DUF4515 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNR6_LEIBR

TriTrypDb:

LbrM.35.0670 , LBRM2903_350012000

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNR6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	98	102	PF00656	0.606
CLV_NRD_NRD_1	103	105	PF00675	0.519
CLV_NRD_NRD_1	115	117	PF00675	0.535
CLV_NRD_NRD_1	139	141	PF00675	0.615
CLV_NRD_NRD_1	251	253	PF00675	0.604
CLV_NRD_NRD_1	43	45	PF00675	0.663
CLV_NRD_NRD_1	66	68	PF00675	0.396
CLV_PCSK_FUR_1	157	161	PF00082	0.609
CLV_PCSK_FUR_1	63	67	PF00082	0.518
CLV_PCSK_KEX2_1	103	105	PF00082	0.447
CLV_PCSK_KEX2_1	115	117	PF00082	0.462
CLV_PCSK_KEX2_1	126	128	PF00082	0.550
CLV_PCSK_KEX2_1	139	141	PF00082	0.473
CLV_PCSK_KEX2_1	159	161	PF00082	0.278
CLV_PCSK_KEX2_1	251	253	PF00082	0.645
CLV_PCSK_KEX2_1	30	32	PF00082	0.524
CLV_PCSK_KEX2_1	43	45	PF00082	0.472
CLV_PCSK_KEX2_1	65	67	PF00082	0.388
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.620
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.546
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.578
CLV_PCSK_PC7_1	99	105	PF00082	0.492
CLV_PCSK_SKI1_1	115	119	PF00082	0.498
CLV_PCSK_SKI1_1	123	127	PF00082	0.477
CLV_PCSK_SKI1_1	175	179	PF00082	0.494
DOC_MAPK_gen_1	238	246	PF00069	0.462
DOC_MAPK_RevD_3	88	104	PF00069	0.569
DOC_PP2B_LxvP_1	184	187	PF13499	0.670
DOC_USP7_MATH_1	119	123	PF00917	0.609
DOC_USP7_MATH_1	230	234	PF00917	0.601
LIG_14-3-3_CanoR_1	127	133	PF00244	0.636
LIG_14-3-3_CanoR_1	139	145	PF00244	0.445
LIG_APCC_ABBA_1	153	158	PF00400	0.483
LIG_BIR_II_1	1	5	PF00653	0.677
LIG_FHA_1	127	133	PF00498	0.573
LIG_FHA_2	213	219	PF00498	0.612
LIG_FHA_2	9	15	PF00498	0.645
LIG_FHA_2	96	102	PF00498	0.571
LIG_LIR_Gen_1	241	250	PF02991	0.575
LIG_LIR_Gen_1	96	105	PF02991	0.522
LIG_LIR_Nem_3	241	246	PF02991	0.546
LIG_LIR_Nem_3	96	100	PF02991	0.526
LIG_NRP_CendR_1	252	255	PF00754	0.462
LIG_SH2_PTP2	243	246	PF00017	0.574
LIG_SH2_STAP1	13	17	PF00017	0.674
LIG_SH2_STAP1	48	52	PF00017	0.697
LIG_SH2_STAT3	26	29	PF00017	0.373
LIG_SH2_STAT5	106	109	PF00017	0.352
LIG_SH2_STAT5	243	246	PF00017	0.574
LIG_SH2_STAT5	97	100	PF00017	0.580
MOD_CK1_1	2	8	PF00069	0.669
MOD_CK2_1	131	137	PF00069	0.538
MOD_CK2_1	145	151	PF00069	0.399
MOD_CK2_1	176	182	PF00069	0.571
MOD_CK2_1	212	218	PF00069	0.606
MOD_CK2_1	47	53	PF00069	0.652
MOD_GlcNHglycan	1	4	PF01048	0.570
MOD_GSK3_1	176	183	PF00069	0.573
MOD_N-GLC_1	119	124	PF02516	0.542
MOD_N-GLC_1	230	235	PF02516	0.601
MOD_N-GLC_1	24	29	PF02516	0.546
MOD_NEK2_1	212	217	PF00069	0.605
MOD_NEK2_1	250	255	PF00069	0.552
MOD_NEK2_1	8	13	PF00069	0.646
MOD_PIKK_1	131	137	PF00454	0.637
MOD_PIKK_1	77	83	PF00454	0.548
MOD_PK_1	140	146	PF00069	0.387
MOD_PKA_1	126	132	PF00069	0.592
MOD_PKA_1	159	165	PF00069	0.600
MOD_PKA_2	126	132	PF00069	0.607
MOD_PKA_2	159	165	PF00069	0.582
MOD_Plk_1	205	211	PF00069	0.505
MOD_Plk_1	212	218	PF00069	0.515
MOD_Plk_1	24	30	PF00069	0.554
MOD_Plk_1	95	101	PF00069	0.576
MOD_SUMO_for_1	216	219	PF00179	0.491
MOD_SUMO_rev_2	122	128	PF00179	0.612
TRG_DiLeu_BaEn_1	166	171	PF01217	0.575
TRG_DiLeu_BaEn_4	23	29	PF01217	0.482
TRG_DiLeu_BaEn_4	241	247	PF01217	0.544
TRG_ENDOCYTIC_2	243	246	PF00928	0.544
TRG_ENDOCYTIC_2	97	100	PF00928	0.496
TRG_ER_diArg_1	114	116	PF00400	0.574
TRG_ER_diArg_1	138	140	PF00400	0.652
TRG_ER_diArg_1	250	252	PF00400	0.458
TRG_ER_diArg_1	63	66	PF00400	0.578
TRG_Pf-PMV_PEXEL_1	116	121	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Y9	Leptomonas seymouri	61%	100%
A0A1X0P948	Trypanosomatidae	30%	100%
A0A3R7P2R3	Trypanosoma rangeli	30%	100%
A0A3S7XAJ5	Leishmania donovani	81%	83%
A4ICS9	Leishmania infantum	81%	83%
D0A2M6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9ASH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q220	Leishmania major	81%	100%
V5DRQ0	Trypanosoma cruzi	29%	100%