Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNU5_LEIBR

TriTrypDb:

LbrM.35.0970 , LBRM2903_350015300

Length:

888

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNU5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	205	209	PF00656	0.451
CLV_C14_Caspase3-7	561	565	PF00656	0.687
CLV_C14_Caspase3-7	627	631	PF00656	0.606
CLV_C14_Caspase3-7	77	81	PF00656	0.546
CLV_NRD_NRD_1	206	208	PF00675	0.517
CLV_NRD_NRD_1	402	404	PF00675	0.815
CLV_NRD_NRD_1	416	418	PF00675	0.431
CLV_NRD_NRD_1	475	477	PF00675	0.546
CLV_NRD_NRD_1	515	517	PF00675	0.596
CLV_NRD_NRD_1	59	61	PF00675	0.523
CLV_NRD_NRD_1	68	70	PF00675	0.591
CLV_PCSK_KEX2_1	159	161	PF00082	0.519
CLV_PCSK_KEX2_1	206	208	PF00082	0.588
CLV_PCSK_KEX2_1	216	218	PF00082	0.605
CLV_PCSK_KEX2_1	402	404	PF00082	0.815
CLV_PCSK_KEX2_1	416	418	PF00082	0.431
CLV_PCSK_KEX2_1	475	477	PF00082	0.546
CLV_PCSK_KEX2_1	515	517	PF00082	0.596
CLV_PCSK_KEX2_1	58	60	PF00082	0.530
CLV_PCSK_KEX2_1	68	70	PF00082	0.589
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.519
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.578
CLV_PCSK_SKI1_1	136	140	PF00082	0.542
CLV_PCSK_SKI1_1	417	421	PF00082	0.446
CLV_PCSK_SKI1_1	703	707	PF00082	0.663
CLV_PCSK_SKI1_1	849	853	PF00082	0.397
DEG_APCC_DBOX_1	309	317	PF00400	0.565
DEG_APCC_DBOX_1	416	424	PF00400	0.459
DEG_APCC_DBOX_1	474	482	PF00400	0.455
DEG_Nend_Nbox_1	1	3	PF02207	0.678
DEG_SCF_FBW7_1	725	732	PF00400	0.574
DEG_SPOP_SBC_1	229	233	PF00917	0.495
DEG_SPOP_SBC_1	748	752	PF00917	0.589
DOC_CKS1_1	726	731	PF01111	0.520
DOC_CKS1_1	806	811	PF01111	0.346
DOC_CYCLIN_RxL_1	140	154	PF00134	0.527
DOC_CYCLIN_yCln2_LP_2	648	654	PF00134	0.545
DOC_MAPK_gen_1	515	525	PF00069	0.488
DOC_MAPK_MEF2A_6	643	650	PF00069	0.555
DOC_MAPK_MEF2A_6	695	702	PF00069	0.525
DOC_MAPK_RevD_3	462	476	PF00069	0.348
DOC_PP2B_LxvP_1	648	651	PF13499	0.559
DOC_PP2B_LxvP_1	737	740	PF13499	0.492
DOC_PP4_FxxP_1	539	542	PF00568	0.598
DOC_PP4_FxxP_1	671	674	PF00568	0.527
DOC_PP4_FxxP_1	735	738	PF00568	0.497
DOC_PP4_FxxP_1	806	809	PF00568	0.476
DOC_PP4_FxxP_1	884	887	PF00568	0.340
DOC_SPAK_OSR1_1	837	841	PF12202	0.467
DOC_USP7_MATH_1	106	110	PF00917	0.566
DOC_USP7_MATH_1	221	225	PF00917	0.578
DOC_USP7_MATH_1	229	233	PF00917	0.572
DOC_USP7_MATH_1	38	42	PF00917	0.580
DOC_USP7_MATH_1	447	451	PF00917	0.496
DOC_USP7_MATH_1	47	51	PF00917	0.496
DOC_USP7_MATH_1	471	475	PF00917	0.616
DOC_USP7_MATH_1	544	548	PF00917	0.586
DOC_USP7_MATH_1	559	563	PF00917	0.653
DOC_USP7_MATH_1	652	656	PF00917	0.566
DOC_USP7_MATH_1	664	668	PF00917	0.627
DOC_USP7_MATH_1	718	722	PF00917	0.771
DOC_USP7_MATH_1	845	849	PF00917	0.389
DOC_USP7_MATH_1	95	99	PF00917	0.681
DOC_WW_Pin1_4	112	117	PF00397	0.719
DOC_WW_Pin1_4	270	275	PF00397	0.481
DOC_WW_Pin1_4	326	331	PF00397	0.623
DOC_WW_Pin1_4	411	416	PF00397	0.595
DOC_WW_Pin1_4	43	48	PF00397	0.534
DOC_WW_Pin1_4	450	455	PF00397	0.589
DOC_WW_Pin1_4	533	538	PF00397	0.758
DOC_WW_Pin1_4	574	579	PF00397	0.694
DOC_WW_Pin1_4	585	590	PF00397	0.761
DOC_WW_Pin1_4	604	609	PF00397	0.509
DOC_WW_Pin1_4	612	617	PF00397	0.622
DOC_WW_Pin1_4	713	718	PF00397	0.600
DOC_WW_Pin1_4	725	730	PF00397	0.639
DOC_WW_Pin1_4	744	749	PF00397	0.469
DOC_WW_Pin1_4	805	810	PF00397	0.344
LIG_14-3-3_CanoR_1	107	113	PF00244	0.535
LIG_14-3-3_CanoR_1	127	134	PF00244	0.531
LIG_14-3-3_CanoR_1	160	166	PF00244	0.405
LIG_14-3-3_CanoR_1	178	186	PF00244	0.544
LIG_14-3-3_CanoR_1	192	198	PF00244	0.403
LIG_14-3-3_CanoR_1	23	29	PF00244	0.680
LIG_14-3-3_CanoR_1	355	361	PF00244	0.488
LIG_14-3-3_CanoR_1	402	410	PF00244	0.549
LIG_14-3-3_CanoR_1	500	506	PF00244	0.369
LIG_14-3-3_CanoR_1	602	609	PF00244	0.532
LIG_14-3-3_CanoR_1	703	711	PF00244	0.619
LIG_14-3-3_CanoR_1	74	82	PF00244	0.540
LIG_Actin_WH2_2	176	194	PF00022	0.514
LIG_Actin_WH2_2	309	327	PF00022	0.452
LIG_BIR_III_2	594	598	PF00653	0.606
LIG_BIR_III_4	294	298	PF00653	0.542
LIG_BIR_III_4	630	634	PF00653	0.639
LIG_BIR_III_4	844	848	PF00653	0.412
LIG_CSL_BTD_1	735	738	PF09270	0.497
LIG_EVH1_1	737	741	PF00568	0.622
LIG_FHA_1	1	7	PF00498	0.510
LIG_FHA_1	133	139	PF00498	0.537
LIG_FHA_1	192	198	PF00498	0.398
LIG_FHA_1	221	227	PF00498	0.488
LIG_FHA_1	281	287	PF00498	0.715
LIG_FHA_1	336	342	PF00498	0.391
LIG_FHA_1	348	354	PF00498	0.381
LIG_FHA_1	40	46	PF00498	0.596
LIG_FHA_1	424	430	PF00498	0.412
LIG_FHA_1	457	463	PF00498	0.476
LIG_FHA_1	482	488	PF00498	0.534
LIG_FHA_1	502	508	PF00498	0.378
LIG_FHA_1	695	701	PF00498	0.649
LIG_FHA_1	704	710	PF00498	0.580
LIG_FHA_1	720	726	PF00498	0.657
LIG_FHA_1	750	756	PF00498	0.559
LIG_FHA_1	77	83	PF00498	0.625
LIG_FHA_1	825	831	PF00498	0.482
LIG_FHA_2	31	37	PF00498	0.622
LIG_FHA_2	694	700	PF00498	0.530
LIG_GBD_Chelix_1	316	324	PF00786	0.564
LIG_LIR_Apic_2	25	29	PF02991	0.534
LIG_LIR_Apic_2	536	542	PF02991	0.583
LIG_LIR_Apic_2	669	674	PF02991	0.646
LIG_LIR_Apic_2	732	738	PF02991	0.627
LIG_LIR_Apic_2	803	809	PF02991	0.489
LIG_LIR_Apic_2	881	887	PF02991	0.316
LIG_LIR_Gen_1	208	215	PF02991	0.568
LIG_LIR_Nem_3	208	213	PF02991	0.573
LIG_LIR_Nem_3	604	609	PF02991	0.509
LIG_MYND_1	364	368	PF01753	0.491
LIG_MYND_1	538	542	PF01753	0.502
LIG_MYND_1	585	589	PF01753	0.699
LIG_SH2_CRK	210	214	PF00017	0.568
LIG_SH2_CRK	26	30	PF00017	0.672
LIG_SH2_CRK	520	524	PF00017	0.614
LIG_SH2_NCK_1	26	30	PF00017	0.610
LIG_SH2_NCK_1	435	439	PF00017	0.382
LIG_SH2_STAP1	342	346	PF00017	0.447
LIG_SH2_STAP1	435	439	PF00017	0.382
LIG_SH2_STAT3	421	424	PF00017	0.328
LIG_SH2_STAT5	609	612	PF00017	0.522
LIG_SH2_STAT5	775	778	PF00017	0.374
LIG_SH3_3	12	18	PF00018	0.541
LIG_SH3_3	358	364	PF00018	0.490
LIG_SH3_3	671	677	PF00018	0.528
LIG_SH3_3	695	701	PF00018	0.568
LIG_SH3_3	714	720	PF00018	0.541
LIG_SH3_3	735	741	PF00018	0.592
LIG_SH3_3	742	748	PF00018	0.542
LIG_SH3_3	755	761	PF00018	0.475
LIG_SUMO_SIM_anti_2	721	728	PF11976	0.546
LIG_SUMO_SIM_anti_2	865	870	PF11976	0.442
LIG_SUMO_SIM_par_1	281	288	PF11976	0.526
LIG_SUMO_SIM_par_1	721	728	PF11976	0.546
LIG_TRAF2_1	285	288	PF00917	0.536
LIG_TRAF2_1	832	835	PF00917	0.501
MOD_CDC14_SPxK_1	414	417	PF00782	0.528
MOD_CDC14_SPxK_1	588	591	PF00782	0.702
MOD_CDK_SPK_2	411	416	PF00069	0.503
MOD_CDK_SPK_2	43	48	PF00069	0.534
MOD_CDK_SPxK_1	411	417	PF00069	0.557
MOD_CDK_SPxK_1	585	591	PF00069	0.701
MOD_CDK_SPxK_1	805	811	PF00069	0.347
MOD_CK1_1	110	116	PF00069	0.555
MOD_CK1_1	117	123	PF00069	0.628
MOD_CK1_1	184	190	PF00069	0.516
MOD_CK1_1	199	205	PF00069	0.375
MOD_CK1_1	232	238	PF00069	0.644
MOD_CK1_1	270	276	PF00069	0.608
MOD_CK1_1	347	353	PF00069	0.523
MOD_CK1_1	411	417	PF00069	0.455
MOD_CK1_1	43	49	PF00069	0.540
MOD_CK1_1	450	456	PF00069	0.572
MOD_CK1_1	50	56	PF00069	0.476
MOD_CK1_1	604	610	PF00069	0.527
MOD_CK1_1	612	618	PF00069	0.618
MOD_CK1_1	624	630	PF00069	0.837
MOD_CK1_1	655	661	PF00069	0.697
MOD_CK1_1	716	722	PF00069	0.664
MOD_CK1_1	727	733	PF00069	0.641
MOD_CK1_1	747	753	PF00069	0.530
MOD_CK1_1	825	831	PF00069	0.340
MOD_CK1_1	873	879	PF00069	0.392
MOD_CK1_1	94	100	PF00069	0.588
MOD_CK2_1	238	244	PF00069	0.455
MOD_CK2_1	471	477	PF00069	0.509
MOD_CK2_1	693	699	PF00069	0.544
MOD_CK2_1	80	86	PF00069	0.637
MOD_CK2_1	829	835	PF00069	0.433
MOD_GlcNHglycan	116	119	PF01048	0.741
MOD_GlcNHglycan	128	131	PF01048	0.587
MOD_GlcNHglycan	223	226	PF01048	0.592
MOD_GlcNHglycan	232	235	PF01048	0.574
MOD_GlcNHglycan	26	29	PF01048	0.702
MOD_GlcNHglycan	307	310	PF01048	0.550
MOD_GlcNHglycan	42	45	PF01048	0.597
MOD_GlcNHglycan	436	439	PF01048	0.452
MOD_GlcNHglycan	449	452	PF01048	0.520
MOD_GlcNHglycan	546	549	PF01048	0.619
MOD_GlcNHglycan	561	564	PF01048	0.615
MOD_GlcNHglycan	603	606	PF01048	0.531
MOD_GlcNHglycan	666	669	PF01048	0.676
MOD_GlcNHglycan	70	74	PF01048	0.625
MOD_GlcNHglycan	729	732	PF01048	0.629
MOD_GlcNHglycan	82	85	PF01048	0.584
MOD_GlcNHglycan	831	834	PF01048	0.372
MOD_GlcNHglycan	860	863	PF01048	0.492
MOD_GlcNHglycan	872	875	PF01048	0.400
MOD_GlcNHglycan	93	96	PF01048	0.564
MOD_GSK3_1	106	113	PF00069	0.638
MOD_GSK3_1	134	141	PF00069	0.543
MOD_GSK3_1	177	184	PF00069	0.533
MOD_GSK3_1	216	223	PF00069	0.494
MOD_GSK3_1	225	232	PF00069	0.569
MOD_GSK3_1	234	241	PF00069	0.520
MOD_GSK3_1	256	263	PF00069	0.445
MOD_GSK3_1	293	300	PF00069	0.542
MOD_GSK3_1	39	46	PF00069	0.626
MOD_GSK3_1	434	441	PF00069	0.497
MOD_GSK3_1	463	470	PF00069	0.528
MOD_GSK3_1	50	57	PF00069	0.520
MOD_GSK3_1	621	628	PF00069	0.611
MOD_GSK3_1	712	719	PF00069	0.694
MOD_GSK3_1	725	732	PF00069	0.606
MOD_GSK3_1	744	751	PF00069	0.564
MOD_GSK3_1	76	83	PF00069	0.690
MOD_GSK3_1	822	829	PF00069	0.406
MOD_GSK3_1	86	93	PF00069	0.569
MOD_N-GLC_1	229	234	PF02516	0.635
MOD_N-GLC_1	621	626	PF02516	0.634
MOD_N-GLC_1	858	863	PF02516	0.490
MOD_N-GLC_1	90	95	PF02516	0.539
MOD_N-GLC_2	425	427	PF02516	0.357
MOD_NEK2_1	186	191	PF00069	0.602
MOD_NEK2_1	280	285	PF00069	0.663
MOD_NEK2_1	346	351	PF00069	0.491
MOD_NEK2_1	423	428	PF00069	0.487
MOD_NEK2_1	434	439	PF00069	0.392
MOD_NEK2_1	467	472	PF00069	0.494
MOD_NEK2_1	54	59	PF00069	0.462
MOD_NEK2_1	804	809	PF00069	0.341
MOD_NEK2_1	826	831	PF00069	0.482
MOD_NEK2_1	870	875	PF00069	0.455
MOD_NEK2_2	501	506	PF00069	0.357
MOD_PIKK_1	184	190	PF00454	0.370
MOD_PIKK_1	216	222	PF00454	0.558
MOD_PIKK_1	235	241	PF00454	0.628
MOD_PIKK_1	354	360	PF00454	0.543
MOD_PIKK_1	680	686	PF00454	0.756
MOD_PK_1	370	376	PF00069	0.509
MOD_PKA_1	216	222	PF00069	0.437
MOD_PKA_2	106	112	PF00069	0.535
MOD_PKA_2	126	132	PF00069	0.548
MOD_PKA_2	177	183	PF00069	0.564
MOD_PKA_2	191	197	PF00069	0.363
MOD_PKA_2	216	222	PF00069	0.437
MOD_PKA_2	22	28	PF00069	0.544
MOD_PKA_2	354	360	PF00069	0.520
MOD_PKA_2	401	407	PF00069	0.680
MOD_PKA_2	499	505	PF00069	0.501
MOD_PKA_2	507	513	PF00069	0.413
MOD_PKA_2	559	565	PF00069	0.550
MOD_PKA_2	601	607	PF00069	0.512
MOD_PKB_1	74	82	PF00069	0.540
MOD_Plk_1	408	414	PF00069	0.487
MOD_Plk_1	655	661	PF00069	0.576
MOD_Plk_4	186	192	PF00069	0.569
MOD_Plk_4	370	376	PF00069	0.531
MOD_Plk_4	425	431	PF00069	0.412
MOD_Plk_4	463	469	PF00069	0.469
MOD_ProDKin_1	112	118	PF00069	0.717
MOD_ProDKin_1	270	276	PF00069	0.488
MOD_ProDKin_1	326	332	PF00069	0.625
MOD_ProDKin_1	411	417	PF00069	0.583
MOD_ProDKin_1	43	49	PF00069	0.531
MOD_ProDKin_1	450	456	PF00069	0.574
MOD_ProDKin_1	533	539	PF00069	0.761
MOD_ProDKin_1	574	580	PF00069	0.690
MOD_ProDKin_1	585	591	PF00069	0.762
MOD_ProDKin_1	604	610	PF00069	0.509
MOD_ProDKin_1	612	618	PF00069	0.620
MOD_ProDKin_1	713	719	PF00069	0.600
MOD_ProDKin_1	725	731	PF00069	0.636
MOD_ProDKin_1	744	750	PF00069	0.472
MOD_ProDKin_1	805	811	PF00069	0.347
MOD_SUMO_rev_2	154	161	PF00179	0.516
TRG_DiLeu_BaEn_1	244	249	PF01217	0.405
TRG_DiLeu_BaEn_1	312	317	PF01217	0.553
TRG_ENDOCYTIC_2	210	213	PF00928	0.571
TRG_ENDOCYTIC_2	520	523	PF00928	0.614
TRG_ER_diArg_1	401	403	PF00400	0.809
TRG_ER_diArg_1	415	417	PF00400	0.444
TRG_ER_diArg_1	505	508	PF00400	0.446
TRG_ER_diArg_1	515	517	PF00400	0.511
TRG_ER_diArg_1	58	60	PF00400	0.593
TRG_ER_diArg_1	67	69	PF00400	0.510
TRG_Pf-PMV_PEXEL_1	146	151	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	65	70	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	774	778	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIS1	Leishmania donovani	61%	100%
A4ICP9	Leishmania infantum	62%	100%
E9ASK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
Q4Q1Z1	Leishmania major	61%	100%