO:0043043 peptide biosynthetic process 5 14
GO:0043170 macromolecule metabolic process 3 14
GO:0043603 amide metabolic process 3 14
GO:0043604 amide biosynthetic process 4 14
GO:0044237 cellular metabolic process 2 14
GO:0044238 primary metabolic process 2 14
GO:0044249 cellular biosynthetic process 3 14
GO:0044260 obsolete cellular macromolecule metabolic process 3 14
GO:0044271 cellular nitrogen compound biosynthetic process 4 14
GO:0071704 organic substance metabolic process 2 14
GO:1901564 organonitrogen compound metabolic process 3 14
GO:1901566 organonitrogen compound biosynthetic process 4 14
GO:1901576 organic substance biosynthetic process 3 14
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 14
GO:0003723 RNA binding 4 14
GO:0003735 structural constituent of ribosome 2 14
GO:0005198 structural molecule activity 1 14
GO:0005488 binding 1 14
GO:0097159 organic cyclic compound binding 2 14
GO:1901363 heterocyclic compound binding 2 14

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 24 26 PF00675 0.320
CLV_NRD_NRD_1 55 57 PF00675 0.320
CLV_PCSK_KEX2_1 24 26 PF00082 0.320
CLV_PCSK_KEX2_1 55 57 PF00082 0.320
CLV_PCSK_PC1ET2_1 24 26 PF00082 0.320
CLV_PCSK_SKI1_1 32 36 PF00082 0.308
DEG_APCC_DBOX_1 108 116 PF00400 0.520
DOC_MAPK_gen_1 122 132 PF00069 0.520
DOC_MAPK_gen_1 32 41 PF00069 0.520
DOC_MAPK_gen_1 47 53 PF00069 0.520
DOC_MAPK_MEF2A_6 32 41 PF00069 0.513
DOC_PP4_FxxP_1 78 81 PF00568 0.534
DOC_SPAK_OSR1_1 77 81 PF12202 0.442
LIG_14-3-3_CanoR_1 142 148 PF00244 0.588
LIG_BIR_II_1 1 5 PF00653 0.582
LIG_FHA_1 144 150 PF00498 0.591
LIG_FHA_1 94 100 PF00498 0.520
LIG_FHA_2 17 23 PF00498 0.534
LIG_FHA_2 47 53 PF00498 0.554
LIG_FHA_2 59 65 PF00498 0.508
LIG_LIR_Gen_1 8 17 PF02991 0.498
LIG_LIR_Nem_3 8 13 PF02991 0.516
LIG_SH2_STAT5 43 46 PF00017 0.622
LIG_SUMO_SIM_anti_2 2 8 PF11976 0.698
LIG_TRAF2_1 61 64 PF00917 0.520
MOD_CK2_1 16 22 PF00069 0.551
MOD_CK2_1 58 64 PF00069 0.509
MOD_Cter_Amidation 22 25 PF01082 0.334
MOD_GlcNHglycan 139 142 PF01048 0.295
MOD_GSK3_1 143 150 PF00069 0.610
MOD_GSK3_1 93 100 PF00069 0.520
MOD_NEK2_1 1 6 PF00069 0.590
MOD_NEK2_1 16 21 PF00069 0.526
MOD_NEK2_1 99 104 PF00069 0.549
MOD_Plk_4 1 7 PF00069 0.658
MOD_Plk_4 99 105 PF00069 0.600
TRG_DiLeu_BaLyEn_6 12 17 PF01217 0.482
TRG_ER_diArg_1 130 133 PF00400 0.515
TRG_NES_CRM1_1 63 74 PF08389 0.442
TRG_NLS_MonoExtC_3 23 28 PF00514 0.513
TRG_NLS_MonoExtN_4 114 120 PF00514 0.520

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4IKD7 Bodo saltans 78% 100%
A0A1D8PQQ5 Candida albicans (strain SC5314 / ATCC MYA-2876) 55% 100%
A0A1X0P911 Trypanosomatidae 91% 100%
A0A381MVV3 Leishmania infantum 95% 100%
A0A3Q8IJW8 Leishmania donovani 95% 100%
A0A3Q8IK98 Leishmania donovani 95% 92%
A0A3R7KMU0 Trypanosoma rangeli 88% 100%
A0A3R7MNW1 Trypanosoma rangeli 88% 100%
A0B9L1 Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) 45% 96%
A0RY01 Cenarchaeum symbiosum (strain A) 36% 67%
A1B050 Paracoccus denitrificans (strain Pd 1222) 28% 100%
A1QZT6 Borrelia turicatae (strain 91E135) 25% 100%
A1RT04 Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3) 37% 100%
A1RWT9 Thermofilum pendens (strain DSM 2475 / Hrk 5) 43% 97%
A1USR6 Bartonella bacilliformis (strain ATCC 35685 / NCTC 12138 / KC583) 27% 100%
A2BK76 Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5) 46% 100%
A2SSW0 Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z) 38% 100%
A3CWH6 Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1) 37% 100%
A3DJJ8 Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) 28% 100%
A3DMQ3 Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1) 44% 100%
A3MUT0 Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1) 37% 100%
A3PGN3 Cereibacter sphaeroides (strain ATCC 17029 / ATH 2.4.9) 29% 100%
A4ICP1 Leishmania infantum 95% 92%
A4WM28 Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6) 38% 100%
A4WVI6 Cereibacter sphaeroides (strain ATCC 17025 / ATH 2.4.3) 29% 100%
A4XLQ5 Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T 6331) 27% 100%
A5ELK5 Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182) 28% 100%
A5FZU3 Acidiphilium cryptum (strain JF-5) 26% 100%
A5IMA8 Thermotoga petrophila (strain ATCC BAA-488 / DSM 13995 / JCM 10881 / RKU-1) 31% 100%
A5IYW1 Mycoplasmopsis agalactiae (strain NCTC 10123 / CIP 59.7 / PG2) 25% 100%
A5JST6 Capra hircus 58% 100%
A5UN52 Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS) 41% 100%
A6LLN8 Thermosipho melanesiensis (strain DSM 12029 / CIP 104789 / BI429) 26% 100%
A6U881 Sinorhizobium medicae (strain WSM419) 30% 100%
A7HM27 Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1) 28% 100%
A7HWT3 Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966) 28% 100%
A7IPP8 Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) 28% 100%
A8ETK3 Aliarcobacter butzleri (strain RM4018) 26% 100%
A8F4T6 Pseudothermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / NBRC 107922 / TMO) 28% 100%
A9H3J7 Gluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / CCUG 37298 / CIP 103539 / LMG 7603 / PAl5) 26% 100%
B0B883 Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B) 23% 100%
B0BCE8 Chlamydia trachomatis serovar L2b (strain UCH-1/proctitis) 23% 100%
B0T2E4 Caulobacter sp. (strain K31) 28% 100%
B1LBL5 Thermotoga sp. (strain RQ2) 31% 100%
B1LWQ2 Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831 / NBRC 15690 / NCIMB 10815 / 0-1) 28% 100%
B1Z771 Methylorubrum populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001) 28% 100%
B1ZNC6 Opitutus terrae (strain DSM 11246 / JCM 15787 / PB90-1) 35% 100%
B2IF93 Beijerinckia indica subsp. indica (strain ATCC 9039 / DSM 1715 / NCIMB 8712) 28% 100%
B2S0K3 Borrelia hermsii (strain HS1 / DAH) 24% 100%
B2UV59 Helicobacter pylori (strain Shi470) 24% 100%
B3CN47 Wolbachia pipientis subsp. Culex pipiens (strain wPip) 28% 100%
B3DVZ3 Methylacidiphilum infernorum (isolate V4) 28% 100%
B3PMM3 Metamycoplasma arthritidis (strain 158L3-1) 25% 100%
B3PWU3 Rhizobium etli (strain CIAT 652) 29% 100%
B3QBV7 Rhodopseudomonas palustris (strain TIE-1) 27% 100%
B5RM58 Borrelia duttonii (strain Ly) 27% 100%
B5RPK4 Borrelia recurrentis (strain A1) 27% 100%
B5Y963 Coprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / OCM 4 / BT) 28% 100%
B5Z8U5 Helicobacter pylori (strain G27) 24% 100%
B5ZZ55 Rhizobium leguminosarum bv. trifolii (strain WSM2304) 29% 100%
B6IRS8 Rhodospirillum centenum (strain ATCC 51521 / SW) 32% 100%
B6JND6 Helicobacter pylori (strain P12) 24% 100%
B7IHX0 Thermosipho africanus (strain TCF52B) 28% 100%
B8H4F6 Caulobacter vibrioides (strain NA1000 / CB15N) 28% 100%
B9JDV0 Agrobacterium radiobacter (strain K84 / ATCC BAA-868) 31% 100%
B9JVQ9 Agrobacterium vitis (strain S4 / ATCC BAA-846) 28% 100%
B9K8B1 Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NBRC 107923 / NS-E) 30% 100%
B9KLB3 Cereibacter sphaeroides (strain KD131 / KCTC 12085) 29% 100%
B9L6U0 Nautilia profundicola (strain ATCC BAA-1463 / DSM 18972 / AmH) 29% 100%
B9MKF6 Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) 28% 100%
C3MB01 Sinorhizobium fredii (strain NBRC 101917 / NGR234) 29% 100%
C4Z2V4 Lachnospira eligens (strain ATCC 27750 / DSM 3376 / VPI C15-48 / C15-B4) 28% 100%
C5CGH7 Kosmotoga olearia (strain ATCC BAA-1733 / DSM 21960 / TBF 19.5.1) 28% 100%
D0A2S1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 86% 100%
E9ASL3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
O26141 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 39% 100%
O27999 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 44% 100%
O74021 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) 45% 100%
P0CE04 Chlamydia trachomatis (strain D/UW-3/Cx) 23% 100%
P0CT66 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 62% 100%
P0CT67 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 62% 100%
P0CX55 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 59% 100%
P0CX56 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 59% 100%
P26872 Marchantia polymorpha 24% 100%
P34788 Arabidopsis thaliana 58% 100%
P39470 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) 40% 90%
P41094 Drosophila melanogaster 58% 100%
P48151 Entamoeba histolytica 57% 99%
P49202 Chlamydomonas reinhardtii 59% 100%
P54019 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 41% 100%
P56020 Helicobacter pylori (strain ATCC 700392 / 26695) 24% 100%
P59752 Chlamydia caviae (strain ATCC VR-813 / DSM 19441 / 03DC25 / GPIC) 25% 100%
P62269 Homo sapiens 58% 100%
P62270 Mus musculus 58% 100%
P62271 Rattus norvegicus 58% 100%
P62272 Sus scrofa 58% 100%
P95986 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 43% 93%
Q00861 Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) 36% 86%
Q07KP0 Rhodopseudomonas palustris (strain BisA53) 27% 100%
Q0ANS2 Maricaulis maris (strain MCS10) 29% 100%
Q0BUM8 Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1) 26% 100%
Q0BYD6 Hyphomonas neptunium (strain ATCC 15444) 29% 100%
Q0W1V6 Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50) 38% 68%
Q12ZR6 Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M) 42% 100%
Q134V1 Rhodopseudomonas palustris (strain BisB5) 28% 100%
Q18G53 Haloquadratum walsbyi (strain DSM 16790 / HBSQ001) 32% 88%
Q1CRW4 Helicobacter pylori (strain HPAG1) 24% 100%
Q1MIB9 Rhizobium leguminosarum bv. viciae (strain 3841) 29% 100%
Q1QN08 Nitrobacter hamburgensis (strain DSM 10229 / NCIMB 13809 / X14) 25% 100%
Q252X2 Chlamydia felis (strain Fe/C-56) 25% 100%
Q28UT0 Jannaschia sp. (strain CCS1) 30% 100%
Q2FT96 Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1) 37% 100%
Q2G5A8 Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CCUG 56034 / CIP 105152 / NBRC 16084 / F199) 27% 100%
Q2IXN8 Rhodopseudomonas palustris (strain HaA2) 28% 100%
Q2K9J4 Rhizobium etli (strain CFN 42 / ATCC 51251) 29% 100%
Q2N9D5 Erythrobacter litoralis (strain HTCC2594) 31% 100%
Q2NFZ3 Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3) 42% 100%
Q2RQY2 Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1) 25% 100%
Q3A9U1 Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901) 30% 100%
Q3IQT9 Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara) 35% 90%
Q3J5Q0 Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) 29% 100%
Q3KLI8 Chlamydia trachomatis serovar A (strain ATCC VR-571B / DSM 19440 / HAR-13) 23% 100%
Q3SSU4 Nitrobacter winogradskyi (strain ATCC 25391 / DSM 10237 / CIP 104748 / NCIMB 11846 / Nb-255) 28% 100%
Q3T0R1 Bos taurus 58% 100%
Q46GC7 Methanosarcina barkeri (strain Fusaro / DSM 804) 43% 94%
Q4Q1Y2 Leishmania major 97% 100%
Q4Q1Y3 Leishmania major 97% 100%
Q5FU05 Gluconobacter oxydans (strain 621H) 29% 100%
Q5JJF1 Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) 45% 100%
Q5L701 Chlamydia abortus (strain DSM 27085 / S26/3) 24% 100%
Q5TJE9 Canis lupus familiaris 58% 100%
Q67JW8 Symbiobacterium thermophilum (strain T / IAM 14863) 27% 100%
Q6KZP8 Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828) 38% 97%
Q6LXN1 Methanococcus maripaludis (strain S2 / LL) 37% 100%
Q6MJ33 Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100) 28% 100%
Q6N4V5 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) 27% 100%
Q73HA7 Wolbachia pipientis wMel 26% 100%
Q74M95 Nanoarchaeum equitans (strain Kin4-M) 40% 100%
Q7UIC7 Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1) 24% 100%
Q7VGC2 Helicobacter hepaticus (strain ATCC 51449 / 3B1) 26% 100%
Q869U7 Dictyostelium discoideum 56% 99%
Q89JA6 Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110) 28% 100%
Q8D1Z0 Wigglesworthia glossinidia brevipalpis 27% 100%
Q8ISP0 Branchiostoma belcheri 58% 100%
Q8IT98 Argopecten irradians 56% 100%
Q8JGS9 Danio rerio 58% 100%
Q8PV19 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) 43% 94%
Q8SRP2 Encephalitozoon cuniculi (strain GB-M1) 44% 100%
Q8TRR2 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) 43% 94%
Q8TVC1 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) 43% 100%
Q8U0E2 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 44% 100%
Q8UE39 Agrobacterium fabrum (strain C58 / ATCC 33970) 29% 100%
Q8ZTV0 Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) 38% 100%
Q90YQ5 Ictalurus punctatus 58% 100%
Q925X7 Rhizobium meliloti (strain 1021) 30% 100%
Q962R1 Spodoptera frugiperda 60% 100%
Q96YV7 Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) 43% 89%
Q97B96 Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) 38% 89%
Q98N35 Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) 29% 100%
Q9A8T1 Caulobacter vibrioides (strain ATCC 19089 / CB15) 28% 100%
Q9HJD6 Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) 38% 89%
Q9PJN2 Chlamydia muridarum (strain MoPn / Nigg) 23% 100%
Q9V1A0 Pyrococcus abyssi (strain GE5 / Orsay) 45% 100%
Q9V2W4 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 34% 89%
Q9X1I5 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) 31% 100%
Q9YB60 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) 42% 100%
Q9Z7S6 Chlamydia pneumoniae 26% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS