Nfu_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NifU-like domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HNU8_LEIBR

TriTrypDb:

LbrM.35.1000 , LBRM2903_350015600

Length:

260

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNU8

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0016226	iron-sulfur cluster assembly	4	11
GO:0022607	cellular component assembly	4	11
GO:0031163	metallo-sulfur cluster assembly	5	11
GO:0044237	cellular metabolic process	2	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0006807	nitrogen compound metabolic process	2	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0097428	protein maturation by iron-sulfur cluster transfer	5	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005506	iron ion binding	6	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11
GO:0051536	iron-sulfur cluster binding	3	11
GO:0051540	metal cluster binding	2	11
GO:0051539	4 iron, 4 sulfur cluster binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.327
CLV_C14_Caspase3-7	184	188	PF00656	0.439
CLV_C14_Caspase3-7	255	259	PF00656	0.427
CLV_NRD_NRD_1	235	237	PF00675	0.389
CLV_NRD_NRD_1	3	5	PF00675	0.481
CLV_NRD_NRD_1	8	10	PF00675	0.457
CLV_PCSK_KEX2_1	3	5	PF00082	0.505
CLV_PCSK_KEX2_1	8	10	PF00082	0.480
CLV_PCSK_PC7_1	4	10	PF00082	0.554
CLV_PCSK_SKI1_1	137	141	PF00082	0.271
CLV_PCSK_SKI1_1	191	195	PF00082	0.255
CLV_PCSK_SKI1_1	223	227	PF00082	0.591
CLV_Separin_Metazoa	138	142	PF03568	0.421
DEG_Nend_Nbox_1	1	3	PF02207	0.428
DOC_CKS1_1	16	21	PF01111	0.286
DOC_CYCLIN_RxL_1	134	142	PF00134	0.286
DOC_MAPK_MEF2A_6	163	171	PF00069	0.445
DOC_PP1_RVXF_1	154	161	PF00149	0.408
DOC_PP1_RVXF_1	46	53	PF00149	0.286
DOC_PP1_RVXF_1	88	94	PF00149	0.321
DOC_PP4_FxxP_1	26	29	PF00568	0.242
DOC_PP4_FxxP_1	72	75	PF00568	0.261
DOC_USP7_MATH_1	29	33	PF00917	0.350
DOC_USP7_UBL2_3	223	227	PF12436	0.473
DOC_WW_Pin1_4	108	113	PF00397	0.392
DOC_WW_Pin1_4	15	20	PF00397	0.242
DOC_WW_Pin1_4	242	247	PF00397	0.559
LIG_14-3-3_CanoR_1	3	7	PF00244	0.529
LIG_deltaCOP1_diTrp_1	87	93	PF00928	0.247
LIG_eIF4E_1	212	218	PF01652	0.384
LIG_FHA_1	162	168	PF00498	0.408
LIG_FHA_1	199	205	PF00498	0.455
LIG_FHA_1	243	249	PF00498	0.506
LIG_FHA_2	115	121	PF00498	0.448
LIG_FHA_2	182	188	PF00498	0.421
LIG_FHA_2	82	88	PF00498	0.307
LIG_LIR_Apic_2	25	29	PF02991	0.325
LIG_LIR_Gen_1	115	123	PF02991	0.424
LIG_LIR_Gen_1	250	257	PF02991	0.499
LIG_LIR_Gen_1	31	38	PF02991	0.265
LIG_LIR_Gen_1	81	91	PF02991	0.259
LIG_LIR_Nem_3	115	119	PF02991	0.403
LIG_LIR_Nem_3	213	218	PF02991	0.395
LIG_LIR_Nem_3	250	254	PF02991	0.498
LIG_LIR_Nem_3	31	36	PF02991	0.247
LIG_LIR_Nem_3	81	86	PF02991	0.253
LIG_LIR_Nem_3	87	91	PF02991	0.242
LIG_MYND_1	242	246	PF01753	0.387
LIG_SH2_CRK	215	219	PF00017	0.455
LIG_SH2_CRK	251	255	PF00017	0.564
LIG_SH2_GRB2like	83	86	PF00017	0.307
LIG_SH2_NCK_1	116	120	PF00017	0.367
LIG_SH2_NCK_1	83	87	PF00017	0.307
LIG_SH2_STAT5	102	105	PF00017	0.239
LIG_SH2_STAT5	116	119	PF00017	0.458
LIG_SH2_STAT5	83	86	PF00017	0.382
LIG_TYR_ITIM	249	254	PF00017	0.587
LIG_WRC_WIRS_1	33	38	PF05994	0.375
LIG_WRC_WIRS_1	95	100	PF05994	0.242
MOD_CDC14_SPxK_1	111	114	PF00782	0.398
MOD_CDK_SPxK_1	108	114	PF00069	0.401
MOD_CK1_1	181	187	PF00069	0.410
MOD_CK1_1	32	38	PF00069	0.440
MOD_CK1_1	81	87	PF00069	0.332
MOD_CK1_1	94	100	PF00069	0.176
MOD_CK2_1	114	120	PF00069	0.444
MOD_CK2_1	86	92	PF00069	0.398
MOD_GSK3_1	161	168	PF00069	0.435
MOD_GSK3_1	174	181	PF00069	0.408
MOD_N-GLC_1	127	132	PF02516	0.276
MOD_N-GLC_2	107	109	PF02516	0.382
MOD_NEK2_1	2	7	PF00069	0.506
MOD_NEK2_1	22	27	PF00069	0.220
MOD_PIKK_1	178	184	PF00454	0.421
MOD_PIKK_1	54	60	PF00454	0.321
MOD_PK_1	76	82	PF00069	0.261
MOD_PKA_2	2	8	PF00069	0.507
MOD_Plk_1	114	120	PF00069	0.461
MOD_Plk_1	91	97	PF00069	0.252
MOD_Plk_2-3	252	258	PF00069	0.392
MOD_Plk_4	114	120	PF00069	0.245
MOD_Plk_4	244	250	PF00069	0.512
MOD_Plk_4	32	38	PF00069	0.375
MOD_Plk_4	94	100	PF00069	0.242
MOD_ProDKin_1	108	114	PF00069	0.401
MOD_ProDKin_1	15	21	PF00069	0.242
MOD_ProDKin_1	242	248	PF00069	0.560
MOD_SUMO_rev_2	151	158	PF00179	0.429
TRG_DiLeu_BaEn_1	213	218	PF01217	0.392
TRG_ENDOCYTIC_2	102	105	PF00928	0.279
TRG_ENDOCYTIC_2	116	119	PF00928	0.426
TRG_ENDOCYTIC_2	215	218	PF00928	0.430
TRG_ENDOCYTIC_2	251	254	PF00928	0.538
TRG_ENDOCYTIC_2	83	86	PF00928	0.291
TRG_ER_diArg_1	2	4	PF00400	0.511
TRG_ER_diArg_1	8	10	PF00400	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2Q0	Leptomonas seymouri	34%	89%
A0A0N1I735	Leptomonas seymouri	83%	100%
A0A0S4IJH0	Bodo saltans	34%	100%
A0A0S4IVB5	Bodo saltans	60%	100%
A0A1X0NST9	Trypanosomatidae	33%	92%
A0A1X0P8F8	Trypanosomatidae	69%	100%
A0A3R7MX73	Trypanosoma rangeli	31%	100%
A0A3S5H7F5	Leishmania donovani	32%	92%
A0A3S7XAI2	Leishmania donovani	92%	87%
A4HEM5	Leishmania braziliensis	34%	100%
A4I1V6	Leishmania infantum	32%	92%
A4ICP6	Leishmania infantum	92%	87%
B3MRT7	Drosophila ananassae	29%	91%
B3NYF7	Drosophila erecta	31%	92%
B4H303	Drosophila persimilis	29%	92%
B4IMF6	Drosophila sechellia	30%	92%
B4JWR9	Drosophila grimshawi	28%	87%
B4M375	Drosophila virilis	28%	87%
B4NE93	Drosophila willistoni	29%	90%
B4PZ52	Drosophila yakuba	31%	92%
B4R3T1	Drosophila simulans	31%	92%
B5DKJ8	Drosophila pseudoobscura pseudoobscura	29%	91%
C9ZS65	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	93%
D0A2R6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9ASK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	86%
E9AY01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	93%
P32860	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
Q4Q1Y8	Leishmania major	89%	100%
Q4Q9H2	Leishmania major	33%	100%
Q8SY96	Drosophila melanogaster	30%	92%
Q9C8J2	Arabidopsis thaliana	34%	95%
Q9LIG6	Arabidopsis thaliana	32%	92%
Q9QZ23	Mus musculus	32%	100%
Q9UMS0	Homo sapiens	32%	100%
Q9UUB8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
V5DRN0	Trypanosoma cruzi	74%	100%