Putative DEAH-box RNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-mRNA splicing factor ATP-dependent RNA helicase, putative

Species:

Leishmania braziliensis

UniProt:

A4HNU7_LEIBR

TriTrypDb:

LbrM.35.0990 , LBRM2903_350015500

Length:

943

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005681	spliceosomal complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HNU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNU7

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016787	hydrolase activity	2	10
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003723	RNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	130	134	PF00656	0.526
CLV_C14_Caspase3-7	612	616	PF00656	0.306
CLV_C14_Caspase3-7	772	776	PF00656	0.607
CLV_NRD_NRD_1	18	20	PF00675	0.488
CLV_NRD_NRD_1	189	191	PF00675	0.384
CLV_NRD_NRD_1	286	288	PF00675	0.216
CLV_NRD_NRD_1	373	375	PF00675	0.216
CLV_NRD_NRD_1	500	502	PF00675	0.210
CLV_NRD_NRD_1	646	648	PF00675	0.229
CLV_NRD_NRD_1	7	9	PF00675	0.517
CLV_NRD_NRD_1	74	76	PF00675	0.595
CLV_NRD_NRD_1	865	867	PF00675	0.566
CLV_NRD_NRD_1	900	902	PF00675	0.424
CLV_NRD_NRD_1	937	939	PF00675	0.510
CLV_PCSK_KEX2_1	189	191	PF00082	0.413
CLV_PCSK_KEX2_1	286	288	PF00082	0.232
CLV_PCSK_KEX2_1	373	375	PF00082	0.216
CLV_PCSK_KEX2_1	646	648	PF00082	0.229
CLV_PCSK_KEX2_1	7	9	PF00082	0.595
CLV_PCSK_KEX2_1	73	75	PF00082	0.573
CLV_PCSK_KEX2_1	839	841	PF00082	0.588
CLV_PCSK_KEX2_1	865	867	PF00082	0.351
CLV_PCSK_KEX2_1	900	902	PF00082	0.442
CLV_PCSK_KEX2_1	904	906	PF00082	0.323
CLV_PCSK_KEX2_1	939	941	PF00082	0.574
CLV_PCSK_PC1ET2_1	839	841	PF00082	0.602
CLV_PCSK_PC1ET2_1	904	906	PF00082	0.357
CLV_PCSK_PC1ET2_1	939	941	PF00082	0.574
CLV_PCSK_PC7_1	369	375	PF00082	0.309
CLV_PCSK_PC7_1	900	906	PF00082	0.389
CLV_PCSK_SKI1_1	14	18	PF00082	0.495
CLV_PCSK_SKI1_1	155	159	PF00082	0.483
CLV_PCSK_SKI1_1	3	7	PF00082	0.602
CLV_PCSK_SKI1_1	335	339	PF00082	0.231
CLV_PCSK_SKI1_1	473	477	PF00082	0.223
CLV_PCSK_SKI1_1	569	573	PF00082	0.394
CLV_PCSK_SKI1_1	690	694	PF00082	0.331
CLV_PCSK_SKI1_1	742	746	PF00082	0.332
CLV_PCSK_SKI1_1	748	752	PF00082	0.303
CLV_PCSK_SKI1_1	75	79	PF00082	0.633
CLV_PCSK_SKI1_1	804	808	PF00082	0.303
CLV_PCSK_SKI1_1	871	875	PF00082	0.533
CLV_PCSK_SKI1_1	890	894	PF00082	0.309
CLV_PCSK_SKI1_1	905	909	PF00082	0.520
CLV_Separin_Metazoa	587	591	PF03568	0.325
DEG_APCC_DBOX_1	197	205	PF00400	0.254
DEG_APCC_DBOX_1	747	755	PF00400	0.338
DEG_Nend_UBRbox_2	1	3	PF02207	0.549
DEG_SCF_FBW7_1	245	251	PF00400	0.364
DOC_AGCK_PIF_1	571	576	PF00069	0.447
DOC_CKS1_1	245	250	PF01111	0.451
DOC_CYCLIN_RxL_1	801	808	PF00134	0.365
DOC_MAPK_gen_1	206	214	PF00069	0.426
DOC_MAPK_gen_1	286	293	PF00069	0.416
DOC_MAPK_gen_1	373	380	PF00069	0.405
DOC_MAPK_gen_1	888	897	PF00069	0.315
DOC_MAPK_HePTP_8	887	899	PF00069	0.404
DOC_MAPK_MEF2A_6	206	214	PF00069	0.405
DOC_MAPK_MEF2A_6	373	382	PF00069	0.405
DOC_MAPK_MEF2A_6	469	478	PF00069	0.416
DOC_MAPK_MEF2A_6	756	765	PF00069	0.397
DOC_MAPK_MEF2A_6	888	897	PF00069	0.321
DOC_PP1_RVXF_1	310	316	PF00149	0.405
DOC_PP2B_LxvP_1	476	479	PF13499	0.416
DOC_PP2B_LxvP_1	614	617	PF13499	0.362
DOC_USP7_MATH_1	125	129	PF00917	0.575
DOC_USP7_MATH_1	138	142	PF00917	0.547
DOC_USP7_MATH_1	248	252	PF00917	0.425
DOC_USP7_MATH_1	304	308	PF00917	0.534
DOC_USP7_MATH_1	510	514	PF00917	0.417
DOC_USP7_MATH_1	60	64	PF00917	0.517
DOC_USP7_MATH_1	829	833	PF00917	0.458
DOC_USP7_MATH_1	912	916	PF00917	0.374
DOC_WW_Pin1_4	101	106	PF00397	0.612
DOC_WW_Pin1_4	244	249	PF00397	0.492
DOC_WW_Pin1_4	482	487	PF00397	0.443
DOC_WW_Pin1_4	493	498	PF00397	0.407
LIG_14-3-3_CanoR_1	137	147	PF00244	0.726
LIG_14-3-3_CanoR_1	279	285	PF00244	0.429
LIG_14-3-3_CanoR_1	357	367	PF00244	0.412
LIG_14-3-3_CanoR_1	558	564	PF00244	0.445
LIG_14-3-3_CanoR_1	569	576	PF00244	0.327
LIG_14-3-3_CanoR_1	590	600	PF00244	0.283
LIG_14-3-3_CanoR_1	640	644	PF00244	0.413
LIG_14-3-3_CanoR_1	865	874	PF00244	0.407
LIG_14-3-3_CanoR_1	87	95	PF00244	0.632
LIG_14-3-3_CanoR_1	900	907	PF00244	0.405
LIG_14-3-3_CanoR_1	97	105	PF00244	0.451
LIG_Actin_WH2_2	356	371	PF00022	0.405
LIG_Actin_WH2_2	710	727	PF00022	0.374
LIG_AP2alpha_1	392	396	PF02296	0.433
LIG_BRCT_BRCA1_1	392	396	PF00533	0.322
LIG_BRCT_BRCA1_1	65	69	PF00533	0.533
LIG_BRCT_BRCA1_1	807	811	PF00533	0.327
LIG_BRCT_BRCA1_1	857	861	PF00533	0.348
LIG_BRCT_BRCA1_2	392	398	PF00533	0.373
LIG_Clathr_ClatBox_1	608	612	PF01394	0.319
LIG_FHA_1	220	226	PF00498	0.413
LIG_FHA_1	317	323	PF00498	0.420
LIG_FHA_1	359	365	PF00498	0.429
LIG_FHA_1	406	412	PF00498	0.360
LIG_FHA_1	617	623	PF00498	0.360
LIG_FHA_1	712	718	PF00498	0.423
LIG_FHA_1	801	807	PF00498	0.271
LIG_FHA_2	164	170	PF00498	0.478
LIG_FHA_2	29	35	PF00498	0.623
LIG_FHA_2	454	460	PF00498	0.491
LIG_FHA_2	582	588	PF00498	0.329
LIG_FHA_2	62	68	PF00498	0.590
LIG_FHA_2	875	881	PF00498	0.619
LIG_LIR_Apic_2	531	535	PF02991	0.447
LIG_LIR_Gen_1	141	152	PF02991	0.539
LIG_LIR_Gen_1	164	175	PF02991	0.616
LIG_LIR_Gen_1	390	400	PF02991	0.466
LIG_LIR_Gen_1	714	724	PF02991	0.442
LIG_LIR_Gen_1	736	745	PF02991	0.434
LIG_LIR_Gen_1	757	765	PF02991	0.499
LIG_LIR_Gen_1	823	830	PF02991	0.357
LIG_LIR_Gen_1	86	95	PF02991	0.524
LIG_LIR_Nem_3	164	170	PF02991	0.625
LIG_LIR_Nem_3	390	395	PF02991	0.464
LIG_LIR_Nem_3	566	571	PF02991	0.341
LIG_LIR_Nem_3	714	719	PF02991	0.358
LIG_LIR_Nem_3	736	741	PF02991	0.436
LIG_LIR_Nem_3	757	761	PF02991	0.481
LIG_LIR_Nem_3	808	814	PF02991	0.293
LIG_LIR_Nem_3	823	827	PF02991	0.283
LIG_LIR_Nem_3	86	91	PF02991	0.552
LIG_MLH1_MIPbox_1	392	396	PF16413	0.322
LIG_MLH1_MIPbox_1	807	811	PF16413	0.327
LIG_NRBOX	363	369	PF00104	0.405
LIG_NRBOX	627	633	PF00104	0.350
LIG_PCNA_yPIPBox_3	710	718	PF02747	0.299
LIG_Pex14_2	392	396	PF04695	0.288
LIG_REV1ctd_RIR_1	393	399	PF16727	0.454
LIG_SH2_CRK	824	828	PF00017	0.251
LIG_SH2_GRB2like	532	535	PF00017	0.447
LIG_SH2_GRB2like	738	741	PF00017	0.322
LIG_SH2_PTP2	716	719	PF00017	0.285
LIG_SH2_PTP2	738	741	PF00017	0.229
LIG_SH2_SRC	230	233	PF00017	0.472
LIG_SH2_SRC	738	741	PF00017	0.322
LIG_SH2_STAT3	533	536	PF00017	0.472
LIG_SH2_STAT5	144	147	PF00017	0.545
LIG_SH2_STAT5	161	164	PF00017	0.428
LIG_SH2_STAT5	228	231	PF00017	0.429
LIG_SH2_STAT5	327	330	PF00017	0.425
LIG_SH2_STAT5	423	426	PF00017	0.324
LIG_SH2_STAT5	464	467	PF00017	0.451
LIG_SH2_STAT5	521	524	PF00017	0.405
LIG_SH2_STAT5	574	577	PF00017	0.397
LIG_SH2_STAT5	716	719	PF00017	0.285
LIG_SH2_STAT5	738	741	PF00017	0.322
LIG_SH2_STAT5	927	930	PF00017	0.373
LIG_SH3_2	835	840	PF14604	0.442
LIG_SH3_3	298	304	PF00018	0.509
LIG_SH3_3	443	449	PF00018	0.445
LIG_SH3_3	649	655	PF00018	0.420
LIG_SH3_3	823	829	PF00018	0.426
LIG_SH3_3	832	838	PF00018	0.590
LIG_SH3_5	419	423	PF00018	0.343
LIG_SUMO_SIM_anti_2	764	769	PF11976	0.352
LIG_SUMO_SIM_par_1	210	217	PF11976	0.406
LIG_SUMO_SIM_par_1	678	684	PF11976	0.429
LIG_TRFH_1	234	238	PF08558	0.509
LIG_TRFH_1	651	655	PF08558	0.472
LIG_UBA3_1	628	636	PF00899	0.410
LIG_WRC_WIRS_1	755	760	PF05994	0.413
MOD_CDK_SPK_2	482	487	PF00069	0.432
MOD_CDK_SPxK_1	244	250	PF00069	0.350
MOD_CK1_1	219	225	PF00069	0.405
MOD_CK1_1	251	257	PF00069	0.429
MOD_CK1_1	358	364	PF00069	0.413
MOD_CK1_1	405	411	PF00069	0.472
MOD_CK1_1	427	433	PF00069	0.388
MOD_CK1_1	482	488	PF00069	0.350
MOD_CK1_1	548	554	PF00069	0.405
MOD_CK1_1	618	624	PF00069	0.350
MOD_CK1_1	63	69	PF00069	0.618
MOD_CK1_1	769	775	PF00069	0.477
MOD_CK1_1	867	873	PF00069	0.566
MOD_CK2_1	145	151	PF00069	0.506
MOD_CK2_1	163	169	PF00069	0.402
MOD_CK2_1	28	34	PF00069	0.561
MOD_CK2_1	289	295	PF00069	0.405
MOD_CK2_1	45	51	PF00069	0.355
MOD_CK2_1	453	459	PF00069	0.468
MOD_CK2_1	482	488	PF00069	0.457
MOD_CK2_1	581	587	PF00069	0.335
MOD_CK2_1	697	703	PF00069	0.421
MOD_CK2_1	847	853	PF00069	0.453
MOD_CK2_1	874	880	PF00069	0.656
MOD_Cter_Amidation	644	647	PF01082	0.229
MOD_Cter_Amidation	863	866	PF01082	0.519
MOD_GlcNHglycan	123	126	PF01048	0.698
MOD_GlcNHglycan	127	130	PF01048	0.668
MOD_GlcNHglycan	140	143	PF01048	0.579
MOD_GlcNHglycan	218	221	PF01048	0.205
MOD_GlcNHglycan	250	253	PF01048	0.205
MOD_GlcNHglycan	383	386	PF01048	0.205
MOD_GlcNHglycan	404	407	PF01048	0.422
MOD_GlcNHglycan	426	429	PF01048	0.359
MOD_GlcNHglycan	550	553	PF01048	0.205
MOD_GlcNHglycan	58	61	PF01048	0.569
MOD_GlcNHglycan	593	596	PF01048	0.425
MOD_GlcNHglycan	699	702	PF01048	0.390
MOD_GlcNHglycan	768	771	PF01048	0.627
MOD_GlcNHglycan	790	793	PF01048	0.597
MOD_GlcNHglycan	807	810	PF01048	0.210
MOD_GlcNHglycan	831	834	PF01048	0.562
MOD_GlcNHglycan	914	917	PF01048	0.409
MOD_GlcNHglycan	921	924	PF01048	0.365
MOD_GSK3_1	121	128	PF00069	0.683
MOD_GSK3_1	133	140	PF00069	0.631
MOD_GSK3_1	216	223	PF00069	0.405
MOD_GSK3_1	244	251	PF00069	0.421
MOD_GSK3_1	252	259	PF00069	0.390
MOD_GSK3_1	316	323	PF00069	0.436
MOD_GSK3_1	453	460	PF00069	0.491
MOD_GSK3_1	544	551	PF00069	0.465
MOD_GSK3_1	56	63	PF00069	0.366
MOD_GSK3_1	693	700	PF00069	0.513
MOD_GSK3_1	769	776	PF00069	0.647
MOD_GSK3_1	908	915	PF00069	0.326
MOD_GSK3_1	96	103	PF00069	0.683
MOD_LATS_1	355	361	PF00433	0.451
MOD_N-GLC_1	773	778	PF02516	0.436
MOD_NEK2_1	280	285	PF00069	0.405
MOD_NEK2_1	402	407	PF00069	0.435
MOD_NEK2_1	434	439	PF00069	0.334
MOD_NEK2_1	589	594	PF00069	0.329
MOD_NEK2_1	641	646	PF00069	0.405
MOD_NEK2_1	733	738	PF00069	0.343
MOD_NEK2_1	874	879	PF00069	0.582
MOD_NEK2_1	899	904	PF00069	0.405
MOD_PIKK_1	220	226	PF00454	0.405
MOD_PIKK_1	280	286	PF00454	0.418
MOD_PIKK_1	545	551	PF00454	0.459
MOD_PIKK_1	559	565	PF00454	0.416
MOD_PK_1	840	846	PF00069	0.702
MOD_PKA_1	865	871	PF00069	0.392
MOD_PKA_1	900	906	PF00069	0.409
MOD_PKA_2	589	595	PF00069	0.313
MOD_PKA_2	639	645	PF00069	0.413
MOD_PKA_2	86	92	PF00069	0.636
MOD_PKA_2	864	870	PF00069	0.621
MOD_PKA_2	899	905	PF00069	0.372
MOD_PKA_2	96	102	PF00069	0.450
MOD_PKB_1	163	171	PF00069	0.371
MOD_Plk_1	163	169	PF00069	0.576
MOD_Plk_1	341	347	PF00069	0.458
MOD_Plk_1	355	361	PF00069	0.356
MOD_Plk_1	510	516	PF00069	0.416
MOD_Plk_1	693	699	PF00069	0.457
MOD_Plk_1	847	853	PF00069	0.532
MOD_Plk_2-3	847	853	PF00069	0.311
MOD_Plk_4	252	258	PF00069	0.350
MOD_Plk_4	28	34	PF00069	0.603
MOD_Plk_4	304	310	PF00069	0.447
MOD_Plk_4	427	433	PF00069	0.408
MOD_Plk_4	45	51	PF00069	0.636
MOD_Plk_4	460	466	PF00069	0.451
MOD_Plk_4	681	687	PF00069	0.438
MOD_Plk_4	822	828	PF00069	0.315
MOD_Plk_4	855	861	PF00069	0.321
MOD_ProDKin_1	101	107	PF00069	0.612
MOD_ProDKin_1	244	250	PF00069	0.492
MOD_ProDKin_1	482	488	PF00069	0.443
MOD_ProDKin_1	493	499	PF00069	0.407
MOD_SUMO_for_1	257	260	PF00179	0.412
MOD_SUMO_for_1	815	818	PF00179	0.355
MOD_SUMO_rev_2	769	779	PF00179	0.650
TRG_AP2beta_CARGO_1	164	174	PF09066	0.502
TRG_DiLeu_BaEn_1	276	281	PF01217	0.491
TRG_DiLeu_BaEn_1	51	56	PF01217	0.579
TRG_DiLeu_BaEn_1	889	894	PF01217	0.310
TRG_DiLeu_BaEn_4	231	237	PF01217	0.509
TRG_DiLeu_BaLyEn_6	471	476	PF01217	0.447
TRG_DiLeu_LyEn_5	276	281	PF01217	0.491
TRG_ENDOCYTIC_2	144	147	PF00928	0.554
TRG_ENDOCYTIC_2	481	484	PF00928	0.405
TRG_ENDOCYTIC_2	568	571	PF00928	0.434
TRG_ENDOCYTIC_2	716	719	PF00928	0.285
TRG_ENDOCYTIC_2	738	741	PF00928	0.343
TRG_ENDOCYTIC_2	824	827	PF00928	0.330
TRG_ER_diArg_1	285	287	PF00400	0.416
TRG_ER_diArg_1	372	374	PF00400	0.429
TRG_ER_diArg_1	6	8	PF00400	0.615
TRG_ER_diArg_1	646	648	PF00400	0.429
TRG_ER_diArg_1	73	75	PF00400	0.598
TRG_ER_diArg_1	745	748	PF00400	0.340
TRG_ER_diArg_1	899	901	PF00400	0.524
TRG_ER_diArg_1	937	940	PF00400	0.544
TRG_NES_CRM1_1	587	599	PF08389	0.307
TRG_NLS_MonoExtC_3	937	942	PF00514	0.556
TRG_NLS_MonoExtN_4	938	943	PF00514	0.612
TRG_Pf-PMV_PEXEL_1	357	362	PF00026	0.216
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5V0	Leptomonas seymouri	36%	100%
A0A0N0P8Y1	Leptomonas seymouri	35%	100%
A0A0N0P9D2	Leptomonas seymouri	36%	100%
A0A0N1I0Z0	Leptomonas seymouri	35%	87%
A0A0N1IKA7	Leptomonas seymouri	34%	100%
A0A0N1PEU4	Leptomonas seymouri	72%	99%
A0A0S4IQ76	Bodo saltans	33%	100%
A0A0S4IR78	Bodo saltans	48%	100%
A0A0S4IS51	Bodo saltans	35%	100%
A0A0S4ITR4	Bodo saltans	37%	88%
A0A0S4IWU8	Bodo saltans	48%	100%
A0A0S4J157	Bodo saltans	37%	100%
A0A0S4JCY8	Bodo saltans	35%	92%
A0A1X0NJ46	Trypanosomatidae	36%	100%
A0A1X0NKY7	Trypanosomatidae	35%	88%
A0A1X0NUZ7	Trypanosomatidae	31%	72%
A0A1X0P0D7	Trypanosomatidae	37%	100%
A0A1X0P872	Trypanosomatidae	59%	100%
A0A1X0P9K6	Trypanosomatidae	37%	100%
A0A3Q8IEC9	Leishmania donovani	30%	87%
A0A3Q8II71	Leishmania donovani	36%	100%
A0A3Q8IJ24	Leishmania donovani	86%	100%
A0A3Q8IWG4	Leishmania donovani	35%	100%
A0A3R7MA90	Trypanosoma rangeli	36%	100%
A0A3R7MLF0	Trypanosoma rangeli	29%	67%
A0A3R7NT42	Trypanosoma rangeli	37%	100%
A0A3S7WYA1	Leishmania donovani	34%	87%
A0A3S7X8Z5	Leishmania donovani	36%	100%
A0A3S7XB01	Leishmania donovani	35%	87%
A0A422MXB1	Trypanosoma rangeli	36%	89%
A0A422N8L3	Trypanosoma rangeli	34%	93%
A1Z9L3	Drosophila melanogaster	39%	76%
A2A4P0	Mus musculus	39%	76%
A4HAT8	Leishmania braziliensis	34%	98%
A4HDG6	Leishmania braziliensis	33%	100%
A4HME2	Leishmania braziliensis	36%	93%
A4HPE9	Leishmania braziliensis	35%	87%
A4HQ83	Leishmania braziliensis	36%	100%
A4I009	Leishmania infantum	29%	87%
A4I0U7	Leishmania infantum	34%	87%
A4IA06	Leishmania infantum	36%	100%
A4IB14	Leishmania infantum	36%	100%
A4ICJ0	Leishmania infantum	35%	87%
A4ICP7	Leishmania infantum	87%	100%
A4IDY1	Leishmania infantum	35%	100%
B0XDC4	Culex quinquefasciatus	29%	68%
B8A4F4	Danio rerio	29%	70%
C9ZMN0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
C9ZNP6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
C9ZQ85	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	75%
D0A2R5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
D0A3F8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	89%
D0A429	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
D0A778	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	90%
E9AEU3	Leishmania major	36%	92%
E9ASK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AT60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	87%
E9AU01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AVY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	87%
E9AWV1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	76%
E9B512	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9B5Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
F4IE66	Arabidopsis thaliana	34%	100%
F4IJV4	Arabidopsis thaliana	42%	90%
F4JMJ3	Arabidopsis thaliana	37%	100%
F4JRJ6	Arabidopsis thaliana	35%	100%
F4K2E9	Arabidopsis thaliana	35%	75%
O22899	Arabidopsis thaliana	36%	100%
O35286	Mus musculus	36%	100%
O42643	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	81%
O42945	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
O43143	Homo sapiens	36%	100%
O45244	Caenorhabditis elegans	38%	94%
O60114	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	66%
O60231	Homo sapiens	37%	91%
O70133	Mus musculus	28%	68%
P20095	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
P24384	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	82%
P34498	Caenorhabditis elegans	38%	83%
P36009	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
P45018	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	33%	72%
P53131	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	100%
Q03319	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
Q09530	Caenorhabditis elegans	40%	79%
Q10752	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	89%
Q14562	Homo sapiens	39%	77%
Q14BI7	Mus musculus	28%	68%
Q17R09	Bos taurus	36%	77%
Q20875	Caenorhabditis elegans	35%	100%
Q28141	Bos taurus	28%	73%
Q2NKY8	Bos taurus	32%	77%
Q38953	Arabidopsis thaliana	39%	81%
Q3MHU3	Rattus norvegicus	29%	68%
Q3ZBE0	Bos taurus	30%	100%
Q4Q0J4	Leishmania major	35%	90%
Q4Q1D7	Leishmania major	35%	100%
Q4Q1Y9	Leishmania major	85%	100%
Q4Q2X4	Leishmania major	36%	100%
Q4QAM3	Leishmania major	34%	83%
Q4QBJ7	Leishmania major	30%	87%
Q54F05	Dictyostelium discoideum	37%	81%
Q54MH3	Dictyostelium discoideum	40%	85%
Q54NJ4	Dictyostelium discoideum	35%	100%
Q5BJS0	Rattus norvegicus	31%	79%
Q5R864	Pongo abelii	38%	100%
Q5RAZ4	Pongo abelii	36%	100%
Q5RBD4	Pongo abelii	37%	100%
Q5XH12	Xenopus laevis	27%	100%
Q5XI69	Rattus norvegicus	38%	100%
Q5ZI74	Gallus gallus	32%	77%
Q68FK8	Xenopus laevis	29%	75%
Q6PE54	Mus musculus	38%	100%
Q767K6	Sus scrofa	40%	90%
Q7K3M5	Drosophila melanogaster	36%	100%
Q7L7V1	Homo sapiens	28%	100%
Q7YR39	Pan troglodytes	37%	90%
Q80VY9	Mus musculus	33%	100%
Q8BZS9	Mus musculus	29%	100%
Q8IX18	Homo sapiens	38%	100%
Q8NDG6	Homo sapiens	29%	68%
Q8TE96	Homo sapiens	30%	100%
Q8VY00	Arabidopsis thaliana	40%	90%
Q924H9	Mus musculus	30%	100%
Q92620	Homo sapiens	36%	77%
Q99PU8	Mus musculus	31%	77%
Q9BKQ8	Caenorhabditis elegans	37%	100%
Q9C6G0	Arabidopsis thaliana	29%	67%
Q9H5Z1	Homo sapiens	37%	100%
Q9H6R0	Homo sapiens	33%	100%
Q9HDY4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	80%
Q9HE06	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
Q9LZQ9	Arabidopsis thaliana	36%	100%
V5B3L7	Trypanosoma cruzi	36%	100%
V5BKH2	Trypanosoma cruzi	37%	100%
V5BND8	Trypanosoma cruzi	28%	67%
V5BPV3	Trypanosoma cruzi	36%	89%
V5BV22	Trypanosoma cruzi	56%	100%
V5C0I9	Trypanosoma cruzi	35%	100%
V5D886	Trypanosoma cruzi	35%	100%