ATP synthase subunit epsilon, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNS2_LEIBR

TriTrypDb:

LbrM.35.0740 , LBRM2903_350012700

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)	4	5
GO:0032991	protein-containing complex	1	5
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	3	5
GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)	4	5
GO:0098796	membrane protein complex	2	5
GO:0098798	mitochondrial protein-containing complex	2	5
GO:0098800	inner mitochondrial membrane protein complex	3	5

Expansion

Sequence features

A4HNS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNS2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0005215	transporter activity	1	5
GO:0005216	monoatomic ion channel activity	4	5
GO:0005261	monoatomic cation channel activity	5	5
GO:0008324	monoatomic cation transmembrane transporter activity	4	5
GO:0015075	monoatomic ion transmembrane transporter activity	3	5
GO:0015078	proton transmembrane transporter activity	5	5
GO:0015252	proton channel activity	6	5
GO:0015267	channel activity	4	5
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	5
GO:0016874	ligase activity	2	5
GO:0022803	passive transmembrane transporter activity	3	5
GO:0022857	transmembrane transporter activity	2	5
GO:0022890	inorganic cation transmembrane transporter activity	4	5
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	3	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.463
CLV_PCSK_KEX2_1	3	5	PF00082	0.463
DEG_APCC_DBOX_1	2	10	PF00400	0.501
DEG_Nend_Nbox_1	1	3	PF02207	0.464
DOC_MAPK_gen_1	3	9	PF00069	0.514
DOC_WW_Pin1_4	43	48	PF00397	0.353
LIG_14-3-3_CanoR_1	3	7	PF00244	0.460
LIG_14-3-3_CanoR_1	43	47	PF00244	0.438
LIG_FHA_1	24	30	PF00498	0.269
LIG_LIR_Apic_2	42	47	PF02991	0.371
LIG_LIR_Gen_1	46	55	PF02991	0.393
LIG_LIR_Nem_3	17	21	PF02991	0.269
LIG_LIR_Nem_3	46	52	PF02991	0.392
LIG_SH2_CRK	44	48	PF00017	0.321
LIG_SH2_GRB2like	21	24	PF00017	0.269
LIG_SH2_NCK_1	44	48	PF00017	0.321
LIG_SH2_PTP2	49	52	PF00017	0.435
LIG_SH2_SRC	21	24	PF00017	0.269
LIG_SH2_STAT5	18	21	PF00017	0.269
LIG_SH2_STAT5	49	52	PF00017	0.410
LIG_TYR_ITIM	19	24	PF00017	0.269
MOD_CK1_1	42	48	PF00069	0.450
MOD_GSK3_1	39	46	PF00069	0.333
MOD_NEK2_1	2	7	PF00069	0.570
MOD_PKA_2	2	8	PF00069	0.457
MOD_PKA_2	39	45	PF00069	0.442
MOD_ProDKin_1	43	49	PF00069	0.355
MOD_SUMO_rev_2	61	66	PF00179	0.450
TRG_ENDOCYTIC_2	21	24	PF00928	0.314
TRG_ENDOCYTIC_2	49	52	PF00928	0.468
TRG_ER_diArg_1	2	4	PF00400	0.474
TRG_ER_diArg_1	37	40	PF00400	0.210

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD63	Leptomonas seymouri	73%	100%
D0A2N2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	97%
E9ASI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
P0DPG3	Trypanosoma brucei brucei	56%	97%