Putative MP18 RNA editing complex protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MP18 RNA editing complex protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HNT0_LEIBR

TriTrypDb:

LbrM.35.0820 , LBRM2903_350013500

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0031019	mitochondrial mRNA editing complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0045293	mRNA editing complex	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4HNT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNT0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0003697	single-stranded DNA binding	5	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003723	RNA binding	4	1
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004519	endonuclease activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	188	190	PF00675	0.537
CLV_NRD_NRD_1	3	5	PF00675	0.546
CLV_PCSK_KEX2_1	188	190	PF00082	0.537
CLV_PCSK_KEX2_1	3	5	PF00082	0.546
DEG_Nend_Nbox_1	1	3	PF02207	0.606
DEG_SPOP_SBC_1	44	48	PF00917	0.474
DOC_MAPK_gen_1	3	10	PF00069	0.438
DOC_MAPK_MEF2A_6	165	174	PF00069	0.436
DOC_PP2B_PxIxI_1	169	175	PF00149	0.377
DOC_USP7_MATH_1	20	24	PF00917	0.668
DOC_USP7_MATH_1	35	39	PF00917	0.470
DOC_USP7_MATH_1	44	48	PF00917	0.527
DOC_WW_Pin1_4	187	192	PF00397	0.611
LIG_14-3-3_CanoR_1	3	9	PF00244	0.518
LIG_14-3-3_CanoR_1	34	42	PF00244	0.465
LIG_14-3-3_CanoR_1	43	53	PF00244	0.464
LIG_AP2alpha_1	129	133	PF02296	0.312
LIG_FHA_1	103	109	PF00498	0.450
LIG_FHA_1	197	203	PF00498	0.648
LIG_FHA_1	88	94	PF00498	0.395
LIG_FHA_2	104	110	PF00498	0.428
LIG_Integrin_isoDGR_2	150	152	PF01839	0.392
LIG_Pex14_2	129	133	PF04695	0.312
LIG_SH2_CRK	2	6	PF00017	0.442
LIG_SH2_PTP2	171	174	PF00017	0.356
LIG_SH2_STAT5	168	171	PF00017	0.402
LIG_SH2_STAT5	92	95	PF00017	0.444
LIG_SH3_1	188	194	PF00018	0.544
LIG_SH3_3	171	177	PF00018	0.411
LIG_SH3_3	188	194	PF00018	0.544
MOD_CK1_1	107	113	PF00069	0.400
MOD_CK1_1	190	196	PF00069	0.670
MOD_CK1_1	205	211	PF00069	0.527
MOD_CK1_1	29	35	PF00069	0.553
MOD_CK1_1	38	44	PF00069	0.549
MOD_CK1_1	46	52	PF00069	0.564
MOD_GlcNHglycan	207	210	PF01048	0.613
MOD_GlcNHglycan	22	25	PF01048	0.685
MOD_GlcNHglycan	48	51	PF01048	0.745
MOD_GlcNHglycan	64	67	PF01048	0.727
MOD_GSK3_1	190	197	PF00069	0.537
MOD_GSK3_1	203	210	PF00069	0.505
MOD_GSK3_1	26	33	PF00069	0.714
MOD_GSK3_1	44	51	PF00069	0.612
MOD_GSK3_1	56	63	PF00069	0.571
MOD_GSK3_1	99	106	PF00069	0.394
MOD_N-GLC_1	203	208	PF02516	0.527
MOD_N-GLC_1	219	224	PF02516	0.566
MOD_N-GLC_1	54	59	PF02516	0.482
MOD_NEK2_1	101	106	PF00069	0.378
MOD_NEK2_1	13	18	PF00069	0.507
MOD_PIKK_1	222	228	PF00454	0.693
MOD_PIKK_1	96	102	PF00454	0.366
MOD_PK_1	4	10	PF00069	0.438
MOD_PK_1	72	78	PF00069	0.446
MOD_Plk_4	179	185	PF00069	0.463
MOD_Plk_4	77	83	PF00069	0.416
MOD_ProDKin_1	187	193	PF00069	0.614
TRG_ENDOCYTIC_2	166	169	PF00928	0.421
TRG_ENDOCYTIC_2	171	174	PF00928	0.356
TRG_ENDOCYTIC_2	2	5	PF00928	0.482
TRG_ER_diArg_1	152	155	PF00400	0.423
TRG_ER_diArg_1	2	4	PF00400	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM19	Leptomonas seymouri	75%	100%
A0A3S7XAD1	Leishmania donovani	79%	100%
A4ICR4	Leishmania infantum	79%	100%
E9ASJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q6T456	Leishmania major	78%	100%