Putative ubiquitin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-like protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HNR4_LEIBR

TriTrypDb:

LbrM.35.0650 , LBRM2903_350011800

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HNR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNR4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006259	DNA metabolic process	4	3
GO:0006281	DNA repair	5	3
GO:0006289	nucleotide-excision repair	6	3
GO:0006508	proteolysis	4	4
GO:0006511	ubiquitin-dependent protein catabolic process	7	4
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	4
GO:0006950	response to stress	2	3
GO:0006974	DNA damage response	4	3
GO:0008152	metabolic process	1	4
GO:0009056	catabolic process	2	4
GO:0009057	macromolecule catabolic process	4	4
GO:0009987	cellular process	1	4
GO:0010498	proteasomal protein catabolic process	5	3
GO:0019538	protein metabolic process	3	4
GO:0019941	modification-dependent protein catabolic process	6	4
GO:0030163	protein catabolic process	4	3
GO:0033554	cellular response to stress	3	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	3
GO:0043170	macromolecule metabolic process	3	4
GO:0043632	modification-dependent macromolecule catabolic process	5	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044248	cellular catabolic process	3	4
GO:0044260	obsolete cellular macromolecule metabolic process	3	4
GO:0044265	obsolete cellular macromolecule catabolic process	4	4
GO:0046483	heterocycle metabolic process	3	3
GO:0050896	response to stimulus	1	3
GO:0051603	proteolysis involved in protein catabolic process	5	4
GO:0051716	cellular response to stimulus	2	3
GO:0071704	organic substance metabolic process	2	4
GO:0090304	nucleic acid metabolic process	4	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:1901564	organonitrogen compound metabolic process	3	4
GO:1901565	organonitrogen compound catabolic process	4	3
GO:1901575	organic substance catabolic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003677	DNA binding	4	3
GO:0003684	damaged DNA binding	5	3
GO:0005488	binding	1	4
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3
GO:0005515	protein binding	2	1
GO:0031593	polyubiquitin modification-dependent protein binding	4	1
GO:0140030	modification-dependent protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	43	47	PF00082	0.211
CLV_PCSK_SKI1_1	49	53	PF00082	0.278
CLV_Separin_Metazoa	219	223	PF03568	0.587
DEG_APCC_DBOX_1	278	286	PF00400	0.420
DEG_SCF_FBW7_1	85	92	PF00400	0.492
DOC_PP2B_LxvP_1	35	38	PF13499	0.533
DOC_PP4_FxxP_1	127	130	PF00568	0.716
DOC_PP4_FxxP_1	265	268	PF00568	0.542
DOC_USP7_MATH_1	122	126	PF00917	0.588
DOC_USP7_MATH_1	232	236	PF00917	0.545
DOC_USP7_MATH_1	89	93	PF00917	0.597
DOC_WW_Pin1_4	164	169	PF00397	0.601
DOC_WW_Pin1_4	200	205	PF00397	0.578
DOC_WW_Pin1_4	250	255	PF00397	0.685
DOC_WW_Pin1_4	85	90	PF00397	0.666
DOC_WW_Pin1_4	99	104	PF00397	0.669
LIG_14-3-3_CanoR_1	72	78	PF00244	0.641
LIG_BRCT_BRCA1_1	261	265	PF00533	0.591
LIG_EH_1	146	150	PF12763	0.633
LIG_FHA_1	12	18	PF00498	0.436
LIG_FHA_1	2	8	PF00498	0.299
LIG_FHA_1	238	244	PF00498	0.573
LIG_FHA_1	251	257	PF00498	0.681
LIG_FHA_1	32	38	PF00498	0.474
LIG_FHA_2	21	27	PF00498	0.516
LIG_IBAR_NPY_1	118	120	PF08397	0.527
LIG_IBAR_NPY_1	223	225	PF08397	0.621
LIG_LIR_Apic_2	125	130	PF02991	0.711
LIG_LIR_Apic_2	262	268	PF02991	0.580
LIG_NRBOX	310	316	PF00104	0.420
LIG_PCNA_yPIPBox_3	214	222	PF02747	0.515
LIG_PCNA_yPIPBox_3	271	279	PF02747	0.349
LIG_PDZ_Class_2	312	317	PF00595	0.480
LIG_PTB_Apo_2	189	196	PF02174	0.527
LIG_SH2_CRK	120	124	PF00017	0.523
LIG_SH2_STAP1	120	124	PF00017	0.542
LIG_SH2_STAT3	198	201	PF00017	0.578
LIG_SH2_STAT3	225	228	PF00017	0.596
LIG_SH2_STAT3	278	281	PF00017	0.299
LIG_SH2_STAT5	198	201	PF00017	0.553
LIG_SH3_3	107	113	PF00018	0.680
LIG_SH3_3	264	270	PF00018	0.610
LIG_SUMO_SIM_par_1	13	19	PF11976	0.472
LIG_TRAF2_1	291	294	PF00917	0.356
LIG_TRAF2_1	38	41	PF00917	0.425
MOD_CK1_1	73	79	PF00069	0.671
MOD_CK1_1	97	103	PF00069	0.635
MOD_CK2_1	20	26	PF00069	0.533
MOD_GlcNHglycan	144	147	PF01048	0.481
MOD_GlcNHglycan	261	264	PF01048	0.587
MOD_GlcNHglycan	57	60	PF01048	0.265
MOD_GSK3_1	200	207	PF00069	0.458
MOD_GSK3_1	233	240	PF00069	0.617
MOD_GSK3_1	255	262	PF00069	0.565
MOD_GSK3_1	76	83	PF00069	0.590
MOD_GSK3_1	84	91	PF00069	0.591
MOD_GSK3_1	93	100	PF00069	0.569
MOD_N-GLC_1	20	25	PF02516	0.271
MOD_N-GLC_1	83	88	PF02516	0.742
MOD_NEK2_1	1	6	PF00069	0.315
MOD_NEK2_1	20	25	PF00069	0.447
MOD_NEK2_1	233	238	PF00069	0.578
MOD_PIKK_1	105	111	PF00454	0.490
MOD_PIKK_1	129	135	PF00454	0.698
MOD_PIKK_1	97	103	PF00454	0.546
MOD_Plk_1	20	26	PF00069	0.485
MOD_ProDKin_1	164	170	PF00069	0.598
MOD_ProDKin_1	200	206	PF00069	0.574
MOD_ProDKin_1	250	256	PF00069	0.684
MOD_ProDKin_1	85	91	PF00069	0.669
MOD_ProDKin_1	99	105	PF00069	0.673
MOD_SUMO_for_1	51	54	PF00179	0.371
TRG_DiLeu_BaEn_1	280	285	PF01217	0.446
TRG_DiLeu_BaEn_3	40	46	PF01217	0.468
TRG_DiLeu_BaLyEn_6	310	315	PF01217	0.299
TRG_ENDOCYTIC_2	120	123	PF00928	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I781	Leptomonas seymouri	61%	100%
A0A0S4JQ29	Bodo saltans	43%	100%
A0A1X0P8J6	Trypanosomatidae	37%	100%
A0A3S7XAB2	Leishmania donovani	80%	100%
A0A422P276	Trypanosoma rangeli	39%	100%
A4ICT1	Leishmania infantum	80%	100%
D0A2M4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9ASH3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
P48510	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	85%
Q4Q222	Leishmania major	80%	100%
V5BZY0	Trypanosoma cruzi	40%	88%