Enriched in surface-labeled proteome protein 14

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Enriched in surface-labeled proteome protein 18

Species:

Leishmania braziliensis

UniProt:

A4HNS6_LEIBR

TriTrypDb:

LbrM.35.0780 , LBRM2903_350013100

Length:

202

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 3
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	1
GO:0009986	cell surface	2	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNS6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.379
CLV_NRD_NRD_1	113	115	PF00675	0.509
CLV_NRD_NRD_1	3	5	PF00675	0.486
CLV_PCSK_KEX2_1	113	115	PF00082	0.511
CLV_PCSK_KEX2_1	3	5	PF00082	0.486
CLV_PCSK_SKI1_1	113	117	PF00082	0.419
CLV_PCSK_SKI1_1	6	10	PF00082	0.682
DEG_APCC_DBOX_1	153	161	PF00400	0.348
DEG_MDM2_SWIB_1	15	23	PF02201	0.331
DOC_CDC14_PxL_1	157	165	PF14671	0.524
DOC_MAPK_MEF2A_6	158	165	PF00069	0.428
DOC_PP2B_LxvP_1	163	166	PF13499	0.504
DOC_PP4_FxxP_1	9	12	PF00568	0.403
DOC_USP7_MATH_1	66	70	PF00917	0.464
DOC_WW_Pin1_4	67	72	PF00397	0.444
DOC_WW_Pin1_4	89	94	PF00397	0.469
LIG_14-3-3_CanoR_1	113	119	PF00244	0.574
LIG_eIF4E_1	175	181	PF01652	0.386
LIG_eIF4E_1	18	24	PF01652	0.316
LIG_FHA_1	114	120	PF00498	0.491
LIG_FHA_1	58	64	PF00498	0.614
LIG_FHA_1	89	95	PF00498	0.399
LIG_FHA_2	147	153	PF00498	0.349
LIG_GBD_Chelix_1	24	32	PF00786	0.499
LIG_Integrin_RGD_1	48	50	PF01839	0.469
LIG_LIR_Gen_1	117	128	PF02991	0.537
LIG_LIR_Gen_1	172	181	PF02991	0.436
LIG_LIR_Nem_3	117	123	PF02991	0.560
LIG_LIR_Nem_3	16	21	PF02991	0.440
LIG_LIR_Nem_3	172	178	PF02991	0.359
LIG_PALB2_WD40_1	15	23	PF16756	0.331
LIG_PDZ_Class_1	197	202	PF00595	0.380
LIG_Pex14_2	15	19	PF04695	0.462
LIG_Pex14_2	9	13	PF04695	0.512
LIG_SH2_STAT5	85	88	PF00017	0.494
LIG_SH3_2	90	95	PF14604	0.471
LIG_SH3_3	87	93	PF00018	0.474
LIG_SUMO_SIM_par_1	69	76	PF11976	0.463
LIG_TRAF2_1	73	76	PF00917	0.461
LIG_TYR_ITIM	118	123	PF00017	0.350
MOD_CDC14_SPxK_1	92	95	PF00782	0.452
MOD_CDK_SPxK_1	89	95	PF00069	0.471
MOD_CK1_1	102	108	PF00069	0.407
MOD_CK2_1	70	76	PF00069	0.532
MOD_GlcNHglycan	171	174	PF01048	0.439
MOD_GlcNHglycan	64	67	PF01048	0.498
MOD_GSK3_1	102	109	PF00069	0.394
MOD_GSK3_1	114	121	PF00069	0.538
MOD_GSK3_1	33	40	PF00069	0.555
MOD_GSK3_1	58	65	PF00069	0.626
MOD_GSK3_1	66	73	PF00069	0.442
MOD_GSK3_1	84	91	PF00069	0.334
MOD_N-GLC_1	52	57	PF02516	0.623
MOD_NEK2_1	13	18	PF00069	0.581
MOD_NEK2_1	197	202	PF00069	0.361
MOD_NEK2_1	28	33	PF00069	0.573
MOD_NEK2_1	37	42	PF00069	0.579
MOD_NEK2_2	174	179	PF00069	0.391
MOD_PK_1	114	120	PF00069	0.379
MOD_PKA_1	113	119	PF00069	0.487
MOD_PKA_2	102	108	PF00069	0.427
MOD_PKA_2	113	119	PF00069	0.535
MOD_PKA_2	130	136	PF00069	0.253
MOD_PKA_2	146	152	PF00069	0.329
MOD_Plk_1	52	58	PF00069	0.725
MOD_Plk_4	114	120	PF00069	0.580
MOD_Plk_4	146	152	PF00069	0.457
MOD_ProDKin_1	67	73	PF00069	0.434
MOD_ProDKin_1	89	95	PF00069	0.471
MOD_SUMO_rev_2	76	84	PF00179	0.491
TRG_DiLeu_BaEn_1	176	181	PF01217	0.450
TRG_DiLeu_BaLyEn_6	192	197	PF01217	0.453
TRG_ENDOCYTIC_2	120	123	PF00928	0.436
TRG_ENDOCYTIC_2	175	178	PF00928	0.336
TRG_ENDOCYTIC_2	18	21	PF00928	0.389
TRG_ER_diArg_1	112	114	PF00400	0.570
TRG_ER_diArg_1	193	196	PF00400	0.464
TRG_ER_diArg_1	2	4	PF00400	0.469
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8L4	Leptomonas seymouri	50%	97%
A0A1X0P888	Trypanosomatidae	26%	100%
A0A3S7XAF9	Leishmania donovani	72%	100%
A4ICR8	Leishmania infantum	74%	100%
D0A2N6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ASI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4Q210	Leishmania major	75%	100%