J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR-repeat-containing chaperone protein DNAJ, putative

Species:

Leishmania braziliensis

UniProt:

A4HNT6_LEIBR

TriTrypDb:

LbrM.35.0880 , LBRM2903_350014300

Length:

844

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNT6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.473
CLV_C14_Caspase3-7	633	637	PF00656	0.402
CLV_NRD_NRD_1	120	122	PF00675	0.546
CLV_NRD_NRD_1	515	517	PF00675	0.418
CLV_NRD_NRD_1	651	653	PF00675	0.317
CLV_NRD_NRD_1	96	98	PF00675	0.694
CLV_NRD_NRD_1	99	101	PF00675	0.674
CLV_PCSK_FUR_1	97	101	PF00082	0.721
CLV_PCSK_KEX2_1	120	122	PF00082	0.546
CLV_PCSK_KEX2_1	514	516	PF00082	0.552
CLV_PCSK_KEX2_1	651	653	PF00082	0.350
CLV_PCSK_KEX2_1	750	752	PF00082	0.647
CLV_PCSK_KEX2_1	96	98	PF00082	0.694
CLV_PCSK_KEX2_1	99	101	PF00082	0.689
CLV_PCSK_PC1ET2_1	514	516	PF00082	0.552
CLV_PCSK_PC1ET2_1	750	752	PF00082	0.517
CLV_PCSK_SKI1_1	310	314	PF00082	0.372
CLV_PCSK_SKI1_1	33	37	PF00082	0.721
CLV_PCSK_SKI1_1	464	468	PF00082	0.420
CLV_PCSK_SKI1_1	489	493	PF00082	0.324
CLV_PCSK_SKI1_1	821	825	PF00082	0.358
CLV_PCSK_SKI1_1	9	13	PF00082	0.678
DEG_APCC_DBOX_1	653	661	PF00400	0.380
DEG_APCC_DBOX_1	99	107	PF00400	0.706
DEG_SPOP_SBC_1	352	356	PF00917	0.511
DOC_CDC14_PxL_1	481	489	PF14671	0.392
DOC_CYCLIN_RxL_1	500	510	PF00134	0.507
DOC_CYCLIN_RxL_1	779	787	PF00134	0.441
DOC_CYCLIN_RxL_1	95	105	PF00134	0.493
DOC_CYCLIN_yCln2_LP_2	7	13	PF00134	0.710
DOC_MAPK_gen_1	651	659	PF00069	0.347
DOC_MAPK_gen_1	96	106	PF00069	0.607
DOC_MAPK_MEF2A_6	277	285	PF00069	0.258
DOC_MAPK_MEF2A_6	651	659	PF00069	0.356
DOC_PP2B_LxvP_1	437	440	PF13499	0.335
DOC_PP4_FxxP_1	387	390	PF00568	0.434
DOC_USP7_MATH_1	20	24	PF00917	0.595
DOC_USP7_MATH_1	217	221	PF00917	0.680
DOC_USP7_MATH_1	26	30	PF00917	0.615
DOC_USP7_MATH_1	351	355	PF00917	0.669
DOC_USP7_MATH_1	375	379	PF00917	0.650
DOC_USP7_MATH_1	42	46	PF00917	0.693
DOC_USP7_MATH_1	438	442	PF00917	0.452
DOC_USP7_MATH_1	524	528	PF00917	0.483
DOC_USP7_MATH_1	592	596	PF00917	0.488
DOC_USP7_MATH_1	637	641	PF00917	0.537
DOC_USP7_MATH_1	740	744	PF00917	0.635
DOC_USP7_UBL2_3	804	808	PF12436	0.353
DOC_WW_Pin1_4	138	143	PF00397	0.677
DOC_WW_Pin1_4	363	368	PF00397	0.633
DOC_WW_Pin1_4	40	45	PF00397	0.663
DOC_WW_Pin1_4	48	53	PF00397	0.581
DOC_WW_Pin1_4	639	644	PF00397	0.443
DOC_WW_Pin1_4	66	71	PF00397	0.537
DOC_WW_Pin1_4	702	707	PF00397	0.524
DOC_WW_Pin1_4	727	732	PF00397	0.711
DOC_WW_Pin1_4	74	79	PF00397	0.699
DOC_WW_Pin1_4	757	762	PF00397	0.824
DOC_WW_Pin1_4	81	86	PF00397	0.732
DOC_WW_Pin1_4	823	828	PF00397	0.399
LIG_14-3-3_CanoR_1	151	160	PF00244	0.499
LIG_14-3-3_CanoR_1	243	248	PF00244	0.265
LIG_14-3-3_CanoR_1	503	508	PF00244	0.277
LIG_14-3-3_CanoR_1	563	571	PF00244	0.327
LIG_14-3-3_CanoR_1	668	672	PF00244	0.535
LIG_14-3-3_CanoR_1	753	762	PF00244	0.779
LIG_14-3-3_CanoR_1	99	104	PF00244	0.737
LIG_Actin_WH2_2	288	303	PF00022	0.333
LIG_Actin_WH2_2	519	536	PF00022	0.391
LIG_BIR_III_4	428	432	PF00653	0.253
LIG_BIR_III_4	57	61	PF00653	0.504
LIG_BRCT_BRCA1_1	110	114	PF00533	0.705
LIG_DLG_GKlike_1	99	106	PF00625	0.486
LIG_FHA_1	110	116	PF00498	0.645
LIG_FHA_1	128	134	PF00498	0.614
LIG_FHA_1	176	182	PF00498	0.672
LIG_FHA_1	244	250	PF00498	0.327
LIG_FHA_1	259	265	PF00498	0.369
LIG_FHA_1	316	322	PF00498	0.348
LIG_FHA_1	500	506	PF00498	0.309
LIG_FHA_1	542	548	PF00498	0.623
LIG_FHA_1	562	568	PF00498	0.327
LIG_FHA_1	596	602	PF00498	0.334
LIG_FHA_1	697	703	PF00498	0.417
LIG_FHA_1	70	76	PF00498	0.576
LIG_FHA_2	257	263	PF00498	0.387
LIG_FHA_2	377	383	PF00498	0.479
LIG_FHA_2	466	472	PF00498	0.317
LIG_FHA_2	824	830	PF00498	0.399
LIG_HCF-1_HBM_1	53	56	PF13415	0.479
LIG_LIR_Apic_2	441	445	PF02991	0.551
LIG_LIR_Gen_1	415	424	PF02991	0.460
LIG_LIR_Gen_1	449	458	PF02991	0.405
LIG_LIR_Nem_3	284	288	PF02991	0.506
LIG_LIR_Nem_3	318	322	PF02991	0.547
LIG_LIR_Nem_3	415	421	PF02991	0.481
LIG_LIR_Nem_3	449	453	PF02991	0.401
LIG_LIR_Nem_3	45	50	PF02991	0.661
LIG_LIR_Nem_3	471	477	PF02991	0.449
LIG_LIR_Nem_3	482	487	PF02991	0.398
LIG_LIR_Nem_3	796	800	PF02991	0.631
LIG_LIR_Nem_3	834	840	PF02991	0.266
LIG_LYPXL_S_1	46	50	PF13949	0.472
LIG_LYPXL_S_1	483	487	PF13949	0.375
LIG_LYPXL_yS_3	47	50	PF13949	0.471
LIG_LYPXL_yS_3	484	487	PF13949	0.375
LIG_MYND_1	138	142	PF01753	0.484
LIG_MYND_1	44	48	PF01753	0.459
LIG_NRBOX	454	460	PF00104	0.436
LIG_PTAP_UEV_1	790	795	PF05743	0.530
LIG_PTB_Apo_2	171	178	PF02174	0.477
LIG_Rb_LxCxE_1	246	262	PF01857	0.273
LIG_SH2_CRK	442	446	PF00017	0.549
LIG_SH2_NCK_1	645	649	PF00017	0.371
LIG_SH2_NCK_1	690	694	PF00017	0.478
LIG_SH2_SRC	214	217	PF00017	0.438
LIG_SH2_SRC	287	290	PF00017	0.447
LIG_SH2_SRC	690	693	PF00017	0.485
LIG_SH2_STAP1	260	264	PF00017	0.394
LIG_SH2_STAP1	315	319	PF00017	0.446
LIG_SH2_STAP1	597	601	PF00017	0.331
LIG_SH2_STAP1	645	649	PF00017	0.363
LIG_SH2_STAP1	690	694	PF00017	0.501
LIG_SH2_STAT3	664	667	PF00017	0.548
LIG_SH2_STAT5	260	263	PF00017	0.532
LIG_SH2_STAT5	287	290	PF00017	0.425
LIG_SH2_STAT5	296	299	PF00017	0.411
LIG_SH2_STAT5	442	445	PF00017	0.471
LIG_SH2_STAT5	597	600	PF00017	0.357
LIG_SH2_STAT5	658	661	PF00017	0.417
LIG_SH2_STAT5	79	82	PF00017	0.657
LIG_SH3_1	82	88	PF00018	0.631
LIG_SH3_3	130	136	PF00018	0.734
LIG_SH3_3	72	78	PF00018	0.761
LIG_SH3_3	788	794	PF00018	0.538
LIG_SH3_3	82	88	PF00018	0.722
LIG_SUMO_SIM_par_1	102	108	PF11976	0.592
LIG_SUMO_SIM_par_1	434	441	PF11976	0.443
LIG_SUMO_SIM_par_1	9	14	PF11976	0.739
LIG_UBA3_1	458	465	PF00899	0.500
LIG_UBA3_1	777	782	PF00899	0.407
LIG_WRC_WIRS_1	282	287	PF05994	0.516
MOD_CDK_SPxxK_3	138	145	PF00069	0.485
MOD_CK1_1	102	108	PF00069	0.653
MOD_CK1_1	110	116	PF00069	0.668
MOD_CK1_1	141	147	PF00069	0.713
MOD_CK1_1	356	362	PF00069	0.573
MOD_CK1_1	562	568	PF00069	0.333
MOD_CK1_1	595	601	PF00069	0.425
MOD_CK1_1	69	75	PF00069	0.630
MOD_CK1_1	732	738	PF00069	0.558
MOD_CK1_1	743	749	PF00069	0.667
MOD_CK1_1	756	762	PF00069	0.754
MOD_CK1_1	81	87	PF00069	0.696
MOD_CK2_1	119	125	PF00069	0.791
MOD_CK2_1	152	158	PF00069	0.617
MOD_CK2_1	256	262	PF00069	0.389
MOD_CK2_1	376	382	PF00069	0.603
MOD_CK2_1	465	471	PF00069	0.414
MOD_CK2_1	59	65	PF00069	0.652
MOD_CK2_1	727	733	PF00069	0.404
MOD_CK2_1	823	829	PF00069	0.399
MOD_Cter_Amidation	748	751	PF01082	0.519
MOD_GlcNHglycan	154	157	PF01048	0.568
MOD_GlcNHglycan	164	167	PF01048	0.547
MOD_GlcNHglycan	201	204	PF01048	0.545
MOD_GlcNHglycan	22	25	PF01048	0.606
MOD_GlcNHglycan	29	32	PF01048	0.676
MOD_GlcNHglycan	343	346	PF01048	0.752
MOD_GlcNHglycan	347	350	PF01048	0.754
MOD_GlcNHglycan	594	597	PF01048	0.373
MOD_GlcNHglycan	61	64	PF01048	0.620
MOD_GlcNHglycan	742	745	PF01048	0.645
MOD_GlcNHglycan	755	758	PF01048	0.670
MOD_GlcNHglycan	763	766	PF01048	0.556
MOD_GlcNHglycan	791	794	PF01048	0.637
MOD_GSK3_1	105	112	PF00069	0.684
MOD_GSK3_1	11	18	PF00069	0.675
MOD_GSK3_1	158	165	PF00069	0.720
MOD_GSK3_1	218	225	PF00069	0.559
MOD_GSK3_1	341	348	PF00069	0.580
MOD_GSK3_1	352	359	PF00069	0.585
MOD_GSK3_1	42	49	PF00069	0.636
MOD_GSK3_1	465	472	PF00069	0.335
MOD_GSK3_1	499	506	PF00069	0.344
MOD_GSK3_1	538	545	PF00069	0.550
MOD_GSK3_1	727	734	PF00069	0.580
MOD_GSK3_1	735	742	PF00069	0.660
MOD_GSK3_1	74	81	PF00069	0.699
MOD_GSK3_1	753	760	PF00069	0.636
MOD_GSK3_1	95	102	PF00069	0.768
MOD_N-GLC_1	108	113	PF02516	0.620
MOD_N-GLC_1	15	20	PF02516	0.704
MOD_N-GLC_1	616	621	PF02516	0.349
MOD_NEK2_1	1	6	PF00069	0.650
MOD_NEK2_1	162	167	PF00069	0.629
MOD_NEK2_1	281	286	PF00069	0.535
MOD_NEK2_1	357	362	PF00069	0.532
MOD_NEK2_1	696	701	PF00069	0.358
MOD_NEK2_1	784	789	PF00069	0.488
MOD_NEK2_2	127	132	PF00069	0.710
MOD_NEK2_2	353	358	PF00069	0.494
MOD_PIKK_1	119	125	PF00454	0.572
MOD_PIKK_1	716	722	PF00454	0.507
MOD_PIKK_1	87	93	PF00454	0.536
MOD_PKA_1	99	105	PF00069	0.708
MOD_PKA_2	119	125	PF00069	0.645
MOD_PKA_2	196	202	PF00069	0.559
MOD_PKA_2	341	347	PF00069	0.570
MOD_PKA_2	357	363	PF00069	0.552
MOD_PKA_2	562	568	PF00069	0.441
MOD_PKA_2	667	673	PF00069	0.535
MOD_PKA_2	95	101	PF00069	0.712
MOD_PKB_1	751	759	PF00069	0.667
MOD_PKB_1	97	105	PF00069	0.712
MOD_Plk_1	158	164	PF00069	0.615
MOD_Plk_1	616	622	PF00069	0.350
MOD_Plk_1	64	70	PF00069	0.495
MOD_Plk_2-3	630	636	PF00069	0.345
MOD_Plk_4	110	116	PF00069	0.662
MOD_Plk_4	243	249	PF00069	0.412
MOD_Plk_4	3	9	PF00069	0.477
MOD_Plk_4	413	419	PF00069	0.436
MOD_Plk_4	42	48	PF00069	0.465
MOD_Plk_4	469	475	PF00069	0.277
MOD_Plk_4	503	509	PF00069	0.306
MOD_Plk_4	784	790	PF00069	0.588
MOD_Plk_4	99	105	PF00069	0.750
MOD_ProDKin_1	138	144	PF00069	0.677
MOD_ProDKin_1	363	369	PF00069	0.632
MOD_ProDKin_1	40	46	PF00069	0.663
MOD_ProDKin_1	48	54	PF00069	0.550
MOD_ProDKin_1	639	645	PF00069	0.442
MOD_ProDKin_1	66	72	PF00069	0.539
MOD_ProDKin_1	702	708	PF00069	0.530
MOD_ProDKin_1	727	733	PF00069	0.717
MOD_ProDKin_1	74	80	PF00069	0.701
MOD_ProDKin_1	757	763	PF00069	0.822
MOD_ProDKin_1	81	87	PF00069	0.724
MOD_ProDKin_1	823	829	PF00069	0.399
MOD_SUMO_rev_2	703	712	PF00179	0.462
MOD_SUMO_rev_2	796	806	PF00179	0.622
TRG_DiLeu_BaEn_1	779	784	PF01217	0.292
TRG_DiLeu_BaLyEn_6	317	322	PF01217	0.320
TRG_ENDOCYTIC_2	319	322	PF00928	0.537
TRG_ENDOCYTIC_2	47	50	PF00928	0.632
TRG_ENDOCYTIC_2	484	487	PF00928	0.372
TRG_ENDOCYTIC_2	810	813	PF00928	0.179
TRG_ER_diArg_1	515	517	PF00400	0.337
TRG_ER_diArg_1	651	654	PF00400	0.328
TRG_ER_diArg_1	96	99	PF00400	0.697
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	599	604	PF00026	0.365

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I741	Leptomonas seymouri	46%	70%
A0A0S4JSA3	Bodo saltans	26%	87%
A0A1X0P885	Trypanosomatidae	30%	87%
A0A3R7RK92	Trypanosoma rangeli	29%	87%
A0A3S7XAG9	Leishmania donovani	74%	99%
A4ICQ8	Leishmania infantum	74%	99%
E9ASJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	99%
Q4Q200	Leishmania major	72%	100%
V5DRP2	Trypanosoma cruzi	29%	100%