Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNT7_LEIBR

TriTrypDb:

LbrM.35.0890 , LBRM2903_350014400

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNT7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	71	75	PF00656	0.553
CLV_NRD_NRD_1	11	13	PF00675	0.726
CLV_NRD_NRD_1	147	149	PF00675	0.326
CLV_NRD_NRD_1	239	241	PF00675	0.569
CLV_NRD_NRD_1	319	321	PF00675	0.752
CLV_NRD_NRD_1	329	331	PF00675	0.621
CLV_PCSK_FUR_1	9	13	PF00082	0.672
CLV_PCSK_KEX2_1	11	13	PF00082	0.728
CLV_PCSK_KEX2_1	147	149	PF00082	0.321
CLV_PCSK_KEX2_1	239	241	PF00082	0.551
CLV_PCSK_KEX2_1	329	331	PF00082	0.641
CLV_PCSK_SKI1_1	234	238	PF00082	0.431
DEG_Nend_UBRbox_3	1	3	PF02207	0.467
DOC_ANK_TNKS_1	275	282	PF00023	0.483
DOC_CKS1_1	112	117	PF01111	0.566
DOC_CKS1_1	263	268	PF01111	0.440
DOC_CYCLIN_yCln2_LP_2	238	244	PF00134	0.635
DOC_MAPK_gen_1	145	152	PF00069	0.334
DOC_PP2B_LxvP_1	157	160	PF13499	0.646
DOC_USP7_MATH_1	137	141	PF00917	0.454
DOC_USP7_MATH_1	161	165	PF00917	0.741
DOC_USP7_MATH_1	176	180	PF00917	0.772
DOC_USP7_MATH_1	204	208	PF00917	0.572
DOC_USP7_MATH_1	280	284	PF00917	0.776
DOC_USP7_MATH_1	307	311	PF00917	0.696
DOC_USP7_MATH_1	312	316	PF00917	0.668
DOC_USP7_MATH_1	40	44	PF00917	0.678
DOC_USP7_MATH_1	88	92	PF00917	0.726
DOC_USP7_MATH_1	94	98	PF00917	0.774
DOC_WW_Pin1_4	111	116	PF00397	0.675
DOC_WW_Pin1_4	18	23	PF00397	0.746
DOC_WW_Pin1_4	262	267	PF00397	0.638
DOC_WW_Pin1_4	310	315	PF00397	0.691
DOC_WW_Pin1_4	86	91	PF00397	0.684
LIG_14-3-3_CanoR_1	225	230	PF00244	0.640
LIG_14-3-3_CanoR_1	276	280	PF00244	0.582
LIG_14-3-3_CanoR_1	66	70	PF00244	0.478
LIG_Actin_WH2_2	229	245	PF00022	0.645
LIG_FHA_2	112	118	PF00498	0.497
LIG_FHA_2	296	302	PF00498	0.474
LIG_FHA_2	39	45	PF00498	0.536
LIG_Integrin_RGD_1	12	14	PF01839	0.587
LIG_LIR_Gen_1	187	197	PF02991	0.389
LIG_LIR_Gen_1	60	70	PF02991	0.362
LIG_LIR_Nem_3	140	146	PF02991	0.525
LIG_LIR_Nem_3	187	193	PF02991	0.438
LIG_LIR_Nem_3	231	236	PF02991	0.484
LIG_LIR_Nem_3	60	65	PF02991	0.449
LIG_SH2_CRK	62	66	PF00017	0.437
LIG_SH2_SRC	338	341	PF00017	0.448
LIG_SH2_STAT5	62	65	PF00017	0.375
LIG_SH3_3	109	115	PF00018	0.513
LIG_SH3_3	153	159	PF00018	0.527
LIG_SH3_3	238	244	PF00018	0.533
LIG_SUMO_SIM_par_1	57	63	PF11976	0.328
LIG_TRAF2_1	114	117	PF00917	0.490
LIG_ULM_U2AF65_1	329	334	PF00076	0.673
MOD_CDK_SPK_2	262	267	PF00069	0.428
MOD_CK1_1	177	183	PF00069	0.552
MOD_CK1_1	245	251	PF00069	0.448
MOD_CK1_1	268	274	PF00069	0.770
MOD_CK1_1	294	300	PF00069	0.629
MOD_CK1_1	310	316	PF00069	0.671
MOD_CK1_1	32	38	PF00069	0.667
MOD_CK1_1	60	66	PF00069	0.520
MOD_CK1_1	68	74	PF00069	0.583
MOD_CK2_1	111	117	PF00069	0.461
MOD_CK2_1	183	189	PF00069	0.640
MOD_CK2_1	295	301	PF00069	0.475
MOD_CK2_1	38	44	PF00069	0.470
MOD_CK2_1	94	100	PF00069	0.674
MOD_GlcNHglycan	100	104	PF01048	0.603
MOD_GlcNHglycan	244	247	PF01048	0.617
MOD_GlcNHglycan	270	273	PF01048	0.719
MOD_GlcNHglycan	277	280	PF01048	0.709
MOD_GlcNHglycan	293	296	PF01048	0.708
MOD_GlcNHglycan	90	93	PF01048	0.737
MOD_GlcNHglycan	96	99	PF01048	0.777
MOD_GSK3_1	174	181	PF00069	0.581
MOD_GSK3_1	18	25	PF00069	0.641
MOD_GSK3_1	270	277	PF00069	0.730
MOD_GSK3_1	282	289	PF00069	0.781
MOD_GSK3_1	291	298	PF00069	0.664
MOD_GSK3_1	306	313	PF00069	0.697
MOD_GSK3_1	65	72	PF00069	0.597
MOD_N-GLC_1	214	219	PF02516	0.593
MOD_N-GLC_1	38	43	PF02516	0.630
MOD_NEK2_1	275	280	PF00069	0.541
MOD_NEK2_1	5	10	PF00069	0.627
MOD_NEK2_2	137	142	PF00069	0.369
MOD_PIKK_1	130	136	PF00454	0.607
MOD_PIKK_1	178	184	PF00454	0.568
MOD_PIKK_1	307	313	PF00454	0.654
MOD_PIKK_1	60	66	PF00454	0.596
MOD_PKA_1	320	326	PF00069	0.645
MOD_PKA_2	242	248	PF00069	0.514
MOD_PKA_2	275	281	PF00069	0.641
MOD_PKA_2	65	71	PF00069	0.592
MOD_Plk_1	295	301	PF00069	0.554
MOD_Plk_4	137	143	PF00069	0.465
MOD_Plk_4	152	158	PF00069	0.441
MOD_Plk_4	228	234	PF00069	0.622
MOD_Plk_4	251	257	PF00069	0.543
MOD_Plk_4	45	51	PF00069	0.664
MOD_ProDKin_1	111	117	PF00069	0.670
MOD_ProDKin_1	18	24	PF00069	0.749
MOD_ProDKin_1	262	268	PF00069	0.643
MOD_ProDKin_1	310	316	PF00069	0.696
MOD_ProDKin_1	86	92	PF00069	0.684
TRG_DiLeu_BaEn_1	119	124	PF01217	0.542
TRG_DiLeu_BaEn_1	189	194	PF01217	0.601
TRG_ENDOCYTIC_2	62	65	PF00928	0.431
TRG_ER_diArg_1	146	148	PF00400	0.307
TRG_ER_diArg_1	238	240	PF00400	0.564
TRG_ER_diArg_1	256	259	PF00400	0.555
TRG_ER_diArg_1	329	332	PF00400	0.672
TRG_ER_diArg_1	9	12	PF00400	0.637

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFS7	Leptomonas seymouri	39%	78%
A0A1X0P881	Trypanosomatidae	25%	74%
A0A3Q8IFT7	Leishmania donovani	68%	79%
A0A422NK60	Trypanosoma rangeli	27%	82%
A4ICQ7	Leishmania infantum	68%	79%
D0A2Q4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	80%
E9ASJ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	79%
Q4Q1Z9	Leishmania major	68%	100%
V5BZW6	Trypanosoma cruzi	24%	82%