Putative GPI transamidase component Tta2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPI transamidase component Tta2, putative

Species:

Leishmania braziliensis

UniProt:

A4HNS5_LEIBR

TriTrypDb:

LbrM.35.0770 , LBRM2903_350013000

Length:

494

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	10
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0008303	caspase complex	5	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0032991	protein-containing complex	1	1
GO:0042765	GPI-anchor transamidase complex	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1905368	peptidase complex	3	1
GO:1905369	endopeptidase complex	4	1

Expansion

Sequence features

A4HNS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNS5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0003923	GPI-anchor transamidase activity	6	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.588
CLV_NRD_NRD_1	11	13	PF00675	0.492
CLV_NRD_NRD_1	214	216	PF00675	0.374
CLV_PCSK_KEX2_1	11	13	PF00082	0.379
CLV_PCSK_KEX2_1	214	216	PF00082	0.372
CLV_PCSK_SKI1_1	21	25	PF00082	0.325
CLV_PCSK_SKI1_1	214	218	PF00082	0.458
CLV_PCSK_SKI1_1	351	355	PF00082	0.329
CLV_PCSK_SKI1_1	391	395	PF00082	0.457
CLV_PCSK_SKI1_1	399	403	PF00082	0.416
CLV_PCSK_SKI1_1	91	95	PF00082	0.738
CLV_Separin_Metazoa	5	9	PF03568	0.585
DEG_APCC_DBOX_1	350	358	PF00400	0.551
DEG_MDM2_SWIB_1	457	465	PF02201	0.447
DEG_ODPH_VHL_1	244	256	PF01847	0.442
DEG_SCF_FBW7_1	246	253	PF00400	0.280
DEG_SPOP_SBC_1	189	193	PF00917	0.324
DOC_CKS1_1	1	6	PF01111	0.715
DOC_CKS1_1	247	252	PF01111	0.370
DOC_CKS1_1	92	97	PF01111	0.498
DOC_CYCLIN_RxL_1	296	307	PF00134	0.670
DOC_CYCLIN_yCln2_LP_2	321	327	PF00134	0.566
DOC_CYCLIN_yCln2_LP_2	369	375	PF00134	0.676
DOC_CYCLIN_yCln2_LP_2	411	417	PF00134	0.373
DOC_MAPK_DCC_7	408	417	PF00069	0.562
DOC_MAPK_DCC_7	91	100	PF00069	0.559
DOC_MAPK_gen_1	408	417	PF00069	0.538
DOC_MAPK_MEF2A_6	308	317	PF00069	0.467
DOC_MAPK_MEF2A_6	408	417	PF00069	0.517
DOC_MAPK_MEF2A_6	91	100	PF00069	0.559
DOC_PP2B_LxvP_1	243	246	PF13499	0.489
DOC_PP2B_LxvP_1	286	289	PF13499	0.640
DOC_PP2B_LxvP_1	301	304	PF13499	0.548
DOC_PP2B_LxvP_1	321	324	PF13499	0.566
DOC_PP2B_LxvP_1	369	372	PF13499	0.633
DOC_PP2B_LxvP_1	411	414	PF13499	0.373
DOC_PP4_MxPP_1	93	96	PF00568	0.403
DOC_USP7_MATH_1	302	306	PF00917	0.511
DOC_USP7_MATH_1	76	80	PF00917	0.481
DOC_WW_Pin1_4	124	129	PF00397	0.317
DOC_WW_Pin1_4	246	251	PF00397	0.323
DOC_WW_Pin1_4	401	406	PF00397	0.700
DOC_WW_Pin1_4	50	55	PF00397	0.509
DOC_WW_Pin1_4	91	96	PF00397	0.497
LIG_14-3-3_CanoR_1	16	20	PF00244	0.652
LIG_14-3-3_CanoR_1	169	178	PF00244	0.556
LIG_14-3-3_CanoR_1	214	220	PF00244	0.611
LIG_14-3-3_CanoR_1	282	287	PF00244	0.600
LIG_14-3-3_CanoR_1	337	347	PF00244	0.710
LIG_14-3-3_CanoR_1	366	372	PF00244	0.657
LIG_14-3-3_CanoR_1	37	41	PF00244	0.429
LIG_14-3-3_CanoR_1	399	404	PF00244	0.653
LIG_14-3-3_CanoR_1	44	48	PF00244	0.438
LIG_Actin_WH2_2	419	437	PF00022	0.349
LIG_BRCT_BRCA1_1	252	256	PF00533	0.205
LIG_BRCT_BRCA1_1	279	283	PF00533	0.682
LIG_BRCT_BRCA1_1	361	365	PF00533	0.568
LIG_eIF4E_1	406	412	PF01652	0.670
LIG_EVH1_2	96	100	PF00568	0.535
LIG_FAT_LD_1	310	318	PF03623	0.459
LIG_FHA_1	1	7	PF00498	0.730
LIG_FHA_1	150	156	PF00498	0.363
LIG_FHA_1	161	167	PF00498	0.481
LIG_FHA_1	204	210	PF00498	0.355
LIG_FHA_1	215	221	PF00498	0.565
LIG_FHA_1	261	267	PF00498	0.374
LIG_FHA_1	31	37	PF00498	0.368
LIG_FHA_1	388	394	PF00498	0.676
LIG_FHA_1	428	434	PF00498	0.409
LIG_FHA_2	109	115	PF00498	0.376
LIG_FHA_2	15	21	PF00498	0.689
LIG_FHA_2	190	196	PF00498	0.556
LIG_FHA_2	392	398	PF00498	0.692
LIG_HP1_1	240	244	PF01393	0.441
LIG_LIR_Apic_2	285	290	PF02991	0.604
LIG_LIR_Gen_1	198	207	PF02991	0.463
LIG_LIR_Gen_1	234	244	PF02991	0.381
LIG_LIR_Gen_1	280	290	PF02991	0.694
LIG_LIR_Gen_1	370	381	PF02991	0.644
LIG_LIR_Nem_3	110	115	PF02991	0.441
LIG_LIR_Nem_3	198	203	PF02991	0.461
LIG_LIR_Nem_3	234	239	PF02991	0.377
LIG_LIR_Nem_3	280	286	PF02991	0.671
LIG_LIR_Nem_3	370	376	PF02991	0.626
LIG_LIR_Nem_3	402	406	PF02991	0.634
LIG_LIR_Nem_3	455	460	PF02991	0.393
LIG_Pex14_1	137	141	PF04695	0.450
LIG_Pex14_2	30	34	PF04695	0.447
LIG_Pex14_2	428	432	PF04695	0.501
LIG_Pex14_2	457	461	PF04695	0.335
LIG_SH2_CRK	269	273	PF00017	0.480
LIG_SH2_CRK	373	377	PF00017	0.627
LIG_SH2_CRK	382	386	PF00017	0.649
LIG_SH2_NCK_1	252	256	PF00017	0.205
LIG_SH2_NCK_1	287	291	PF00017	0.605
LIG_SH2_SRC	273	276	PF00017	0.535
LIG_SH2_SRC	287	290	PF00017	0.646
LIG_SH2_SRC	462	465	PF00017	0.483
LIG_SH2_STAP1	252	256	PF00017	0.232
LIG_SH2_STAP1	269	273	PF00017	0.414
LIG_SH2_STAP1	275	279	PF00017	0.596
LIG_SH2_STAP1	462	466	PF00017	0.546
LIG_SH2_STAT3	129	132	PF00017	0.481
LIG_SH2_STAT3	297	300	PF00017	0.671
LIG_SH2_STAT3	333	336	PF00017	0.703
LIG_SH2_STAT5	130	133	PF00017	0.384
LIG_SH2_STAT5	138	141	PF00017	0.351
LIG_SH2_STAT5	273	276	PF00017	0.437
LIG_SH2_STAT5	297	300	PF00017	0.587
LIG_SH2_STAT5	333	336	PF00017	0.680
LIG_SH2_STAT5	373	376	PF00017	0.630
LIG_SH2_STAT5	406	409	PF00017	0.625
LIG_SH2_STAT5	429	432	PF00017	0.342
LIG_SH2_STAT5	50	53	PF00017	0.531
LIG_SH2_STAT5	81	84	PF00017	0.559
LIG_SH3_3	180	186	PF00018	0.335
LIG_SH3_3	324	330	PF00018	0.564
LIG_SUMO_SIM_anti_2	359	365	PF11976	0.604
LIG_SUMO_SIM_anti_2	60	66	PF11976	0.343
LIG_SUMO_SIM_par_1	185	196	PF11976	0.487
LIG_SUMO_SIM_par_1	203	208	PF11976	0.197
LIG_SUMO_SIM_par_1	390	397	PF11976	0.663
LIG_SUMO_SIM_par_1	420	427	PF11976	0.227
LIG_TRFH_1	182	186	PF08558	0.355
LIG_TYR_ITIM	371	376	PF00017	0.637
LIG_TYR_ITIM	460	465	PF00017	0.528
LIG_WRC_WIRS_1	197	202	PF05994	0.480
LIG_WRC_WIRS_1	303	308	PF05994	0.660
LIG_WRC_WIRS_1	31	36	PF05994	0.408
LIG_WRC_WIRS_1	40	45	PF05994	0.509
MOD_CDK_SPxxK_3	401	408	PF00069	0.695
MOD_CK1_1	103	109	PF00069	0.335
MOD_CK1_1	168	174	PF00069	0.634
MOD_CK1_1	196	202	PF00069	0.480
MOD_CK1_1	338	344	PF00069	0.552
MOD_CK1_1	404	410	PF00069	0.662
MOD_CK1_1	427	433	PF00069	0.421
MOD_CK2_1	108	114	PF00069	0.364
MOD_CK2_1	14	20	PF00069	0.698
MOD_CK2_1	189	195	PF00069	0.560
MOD_GlcNHglycan	156	159	PF01048	0.433
MOD_GlcNHglycan	171	174	PF01048	0.212
MOD_GlcNHglycan	340	343	PF01048	0.458
MOD_GlcNHglycan	68	72	PF01048	0.714
MOD_GlcNHglycan	78	81	PF01048	0.730
MOD_GlcNHglycan	82	85	PF01048	0.732
MOD_GSK3_1	100	107	PF00069	0.434
MOD_GSK3_1	165	172	PF00069	0.543
MOD_GSK3_1	189	196	PF00069	0.546
MOD_GSK3_1	246	253	PF00069	0.327
MOD_GSK3_1	273	280	PF00069	0.459
MOD_GSK3_1	387	394	PF00069	0.633
MOD_GSK3_1	39	46	PF00069	0.585
MOD_GSK3_1	76	83	PF00069	0.555
MOD_NEK2_1	100	105	PF00069	0.456
MOD_NEK2_1	154	159	PF00069	0.440
MOD_NEK2_1	188	193	PF00069	0.408
MOD_NEK2_1	203	208	PF00069	0.233
MOD_NEK2_1	30	35	PF00069	0.447
MOD_NEK2_1	364	369	PF00069	0.527
MOD_NEK2_1	381	386	PF00069	0.567
MOD_NEK2_1	424	429	PF00069	0.366
MOD_NEK2_1	434	439	PF00069	0.409
MOD_PIKK_1	364	370	PF00454	0.577
MOD_PIKK_1	483	489	PF00454	0.579
MOD_PIKK_1	74	80	PF00454	0.445
MOD_PK_1	215	221	PF00069	0.561
MOD_PKA_1	214	220	PF00069	0.567
MOD_PKA_2	15	21	PF00069	0.606
MOD_PKA_2	168	174	PF00069	0.634
MOD_PKA_2	214	220	PF00069	0.524
MOD_PKA_2	336	342	PF00069	0.555
MOD_PKA_2	36	42	PF00069	0.405
MOD_PKA_2	43	49	PF00069	0.452
MOD_PKA_2	434	440	PF00069	0.485
MOD_PKB_1	335	343	PF00069	0.551
MOD_Plk_1	107	113	PF00069	0.476
MOD_Plk_1	424	430	PF00069	0.480
MOD_Plk_2-3	108	114	PF00069	0.449
MOD_Plk_4	215	221	PF00069	0.528
MOD_Plk_4	282	288	PF00069	0.588
MOD_Plk_4	30	36	PF00069	0.406
MOD_Plk_4	316	322	PF00069	0.507
MOD_Plk_4	359	365	PF00069	0.576
MOD_Plk_4	424	430	PF00069	0.408
MOD_Plk_4	57	63	PF00069	0.354
MOD_ProDKin_1	124	130	PF00069	0.317
MOD_ProDKin_1	246	252	PF00069	0.326
MOD_ProDKin_1	401	407	PF00069	0.699
MOD_ProDKin_1	50	56	PF00069	0.510
MOD_ProDKin_1	91	97	PF00069	0.498
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.660
TRG_DiLeu_BaLyEn_6	407	412	PF01217	0.688
TRG_ENDOCYTIC_2	138	141	PF00928	0.397
TRG_ENDOCYTIC_2	179	182	PF00928	0.406
TRG_ENDOCYTIC_2	269	272	PF00928	0.456
TRG_ENDOCYTIC_2	373	376	PF00928	0.586
TRG_ENDOCYTIC_2	382	385	PF00928	0.537
TRG_ENDOCYTIC_2	462	465	PF00928	0.548
TRG_ER_diArg_1	11	13	PF00400	0.680
TRG_ER_diArg_1	334	337	PF00400	0.630
TRG_ER_diArg_1	408	411	PF00400	0.670

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Y0	Leptomonas seymouri	63%	96%
A0A1X0P8I4	Trypanosomatidae	36%	100%
A0A3Q8IIQ8	Leishmania donovani	80%	100%
A0A422P255	Trypanosoma rangeli	38%	100%
A4ICR9	Leishmania infantum	80%	100%
D0A2N5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ASI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q211	Leishmania major	80%	100%
V5BZX2	Trypanosoma cruzi	39%	100%