Zinc_finger_protein_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger protein family member, putative

Species:

Leishmania braziliensis

UniProt:

A4HNU4_LEIBR

TriTrypDb:

LbrM.35.0960 , LBRM2903_350015200

Length:

789

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNU4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	447	451	PF00656	0.773
CLV_C14_Caspase3-7	755	759	PF00656	0.809
CLV_NRD_NRD_1	407	409	PF00675	0.605
CLV_NRD_NRD_1	493	495	PF00675	0.709
CLV_NRD_NRD_1	571	573	PF00675	0.643
CLV_PCSK_FUR_1	246	250	PF00082	0.581
CLV_PCSK_FUR_1	405	409	PF00082	0.651
CLV_PCSK_KEX2_1	248	250	PF00082	0.601
CLV_PCSK_KEX2_1	407	409	PF00082	0.599
CLV_PCSK_KEX2_1	493	495	PF00082	0.709
CLV_PCSK_KEX2_1	571	573	PF00082	0.610
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.703
CLV_PCSK_SKI1_1	345	349	PF00082	0.519
CLV_PCSK_SKI1_1	455	459	PF00082	0.801
CLV_PCSK_SKI1_1	725	729	PF00082	0.809
CLV_PCSK_SKI1_1	737	741	PF00082	0.581
CLV_PCSK_SKI1_1	751	755	PF00082	0.763
CLV_Separin_Metazoa	411	415	PF03568	0.540
DEG_Nend_Nbox_1	1	3	PF02207	0.783
DEG_SPOP_SBC_1	674	678	PF00917	0.829
DEG_SPOP_SBC_1	708	712	PF00917	0.820
DOC_CKS1_1	554	559	PF01111	0.713
DOC_CKS1_1	719	724	PF01111	0.829
DOC_CYCLIN_RxL_1	342	351	PF00134	0.521
DOC_CYCLIN_yCln2_LP_2	122	128	PF00134	0.634
DOC_MAPK_DCC_7	494	504	PF00069	0.555
DOC_MAPK_gen_1	280	290	PF00069	0.496
DOC_MAPK_gen_1	353	360	PF00069	0.503
DOC_MAPK_gen_1	403	412	PF00069	0.551
DOC_MAPK_gen_1	568	576	PF00069	0.649
DOC_MAPK_MEF2A_6	223	230	PF00069	0.490
DOC_MAPK_MEF2A_6	353	362	PF00069	0.603
DOC_PP1_RVXF_1	733	739	PF00149	0.545
DOC_PP2B_LxvP_1	122	125	PF13499	0.646
DOC_PP4_FxxP_1	143	146	PF00568	0.561
DOC_PP4_FxxP_1	664	667	PF00568	0.571
DOC_USP7_MATH_1	229	233	PF00917	0.456
DOC_USP7_MATH_1	29	33	PF00917	0.612
DOC_USP7_MATH_1	487	491	PF00917	0.726
DOC_USP7_MATH_1	520	524	PF00917	0.704
DOC_USP7_MATH_1	528	532	PF00917	0.711
DOC_USP7_MATH_1	708	712	PF00917	0.719
DOC_USP7_MATH_1	726	730	PF00917	0.504
DOC_USP7_MATH_1	742	746	PF00917	0.731
DOC_USP7_MATH_1	749	753	PF00917	0.700
DOC_USP7_MATH_1	765	769	PF00917	0.651
DOC_USP7_MATH_1	9	13	PF00917	0.523
DOC_WW_Pin1_4	392	397	PF00397	0.634
DOC_WW_Pin1_4	412	417	PF00397	0.382
DOC_WW_Pin1_4	425	430	PF00397	0.451
DOC_WW_Pin1_4	47	52	PF00397	0.548
DOC_WW_Pin1_4	5	10	PF00397	0.696
DOC_WW_Pin1_4	553	558	PF00397	0.716
DOC_WW_Pin1_4	575	580	PF00397	0.668
DOC_WW_Pin1_4	662	667	PF00397	0.757
DOC_WW_Pin1_4	718	723	PF00397	0.830
LIG_14-3-3_CanoR_1	494	500	PF00244	0.705
LIG_14-3-3_CanoR_1	508	518	PF00244	0.676
LIG_14-3-3_CanoR_1	751	757	PF00244	0.744
LIG_Actin_WH2_2	317	332	PF00022	0.351
LIG_BIR_III_4	97	101	PF00653	0.589
LIG_BRCT_BRCA1_1	193	197	PF00533	0.493
LIG_BRCT_BRCA1_1	231	235	PF00533	0.466
LIG_BRCT_BRCA1_1	310	314	PF00533	0.342
LIG_BRCT_BRCA1_1	514	518	PF00533	0.644
LIG_BRCT_BRCA1_1	660	664	PF00533	0.797
LIG_BRCT_BRCA1_2	231	237	PF00533	0.462
LIG_Clathr_ClatBox_1	669	673	PF01394	0.819
LIG_deltaCOP1_diTrp_1	659	664	PF00928	0.798
LIG_FHA_1	212	218	PF00498	0.502
LIG_FHA_1	234	240	PF00498	0.471
LIG_FHA_1	272	278	PF00498	0.648
LIG_FHA_1	490	496	PF00498	0.687
LIG_FHA_1	783	789	PF00498	0.613
LIG_FHA_2	321	327	PF00498	0.488
LIG_FHA_2	34	40	PF00498	0.554
LIG_FHA_2	456	462	PF00498	0.640
LIG_FHA_2	60	66	PF00498	0.552
LIG_HP1_1	125	129	PF01393	0.379
LIG_IBAR_NPY_1	519	521	PF08397	0.689
LIG_Integrin_isoDGR_2	90	92	PF01839	0.794
LIG_LIR_Apic_2	19	24	PF02991	0.804
LIG_LIR_Apic_2	661	667	PF02991	0.605
LIG_LIR_Apic_2	703	708	PF02991	0.816
LIG_LIR_Gen_1	212	222	PF02991	0.505
LIG_LIR_Gen_1	303	314	PF02991	0.451
LIG_LIR_Gen_1	388	396	PF02991	0.513
LIG_LIR_Gen_1	531	538	PF02991	0.760
LIG_LIR_Nem_3	212	218	PF02991	0.443
LIG_LIR_Nem_3	303	309	PF02991	0.457
LIG_LIR_Nem_3	311	316	PF02991	0.459
LIG_LIR_Nem_3	388	392	PF02991	0.412
LIG_LIR_Nem_3	515	521	PF02991	0.658
LIG_LIR_Nem_3	531	537	PF02991	0.723
LIG_LIR_Nem_3	77	82	PF02991	0.661
LIG_MLH1_MIPbox_1	310	314	PF16413	0.342
LIG_PALB2_WD40_1	301	309	PF16756	0.508
LIG_Pex14_2	302	306	PF04695	0.506
LIG_Pex14_2	658	662	PF04695	0.800
LIG_PTB_Apo_2	699	706	PF02174	0.565
LIG_PTB_Phospho_1	699	705	PF10480	0.567
LIG_SH2_CRK	21	25	PF00017	0.797
LIG_SH2_CRK	521	525	PF00017	0.814
LIG_SH2_CRK	6	10	PF00017	0.578
LIG_SH2_CRK	627	631	PF00017	0.834
LIG_SH2_NCK_1	21	25	PF00017	0.810
LIG_SH2_NCK_1	40	44	PF00017	0.503
LIG_SH2_PTP2	240	243	PF00017	0.635
LIG_SH2_SRC	21	24	PF00017	0.800
LIG_SH2_SRC	240	243	PF00017	0.533
LIG_SH2_SRC	38	41	PF00017	0.527
LIG_SH2_STAP1	18	22	PF00017	0.816
LIG_SH2_STAP1	64	68	PF00017	0.557
LIG_SH2_STAT3	107	110	PF00017	0.802
LIG_SH2_STAT5	184	187	PF00017	0.550
LIG_SH2_STAT5	240	243	PF00017	0.645
LIG_SH2_STAT5	313	316	PF00017	0.493
LIG_SH2_STAT5	382	385	PF00017	0.420
LIG_SH2_STAT5	555	558	PF00017	0.818
LIG_SH2_STAT5	760	763	PF00017	0.571
LIG_SH2_STAT5	79	82	PF00017	0.560
LIG_SH3_3	124	130	PF00018	0.501
LIG_SH3_3	143	149	PF00018	0.373
LIG_SH3_3	223	229	PF00018	0.497
LIG_SH3_3	321	327	PF00018	0.488
LIG_SUMO_SIM_par_1	572	578	PF11976	0.647
LIG_TRAF2_1	163	166	PF00917	0.478
LIG_TRAF2_1	443	446	PF00917	0.602
LIG_TRFH_1	314	318	PF08558	0.496
MOD_CDK_SPxxK_3	718	725	PF00069	0.830
MOD_CK1_1	486	492	PF00069	0.665
MOD_CK1_1	512	518	PF00069	0.654
MOD_CK1_1	523	529	PF00069	0.702
MOD_CK1_1	564	570	PF00069	0.773
MOD_CK1_1	59	65	PF00069	0.608
MOD_CK1_1	598	604	PF00069	0.640
MOD_CK1_1	675	681	PF00069	0.736
MOD_CK1_1	701	707	PF00069	0.811
MOD_CK1_1	710	716	PF00069	0.830
MOD_CK1_1	729	735	PF00069	0.501
MOD_CK1_1	741	747	PF00069	0.697
MOD_CK1_1	752	758	PF00069	0.630
MOD_CK1_1	759	765	PF00069	0.517
MOD_CK1_1	768	774	PF00069	0.730
MOD_CK2_1	523	529	PF00069	0.714
MOD_CK2_1	581	587	PF00069	0.638
MOD_CK2_1	59	65	PF00069	0.550
MOD_CMANNOS	281	284	PF00535	0.518
MOD_GlcNHglycan	138	141	PF01048	0.598
MOD_GlcNHglycan	31	34	PF01048	0.553
MOD_GlcNHglycan	41	44	PF01048	0.698
MOD_GlcNHglycan	464	467	PF01048	0.642
MOD_GlcNHglycan	47	50	PF01048	0.679
MOD_GlcNHglycan	485	488	PF01048	0.780
MOD_GlcNHglycan	542	545	PF01048	0.753
MOD_GlcNHglycan	597	600	PF01048	0.618
MOD_GlcNHglycan	728	731	PF01048	0.657
MOD_GlcNHglycan	740	743	PF01048	0.721
MOD_GlcNHglycan	751	754	PF01048	0.637
MOD_GSK3_1	129	136	PF00069	0.518
MOD_GSK3_1	229	236	PF00069	0.415
MOD_GSK3_1	29	36	PF00069	0.620
MOD_GSK3_1	479	486	PF00069	0.705
MOD_GSK3_1	5	12	PF00069	0.669
MOD_GSK3_1	56	63	PF00069	0.681
MOD_GSK3_1	658	665	PF00069	0.798
MOD_GSK3_1	672	679	PF00069	0.518
MOD_GSK3_1	707	714	PF00069	0.749
MOD_GSK3_1	725	732	PF00069	0.645
MOD_GSK3_1	737	744	PF00069	0.619
MOD_GSK3_1	752	759	PF00069	0.683
MOD_GSK3_1	765	772	PF00069	0.837
MOD_N-GLC_1	487	492	PF02516	0.712
MOD_N-GLC_1	495	500	PF02516	0.699
MOD_N-GLC_1	681	686	PF02516	0.796
MOD_N-GLC_1	701	706	PF02516	0.802
MOD_N-GLC_1	86	91	PF02516	0.663
MOD_NEK2_1	17	22	PF00069	0.696
MOD_NEK2_1	190	195	PF00069	0.530
MOD_NEK2_1	233	238	PF00069	0.475
MOD_NEK2_1	329	334	PF00069	0.509
MOD_NEK2_1	348	353	PF00069	0.423
MOD_NEK2_1	462	467	PF00069	0.580
MOD_NEK2_1	495	500	PF00069	0.699
MOD_NEK2_1	562	567	PF00069	0.645
MOD_NEK2_1	581	586	PF00069	0.585
MOD_NEK2_1	595	600	PF00069	0.599
MOD_NEK2_1	658	663	PF00069	0.798
MOD_NEK2_1	672	677	PF00069	0.517
MOD_NEK2_1	698	703	PF00069	0.794
MOD_NEK2_1	738	743	PF00069	0.693
MOD_NEK2_1	766	771	PF00069	0.829
MOD_NEK2_2	33	38	PF00069	0.806
MOD_OFUCOSY	367	372	PF10250	0.630
MOD_PIKK_1	711	717	PF00454	0.826
MOD_PK_1	213	219	PF00069	0.595
MOD_PK_1	354	360	PF00069	0.486
MOD_PK_1	681	687	PF00069	0.853
MOD_PKA_2	540	546	PF00069	0.726
MOD_PKA_2	776	782	PF00069	0.790
MOD_Plk_1	190	196	PF00069	0.588
MOD_Plk_1	211	217	PF00069	0.557
MOD_Plk_1	487	493	PF00069	0.712
MOD_Plk_1	495	501	PF00069	0.700
MOD_Plk_1	56	62	PF00069	0.543
MOD_Plk_1	658	664	PF00069	0.799
MOD_Plk_1	701	707	PF00069	0.817
MOD_Plk_2-3	320	326	PF00069	0.485
MOD_Plk_4	129	135	PF00069	0.482
MOD_Plk_4	191	197	PF00069	0.592
MOD_Plk_4	229	235	PF00069	0.417
MOD_Plk_4	33	39	PF00069	0.619
MOD_Plk_4	581	587	PF00069	0.638
MOD_Plk_4	74	80	PF00069	0.544
MOD_Plk_4	776	782	PF00069	0.785
MOD_ProDKin_1	392	398	PF00069	0.635
MOD_ProDKin_1	412	418	PF00069	0.384
MOD_ProDKin_1	425	431	PF00069	0.455
MOD_ProDKin_1	47	53	PF00069	0.549
MOD_ProDKin_1	5	11	PF00069	0.696
MOD_ProDKin_1	553	559	PF00069	0.713
MOD_ProDKin_1	575	581	PF00069	0.673
MOD_ProDKin_1	662	668	PF00069	0.755
MOD_ProDKin_1	718	724	PF00069	0.829
MOD_SUMO_rev_2	216	225	PF00179	0.611
MOD_SUMO_rev_2	447	457	PF00179	0.795
TRG_DiLeu_BaEn_4	401	407	PF01217	0.618
TRG_DiLeu_BaLyEn_6	665	670	PF01217	0.793
TRG_ENDOCYTIC_2	313	316	PF00928	0.493
TRG_ENDOCYTIC_2	382	385	PF00928	0.415
TRG_ENDOCYTIC_2	389	392	PF00928	0.413
TRG_ENDOCYTIC_2	521	524	PF00928	0.714
TRG_ENDOCYTIC_2	534	537	PF00928	0.727
TRG_ENDOCYTIC_2	627	630	PF00928	0.834
TRG_ER_diArg_1	405	408	PF00400	0.643
TRG_ER_diArg_1	493	495	PF00400	0.709
TRG_ER_diArg_1	570	572	PF00400	0.651
TRG_NLS_MonoExtN_4	246	252	PF00514	0.706
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDN9	Leptomonas seymouri	58%	100%
A0A3S7XAM4	Leishmania donovani	81%	100%
A4ICQ0	Leishmania infantum	81%	100%
E9ASK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q1Z2	Leishmania major	81%	99%