ATP synthase subunit epsilon, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNS2_LEIBR

TriTrypDb:

LbrM.35.0740 , LBRM2903_350012700

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

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Cellular components
Term	Name	Level	Count
GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)	4	5
GO:0032991	protein-containing complex	1	5
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	3	5
GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)	4	5
GO:0098796	membrane protein complex	2	5
GO:0098798	mitochondrial protein-containing complex	2	5
GO:0098800	inner mitochondrial membrane protein complex	3	5

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Expansion

Sequence features

A4HNS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNS2

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0005215	transporter activity	1	5
GO:0005216	monoatomic ion channel activity	4	5
GO:0005261	monoatomic cation channel activity	5	5
GO:0008324	monoatomic cation transmembrane transporter activity	4	5
GO:0015075	monoatomic ion transmembrane transporter activity	3	5
GO:0015078	proton transmembrane transporter activity	5	5
GO:0015252	proton channel activity	6	5
GO:0015267	channel activity	4	5
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	5

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.463
CLV_PCSK_KEX2_1	3	5	PF00082	0.463
DEG_APCC_DBOX_1	2	10	PF00400	0.501
DEG_Nend_Nbox_1	1	3	PF02207	0.464
DOC_MAPK_gen_1	3	9	PF00069	0.514
DOC_WW_Pin1_4	43	48	PF00397	0.353
LIG_14-3-3_CanoR_1	3	7	PF00244	0.460
LIG_14-3-3_CanoR_1	43	47	PF00244	0.438
LIG_FHA_1	24	30	PF00498	0.269
LIG_LIR_Apic_2	42	47	PF02991	0.371

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD63	Leptomonas seymouri	73%	100%
D0A2N2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	97%
E9ASI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
P0DPG3	Trypanosoma brucei brucei	56%	97%

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