EamA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EamA-like transporter family, putative

Species:

Leishmania braziliensis

UniProt:

A4HNS7_LEIBR

TriTrypDb:

LbrM.35.0790 , LBRM2903_350013200

Length:

462

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 7
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0000139	Golgi membrane	5	2
GO:0031090	organelle membrane	3	2
GO:0098588	bounding membrane of organelle	4	2

Expansion

Sequence features

A4HNS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNS7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	4
GO:0009987	cellular process	1	3
GO:0051179	localization	1	4
GO:0051234	establishment of localization	2	4
GO:0055085	transmembrane transport	2	3
GO:0008643	carbohydrate transport	5	1
GO:0071702	organic substance transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	5
GO:0022857	transmembrane transporter activity	2	5
GO:0005338	nucleotide-sugar transmembrane transporter activity	4	2
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	5	2
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	2
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	324	326	PF00675	0.441
CLV_NRD_NRD_1	444	446	PF00675	0.450
CLV_PCSK_KEX2_1	100	102	PF00082	0.439
CLV_PCSK_KEX2_1	444	446	PF00082	0.458
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.405
CLV_PCSK_SKI1_1	367	371	PF00082	0.329
CLV_PCSK_SKI1_1	445	449	PF00082	0.330
DOC_CDC14_PxL_1	242	250	PF14671	0.487
DOC_CYCLIN_yCln2_LP_2	126	129	PF00134	0.206
DOC_MAPK_DCC_7	241	250	PF00069	0.470
DOC_MAPK_gen_1	241	250	PF00069	0.470
DOC_MAPK_gen_1	304	312	PF00069	0.273
DOC_MAPK_MEF2A_6	155	164	PF00069	0.235
DOC_MAPK_MEF2A_6	241	250	PF00069	0.470
DOC_MAPK_MEF2A_6	304	312	PF00069	0.302
DOC_MAPK_RevD_3	77	90	PF00069	0.268
DOC_PP2B_LxvP_1	126	129	PF13499	0.206
DOC_PP2B_LxvP_1	310	313	PF13499	0.376
DOC_PP2B_LxvP_1	376	379	PF13499	0.382
DOC_PP4_FxxP_1	204	207	PF00568	0.182
DOC_PP4_FxxP_1	40	43	PF00568	0.472
DOC_PP4_FxxP_1	61	64	PF00568	0.292
DOC_WW_Pin1_4	203	208	PF00397	0.285
DOC_WW_Pin1_4	6	11	PF00397	0.206
LIG_14-3-3_CanoR_1	155	160	PF00244	0.235
LIG_14-3-3_CanoR_1	325	329	PF00244	0.243
LIG_14-3-3_CanoR_1	367	372	PF00244	0.372
LIG_14-3-3_CanoR_1	406	416	PF00244	0.585
LIG_14-3-3_CanoR_1	56	62	PF00244	0.409
LIG_Actin_WH2_2	16	31	PF00022	0.502
LIG_BIR_II_1	1	5	PF00653	0.634
LIG_BRCT_BRCA1_1	13	17	PF00533	0.366
LIG_BRCT_BRCA1_1	339	343	PF00533	0.453
LIG_BRCT_BRCA1_1	73	77	PF00533	0.430
LIG_Clathr_ClatBox_1	281	285	PF01394	0.269
LIG_deltaCOP1_diTrp_1	178	184	PF00928	0.328
LIG_EH_1	120	124	PF12763	0.470
LIG_EH1_1	183	191	PF00400	0.206
LIG_FHA_1	105	111	PF00498	0.688
LIG_FHA_1	23	29	PF00498	0.410
LIG_FHA_1	251	257	PF00498	0.509
LIG_FHA_1	260	266	PF00498	0.310
LIG_FHA_1	307	313	PF00498	0.358
LIG_FHA_1	356	362	PF00498	0.551
LIG_FHA_1	368	374	PF00498	0.296
LIG_FHA_2	173	179	PF00498	0.508
LIG_FHA_2	408	414	PF00498	0.665
LIG_FHA_2	446	452	PF00498	0.697
LIG_LIR_Apic_2	115	119	PF02991	0.572
LIG_LIR_Apic_2	202	207	PF02991	0.182
LIG_LIR_Apic_2	38	43	PF02991	0.460
LIG_LIR_Apic_2	60	64	PF02991	0.311
LIG_LIR_Gen_1	149	159	PF02991	0.253
LIG_LIR_Gen_1	171	182	PF02991	0.482
LIG_LIR_Gen_1	294	303	PF02991	0.355
LIG_LIR_Gen_1	383	394	PF02991	0.271
LIG_LIR_Gen_1	410	420	PF02991	0.613
LIG_LIR_Gen_1	74	85	PF02991	0.357
LIG_LIR_Nem_3	149	154	PF02991	0.269
LIG_LIR_Nem_3	158	164	PF02991	0.299
LIG_LIR_Nem_3	166	172	PF02991	0.316
LIG_LIR_Nem_3	294	300	PF02991	0.358
LIG_LIR_Nem_3	383	389	PF02991	0.353
LIG_LIR_Nem_3	410	415	PF02991	0.668
LIG_LIR_Nem_3	66	72	PF02991	0.329
LIG_LIR_Nem_3	74	80	PF02991	0.376
LIG_MLH1_MIPbox_1	339	343	PF16413	0.453
LIG_NRBOX	186	192	PF00104	0.408
LIG_NRBOX	216	222	PF00104	0.421
LIG_NRBOX	372	378	PF00104	0.470
LIG_PCNA_yPIPBox_3	211	221	PF02747	0.294
LIG_Pex14_1	180	184	PF04695	0.461
LIG_Pex14_2	382	386	PF04695	0.344
LIG_Pex14_2	61	65	PF04695	0.304
LIG_PTB_Apo_2	398	405	PF02174	0.421
LIG_SH2_CRK	151	155	PF00017	0.306
LIG_SH2_CRK	243	247	PF00017	0.446
LIG_SH2_CRK	297	301	PF00017	0.358
LIG_SH2_GRB2like	297	300	PF00017	0.356
LIG_SH2_NCK_1	297	301	PF00017	0.358
LIG_SH2_PTP2	116	119	PF00017	0.461
LIG_SH2_SRC	314	317	PF00017	0.354
LIG_SH2_STAP1	314	318	PF00017	0.360
LIG_SH2_STAT5	116	119	PF00017	0.461
LIG_SH2_STAT5	167	170	PF00017	0.321
LIG_SH2_STAT5	297	300	PF00017	0.356
LIG_SH2_STAT5	337	340	PF00017	0.332
LIG_SH2_STAT5	354	357	PF00017	0.520
LIG_SH3_1	116	122	PF00018	0.646
LIG_SH3_3	116	122	PF00018	0.577
LIG_SH3_3	270	276	PF00018	0.364
LIG_SH3_3	446	452	PF00018	0.601
LIG_SUMO_SIM_anti_2	262	267	PF11976	0.382
LIG_SUMO_SIM_anti_2	434	440	PF11976	0.516
LIG_SUMO_SIM_par_1	280	286	PF11976	0.426
LIG_SUMO_SIM_par_1	358	365	PF11976	0.560
LIG_SUMO_SIM_par_1	9	14	PF11976	0.206
LIG_TRAF2_1	207	210	PF00917	0.182
LIG_TRAF2_1	283	286	PF00917	0.414
LIG_TYR_ITIM	165	170	PF00017	0.206
LIG_TYR_ITIM	312	317	PF00017	0.356
LIG_UBA3_1	453	460	PF00899	0.563
LIG_UBA3_1	81	90	PF00899	0.365
LIG_WRC_WIRS_1	339	344	PF05994	0.206
MOD_CK1_1	205	211	PF00069	0.203
MOD_CK1_1	6	12	PF00069	0.287
MOD_CK2_1	172	178	PF00069	0.487
MOD_CK2_1	203	209	PF00069	0.279
MOD_CK2_1	377	383	PF00069	0.384
MOD_CK2_1	445	451	PF00069	0.696
MOD_GlcNHglycan	293	296	PF01048	0.622
MOD_GlcNHglycan	334	337	PF01048	0.391
MOD_GlcNHglycan	355	358	PF01048	0.269
MOD_GlcNHglycan	5	8	PF01048	0.423
MOD_GSK3_1	199	206	PF00069	0.182
MOD_GSK3_1	291	298	PF00069	0.371
MOD_GSK3_1	353	360	PF00069	0.561
MOD_GSK3_1	407	414	PF00069	0.567
MOD_N-GLC_1	298	303	PF02516	0.598
MOD_N-GLC_2	345	347	PF02516	0.352
MOD_NEK2_1	1	6	PF00069	0.617
MOD_NEK2_1	143	148	PF00069	0.342
MOD_NEK2_1	154	159	PF00069	0.328
MOD_NEK2_1	19	24	PF00069	0.344
MOD_NEK2_1	261	266	PF00069	0.387
MOD_NEK2_1	332	337	PF00069	0.251
MOD_NEK2_1	362	367	PF00069	0.391
MOD_NEK2_1	57	62	PF00069	0.349
MOD_NEK2_2	30	35	PF00069	0.242
MOD_PIKK_1	407	413	PF00454	0.592
MOD_PIKK_1	63	69	PF00454	0.362
MOD_PKA_2	154	160	PF00069	0.328
MOD_PKA_2	172	178	PF00069	0.470
MOD_PKA_2	199	205	PF00069	0.221
MOD_PKA_2	324	330	PF00069	0.386
MOD_Plk_1	298	304	PF00069	0.399
MOD_Plk_1	445	451	PF00069	0.720
MOD_Plk_4	11	17	PF00069	0.312
MOD_Plk_4	133	139	PF00069	0.279
MOD_Plk_4	146	152	PF00069	0.234
MOD_Plk_4	155	161	PF00069	0.328
MOD_Plk_4	261	267	PF00069	0.385
MOD_Plk_4	298	304	PF00069	0.406
MOD_Plk_4	324	330	PF00069	0.268
MOD_Plk_4	338	344	PF00069	0.347
MOD_Plk_4	347	353	PF00069	0.441
MOD_Plk_4	357	363	PF00069	0.523
MOD_Plk_4	367	373	PF00069	0.123
MOD_Plk_4	377	383	PF00069	0.123
MOD_Plk_4	411	417	PF00069	0.512
MOD_Plk_4	88	94	PF00069	0.596
MOD_ProDKin_1	203	209	PF00069	0.285
MOD_ProDKin_1	6	12	PF00069	0.206
TRG_DiLeu_BaEn_1	75	80	PF01217	0.382
TRG_ENDOCYTIC_2	151	154	PF00928	0.317
TRG_ENDOCYTIC_2	167	170	PF00928	0.268
TRG_ENDOCYTIC_2	297	300	PF00928	0.370
TRG_ENDOCYTIC_2	314	317	PF00928	0.368
TRG_NES_CRM1_1	430	442	PF08389	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAC3	Leptomonas seymouri	61%	98%
A0A0S4JLV3	Bodo saltans	33%	100%
A0A0S4JVX5	Bodo saltans	34%	100%
A0A1X0P938	Trypanosomatidae	46%	100%
A0A3Q8INC1	Leishmania donovani	74%	100%
A0A3R7N2L5	Trypanosoma rangeli	46%	100%
A4ICR7	Leishmania infantum	74%	100%
E9ASI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q09875	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q4Q209	Leishmania major	72%	100%
Q5RFT1	Pongo abelii	30%	100%
Q5RKH7	Rattus norvegicus	30%	100%
Q8N357	Homo sapiens	29%	100%
Q8VE96	Mus musculus	29%	100%