C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNT4_LEIBR

TriTrypDb:

LbrM.35.0860 , LBRM2903_350014000

Length:

528

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNT4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNT4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	252	256	PF00656	0.633
CLV_C14_Caspase3-7	354	358	PF00656	0.434
CLV_NRD_NRD_1	463	465	PF00675	0.474
CLV_NRD_NRD_1	499	501	PF00675	0.468
CLV_PCSK_KEX2_1	465	467	PF00082	0.425
CLV_PCSK_PC1ET2_1	465	467	PF00082	0.425
CLV_PCSK_SKI1_1	196	200	PF00082	0.345
CLV_PCSK_SKI1_1	268	272	PF00082	0.388
DEG_Nend_Nbox_1	1	3	PF02207	0.520
DOC_CDC14_PxL_1	410	418	PF14671	0.426
DOC_CKS1_1	105	110	PF01111	0.545
DOC_MAPK_gen_1	196	203	PF00069	0.418
DOC_MAPK_gen_1	265	275	PF00069	0.381
DOC_MAPK_MEF2A_6	196	203	PF00069	0.418
DOC_MAPK_MEF2A_6	265	273	PF00069	0.383
DOC_MAPK_MEF2A_6	415	424	PF00069	0.401
DOC_MAPK_NFAT4_5	268	276	PF00069	0.398
DOC_MAPK_RevD_3	488	501	PF00069	0.422
DOC_PP2B_LxvP_1	365	368	PF13499	0.423
DOC_PP4_FxxP_1	275	278	PF00568	0.404
DOC_PP4_MxPP_1	106	109	PF00568	0.539
DOC_USP7_MATH_1	227	231	PF00917	0.691
DOC_USP7_MATH_1	254	258	PF00917	0.533
DOC_USP7_MATH_1	335	339	PF00917	0.363
DOC_USP7_MATH_1	56	60	PF00917	0.678
DOC_USP7_UBL2_3	261	265	PF12436	0.477
DOC_USP7_UBL2_3	305	309	PF12436	0.451
DOC_USP7_UBL2_3	360	364	PF12436	0.462
DOC_USP7_UBL2_3	448	452	PF12436	0.411
DOC_WW_Pin1_4	104	109	PF00397	0.596
DOC_WW_Pin1_4	182	187	PF00397	0.510
DOC_WW_Pin1_4	274	279	PF00397	0.332
DOC_WW_Pin1_4	40	45	PF00397	0.532
DOC_WW_Pin1_4	59	64	PF00397	0.507
LIG_14-3-3_CanoR_1	205	211	PF00244	0.489
LIG_APCC_ABBA_1	349	354	PF00400	0.430
LIG_BRCT_BRCA1_1	483	487	PF00533	0.396
LIG_eIF4E_1	436	442	PF01652	0.439
LIG_FHA_1	183	189	PF00498	0.479
LIG_FHA_1	193	199	PF00498	0.442
LIG_FHA_1	264	270	PF00498	0.438
LIG_FHA_1	419	425	PF00498	0.391
LIG_FHA_2	207	213	PF00498	0.558
LIG_FHA_2	430	436	PF00498	0.465
LIG_FHA_2	491	497	PF00498	0.424
LIG_LIR_Apic_2	274	278	PF02991	0.405
LIG_LIR_Apic_2	296	300	PF02991	0.510
LIG_LIR_Apic_2	329	335	PF02991	0.382
LIG_LIR_Gen_1	345	352	PF02991	0.425
LIG_LIR_Gen_1	484	492	PF02991	0.377
LIG_LIR_Nem_3	296	302	PF02991	0.412
LIG_LIR_Nem_3	329	334	PF02991	0.381
LIG_LIR_Nem_3	431	436	PF02991	0.417
LIG_LIR_Nem_3	484	490	PF02991	0.377
LIG_LYPXL_yS_3	57	60	PF13949	0.538
LIG_PDZ_Class_1	523	528	PF00595	0.500
LIG_Pex14_2	359	363	PF04695	0.396
LIG_PTB_Apo_2	162	169	PF02174	0.580
LIG_SH2_CRK	332	336	PF00017	0.414
LIG_SH2_CRK	87	91	PF00017	0.535
LIG_SH2_STAP1	207	211	PF00017	0.511
LIG_SH2_STAP1	454	458	PF00017	0.626
LIG_SH2_STAT3	119	122	PF00017	0.650
LIG_SH2_STAT3	155	158	PF00017	0.705
LIG_SH2_STAT3	169	172	PF00017	0.506
LIG_SH2_STAT3	450	453	PF00017	0.409
LIG_SH2_STAT3	46	49	PF00017	0.703
LIG_SH2_STAT3	78	81	PF00017	0.593
LIG_SH2_STAT3	89	92	PF00017	0.611
LIG_SH2_STAT5	167	170	PF00017	0.656
LIG_SH2_STAT5	297	300	PF00017	0.439
LIG_SH2_STAT5	340	343	PF00017	0.370
LIG_SH2_STAT5	348	351	PF00017	0.450
LIG_SH2_STAT5	54	57	PF00017	0.615
LIG_SH3_3	106	112	PF00018	0.612
LIG_SH3_3	411	417	PF00018	0.456
LIG_TRAF2_1	493	496	PF00917	0.476
LIG_TYR_ITIM	55	60	PF00017	0.538
LIG_TYR_ITSM	327	334	PF00017	0.372
MOD_CDK_SPK_2	274	279	PF00069	0.413
MOD_CK1_1	104	110	PF00069	0.568
MOD_CK1_1	230	236	PF00069	0.567
MOD_CK1_1	274	280	PF00069	0.330
MOD_CK1_1	418	424	PF00069	0.362
MOD_CK1_1	429	435	PF00069	0.487
MOD_CK1_1	460	466	PF00069	0.470
MOD_CK1_1	59	65	PF00069	0.649
MOD_CK2_1	236	242	PF00069	0.642
MOD_CK2_1	490	496	PF00069	0.428
MOD_Cter_Amidation	310	313	PF01082	0.435
MOD_GlcNHglycan	225	228	PF01048	0.677
MOD_GlcNHglycan	255	259	PF01048	0.535
MOD_GlcNHglycan	284	287	PF01048	0.475
MOD_GlcNHglycan	335	338	PF01048	0.292
MOD_GlcNHglycan	344	347	PF01048	0.349
MOD_GlcNHglycan	396	400	PF01048	0.448
MOD_GlcNHglycan	8	11	PF01048	0.607
MOD_GSK3_1	219	226	PF00069	0.632
MOD_GSK3_1	227	234	PF00069	0.600
MOD_GSK3_1	335	342	PF00069	0.357
MOD_GSK3_1	395	402	PF00069	0.482
MOD_N-GLC_1	124	129	PF02516	0.671
MOD_N-GLC_1	230	235	PF02516	0.539
MOD_N-GLC_1	236	241	PF02516	0.532
MOD_N-GLC_1	399	404	PF02516	0.413
MOD_N-GLC_2	129	131	PF02516	0.563
MOD_NEK2_1	236	241	PF00069	0.535
MOD_NEK2_1	271	276	PF00069	0.423
MOD_NEK2_1	282	287	PF00069	0.485
MOD_NEK2_1	295	300	PF00069	0.352
MOD_NEK2_1	481	486	PF00069	0.387
MOD_NEK2_2	335	340	PF00069	0.362
MOD_OFUCOSY	479	485	PF10250	0.373
MOD_PIKK_1	107	113	PF00454	0.686
MOD_PIKK_1	72	78	PF00454	0.747
MOD_PK_1	197	203	PF00069	0.412
MOD_PKA_1	500	506	PF00069	0.396
MOD_Plk_1	230	236	PF00069	0.538
MOD_Plk_1	254	260	PF00069	0.585
MOD_Plk_1	295	301	PF00069	0.418
MOD_Plk_1	399	405	PF00069	0.412
MOD_Plk_1	418	424	PF00069	0.401
MOD_Plk_4	101	107	PF00069	0.723
MOD_Plk_4	163	169	PF00069	0.557
MOD_Plk_4	231	237	PF00069	0.622
MOD_Plk_4	271	277	PF00069	0.426
MOD_Plk_4	335	341	PF00069	0.360
MOD_Plk_4	347	353	PF00069	0.378
MOD_ProDKin_1	104	110	PF00069	0.597
MOD_ProDKin_1	182	188	PF00069	0.497
MOD_ProDKin_1	274	280	PF00069	0.330
MOD_ProDKin_1	40	46	PF00069	0.534
MOD_ProDKin_1	59	65	PF00069	0.503
MOD_SUMO_rev_2	234	241	PF00179	0.676
MOD_SUMO_rev_2	257	267	PF00179	0.576
MOD_SUMO_rev_2	306	314	PF00179	0.473
MOD_SUMO_rev_2	494	503	PF00179	0.462
TRG_DiLeu_BaEn_2	482	488	PF01217	0.381
TRG_ENDOCYTIC_2	207	210	PF00928	0.501
TRG_ENDOCYTIC_2	331	334	PF00928	0.374
TRG_ENDOCYTIC_2	348	351	PF00928	0.427
TRG_ENDOCYTIC_2	57	60	PF00928	0.538
TRG_ER_diArg_1	464	467	PF00400	0.444
TRG_NES_CRM1_1	382	396	PF08389	0.317
TRG_NLS_MonoExtN_4	462	468	PF00514	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7W2	Leptomonas seymouri	67%	100%
A0A3S7XAD2	Leishmania donovani	84%	97%
A4ICR0	Leishmania infantum	84%	97%
E9ASJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	98%
Q4Q202	Leishmania major	84%	100%