LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Putative mitogen-activated protein kinase kinase 5

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative mitogen-activated protein kinase kinase 5
Gene product:
mitogen-activated protein kinase kinase 5
Species:
Leishmania braziliensis
UniProt:
A4HNU6_LEIBR
TriTrypDb:
LbrM.35.0980 , LBRM2903_350015400 *
Length:
526

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 25
NetGPI no yes: 0, no: 25
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 4
GO:0110165 cellular anatomical entity 1 4

Expansion

Sequence features

A4HNU6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNU6

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 26
GO:0006793 phosphorus metabolic process 3 26
GO:0006796 phosphate-containing compound metabolic process 4 26
GO:0006807 nitrogen compound metabolic process 2 26
GO:0008152 metabolic process 1 26
GO:0009987 cellular process 1 26
GO:0016310 phosphorylation 5 26
GO:0019538 protein metabolic process 3 26
GO:0036211 protein modification process 4 26
GO:0043170 macromolecule metabolic process 3 26
GO:0043412 macromolecule modification 4 26
GO:0044237 cellular metabolic process 2 26
GO:0044238 primary metabolic process 2 26
GO:0071704 organic substance metabolic process 2 26
GO:1901564 organonitrogen compound metabolic process 3 26
GO:0000165 MAPK cascade 4 1
GO:0001932 regulation of protein phosphorylation 7 1
GO:0001934 positive regulation of protein phosphorylation 8 1
GO:0007165 signal transduction 2 1
GO:0009893 positive regulation of metabolic process 4 1
GO:0009966 regulation of signal transduction 4 1
GO:0009967 positive regulation of signal transduction 5 1
GO:0010562 positive regulation of phosphorus metabolic process 6 1
GO:0010604 positive regulation of macromolecule metabolic process 5 1
GO:0010646 regulation of cell communication 4 1
GO:0010647 positive regulation of cell communication 5 1
GO:0019220 regulation of phosphate metabolic process 6 1
GO:0019222 regulation of metabolic process 3 1
GO:0023051 regulation of signaling 3 1
GO:0023056 positive regulation of signaling 4 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031325 positive regulation of cellular metabolic process 5 1
GO:0031399 regulation of protein modification process 6 1
GO:0031401 positive regulation of protein modification process 7 1
GO:0033674 positive regulation of kinase activity 6 1
GO:0035556 intracellular signal transduction 3 1
GO:0042325 regulation of phosphorylation 7 1
GO:0042327 positive regulation of phosphorylation 8 1
GO:0043085 positive regulation of catalytic activity 4 1
GO:0043405 regulation of MAP kinase activity 8 1
GO:0043406 positive regulation of MAP kinase activity 8 1
GO:0043408 regulation of MAPK cascade 6 1
GO:0043410 positive regulation of MAPK cascade 7 1
GO:0043549 regulation of kinase activity 5 1
GO:0044093 positive regulation of molecular function 3 1
GO:0045859 regulation of protein kinase activity 6 1
GO:0045860 positive regulation of protein kinase activity 7 1
GO:0045937 positive regulation of phosphate metabolic process 7 1
GO:0046777 protein autophosphorylation 6 1
GO:0048518 positive regulation of biological process 3 1
GO:0048522 positive regulation of cellular process 4 1
GO:0048583 regulation of response to stimulus 3 1
GO:0048584 positive regulation of response to stimulus 4 1
GO:0050789 regulation of biological process 2 1
GO:0050790 regulation of catalytic activity 3 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051173 positive regulation of nitrogen compound metabolic process 5 1
GO:0051174 regulation of phosphorus metabolic process 5 1
GO:0051246 regulation of protein metabolic process 5 1
GO:0051247 positive regulation of protein metabolic process 6 1
GO:0051338 regulation of transferase activity 4 1
GO:0051347 positive regulation of transferase activity 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0065009 regulation of molecular function 2 1
GO:0071900 regulation of protein serine/threonine kinase activity 7 1
GO:0071902 positive regulation of protein serine/threonine kinase activity 8 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1902531 regulation of intracellular signal transduction 5 1
GO:1902533 positive regulation of intracellular signal transduction 6 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 26
GO:0003824 catalytic activity 1 26
GO:0004672 protein kinase activity 3 26
GO:0005488 binding 1 26
GO:0005524 ATP binding 5 26
GO:0016301 kinase activity 4 26
GO:0016740 transferase activity 2 26
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 26
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 26
GO:0017076 purine nucleotide binding 4 26
GO:0030554 adenyl nucleotide binding 5 26
GO:0032553 ribonucleotide binding 3 26
GO:0032555 purine ribonucleotide binding 4 26
GO:0032559 adenyl ribonucleotide binding 5 26
GO:0035639 purine ribonucleoside triphosphate binding 4 26
GO:0036094 small molecule binding 2 26
GO:0043167 ion binding 2 26
GO:0043168 anion binding 3 26
GO:0097159 organic cyclic compound binding 2 26
GO:0097367 carbohydrate derivative binding 2 26
GO:0140096 catalytic activity, acting on a protein 2 26
GO:1901265 nucleoside phosphate binding 3 26
GO:1901363 heterocyclic compound binding 2 26
GO:0004674 protein serine/threonine kinase activity 4 12
GO:0004707 MAP kinase activity 5 4
GO:0004708 MAP kinase kinase activity 5 1
GO:0004712 protein serine/threonine/tyrosine kinase activity 4 1
GO:0005515 protein binding 2 1
GO:0019899 enzyme binding 3 1
GO:0019900 kinase binding 4 1
GO:0019901 protein kinase binding 5 1
GO:0051019 mitogen-activated protein kinase binding 6 1
GO:0004140 dephospho-CoA kinase activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 136 140 PF00656 0.212
CLV_C14_Caspase3-7 207 211 PF00656 0.231
CLV_C14_Caspase3-7 442 446 PF00656 0.499
CLV_NRD_NRD_1 102 104 PF00675 0.224
CLV_NRD_NRD_1 304 306 PF00675 0.280
CLV_NRD_NRD_1 420 422 PF00675 0.520
CLV_NRD_NRD_1 506 508 PF00675 0.518
CLV_NRD_NRD_1 74 76 PF00675 0.235
CLV_NRD_NRD_1 79 81 PF00675 0.232
CLV_PCSK_KEX2_1 102 104 PF00082 0.230
CLV_PCSK_KEX2_1 304 306 PF00082 0.232
CLV_PCSK_KEX2_1 415 417 PF00082 0.448
CLV_PCSK_KEX2_1 420 422 PF00082 0.385
CLV_PCSK_KEX2_1 506 508 PF00082 0.505
CLV_PCSK_KEX2_1 74 76 PF00082 0.258
CLV_PCSK_KEX2_1 79 81 PF00082 0.236
CLV_PCSK_PC1ET2_1 415 417 PF00082 0.448
CLV_PCSK_PC7_1 416 422 PF00082 0.400
CLV_PCSK_PC7_1 75 81 PF00082 0.174
CLV_PCSK_SKI1_1 159 163 PF00082 0.275
CLV_PCSK_SKI1_1 177 181 PF00082 0.315
CLV_PCSK_SKI1_1 313 317 PF00082 0.176
CLV_PCSK_SKI1_1 416 420 PF00082 0.424
CLV_PCSK_SKI1_1 507 511 PF00082 0.502
CLV_PCSK_SKI1_1 88 92 PF00082 0.266
DEG_APCC_DBOX_1 101 109 PF00400 0.214
DEG_APCC_DBOX_1 158 166 PF00400 0.212
DEG_APCC_DBOX_1 431 439 PF00400 0.479
DEG_SCF_TRCP1_1 483 488 PF00400 0.496
DOC_CKS1_1 113 118 PF01111 0.221
DOC_CYCLIN_yClb1_LxF_4 521 526 PF00134 0.429
DOC_CYCLIN_yCln2_LP_2 145 151 PF00134 0.221
DOC_CYCLIN_yCln2_LP_2 345 348 PF00134 0.496
DOC_MAPK_MEF2A_6 451 460 PF00069 0.485
DOC_PP2B_LxvP_1 280 283 PF13499 0.280
DOC_PP2B_LxvP_1 345 348 PF13499 0.487
DOC_PP4_FxxP_1 113 116 PF00568 0.221
DOC_USP7_MATH_1 348 352 PF00917 0.758
DOC_USP7_MATH_1 355 359 PF00917 0.575
DOC_USP7_MATH_1 371 375 PF00917 0.674
DOC_USP7_MATH_1 436 440 PF00917 0.569
DOC_USP7_MATH_1 443 447 PF00917 0.541
DOC_USP7_MATH_1 473 477 PF00917 0.555
DOC_WW_Pin1_4 112 117 PF00397 0.248
DOC_WW_Pin1_4 219 224 PF00397 0.304
DOC_WW_Pin1_4 298 303 PF00397 0.234
DOC_WW_Pin1_4 321 326 PF00397 0.543
DOC_WW_Pin1_4 333 338 PF00397 0.582
DOC_WW_Pin1_4 350 355 PF00397 0.521
DOC_WW_Pin1_4 376 381 PF00397 0.619
DOC_WW_Pin1_4 384 389 PF00397 0.598
LIG_14-3-3_CanoR_1 258 267 PF00244 0.329
LIG_14-3-3_CanoR_1 370 380 PF00244 0.638
LIG_14-3-3_CanoR_1 506 512 PF00244 0.505
LIG_Actin_WH2_2 244 260 PF00022 0.251
LIG_APCC_ABBAyCdc20_2 172 178 PF00400 0.275
LIG_BIR_II_1 1 5 PF00653 0.489
LIG_FHA_1 113 119 PF00498 0.333
LIG_FHA_1 169 175 PF00498 0.377
LIG_FHA_1 188 194 PF00498 0.364
LIG_FHA_1 307 313 PF00498 0.404
LIG_FHA_1 334 340 PF00498 0.765
LIG_FHA_1 463 469 PF00498 0.515
LIG_FHA_1 506 512 PF00498 0.484
LIG_FHA_2 205 211 PF00498 0.241
LIG_FHA_2 305 311 PF00498 0.320
LIG_FHA_2 394 400 PF00498 0.380
LIG_FHA_2 440 446 PF00498 0.499
LIG_FHA_2 499 505 PF00498 0.522
LIG_GBD_Chelix_1 406 414 PF00786 0.315
LIG_LIR_Apic_2 112 116 PF02991 0.240
LIG_LIR_Apic_2 217 223 PF02991 0.324
LIG_LIR_Gen_1 130 138 PF02991 0.212
LIG_LIR_LC3C_4 239 244 PF02991 0.232
LIG_LIR_Nem_3 143 149 PF02991 0.271
LIG_LIR_Nem_3 229 233 PF02991 0.469
LIG_LIR_Nem_3 263 269 PF02991 0.240
LIG_NRBOX 520 526 PF00104 0.486
LIG_PDZ_Class_2 521 526 PF00595 0.488
LIG_Pex14_2 121 125 PF04695 0.212
LIG_SH2_CRK 146 150 PF00017 0.221
LIG_SH2_CRK 254 258 PF00017 0.230
LIG_SH2_STAT5 117 120 PF00017 0.300
LIG_SH2_STAT5 167 170 PF00017 0.311
LIG_SH2_STAT5 47 50 PF00017 0.350
LIG_SH3_3 145 151 PF00018 0.292
LIG_SH3_3 296 302 PF00018 0.280
LIG_SH3_3 334 340 PF00018 0.563
LIG_SUMO_SIM_anti_2 52 61 PF11976 0.332
LIG_SUMO_SIM_par_1 46 53 PF11976 0.356
MOD_CDC14_SPxK_1 222 225 PF00782 0.280
MOD_CDC14_SPxK_1 301 304 PF00782 0.221
MOD_CDK_SPxK_1 219 225 PF00069 0.280
MOD_CDK_SPxK_1 298 304 PF00069 0.221
MOD_CDK_SPxxK_3 298 305 PF00069 0.221
MOD_CDK_SPxxK_3 384 391 PF00069 0.522
MOD_CK1_1 373 379 PF00069 0.533
MOD_CK1_1 439 445 PF00069 0.657
MOD_CK1_1 481 487 PF00069 0.495
MOD_CK1_1 69 75 PF00069 0.231
MOD_CK2_1 138 144 PF00069 0.305
MOD_CK2_1 14 20 PF00069 0.486
MOD_CK2_1 199 205 PF00069 0.253
MOD_CK2_1 384 390 PF00069 0.528
MOD_CK2_1 427 433 PF00069 0.591
MOD_CK2_1 49 55 PF00069 0.328
MOD_GlcNHglycan 294 297 PF01048 0.352
MOD_GlcNHglycan 375 378 PF01048 0.497
MOD_GlcNHglycan 480 483 PF01048 0.603
MOD_GlcNHglycan 485 488 PF01048 0.636
MOD_GlcNHglycan 69 72 PF01048 0.345
MOD_GSK3_1 199 206 PF00069 0.329
MOD_GSK3_1 210 217 PF00069 0.312
MOD_GSK3_1 28 35 PF00069 0.373
MOD_GSK3_1 320 327 PF00069 0.542
MOD_GSK3_1 331 338 PF00069 0.546
MOD_GSK3_1 365 372 PF00069 0.663
MOD_GSK3_1 376 383 PF00069 0.688
MOD_GSK3_1 39 46 PF00069 0.461
MOD_GSK3_1 439 446 PF00069 0.598
MOD_GSK3_1 456 463 PF00069 0.588
MOD_GSK3_1 481 488 PF00069 0.522
MOD_GSK3_1 507 514 PF00069 0.514
MOD_N-GLC_2 187 189 PF02516 0.174
MOD_NEK2_1 168 173 PF00069 0.269
MOD_NEK2_1 185 190 PF00069 0.370
MOD_NEK2_1 198 203 PF00069 0.260
MOD_NEK2_1 204 209 PF00069 0.272
MOD_NEK2_1 214 219 PF00069 0.374
MOD_NEK2_1 369 374 PF00069 0.507
MOD_NEK2_1 419 424 PF00069 0.379
MOD_NEK2_1 460 465 PF00069 0.513
MOD_PIKK_1 39 45 PF00454 0.320
MOD_PKA_1 304 310 PF00069 0.232
MOD_PKA_2 304 310 PF00069 0.319
MOD_PKA_2 369 375 PF00069 0.687
MOD_PKA_2 39 45 PF00069 0.357
MOD_PKA_2 419 425 PF00069 0.512
MOD_PKA_2 478 484 PF00069 0.584
MOD_PKA_2 505 511 PF00069 0.525
MOD_PKA_2 78 84 PF00069 0.232
MOD_Plk_1 401 407 PF00069 0.310
MOD_Plk_1 436 442 PF00069 0.479
MOD_Plk_1 511 517 PF00069 0.425
MOD_Plk_2-3 14 20 PF00069 0.393
MOD_Plk_2-3 393 399 PF00069 0.393
MOD_Plk_4 127 133 PF00069 0.227
MOD_Plk_4 210 216 PF00069 0.333
MOD_Plk_4 28 34 PF00069 0.374
MOD_Plk_4 380 386 PF00069 0.472
MOD_Plk_4 43 49 PF00069 0.330
MOD_ProDKin_1 112 118 PF00069 0.248
MOD_ProDKin_1 219 225 PF00069 0.304
MOD_ProDKin_1 298 304 PF00069 0.234
MOD_ProDKin_1 321 327 PF00069 0.551
MOD_ProDKin_1 333 339 PF00069 0.581
MOD_ProDKin_1 350 356 PF00069 0.523
MOD_ProDKin_1 376 382 PF00069 0.618
MOD_ProDKin_1 384 390 PF00069 0.592
MOD_SUMO_for_1 414 417 PF00179 0.323
MOD_SUMO_rev_2 188 196 PF00179 0.284
TRG_DiLeu_BaEn_1 520 525 PF01217 0.476
TRG_DiLeu_BaEn_2 127 133 PF01217 0.212
TRG_ENDOCYTIC_2 122 125 PF00928 0.304
TRG_ENDOCYTIC_2 146 149 PF00928 0.222
TRG_ENDOCYTIC_2 254 257 PF00928 0.253
TRG_ER_diArg_1 101 103 PF00400 0.223
TRG_ER_diArg_1 304 306 PF00400 0.280
TRG_ER_diArg_1 419 421 PF00400 0.361
TRG_ER_diArg_1 505 507 PF00400 0.505
TRG_ER_diArg_1 73 75 PF00400 0.235

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0B6 Leptomonas seymouri 57% 98%
A0A0N1I0C1 Leptomonas seymouri 28% 100%
A0A0S4J7K5 Bodo saltans 24% 89%
A0A1X0P919 Trypanosomatidae 56% 100%
A0A3Q8IND3 Leishmania donovani 77% 100%
A0A3S5IRC3 Trypanosoma rangeli 56% 100%
A0A3S7WYP4 Leishmania donovani 34% 100%
A0A3S7X2W3 Leishmania donovani 35% 100%
A0A3S7X7Y2 Leishmania donovani 34% 100%
A0A422NT49 Trypanosoma rangeli 27% 74%
A4HAS1 Leishmania braziliensis 34% 100%
A4HDU3 Leishmania braziliensis 34% 100%
A4HFA1 Leishmania braziliensis 30% 100%
A4HFC9 Leishmania braziliensis 26% 80%
A4HHN1 Leishmania braziliensis 35% 100%
A4I140 Leishmania infantum 34% 100%
A4I4U6 Leishmania infantum 35% 100%
A4I9Y5 Leishmania infantum 34% 100%
A4ICP8 Leishmania infantum 77% 100%
B4HBU3 Drosophila persimilis 28% 68%
E9ALJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9APX7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 74%
E9ASK6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 100%
E9AX78 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9AYN8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B4Z4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
P54739 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) 28% 97%
Q0PKV7 Leishmania mexicana 77% 100%
Q2LYK3 Drosophila pseudoobscura pseudoobscura 28% 68%
Q4Q1Z0 Leishmania major 77% 98%
Q4Q2Z2 Leishmania major 33% 100%
Q4QA98 Leishmania major 33% 100%
Q4QFK4 Leishmania major 28% 84%
Q9Y077 Leishmania major 35% 100%
V5C234 Trypanosoma cruzi 27% 97%
V5DCD4 Trypanosoma cruzi 24% 90%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS