Zinc finger (CCCH type) motif-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNT3_LEIBR

TriTrypDb:

LbrM.35.0850 , LBRM2903_350013900

Length:

496

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNT3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.491
CLV_C14_Caspase3-7	378	382	PF00656	0.839
CLV_C14_Caspase3-7	71	75	PF00656	0.384
CLV_MEL_PAP_1	420	426	PF00089	0.772
CLV_NRD_NRD_1	32	34	PF00675	0.689
CLV_NRD_NRD_1	38	40	PF00675	0.609
CLV_NRD_NRD_1	481	483	PF00675	0.747
CLV_PCSK_KEX2_1	32	34	PF00082	0.639
CLV_PCSK_KEX2_1	38	40	PF00082	0.538
CLV_PCSK_KEX2_1	481	483	PF00082	0.747
CLV_PCSK_SKI1_1	115	119	PF00082	0.569
DEG_SCF_FBW7_1	309	314	PF00400	0.550
DEG_SPOP_SBC_1	311	315	PF00917	0.699
DEG_SPOP_SBC_1	325	329	PF00917	0.529
DEG_SPOP_SBC_1	490	494	PF00917	0.796
DOC_CKS1_1	228	233	PF01111	0.577
DOC_CKS1_1	441	446	PF01111	0.764
DOC_MAPK_DCC_7	256	266	PF00069	0.516
DOC_MAPK_DCC_7	430	440	PF00069	0.775
DOC_MAPK_FxFP_2	118	121	PF00069	0.470
DOC_MAPK_MEF2A_6	285	294	PF00069	0.477
DOC_MAPK_MEF2A_6	434	442	PF00069	0.751
DOC_PP2B_LxvP_1	385	388	PF13499	0.568
DOC_PP2B_LxvP_1	488	491	PF13499	0.555
DOC_PP4_FxxP_1	118	121	PF00568	0.470
DOC_PP4_FxxP_1	50	53	PF00568	0.481
DOC_USP7_MATH_1	26	30	PF00917	0.651
DOC_USP7_MATH_1	403	407	PF00917	0.550
DOC_USP7_MATH_1	491	495	PF00917	0.542
DOC_USP7_MATH_2	299	305	PF00917	0.778
DOC_WW_Pin1_4	106	111	PF00397	0.580
DOC_WW_Pin1_4	126	131	PF00397	0.226
DOC_WW_Pin1_4	21	26	PF00397	0.688
DOC_WW_Pin1_4	227	232	PF00397	0.529
DOC_WW_Pin1_4	293	298	PF00397	0.539
DOC_WW_Pin1_4	305	310	PF00397	0.714
DOC_WW_Pin1_4	31	36	PF00397	0.686
DOC_WW_Pin1_4	331	336	PF00397	0.695
DOC_WW_Pin1_4	422	427	PF00397	0.796
DOC_WW_Pin1_4	433	438	PF00397	0.677
DOC_WW_Pin1_4	440	445	PF00397	0.641
DOC_WW_Pin1_4	453	458	PF00397	0.500
DOC_WW_Pin1_4	475	480	PF00397	0.700
DOC_WW_Pin1_4	486	491	PF00397	0.713
LIG_14-3-3_CanoR_1	38	42	PF00244	0.594
LIG_14-3-3_CanoR_1	44	49	PF00244	0.514
LIG_14-3-3_CanoR_1	9	19	PF00244	0.781
LIG_APCC_ABBA_1	132	137	PF00400	0.452
LIG_APCC_ABBA_1	153	158	PF00400	0.489
LIG_BRCT_BRCA1_1	491	495	PF00533	0.542
LIG_FHA_1	256	262	PF00498	0.614
LIG_FHA_1	272	278	PF00498	0.341
LIG_FHA_1	326	332	PF00498	0.636
LIG_FHA_1	475	481	PF00498	0.845
LIG_FHA_2	228	234	PF00498	0.527
LIG_FHA_2	247	253	PF00498	0.598
LIG_FHA_2	69	75	PF00498	0.635
LIG_IBAR_NPY_1	484	486	PF08397	0.724
LIG_Integrin_isoDGR_2	36	38	PF01839	0.662
LIG_Integrin_isoDGR_2	390	392	PF01839	0.786
LIG_LIR_Apic_2	116	121	PF02991	0.474
LIG_LIR_Apic_2	47	53	PF02991	0.486
LIG_LIR_Gen_1	149	156	PF02991	0.482
LIG_LIR_Nem_3	149	155	PF02991	0.571
LIG_LIR_Nem_3	196	201	PF02991	0.500
LIG_NRBOX	103	109	PF00104	0.570
LIG_PCNA_yPIPBox_3	213	226	PF02747	0.391
LIG_SH2_CRK	136	140	PF00017	0.450
LIG_SH2_CRK	412	416	PF00017	0.681
LIG_SH2_NCK_1	136	140	PF00017	0.450
LIG_SH2_NCK_1	251	255	PF00017	0.496
LIG_SH2_PTP2	152	155	PF00017	0.484
LIG_SH2_PTP2	96	99	PF00017	0.548
LIG_SH2_SRC	136	139	PF00017	0.452
LIG_SH2_SRC	251	254	PF00017	0.495
LIG_SH2_SRC	96	99	PF00017	0.548
LIG_SH2_STAP1	251	255	PF00017	0.496
LIG_SH2_STAP1	351	355	PF00017	0.511
LIG_SH2_STAT3	396	399	PF00017	0.824
LIG_SH2_STAT5	103	106	PF00017	0.425
LIG_SH2_STAT5	128	131	PF00017	0.513
LIG_SH2_STAT5	152	155	PF00017	0.532
LIG_SH2_STAT5	375	378	PF00017	0.836
LIG_SH2_STAT5	96	99	PF00017	0.459
LIG_SH3_3	222	228	PF00018	0.463
LIG_SH3_3	438	444	PF00018	0.724
LIG_SH3_3	94	100	PF00018	0.456
LIG_SUMO_SIM_par_1	456	462	PF11976	0.707
LIG_TRAF2_1	299	302	PF00917	0.759
LIG_TRAF2_1	369	372	PF00917	0.689
LIG_TRAF2_1	40	43	PF00917	0.559
LIG_TRFH_1	486	490	PF08558	0.719
MOD_CDC14_SPxK_1	334	337	PF00782	0.544
MOD_CDC14_SPxK_1	436	439	PF00782	0.663
MOD_CDC14_SPxK_1	478	481	PF00782	0.741
MOD_CDK_SPxK_1	331	337	PF00069	0.546
MOD_CDK_SPxK_1	433	439	PF00069	0.674
MOD_CDK_SPxK_1	475	481	PF00069	0.743
MOD_CDK_SPxxK_3	31	38	PF00069	0.678
MOD_CDK_SPxxK_3	475	482	PF00069	0.742
MOD_CK1_1	13	19	PF00069	0.686
MOD_CK1_1	24	30	PF00069	0.692
MOD_CK1_1	304	310	PF00069	0.813
MOD_CK1_1	456	462	PF00069	0.721
MOD_CK1_1	475	481	PF00069	0.743
MOD_CK1_1	489	495	PF00069	0.595
MOD_CK2_1	24	30	PF00069	0.632
MOD_CK2_1	246	252	PF00069	0.594
MOD_CK2_1	37	43	PF00069	0.533
MOD_CK2_1	51	57	PF00069	0.507
MOD_Cter_Amidation	30	33	PF01082	0.699
MOD_Cter_Amidation	36	39	PF01082	0.648
MOD_GlcNHglycan	15	18	PF01048	0.608
MOD_GlcNHglycan	2	5	PF01048	0.789
MOD_GlcNHglycan	26	29	PF01048	0.691
MOD_GlcNHglycan	319	322	PF01048	0.737
MOD_GlcNHglycan	431	434	PF01048	0.769
MOD_GlcNHglycan	461	464	PF01048	0.723
MOD_GlcNHglycan	465	468	PF01048	0.725
MOD_GlcNHglycan	89	92	PF01048	0.543
MOD_GSK3_1	200	207	PF00069	0.486
MOD_GSK3_1	242	249	PF00069	0.586
MOD_GSK3_1	301	308	PF00069	0.805
MOD_GSK3_1	312	319	PF00069	0.614
MOD_GSK3_1	327	334	PF00069	0.530
MOD_GSK3_1	429	436	PF00069	0.776
MOD_GSK3_1	459	466	PF00069	0.826
MOD_GSK3_1	486	493	PF00069	0.787
MOD_GSK3_1	51	58	PF00069	0.574
MOD_GSK3_1	9	16	PF00069	0.683
MOD_N-GLC_1	305	310	PF02516	0.563
MOD_N-GLC_1	381	386	PF02516	0.615
MOD_N-GLC_1	9	14	PF02516	0.716
MOD_N-GLC_2	92	94	PF02516	0.486
MOD_NEK2_1	317	322	PF00069	0.656
MOD_NEK2_1	474	479	PF00069	0.676
MOD_NEK2_1	79	84	PF00069	0.475
MOD_PIKK_1	246	252	PF00454	0.594
MOD_PIKK_1	375	381	PF00454	0.666
MOD_PIKK_1	467	473	PF00454	0.829
MOD_PKA_2	204	210	PF00069	0.439
MOD_PKA_2	255	261	PF00069	0.380
MOD_PKA_2	37	43	PF00069	0.593
MOD_PKA_2	373	379	PF00069	0.609
MOD_PKA_2	429	435	PF00069	0.698
MOD_Plk_1	380	386	PF00069	0.735
MOD_Plk_4	113	119	PF00069	0.449
MOD_Plk_4	79	85	PF00069	0.462
MOD_ProDKin_1	106	112	PF00069	0.576
MOD_ProDKin_1	126	132	PF00069	0.225
MOD_ProDKin_1	21	27	PF00069	0.687
MOD_ProDKin_1	227	233	PF00069	0.532
MOD_ProDKin_1	293	299	PF00069	0.548
MOD_ProDKin_1	305	311	PF00069	0.709
MOD_ProDKin_1	31	37	PF00069	0.681
MOD_ProDKin_1	331	337	PF00069	0.698
MOD_ProDKin_1	422	428	PF00069	0.794
MOD_ProDKin_1	433	439	PF00069	0.674
MOD_ProDKin_1	440	446	PF00069	0.651
MOD_ProDKin_1	453	459	PF00069	0.499
MOD_ProDKin_1	475	481	PF00069	0.703
MOD_ProDKin_1	486	492	PF00069	0.713
MOD_SUMO_rev_2	109	117	PF00179	0.585
TRG_DiLeu_BaLyEn_6	103	108	PF01217	0.562
TRG_ENDOCYTIC_2	120	123	PF00928	0.433
TRG_ENDOCYTIC_2	135	138	PF00928	0.417
TRG_ENDOCYTIC_2	152	155	PF00928	0.484
TRG_ENDOCYTIC_2	214	217	PF00928	0.591
TRG_ENDOCYTIC_2	412	415	PF00928	0.808
TRG_ENDOCYTIC_2	96	99	PF00928	0.548
TRG_ER_diArg_1	19	22	PF00400	0.551
TRG_ER_diArg_1	480	482	PF00400	0.744
TRG_Pf-PMV_PEXEL_1	348	352	PF00026	0.689

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P889	Leptomonas seymouri	62%	100%
A0A3S7XAD0	Leishmania donovani	86%	98%
A4ICR1	Leishmania infantum	86%	98%
E9ASJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q203	Leishmania major	84%	100%