DUF4470 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNU1_LEIBR

TriTrypDb:

LbrM.35.0930 , LBRM2903_350014900

Length:

459

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNU1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.315
CLV_C14_Caspase3-7	276	280	PF00656	0.328
CLV_NRD_NRD_1	157	159	PF00675	0.594
CLV_NRD_NRD_1	230	232	PF00675	0.530
CLV_NRD_NRD_1	3	5	PF00675	0.417
CLV_NRD_NRD_1	54	56	PF00675	0.588
CLV_PCSK_FUR_1	440	444	PF00082	0.571
CLV_PCSK_KEX2_1	230	232	PF00082	0.530
CLV_PCSK_KEX2_1	3	5	PF00082	0.417
CLV_PCSK_KEX2_1	442	444	PF00082	0.685
CLV_PCSK_KEX2_1	54	56	PF00082	0.619
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.685
CLV_PCSK_SKI1_1	139	143	PF00082	0.491
CLV_PCSK_SKI1_1	159	163	PF00082	0.420
CLV_PCSK_SKI1_1	213	217	PF00082	0.570
CLV_PCSK_SKI1_1	230	234	PF00082	0.523
CLV_PCSK_SKI1_1	319	323	PF00082	0.444
CLV_PCSK_SKI1_1	353	357	PF00082	0.587
CLV_PCSK_SKI1_1	430	434	PF00082	0.541
CLV_PCSK_SKI1_1	55	59	PF00082	0.574
CLV_PCSK_SKI1_1	8	12	PF00082	0.336
CLV_PCSK_SKI1_1	94	98	PF00082	0.515
CLV_Separin_Metazoa	350	354	PF03568	0.221
DEG_APCC_DBOX_1	54	62	PF00400	0.408
DEG_APCC_DBOX_1	93	101	PF00400	0.327
DOC_CDC14_PxL_1	175	183	PF14671	0.299
DOC_CYCLIN_RxL_1	208	221	PF00134	0.304
DOC_CYCLIN_RxL_1	52	62	PF00134	0.392
DOC_CYCLIN_yCln2_LP_2	83	89	PF00134	0.392
DOC_MAPK_gen_1	155	163	PF00069	0.359
DOC_MAPK_MEF2A_6	189	196	PF00069	0.292
DOC_PP1_RVXF_1	157	164	PF00149	0.337
DOC_PP2B_LxvP_1	123	126	PF13499	0.376
DOC_PP2B_LxvP_1	76	79	PF13499	0.397
DOC_USP7_MATH_1	177	181	PF00917	0.307
DOC_USP7_MATH_1	211	215	PF00917	0.274
DOC_USP7_MATH_1	26	30	PF00917	0.430
DOC_USP7_MATH_1	312	316	PF00917	0.429
DOC_USP7_UBL2_3	271	275	PF12436	0.336
DOC_USP7_UBL2_3	379	383	PF12436	0.253
DOC_USP7_UBL2_3	433	437	PF12436	0.311
LIG_14-3-3_CanoR_1	213	218	PF00244	0.363
LIG_14-3-3_CanoR_1	246	252	PF00244	0.316
LIG_14-3-3_CanoR_1	353	360	PF00244	0.262
LIG_14-3-3_CanoR_1	446	454	PF00244	0.527
LIG_BIR_III_4	279	283	PF00653	0.311
LIG_BRCT_BRCA1_1	164	168	PF00533	0.229
LIG_BRCT_BRCA1_1	377	381	PF00533	0.281
LIG_BRCT_BRCA1_2	377	383	PF00533	0.224
LIG_FHA_1	219	225	PF00498	0.415
LIG_FHA_1	257	263	PF00498	0.304
LIG_FHA_1	320	326	PF00498	0.304
LIG_FHA_1	346	352	PF00498	0.414
LIG_FHA_1	354	360	PF00498	0.381
LIG_FHA_1	393	399	PF00498	0.314
LIG_FHA_1	429	435	PF00498	0.396
LIG_FHA_1	71	77	PF00498	0.416
LIG_FHA_2	148	154	PF00498	0.260
LIG_FHA_2	238	244	PF00498	0.396
LIG_FHA_2	338	344	PF00498	0.414
LIG_GBD_Chelix_1	111	119	PF00786	0.525
LIG_GBD_Chelix_1	398	406	PF00786	0.575
LIG_IBAR_NPY_1	204	206	PF08397	0.394
LIG_LIR_Gen_1	165	176	PF02991	0.271
LIG_LIR_Gen_1	422	429	PF02991	0.391
LIG_LIR_Gen_1	60	71	PF02991	0.410
LIG_LIR_Nem_3	165	171	PF02991	0.280
LIG_LIR_Nem_3	17	22	PF02991	0.580
LIG_LIR_Nem_3	254	260	PF02991	0.337
LIG_LIR_Nem_3	327	333	PF02991	0.289
LIG_LIR_Nem_3	339	344	PF02991	0.308
LIG_LIR_Nem_3	422	426	PF02991	0.401
LIG_LIR_Nem_3	60	66	PF02991	0.407
LIG_LIR_Nem_3	81	87	PF02991	0.363
LIG_LYPXL_yS_3	178	181	PF13949	0.301
LIG_MLH1_MIPbox_1	377	381	PF16413	0.281
LIG_PCNA_APIM_2	377	383	PF02747	0.224
LIG_PCNA_PIPBox_1	374	383	PF02747	0.292
LIG_Pex14_2	19	23	PF04695	0.461
LIG_SH2_CRK	206	210	PF00017	0.316
LIG_SH2_CRK	295	299	PF00017	0.353
LIG_SH2_SRC	416	419	PF00017	0.379
LIG_SH2_STAP1	206	210	PF00017	0.357
LIG_SH2_STAT5	110	113	PF00017	0.304
LIG_SH2_STAT5	184	187	PF00017	0.287
LIG_SH2_STAT5	35	38	PF00017	0.470
LIG_SH2_STAT5	380	383	PF00017	0.304
LIG_SH3_3	448	454	PF00018	0.504
LIG_SUMO_SIM_anti_2	190	196	PF11976	0.337
LIG_SUMO_SIM_anti_2	364	370	PF11976	0.417
LIG_SUMO_SIM_par_1	258	264	PF11976	0.289
LIG_SUMO_SIM_par_1	364	370	PF11976	0.375
LIG_UBA3_1	402	410	PF00899	0.305
LIG_UBA3_1	425	433	PF00899	0.384
LIG_UBA3_1	83	91	PF00899	0.369
LIG_WRC_WIRS_1	217	222	PF05994	0.353
MOD_CK1_1	29	35	PF00069	0.276
MOD_CK1_1	389	395	PF00069	0.404
MOD_CK1_1	419	425	PF00069	0.317
MOD_CK2_1	147	153	PF00069	0.256
MOD_CK2_1	177	183	PF00069	0.389
MOD_CK2_1	237	243	PF00069	0.238
MOD_CK2_1	337	343	PF00069	0.427
MOD_Cter_Amidation	316	319	PF01082	0.673
MOD_GlcNHglycan	248	251	PF01048	0.496
MOD_GlcNHglycan	455	458	PF01048	0.787
MOD_GlcNHglycan	46	49	PF01048	0.718
MOD_GSK3_1	147	154	PF00069	0.420
MOD_GSK3_1	246	253	PF00069	0.365
MOD_GSK3_1	25	32	PF00069	0.474
MOD_GSK3_1	256	263	PF00069	0.312
MOD_GSK3_1	44	51	PF00069	0.424
MOD_N-GLC_1	288	293	PF02516	0.519
MOD_NEK2_1	218	223	PF00069	0.308
MOD_NEK2_1	260	265	PF00069	0.286
MOD_PIKK_1	153	159	PF00454	0.387
MOD_PIKK_1	218	224	PF00454	0.312
MOD_PIKK_1	8	14	PF00454	0.676
MOD_PKA_1	442	448	PF00069	0.497
MOD_PKA_2	199	205	PF00069	0.348
MOD_PKA_2	245	251	PF00069	0.280
MOD_PKA_2	442	448	PF00069	0.458
MOD_Plk_1	119	125	PF00069	0.368
MOD_Plk_1	142	148	PF00069	0.376
MOD_Plk_1	288	294	PF00069	0.319
MOD_Plk_1	386	392	PF00069	0.380
MOD_Plk_2-3	72	78	PF00069	0.467
MOD_Plk_4	213	219	PF00069	0.365
MOD_Plk_4	237	243	PF00069	0.391
MOD_Plk_4	256	262	PF00069	0.393
MOD_Plk_4	30	36	PF00069	0.260
MOD_SUMO_for_1	436	439	PF00179	0.313
TRG_DiLeu_BaEn_1	350	355	PF01217	0.349
TRG_DiLeu_BaEn_2	325	331	PF01217	0.304
TRG_DiLeu_BaLyEn_6	53	58	PF01217	0.389
TRG_ENDOCYTIC_2	178	181	PF00928	0.321
TRG_ENDOCYTIC_2	206	209	PF00928	0.345
TRG_ENDOCYTIC_2	295	298	PF00928	0.350
TRG_ENDOCYTIC_2	371	374	PF00928	0.286
TRG_ENDOCYTIC_2	423	426	PF00928	0.399
TRG_ER_diArg_1	2	4	PF00400	0.628
TRG_ER_diArg_1	230	232	PF00400	0.341
TRG_ER_diArg_1	53	55	PF00400	0.414
TRG_ER_FFAT_1	339	350	PF00635	0.360
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	303	307	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM88	Leptomonas seymouri	84%	100%
A0A0S4JVF0	Bodo saltans	58%	100%
A0A1X0P8C7	Trypanosomatidae	68%	100%
A0A3Q8IQJ6	Leishmania donovani	90%	100%
A0A3R7MNS3	Trypanosoma rangeli	68%	100%
A4ICQ3	Leishmania infantum	91%	100%
D0A2Q6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9ASK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q1Z5	Leishmania major	90%	100%