ADP-ribosylation factor-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ADP-ribosylation factor-like protein

Species:

Leishmania braziliensis

UniProt:

A4HNU2_LEIBR

TriTrypDb:

LbrM.35.0940 , LBRM2903_350015000

Length:

287

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNU2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0003924	GTPase activity	7	11
GO:0005488	binding	1	11
GO:0005525	GTP binding	5	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0019001	guanyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032561	guanyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	82	84	PF00082	0.419
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.419
CLV_PCSK_SKI1_1	188	192	PF00082	0.305
CLV_PCSK_SKI1_1	26	30	PF00082	0.566
CLV_PCSK_SKI1_1	40	44	PF00082	0.343
CLV_PCSK_SKI1_1	83	87	PF00082	0.311
DEG_APCC_DBOX_1	39	47	PF00400	0.468
DOC_CYCLIN_RxL_1	23	33	PF00134	0.551
DOC_CYCLIN_RxL_1	37	47	PF00134	0.411
DOC_MAPK_gen_1	111	119	PF00069	0.348
DOC_MAPK_gen_1	186	193	PF00069	0.365
DOC_MAPK_gen_1	80	87	PF00069	0.417
DOC_MAPK_MEF2A_6	111	119	PF00069	0.379
DOC_MAPK_MEF2A_6	186	193	PF00069	0.325
DOC_USP7_MATH_1	261	265	PF00917	0.550
DOC_WW_Pin1_4	111	116	PF00397	0.316
LIG_14-3-3_CanoR_1	168	176	PF00244	0.243
LIG_14-3-3_CanoR_1	83	88	PF00244	0.419
LIG_BIR_II_1	1	5	PF00653	0.540
LIG_EH_1	33	37	PF12763	0.481
LIG_FHA_1	112	118	PF00498	0.255
LIG_FHA_1	227	233	PF00498	0.392
LIG_FHA_1	23	29	PF00498	0.495
LIG_FHA_1	96	102	PF00498	0.283
LIG_FHA_2	235	241	PF00498	0.453
LIG_GBD_Chelix_1	238	246	PF00786	0.417
LIG_LIR_Gen_1	250	261	PF02991	0.423
LIG_LIR_Gen_1	33	43	PF02991	0.465
LIG_LIR_Nem_3	116	122	PF02991	0.389
LIG_LIR_Nem_3	152	157	PF02991	0.449
LIG_LIR_Nem_3	250	256	PF02991	0.401
LIG_LIR_Nem_3	33	39	PF02991	0.446
LIG_NRBOX	38	44	PF00104	0.545
LIG_PCNA_PIPBox_1	13	22	PF02747	0.374
LIG_PCNA_yPIPBox_3	12	20	PF02747	0.379
LIG_Pex14_1	146	150	PF04695	0.305
LIG_Pex14_2	142	146	PF04695	0.305
LIG_SH2_CRK	154	158	PF00017	0.197
LIG_SH2_CRK	224	228	PF00017	0.259
LIG_SH2_CRK	253	257	PF00017	0.533
LIG_SH2_STAP1	253	257	PF00017	0.500
LIG_SH2_STAT3	10	13	PF00017	0.398
LIG_SH2_STAT5	113	116	PF00017	0.450
LIG_SH2_STAT5	158	161	PF00017	0.339
LIG_SH2_STAT5	184	187	PF00017	0.367
LIG_SH2_STAT5	38	41	PF00017	0.472
LIG_SH3_3	29	35	PF00018	0.496
LIG_SH3_5	125	129	PF00018	0.414
LIG_SUMO_SIM_par_1	98	106	PF11976	0.367
LIG_TYR_ITIM	175	180	PF00017	0.197
LIG_UBA3_1	19	26	PF00899	0.509
LIG_UBA3_1	190	197	PF00899	0.348
MOD_CK1_1	162	168	PF00069	0.417
MOD_CK2_1	234	240	PF00069	0.311
MOD_CK2_1	75	81	PF00069	0.439
MOD_CK2_1	99	105	PF00069	0.450
MOD_GlcNHglycan	105	108	PF01048	0.320
MOD_GlcNHglycan	161	164	PF01048	0.304
MOD_GlcNHglycan	77	80	PF01048	0.696
MOD_GSK3_1	52	59	PF00069	0.482
MOD_GSK3_1	95	102	PF00069	0.325
MOD_N-GLC_2	130	132	PF02516	0.417
MOD_NEK2_1	176	181	PF00069	0.394
MOD_NEK2_1	22	27	PF00069	0.468
MOD_PIKK_1	56	62	PF00454	0.669
MOD_PIKK_1	72	78	PF00454	0.667
MOD_PKA_2	167	173	PF00069	0.319
MOD_Plk_2-3	234	240	PF00069	0.353
MOD_Plk_4	234	240	PF00069	0.236
MOD_Plk_4	99	105	PF00069	0.361
MOD_ProDKin_1	111	117	PF00069	0.316
MOD_SUMO_for_1	267	270	PF00179	0.519
MOD_SUMO_rev_2	105	114	PF00179	0.450
TRG_DiLeu_BaLyEn_6	186	191	PF01217	0.348
TRG_ENDOCYTIC_2	154	157	PF00928	0.197
TRG_ENDOCYTIC_2	177	180	PF00928	0.349
TRG_ENDOCYTIC_2	224	227	PF00928	0.234
TRG_ENDOCYTIC_2	253	256	PF00928	0.388
TRG_ENDOCYTIC_2	38	41	PF00928	0.495
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	197	201	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	40	45	PF00026	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P886	Leptomonas seymouri	69%	94%
A0A0S4JWF1	Bodo saltans	43%	100%
A0A1X0P0D4	Trypanosomatidae	28%	100%
A0A1X0P850	Trypanosomatidae	55%	100%
A0A221LG87	Leishmania donovani	30%	100%
A0A3S5H5A9	Leishmania donovani	31%	100%
A0A3S7XAE0	Leishmania donovani	81%	96%
A0A422NK26	Trypanosoma rangeli	54%	89%
A4H3W8	Leishmania braziliensis	30%	100%
A4HS43	Leishmania infantum	31%	100%
A4HSC6	Leishmania infantum	30%	100%
A4ICQ2	Leishmania infantum	81%	95%
D0A2Q7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AKA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9ASK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	95%
Q3SXY8	Homo sapiens	35%	67%
Q4Q1Z4	Leishmania major	81%	100%
Q4QJK0	Leishmania major	30%	100%
Q5H913	Homo sapiens	30%	99%
Q640N2	Mus musculus	37%	67%
Q6AXT3	Rattus norvegicus	31%	73%
Q8JHI3	Danio rerio	36%	71%
Q9D416	Mus musculus	30%	77%
Q9U0T6	Leishmania major	30%	100%