DUF3592 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF3592), putative

Species:

Leishmania braziliensis

UniProt:

A4HNS3_LEIBR

TriTrypDb:

LbrM.35.0750 , LBRM2903_350012800

Length:

188

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HNS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNS3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	158	164	PF00089	0.661
CLV_NRD_NRD_1	160	162	PF00675	0.574
CLV_PCSK_KEX2_1	160	162	PF00082	0.574
DOC_PP1_RVXF_1	7	13	PF00149	0.279
DOC_USP7_MATH_1	108	112	PF00917	0.448
DOC_USP7_MATH_1	122	126	PF00917	0.426
DOC_USP7_UBL2_3	176	180	PF12436	0.447
LIG_14-3-3_CanoR_1	33	42	PF00244	0.442
LIG_14-3-3_CanoR_1	56	62	PF00244	0.442
LIG_Actin_WH2_2	155	171	PF00022	0.373
LIG_EH1_1	126	134	PF00400	0.410
LIG_FHA_1	5	11	PF00498	0.255
LIG_FHA_1	97	103	PF00498	0.442
LIG_FHA_2	44	50	PF00498	0.442
LIG_LIR_LC3C_4	99	103	PF02991	0.455
LIG_LIR_Nem_3	59	64	PF02991	0.503
LIG_Pex14_2	135	139	PF04695	0.410
LIG_Pex14_2	8	12	PF04695	0.279
LIG_PTB_Apo_2	147	154	PF02174	0.357
LIG_PTB_Phospho_1	147	153	PF10480	0.355
LIG_SH2_CRK	153	157	PF00017	0.406
LIG_SH2_CRK	21	25	PF00017	0.259
LIG_SH2_GRB2like	104	107	PF00017	0.442
LIG_SH2_NCK_1	105	109	PF00017	0.507
LIG_SH2_STAT5	18	21	PF00017	0.249
LIG_SH2_STAT5	4	7	PF00017	0.251
LIG_SH2_STAT5	61	64	PF00017	0.489
LIG_SH2_STAT5	73	76	PF00017	0.444
LIG_SH3_1	104	110	PF00018	0.442
LIG_SH3_3	104	110	PF00018	0.442
LIG_SH3_3	86	92	PF00018	0.442
LIG_WRC_WIRS_1	132	137	PF05994	0.410
LIG_WRC_WIRS_1	5	10	PF05994	0.255
MOD_CK1_1	131	137	PF00069	0.436
MOD_CK1_1	90	96	PF00069	0.592
MOD_GlcNHglycan	112	115	PF01048	0.260
MOD_GlcNHglycan	165	168	PF01048	0.676
MOD_GlcNHglycan	184	187	PF01048	0.725
MOD_GlcNHglycan	79	82	PF01048	0.242
MOD_GSK3_1	52	59	PF00069	0.536
MOD_NEK2_1	19	24	PF00069	0.336
MOD_NEK2_2	122	127	PF00069	0.465
MOD_NEK2_2	4	9	PF00069	0.255
MOD_NEK2_2	43	48	PF00069	0.442
MOD_PIKK_1	19	25	PF00454	0.197
MOD_PIKK_1	96	102	PF00454	0.447
MOD_PKA_2	35	41	PF00069	0.456
MOD_Plk_4	122	128	PF00069	0.455
MOD_Plk_4	131	137	PF00069	0.283
MOD_Plk_4	143	149	PF00069	0.323
MOD_Plk_4	43	49	PF00069	0.442
MOD_Plk_4	57	63	PF00069	0.442
MOD_Plk_4	90	96	PF00069	0.536
TRG_ENDOCYTIC_2	153	156	PF00928	0.409
TRG_ENDOCYTIC_2	16	19	PF00928	0.279
TRG_ENDOCYTIC_2	21	24	PF00928	0.279
TRG_ER_diArg_1	160	162	PF00400	0.374
TRG_Pf-PMV_PEXEL_1	25	29	PF00026	0.255

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P892	Leptomonas seymouri	89%	100%
A0A1X0P871	Trypanosomatidae	78%	100%
A0A3S7XAC1	Leishmania donovani	94%	100%
A0A422P2C4	Trypanosoma rangeli	74%	99%
A4ICS1	Leishmania infantum	95%	100%
D0A2N3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	100%
E9ASI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q213	Leishmania major	95%	100%
V5B9Z4	Trypanosoma cruzi	76%	71%