LRRcap domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein C21orf2 homolog, putative

Species:

Leishmania braziliensis

UniProt:

A4HNT1_LEIBR

TriTrypDb:

LbrM.35.0830 , LBRM2903_350013600

Length:

260

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	10

Expansion

Sequence features

A4HNT1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNT1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.496
CLV_NRD_NRD_1	132	134	PF00675	0.292
CLV_NRD_NRD_1	73	75	PF00675	0.231
CLV_PCSK_FUR_1	162	166	PF00082	0.489
CLV_PCSK_KEX2_1	138	140	PF00082	0.304
CLV_PCSK_KEX2_1	164	166	PF00082	0.611
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.296
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.529
CLV_PCSK_SKI1_1	10	14	PF00082	0.433
CLV_PCSK_SKI1_1	138	142	PF00082	0.269
CLV_PCSK_SKI1_1	204	208	PF00082	0.605
CLV_PCSK_SKI1_1	215	219	PF00082	0.369
DEG_APCC_DBOX_1	214	222	PF00400	0.507
DEG_Nend_UBRbox_2	1	3	PF02207	0.366
DOC_CDC14_PxL_1	87	95	PF14671	0.430
DOC_MAPK_gen_1	119	128	PF00069	0.355
DOC_MAPK_gen_1	42	51	PF00069	0.496
DOC_MAPK_MEF2A_6	88	95	PF00069	0.480
DOC_PP1_RVXF_1	202	209	PF00149	0.611
DOC_USP7_MATH_1	166	170	PF00917	0.709
DOC_USP7_MATH_1	180	184	PF00917	0.597
DOC_USP7_MATH_1	50	54	PF00917	0.368
DOC_USP7_UBL2_3	134	138	PF12436	0.496
DOC_USP7_UBL2_3	15	19	PF12436	0.445
DOC_USP7_UBL2_3	246	250	PF12436	0.556
DOC_WW_Pin1_4	151	156	PF00397	0.630
DOC_WW_Pin1_4	157	162	PF00397	0.659
DOC_WW_Pin1_4	178	183	PF00397	0.697
LIG_14-3-3_CanoR_1	139	145	PF00244	0.513
LIG_14-3-3_CanoR_1	74	79	PF00244	0.424
LIG_BIR_III_2	179	183	PF00653	0.483
LIG_FHA_1	90	96	PF00498	0.440
LIG_FHA_2	127	133	PF00498	0.455
LIG_FHA_2	193	199	PF00498	0.698
LIG_FHA_2	75	81	PF00498	0.419
LIG_LIR_Nem_3	111	115	PF02991	0.387
LIG_SH2_CRK	115	119	PF00017	0.430
LIG_SH2_STAT5	115	118	PF00017	0.411
LIG_SH2_STAT5	72	75	PF00017	0.413
LIG_SUMO_SIM_anti_2	220	227	PF11976	0.483
LIG_SUMO_SIM_anti_2	231	237	PF11976	0.420
LIG_SUMO_SIM_anti_2	35	41	PF11976	0.430
LIG_SUMO_SIM_anti_2	92	97	PF11976	0.467
LIG_SUMO_SIM_par_1	217	223	PF11976	0.457
LIG_SUMO_SIM_par_1	47	53	PF11976	0.409
LIG_TRAF2_1	129	132	PF00917	0.393
LIG_TRAF2_1	195	198	PF00917	0.591
LIG_UBA3_1	67	75	PF00899	0.467
MOD_CDK_SPK_2	157	162	PF00069	0.627
MOD_CDK_SPxxK_3	157	164	PF00069	0.631
MOD_CK1_1	151	157	PF00069	0.614
MOD_CK1_1	175	181	PF00069	0.620
MOD_CK1_1	183	189	PF00069	0.578
MOD_CK1_1	220	226	PF00069	0.379
MOD_CK2_1	126	132	PF00069	0.413
MOD_CK2_1	192	198	PF00069	0.614
MOD_GlcNHglycan	166	169	PF01048	0.630
MOD_GlcNHglycan	185	188	PF01048	0.557
MOD_GlcNHglycan	201	204	PF01048	0.527
MOD_GlcNHglycan	211	214	PF01048	0.473
MOD_GlcNHglycan	83	87	PF01048	0.222
MOD_GSK3_1	13	20	PF00069	0.436
MOD_GSK3_1	164	171	PF00069	0.619
MOD_GSK3_1	174	181	PF00069	0.607
MOD_GSK3_1	183	190	PF00069	0.580
MOD_GSK3_1	252	259	PF00069	0.462
MOD_GSK3_1	50	57	PF00069	0.363
MOD_N-GLC_1	54	59	PF02516	0.296
MOD_NEK2_1	13	18	PF00069	0.359
MOD_NEK2_1	149	154	PF00069	0.529
MOD_NEK2_1	207	212	PF00069	0.509
MOD_NEK2_1	217	222	PF00069	0.456
MOD_PIKK_1	252	258	PF00454	0.381
MOD_PKA_1	138	144	PF00069	0.463
MOD_PKA_1	164	170	PF00069	0.693
MOD_PKA_1	74	80	PF00069	0.355
MOD_PKA_2	138	144	PF00069	0.496
MOD_PKA_2	164	170	PF00069	0.573
MOD_Plk_1	226	232	PF00069	0.431
MOD_Plk_1	35	41	PF00069	0.413
MOD_Plk_1	54	60	PF00069	0.496
MOD_Plk_1	82	88	PF00069	0.496
MOD_Plk_4	217	223	PF00069	0.401
MOD_Plk_4	63	69	PF00069	0.355
MOD_Plk_4	91	97	PF00069	0.462
MOD_ProDKin_1	151	157	PF00069	0.638
MOD_ProDKin_1	178	184	PF00069	0.696
MOD_SUMO_rev_2	127	136	PF00179	0.481
TRG_DiLeu_BaEn_1	231	236	PF01217	0.515
TRG_ENDOCYTIC_2	109	112	PF00928	0.437
TRG_ER_diArg_1	118	121	PF00400	0.355
TRG_Pf-PMV_PEXEL_1	5	9	PF00026	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7V8	Leptomonas seymouri	62%	100%
A0A0S4JS78	Bodo saltans	43%	100%
A0A3S7XAD6	Leishmania donovani	83%	100%
A4ICR3	Leishmania infantum	83%	100%
D0A2P1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	95%
E9ASJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
O43822	Homo sapiens	35%	100%
Q4Q205	Leishmania major	80%	100%
Q8C6G1	Mus musculus	36%	100%
V5DRP5	Trypanosoma cruzi	43%	94%