LeishMANIAdb
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Putative SNF1-related protein kinase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative SNF1-related protein kinase
Gene product:
SNF1-related protein kinases, putative
Species:
Leishmania braziliensis
UniProt:
A4HNV0_LEIBR
TriTrypDb:
LbrM.35.1020 , LBRM2903_350015800
Length:
794

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNV0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNV0

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 10
GO:0006793 phosphorus metabolic process 3 10
GO:0006796 phosphate-containing compound metabolic process 4 10
GO:0006807 nitrogen compound metabolic process 2 10
GO:0008152 metabolic process 1 10
GO:0009987 cellular process 1 10
GO:0016310 phosphorylation 5 10
GO:0019538 protein metabolic process 3 10
GO:0036211 protein modification process 4 10
GO:0043170 macromolecule metabolic process 3 10
GO:0043412 macromolecule modification 4 10
GO:0044237 cellular metabolic process 2 10
GO:0044238 primary metabolic process 2 10
GO:0071704 organic substance metabolic process 2 10
GO:1901564 organonitrogen compound metabolic process 3 10
GO:0007165 signal transduction 2 1
GO:0035556 intracellular signal transduction 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 10
GO:0003824 catalytic activity 1 10
GO:0004672 protein kinase activity 3 10
GO:0005488 binding 1 10
GO:0005524 ATP binding 5 10
GO:0016301 kinase activity 4 10
GO:0016740 transferase activity 2 10
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 10
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 10
GO:0017076 purine nucleotide binding 4 10
GO:0030554 adenyl nucleotide binding 5 10
GO:0032553 ribonucleotide binding 3 10
GO:0032555 purine ribonucleotide binding 4 10
GO:0032559 adenyl ribonucleotide binding 5 10
GO:0035639 purine ribonucleoside triphosphate binding 4 10
GO:0036094 small molecule binding 2 10
GO:0043167 ion binding 2 10
GO:0043168 anion binding 3 10
GO:0097159 organic cyclic compound binding 2 10
GO:0097367 carbohydrate derivative binding 2 10
GO:0140096 catalytic activity, acting on a protein 2 10
GO:1901265 nucleoside phosphate binding 3 10
GO:1901363 heterocyclic compound binding 2 10
GO:0004674 protein serine/threonine kinase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 639 643 PF00656 0.530
CLV_MEL_PAP_1 14 20 PF00089 0.607
CLV_NRD_NRD_1 356 358 PF00675 0.611
CLV_NRD_NRD_1 53 55 PF00675 0.338
CLV_NRD_NRD_1 554 556 PF00675 0.764
CLV_PCSK_KEX2_1 356 358 PF00082 0.608
CLV_PCSK_KEX2_1 554 556 PF00082 0.764
CLV_PCSK_KEX2_1 562 564 PF00082 0.643
CLV_PCSK_KEX2_1 577 579 PF00082 0.492
CLV_PCSK_KEX2_1 68 70 PF00082 0.472
CLV_PCSK_PC1ET2_1 562 564 PF00082 0.643
CLV_PCSK_PC1ET2_1 577 579 PF00082 0.492
CLV_PCSK_PC1ET2_1 68 70 PF00082 0.472
CLV_PCSK_SKI1_1 123 127 PF00082 0.329
CLV_PCSK_SKI1_1 144 148 PF00082 0.329
CLV_PCSK_SKI1_1 281 285 PF00082 0.542
CLV_PCSK_SKI1_1 46 50 PF00082 0.348
CLV_PCSK_SKI1_1 554 558 PF00082 0.705
CLV_PCSK_SKI1_1 559 563 PF00082 0.717
CLV_PCSK_SKI1_1 62 66 PF00082 0.297
CLV_PCSK_SKI1_1 69 73 PF00082 0.314
DEG_APCC_DBOX_1 45 53 PF00400 0.441
DEG_SPOP_SBC_1 689 693 PF00917 0.619
DOC_CKS1_1 376 381 PF01111 0.686
DOC_CKS1_1 474 479 PF01111 0.554
DOC_CYCLIN_RxL_1 276 285 PF00134 0.558
DOC_CYCLIN_yCln2_LP_2 505 508 PF00134 0.600
DOC_MAPK_DCC_7 374 382 PF00069 0.561
DOC_MAPK_gen_1 44 51 PF00069 0.372
DOC_MAPK_gen_1 66 76 PF00069 0.348
DOC_MAPK_gen_1 90 98 PF00069 0.441
DOC_MAPK_MEF2A_6 44 51 PF00069 0.372
DOC_MAPK_MEF2A_6 723 731 PF00069 0.588
DOC_MAPK_MEF2A_6 90 99 PF00069 0.377
DOC_MAPK_NFAT4_5 92 100 PF00069 0.402
DOC_MAPK_RevD_3 541 555 PF00069 0.711
DOC_PP2B_LxvP_1 491 494 PF13499 0.658
DOC_PP2B_LxvP_1 504 507 PF13499 0.521
DOC_USP7_MATH_1 388 392 PF00917 0.477
DOC_USP7_MATH_1 512 516 PF00917 0.728
DOC_USP7_MATH_1 529 533 PF00917 0.446
DOC_USP7_MATH_1 591 595 PF00917 0.651
DOC_USP7_UBL2_3 406 410 PF12436 0.680
DOC_USP7_UBL2_3 68 72 PF12436 0.455
DOC_USP7_UBL2_3 728 732 PF12436 0.497
DOC_WW_Pin1_4 180 185 PF00397 0.318
DOC_WW_Pin1_4 320 325 PF00397 0.575
DOC_WW_Pin1_4 375 380 PF00397 0.628
DOC_WW_Pin1_4 473 478 PF00397 0.758
DOC_WW_Pin1_4 569 574 PF00397 0.712
DOC_WW_Pin1_4 615 620 PF00397 0.701
DOC_WW_Pin1_4 640 645 PF00397 0.781
LIG_14-3-3_CanoR_1 138 148 PF00244 0.441
LIG_14-3-3_CanoR_1 263 267 PF00244 0.346
LIG_14-3-3_CanoR_1 281 287 PF00244 0.382
LIG_14-3-3_CanoR_1 296 302 PF00244 0.521
LIG_14-3-3_CanoR_1 342 351 PF00244 0.707
LIG_14-3-3_CanoR_1 554 559 PF00244 0.656
LIG_14-3-3_CanoR_1 613 622 PF00244 0.796
LIG_14-3-3_CanoR_1 735 739 PF00244 0.600
LIG_Actin_WH2_2 682 700 PF00022 0.453
LIG_AP2alpha_2 511 513 PF02296 0.699
LIG_BIR_II_1 1 5 PF00653 0.691
LIG_BRCT_BRCA1_1 226 230 PF00533 0.231
LIG_BRCT_BRCA1_1 578 582 PF00533 0.634
LIG_BRCT_BRCA1_2 226 232 PF00533 0.231
LIG_EVH1_1 491 495 PF00568 0.546
LIG_FHA_1 298 304 PF00498 0.624
LIG_FHA_1 40 46 PF00498 0.472
LIG_FHA_1 531 537 PF00498 0.645
LIG_FHA_1 591 597 PF00498 0.670
LIG_FHA_1 616 622 PF00498 0.540
LIG_FHA_1 766 772 PF00498 0.557
LIG_FHA_2 140 146 PF00498 0.441
LIG_FHA_2 376 382 PF00498 0.689
LIG_FHA_2 661 667 PF00498 0.697
LIG_FHA_2 690 696 PF00498 0.585
LIG_FHA_2 734 740 PF00498 0.626
LIG_FHA_2 89 95 PF00498 0.329
LIG_GBD_Chelix_1 758 766 PF00786 0.508
LIG_LIR_Apic_2 183 189 PF02991 0.314
LIG_LIR_Apic_2 235 241 PF02991 0.331
LIG_LIR_Apic_2 373 379 PF02991 0.655
LIG_LIR_Gen_1 124 134 PF02991 0.300
LIG_LIR_Gen_1 285 292 PF02991 0.536
LIG_LIR_Gen_1 31 39 PF02991 0.402
LIG_LIR_Gen_1 365 375 PF02991 0.571
LIG_LIR_Gen_1 515 525 PF02991 0.607
LIG_LIR_Gen_1 579 588 PF02991 0.768
LIG_LIR_Gen_1 699 709 PF02991 0.601
LIG_LIR_Gen_1 716 727 PF02991 0.396
LIG_LIR_Nem_3 106 111 PF02991 0.329
LIG_LIR_Nem_3 124 129 PF02991 0.329
LIG_LIR_Nem_3 227 233 PF02991 0.358
LIG_LIR_Nem_3 285 291 PF02991 0.502
LIG_LIR_Nem_3 31 35 PF02991 0.383
LIG_LIR_Nem_3 365 370 PF02991 0.533
LIG_LIR_Nem_3 395 400 PF02991 0.551
LIG_LIR_Nem_3 454 458 PF02991 0.775
LIG_LIR_Nem_3 515 520 PF02991 0.599
LIG_LIR_Nem_3 579 585 PF02991 0.777
LIG_LIR_Nem_3 716 722 PF02991 0.532
LIG_LIR_Nem_3 83 89 PF02991 0.441
LIG_LYPXL_SIV_4 755 763 PF13949 0.589
LIG_LYPXL_yS_3 724 727 PF13949 0.577
LIG_MYND_1 273 277 PF01753 0.402
LIG_NRBOX 251 257 PF00104 0.372
LIG_PCNA_yPIPBox_3 246 256 PF02747 0.418
LIG_Pex14_1 513 517 PF04695 0.693
LIG_Pex14_1 711 715 PF04695 0.601
LIG_Pex14_2 677 681 PF04695 0.596
LIG_Rb_pABgroove_1 80 88 PF01858 0.348
LIG_SH2_CRK 212 216 PF00017 0.329
LIG_SH2_CRK 288 292 PF00017 0.537
LIG_SH2_CRK 367 371 PF00017 0.553
LIG_SH2_CRK 438 442 PF00017 0.644
LIG_SH2_CRK 517 521 PF00017 0.605
LIG_SH2_CRK 86 90 PF00017 0.329
LIG_SH2_GRB2like 367 370 PF00017 0.531
LIG_SH2_NCK_1 186 190 PF00017 0.329
LIG_SH2_NCK_1 517 521 PF00017 0.681
LIG_SH2_PTP2 238 241 PF00017 0.354
LIG_SH2_PTP2 400 403 PF00017 0.703
LIG_SH2_SRC 238 241 PF00017 0.441
LIG_SH2_STAP1 288 292 PF00017 0.458
LIG_SH2_STAP1 367 371 PF00017 0.527
LIG_SH2_STAP1 715 719 PF00017 0.589
LIG_SH2_STAP1 756 760 PF00017 0.606
LIG_SH2_STAT5 101 104 PF00017 0.329
LIG_SH2_STAT5 110 113 PF00017 0.329
LIG_SH2_STAT5 135 138 PF00017 0.329
LIG_SH2_STAT5 238 241 PF00017 0.260
LIG_SH2_STAT5 243 246 PF00017 0.260
LIG_SH2_STAT5 282 285 PF00017 0.480
LIG_SH2_STAT5 302 305 PF00017 0.319
LIG_SH2_STAT5 363 366 PF00017 0.644
LIG_SH2_STAT5 400 403 PF00017 0.580
LIG_SH2_STAT5 718 721 PF00017 0.504
LIG_SH3_2 474 479 PF14604 0.554
LIG_SH3_3 254 260 PF00018 0.329
LIG_SH3_3 274 280 PF00018 0.231
LIG_SH3_3 471 477 PF00018 0.545
LIG_SH3_3 489 495 PF00018 0.761
LIG_SH3_3 517 523 PF00018 0.617
LIG_SH3_3 582 588 PF00018 0.701
LIG_SH3_3 719 725 PF00018 0.468
LIG_SUMO_SIM_anti_2 222 230 PF11976 0.472
LIG_SUMO_SIM_anti_2 309 314 PF11976 0.397
LIG_SUMO_SIM_anti_2 94 100 PF11976 0.336
LIG_SUMO_SIM_par_1 304 311 PF11976 0.405
LIG_SUMO_SIM_par_1 94 100 PF11976 0.336
LIG_TRAF2_1 333 336 PF00917 0.511
LIG_TRAF2_1 412 415 PF00917 0.747
LIG_TYR_ITIM 210 215 PF00017 0.329
LIG_TYR_ITIM 286 291 PF00017 0.445
LIG_TYR_ITIM 398 403 PF00017 0.557
LIG_TYR_ITIM 722 727 PF00017 0.565
MOD_CDC14_SPxK_1 643 646 PF00782 0.530
MOD_CDK_SPK_2 615 620 PF00069 0.541
MOD_CDK_SPxK_1 473 479 PF00069 0.554
MOD_CDK_SPxK_1 640 646 PF00069 0.532
MOD_CK1_1 168 174 PF00069 0.367
MOD_CK1_1 180 186 PF00069 0.274
MOD_CK1_1 224 230 PF00069 0.476
MOD_CK1_1 242 248 PF00069 0.427
MOD_CK1_1 323 329 PF00069 0.377
MOD_CK1_1 425 431 PF00069 0.687
MOD_CK1_1 498 504 PF00069 0.632
MOD_CK1_1 532 538 PF00069 0.440
MOD_CK1_1 568 574 PF00069 0.677
MOD_CK1_1 590 596 PF00069 0.727
MOD_CK1_1 615 621 PF00069 0.689
MOD_CK1_1 693 699 PF00069 0.588
MOD_CK1_1 748 754 PF00069 0.528
MOD_CK1_1 785 791 PF00069 0.649
MOD_CK2_1 100 106 PF00069 0.329
MOD_CK2_1 375 381 PF00069 0.665
MOD_CK2_1 418 424 PF00069 0.744
MOD_CK2_1 456 462 PF00069 0.759
MOD_CK2_1 623 629 PF00069 0.700
MOD_CK2_1 689 695 PF00069 0.592
MOD_CK2_1 734 740 PF00069 0.536
MOD_CK2_1 758 764 PF00069 0.581
MOD_GlcNHglycan 102 105 PF01048 0.329
MOD_GlcNHglycan 192 195 PF01048 0.348
MOD_GlcNHglycan 424 427 PF01048 0.760
MOD_GlcNHglycan 449 452 PF01048 0.642
MOD_GlcNHglycan 514 517 PF01048 0.719
MOD_GlcNHglycan 579 582 PF01048 0.636
MOD_GlcNHglycan 589 592 PF01048 0.573
MOD_GlcNHglycan 62 65 PF01048 0.441
MOD_GlcNHglycan 750 753 PF01048 0.520
MOD_GSK3_1 156 163 PF00069 0.441
MOD_GSK3_1 176 183 PF00069 0.144
MOD_GSK3_1 292 299 PF00069 0.580
MOD_GSK3_1 311 318 PF00069 0.532
MOD_GSK3_1 418 425 PF00069 0.650
MOD_GSK3_1 447 454 PF00069 0.631
MOD_GSK3_1 456 463 PF00069 0.601
MOD_GSK3_1 469 476 PF00069 0.638
MOD_GSK3_1 495 502 PF00069 0.586
MOD_GSK3_1 550 557 PF00069 0.629
MOD_GSK3_1 56 63 PF00069 0.331
MOD_GSK3_1 563 570 PF00069 0.655
MOD_GSK3_1 583 590 PF00069 0.561
MOD_GSK3_1 608 615 PF00069 0.625
MOD_GSK3_1 630 637 PF00069 0.673
MOD_GSK3_1 660 667 PF00069 0.634
MOD_GSK3_1 689 696 PF00069 0.501
MOD_GSK3_1 781 788 PF00069 0.683
MOD_LATS_1 528 534 PF00433 0.696
MOD_LATS_1 575 581 PF00433 0.528
MOD_N-GLC_1 224 229 PF02516 0.420
MOD_N-GLC_1 418 423 PF02516 0.573
MOD_N-GLC_1 451 456 PF02516 0.700
MOD_N-GLC_1 640 645 PF02516 0.687
MOD_N-GLC_1 689 694 PF02516 0.624
MOD_N-GLC_2 772 774 PF02516 0.371
MOD_NEK2_1 1 6 PF00069 0.690
MOD_NEK2_1 165 170 PF00069 0.339
MOD_NEK2_1 176 181 PF00069 0.310
MOD_NEK2_1 215 220 PF00069 0.377
MOD_NEK2_1 221 226 PF00069 0.318
MOD_NEK2_1 297 302 PF00069 0.592
MOD_NEK2_1 422 427 PF00069 0.663
MOD_NEK2_1 429 434 PF00069 0.579
MOD_NEK2_1 460 465 PF00069 0.679
MOD_NEK2_1 550 555 PF00069 0.672
MOD_NEK2_1 567 572 PF00069 0.596
MOD_NEK2_1 632 637 PF00069 0.733
MOD_NEK2_1 688 693 PF00069 0.583
MOD_NEK2_2 156 161 PF00069 0.372
MOD_NEK2_2 282 287 PF00069 0.504
MOD_NEK2_2 664 669 PF00069 0.696
MOD_PIKK_1 1 7 PF00454 0.689
MOD_PIKK_1 401 407 PF00454 0.680
MOD_PIKK_1 429 435 PF00454 0.671
MOD_PIKK_1 634 640 PF00454 0.525
MOD_PIKK_1 746 752 PF00454 0.430
MOD_PIKK_1 782 788 PF00454 0.605
MOD_PKA_1 406 412 PF00069 0.638
MOD_PKA_1 554 560 PF00069 0.762
MOD_PKA_1 562 568 PF00069 0.653
MOD_PKA_1 577 583 PF00069 0.471
MOD_PKA_2 139 145 PF00069 0.441
MOD_PKA_2 262 268 PF00069 0.329
MOD_PKA_2 28 34 PF00069 0.329
MOD_PKA_2 554 560 PF00069 0.731
MOD_PKA_2 562 568 PF00069 0.689
MOD_PKA_2 577 583 PF00069 0.659
MOD_PKA_2 612 618 PF00069 0.768
MOD_PKA_2 734 740 PF00069 0.595
MOD_Plk_1 224 230 PF00069 0.420
MOD_Plk_1 292 298 PF00069 0.622
MOD_Plk_1 418 424 PF00069 0.655
MOD_Plk_1 451 457 PF00069 0.698
MOD_Plk_1 461 467 PF00069 0.685
MOD_Plk_1 484 490 PF00069 0.650
MOD_Plk_1 563 569 PF00069 0.646
MOD_Plk_2-3 262 268 PF00069 0.329
MOD_Plk_4 239 245 PF00069 0.435
MOD_Plk_4 297 303 PF00069 0.604
MOD_Plk_4 326 332 PF00069 0.592
MOD_Plk_4 396 402 PF00069 0.588
MOD_Plk_4 425 431 PF00069 0.661
MOD_Plk_4 532 538 PF00069 0.560
MOD_Plk_4 591 597 PF00069 0.590
MOD_Plk_4 6 12 PF00069 0.504
MOD_Plk_4 664 670 PF00069 0.697
MOD_Plk_4 758 764 PF00069 0.551
MOD_ProDKin_1 180 186 PF00069 0.318
MOD_ProDKin_1 320 326 PF00069 0.576
MOD_ProDKin_1 375 381 PF00069 0.633
MOD_ProDKin_1 473 479 PF00069 0.763
MOD_ProDKin_1 569 575 PF00069 0.708
MOD_ProDKin_1 615 621 PF00069 0.701
MOD_ProDKin_1 640 646 PF00069 0.783
MOD_SUMO_for_1 146 149 PF00179 0.329
MOD_SUMO_for_1 561 564 PF00179 0.771
MOD_SUMO_for_1 67 70 PF00179 0.472
MOD_SUMO_for_1 704 707 PF00179 0.490
MOD_SUMO_rev_2 368 375 PF00179 0.613
MOD_SUMO_rev_2 739 748 PF00179 0.494
TRG_ENDOCYTIC_2 212 215 PF00928 0.329
TRG_ENDOCYTIC_2 288 291 PF00928 0.446
TRG_ENDOCYTIC_2 363 366 PF00928 0.564
TRG_ENDOCYTIC_2 367 370 PF00928 0.528
TRG_ENDOCYTIC_2 400 403 PF00928 0.544
TRG_ENDOCYTIC_2 438 441 PF00928 0.644
TRG_ENDOCYTIC_2 517 520 PF00928 0.576
TRG_ENDOCYTIC_2 701 704 PF00928 0.441
TRG_ENDOCYTIC_2 718 721 PF00928 0.434
TRG_ENDOCYTIC_2 724 727 PF00928 0.551
TRG_ENDOCYTIC_2 86 89 PF00928 0.329
TRG_ER_diArg_1 356 358 PF00400 0.641
TRG_ER_diArg_1 554 556 PF00400 0.764
TRG_ER_diArg_1 766 769 PF00400 0.476
TRG_Pf-PMV_PEXEL_1 123 127 PF00026 0.329
TRG_Pf-PMV_PEXEL_1 54 58 PF00026 0.441

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7V2 Leptomonas seymouri 70% 98%
A0A1X0P956 Trypanosomatidae 54% 100%
A0A3R7KDE9 Trypanosoma rangeli 47% 100%
A0A3S7XAF4 Leishmania donovani 81% 100%
A4ICP4 Leishmania infantum 81% 100%
D0A2R8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
Q4Q1Y6 Leishmania major 81% 100%
V5BQE9 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS