LeishMANIAdb
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Protein phosphatase 2C-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein phosphatase 2C-like protein
Gene product:
protein phosphatase 2C-like protein
Species:
Leishmania braziliensis
UniProt:
A4HNR1_LEIBR
TriTrypDb:
LbrM.35.0620 , LBRM2903_350011700
Length:
298

Annotations

LeishMANIAdb annotations

This large family encompasses many diverse protein phosphatases. Some appear to have evolved transmembrane segments. Very tentatively they might regulate transmembrane receptor kinases.. The TM and non-TM groups diverged early in Eukaryota and appear to be distinct enough that they probably should not be part of the same cluster. This latter group has not expanded.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNR1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNR1

Function

Biological processes
Term Name Level Count
GO:0006470 protein dephosphorylation 5 16
GO:0006793 phosphorus metabolic process 3 16
GO:0006796 phosphate-containing compound metabolic process 4 16
GO:0006807 nitrogen compound metabolic process 2 16
GO:0008152 metabolic process 1 16
GO:0009987 cellular process 1 16
GO:0016311 dephosphorylation 5 16
GO:0019538 protein metabolic process 3 16
GO:0036211 protein modification process 4 16
GO:0043170 macromolecule metabolic process 3 16
GO:0043412 macromolecule modification 4 16
GO:0044237 cellular metabolic process 2 16
GO:0044238 primary metabolic process 2 16
GO:0071704 organic substance metabolic process 2 16
GO:1901564 organonitrogen compound metabolic process 3 16
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 16
GO:0004721 phosphoprotein phosphatase activity 3 16
GO:0004722 protein serine/threonine phosphatase activity 4 16
GO:0016787 hydrolase activity 2 16
GO:0016788 hydrolase activity, acting on ester bonds 3 16
GO:0016791 phosphatase activity 5 16
GO:0042578 phosphoric ester hydrolase activity 4 16
GO:0140096 catalytic activity, acting on a protein 2 16
GO:0017018 myosin phosphatase activity 5 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 32 34 PF00675 0.263
CLV_PCSK_SKI1_1 134 138 PF00082 0.319
DEG_SCF_FBW7_1 207 214 PF00400 0.406
DOC_MAPK_gen_1 139 148 PF00069 0.406
DOC_MAPK_HePTP_8 136 148 PF00069 0.406
DOC_MAPK_MEF2A_6 139 148 PF00069 0.406
DOC_MAPK_MEF2A_6 172 179 PF00069 0.406
DOC_MAPK_MEF2A_6 250 259 PF00069 0.406
DOC_MAPK_NFAT4_5 172 180 PF00069 0.406
DOC_PP2B_PxIxI_1 204 210 PF00149 0.406
DOC_PP4_FxxP_1 291 294 PF00568 0.475
DOC_USP7_MATH_1 130 134 PF00917 0.263
DOC_USP7_MATH_1 211 215 PF00917 0.361
DOC_USP7_UBL2_3 246 250 PF12436 0.232
DOC_WW_Pin1_4 207 212 PF00397 0.400
LIG_14-3-3_CanoR_1 33 37 PF00244 0.295
LIG_Actin_WH2_2 9 25 PF00022 0.482
LIG_APCC_ABBA_1 82 87 PF00400 0.306
LIG_BRCT_BRCA1_1 13 17 PF00533 0.501
LIG_FHA_1 17 23 PF00498 0.334
LIG_FHA_1 283 289 PF00498 0.345
LIG_FHA_2 13 19 PF00498 0.491
LIG_FHA_2 4 10 PF00498 0.532
LIG_Integrin_isoDGR_2 170 172 PF01839 0.406
LIG_LIR_Apic_2 290 294 PF02991 0.470
LIG_LIR_Gen_1 10 17 PF02991 0.536
LIG_LIR_Gen_1 215 226 PF02991 0.318
LIG_LIR_Nem_3 10 16 PF02991 0.538
LIG_LIR_Nem_3 215 221 PF02991 0.308
LIG_LIR_Nem_3 224 230 PF02991 0.303
LIG_LIR_Nem_3 51 57 PF02991 0.361
LIG_NRBOX 74 80 PF00104 0.406
LIG_Pex14_2 13 17 PF04695 0.501
LIG_Pex14_2 291 295 PF04695 0.397
LIG_Pex14_2 54 58 PF04695 0.278
LIG_Pex14_2 93 97 PF04695 0.263
LIG_REV1ctd_RIR_1 293 298 PF16727 0.405
LIG_SH2_STAT5 119 122 PF00017 0.406
LIG_SH2_STAT5 69 72 PF00017 0.278
LIG_SH3_3 149 155 PF00018 0.405
LIG_SH3_4 7 14 PF00018 0.510
LIG_SUMO_SIM_anti_2 258 264 PF11976 0.406
LIG_SUMO_SIM_anti_2 285 290 PF11976 0.433
LIG_SUMO_SIM_par_1 144 149 PF11976 0.406
LIG_SUMO_SIM_par_1 253 258 PF11976 0.416
LIG_SUMO_SIM_par_1 284 290 PF11976 0.435
LIG_TRAF2_1 155 158 PF00917 0.406
LIG_TRAF2_1 231 234 PF00917 0.322
LIG_UBA3_1 74 80 PF00899 0.406
MOD_CDK_SPxK_1 207 213 PF00069 0.306
MOD_CK1_1 110 116 PF00069 0.410
MOD_CK2_1 12 18 PF00069 0.352
MOD_CK2_1 211 217 PF00069 0.363
MOD_CK2_1 228 234 PF00069 0.240
MOD_CK2_1 3 9 PF00069 0.403
MOD_CK2_1 93 99 PF00069 0.356
MOD_GlcNHglycan 110 113 PF01048 0.411
MOD_GSK3_1 107 114 PF00069 0.276
MOD_GSK3_1 12 19 PF00069 0.397
MOD_GSK3_1 205 212 PF00069 0.413
MOD_GSK3_1 278 285 PF00069 0.462
MOD_GSK3_1 3 10 PF00069 0.420
MOD_GSK3_1 60 67 PF00069 0.457
MOD_N-GLC_1 282 287 PF02516 0.351
MOD_NEK2_1 108 113 PF00069 0.372
MOD_NEK2_1 17 22 PF00069 0.424
MOD_NEK2_1 177 182 PF00069 0.335
MOD_NEK2_1 238 243 PF00069 0.367
MOD_NEK2_1 271 276 PF00069 0.449
MOD_NEK2_1 93 98 PF00069 0.347
MOD_PIKK_1 7 13 PF00454 0.536
MOD_PIKK_1 99 105 PF00454 0.176
MOD_PKA_2 32 38 PF00069 0.319
MOD_Plk_1 17 23 PF00069 0.326
MOD_Plk_1 192 198 PF00069 0.372
MOD_Plk_1 205 211 PF00069 0.346
MOD_Plk_1 257 263 PF00069 0.428
MOD_Plk_1 282 288 PF00069 0.350
MOD_Plk_1 64 70 PF00069 0.306
MOD_Plk_1 93 99 PF00069 0.345
MOD_Plk_4 12 18 PF00069 0.524
MOD_Plk_4 238 244 PF00069 0.386
MOD_Plk_4 282 288 PF00069 0.340
MOD_ProDKin_1 207 213 PF00069 0.400
MOD_SUMO_rev_2 147 153 PF00179 0.335
TRG_DiLeu_BaEn_1 234 239 PF01217 0.322
TRG_Pf-PMV_PEXEL_1 181 185 PF00026 0.263
TRG_Pf-PMV_PEXEL_1 269 273 PF00026 0.334

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5C7 Leptomonas seymouri 39% 75%
A0A0N0P8F8 Leptomonas seymouri 40% 100%
A0A0N1I0H9 Leptomonas seymouri 83% 100%
A0A0N1I8W9 Leptomonas seymouri 34% 68%
A0A0N1IHU6 Leptomonas seymouri 30% 73%
A0A0N1PAL8 Leptomonas seymouri 37% 78%
A0A0N1PEL9 Leptomonas seymouri 32% 80%
A0A0S4IY95 Bodo saltans 38% 83%
A0A0S4J0A6 Bodo saltans 34% 73%
A0A0S4JHB4 Bodo saltans 32% 78%
A0A0S4JPC3 Bodo saltans 52% 100%
A0A0S4JPM8 Bodo saltans 39% 79%
A0A0S4KJV9 Bodo saltans 40% 69%
A0A1X0NRG3 Trypanosomatidae 41% 94%
A0A1X0NVC4 Trypanosomatidae 38% 73%
A0A1X0P2A0 Trypanosomatidae 31% 78%
A0A1X0P568 Trypanosomatidae 32% 73%
A0A1X0P991 Trypanosomatidae 56% 100%
A0A1X0PAN4 Trypanosomatidae 26% 93%
A0A3Q8IEK6 Leishmania donovani 42% 95%
A0A3Q8IFG7 Leishmania donovani 36% 78%
A0A3Q8IK65 Leishmania donovani 94% 100%
A0A3Q8IL63 Leishmania donovani 31% 76%
A0A3S7WTA2 Leishmania donovani 40% 74%
A0A3S7WZ14 Leishmania donovani 31% 73%
A0A3S7X808 Leishmania donovani 32% 66%
A0A422N8D7 Trypanosoma rangeli 28% 94%
A0A422NAJ1 Trypanosoma rangeli 41% 94%
A0A422NBV9 Trypanosoma rangeli 32% 73%
A0A422NL94 Trypanosoma rangeli 41% 68%
A0A422NML6 Trypanosoma rangeli 33% 78%
A0A422NS77 Trypanosoma rangeli 37% 72%
A0A422P293 Trypanosoma rangeli 54% 100%
A0BLX0 Paramecium tetraurelia 34% 99%
A0BQL0 Paramecium tetraurelia 36% 99%
A0CUB5 Paramecium tetraurelia 33% 100%
A0DSB3 Paramecium tetraurelia 34% 100%
A0DTY1 Paramecium tetraurelia 33% 99%
A3A8W2 Oryza sativa subsp. japonica 32% 88%
A4H7Y6 Leishmania braziliensis 40% 100%
A4HAW5 Leishmania braziliensis 32% 100%
A4HAW6 Leishmania braziliensis 31% 66%
A4HE10 Leishmania braziliensis 29% 100%
A4HG10 Leishmania braziliensis 42% 100%
A4HHY5 Leishmania braziliensis 37% 100%
A4HWB4 Leishmania infantum 40% 74%
A4I1B7 Leishmania infantum 31% 73%
A4I329 Leishmania infantum 42% 95%
A4I565 Leishmania infantum 36% 78%
A4IA25 Leishmania infantum 31% 76%
A4IA26 Leishmania infantum 31% 66%
A4ICT4 Leishmania infantum 94% 100%
A5PJZ2 Bos taurus 31% 83%
C9ZJK2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 93%
C9ZMJ7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 95%
C9ZNW4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 70%
C9ZQJ2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 78%
D0A2L9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 100%
D0A5L0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 73%
D0AA51 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 69%
E9ACV0 Leishmania major 41% 100%
E9AQ14 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 74%
E9ASH0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
E9AXF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 73%
E9AZD9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 95%
E9B0G2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 78%
E9B540 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 76%
E9B541 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
O04719 Arabidopsis thaliana 31% 70%
O14189 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 30% 67%
O62829 Bos taurus 39% 78%
O64583 Arabidopsis thaliana 29% 88%
O80492 Arabidopsis thaliana 30% 70%
O80871 Arabidopsis thaliana 33% 75%
O81716 Arabidopsis thaliana 35% 84%
O81760 Arabidopsis thaliana 27% 78%
O82637 Arabidopsis thaliana 32% 91%
P20650 Rattus norvegicus 39% 78%
P35182 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 31% 100%
P35813 Homo sapiens 39% 78%
P35814 Oryctolagus cuniculus 39% 78%
P35815 Rattus norvegicus 39% 76%
P36982 Leishmania chagasi 31% 73%
P36993 Mus musculus 38% 76%
P38089 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 76%
P40371 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 35% 86%
P49443 Mus musculus 39% 78%
P49444 Paramecium tetraurelia 35% 99%
P49594 Caenorhabditis elegans 25% 66%
P49596 Caenorhabditis elegans 41% 84%
P49597 Arabidopsis thaliana 31% 69%
P49598 Arabidopsis thaliana 33% 75%
P49599 Arabidopsis thaliana 28% 77%
P93006 Arabidopsis thaliana 34% 78%
Q09172 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 40% 81%
Q09173 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 41% 72%
Q0D673 Oryza sativa subsp. japonica 31% 100%
Q0DBU3 Oryza sativa subsp. japonica 33% 85%
Q0IIF0 Bos taurus 30% 81%
Q0J2L7 Oryza sativa subsp. japonica 33% 83%
Q0J2R1 Oryza sativa subsp. japonica 32% 81%
Q0JAA0 Oryza sativa subsp. japonica 32% 93%
Q0JL75 Oryza sativa subsp. japonica 31% 79%
Q0V7V2 Arabidopsis thaliana 25% 78%
Q10MN6 Oryza sativa subsp. japonica 27% 69%
Q10MX1 Oryza sativa subsp. japonica 32% 76%
Q10S32 Oryza sativa subsp. japonica 26% 75%
Q2PC20 Bos taurus 29% 80%
Q2QN36 Oryza sativa subsp. japonica 27% 76%
Q2QWE3 Oryza sativa subsp. japonica 30% 71%
Q2R637 Oryza sativa subsp. japonica 29% 69%
Q2RBJ6 Oryza sativa subsp. japonica 28% 71%
Q3EAF9 Arabidopsis thaliana 33% 78%
Q4PSE8 Arabidopsis thaliana 34% 67%
Q4Q225 Leishmania major 93% 100%
Q4Q2U5 Leishmania major 31% 66%
Q4Q2U6 Leishmania major 32% 100%
Q4Q7S1 Leishmania major 36% 100%
Q4QA19 Leishmania major 31% 100%
Q4QFG7 Leishmania major 38% 100%
Q501F9 Arabidopsis thaliana 30% 81%
Q53Q11 Oryza sativa subsp. japonica 28% 75%
Q5JKN1 Oryza sativa subsp. japonica 26% 77%
Q5N9N2 Oryza sativa subsp. japonica 33% 72%
Q5PNS9 Arabidopsis thaliana 28% 74%
Q5R522 Pongo abelii 31% 91%
Q5SGD2 Homo sapiens 31% 83%
Q5SMK6 Oryza sativa subsp. japonica 33% 83%
Q5SN75 Oryza sativa subsp. japonica 31% 74%
Q5Z6F5 Oryza sativa subsp. japonica 33% 91%
Q5Z8P0 Oryza sativa subsp. japonica 26% 76%
Q652Z7 Oryza sativa subsp. japonica 37% 79%
Q653S3 Oryza sativa subsp. japonica 36% 82%
Q65XG6 Oryza sativa subsp. japonica 35% 72%
Q65XK7 Oryza sativa subsp. japonica 32% 78%
Q67J17 Oryza sativa subsp. japonica 26% 71%
Q67UP9 Oryza sativa subsp. japonica 35% 81%
Q67UX7 Oryza sativa subsp. japonica 34% 86%
Q69QZ0 Oryza sativa subsp. japonica 32% 84%
Q69VD9 Oryza sativa subsp. japonica 30% 81%
Q6AUQ4 Oryza sativa subsp. japonica 31% 77%
Q6EN45 Oryza sativa subsp. japonica 32% 82%
Q6ETK3 Oryza sativa subsp. japonica 36% 82%
Q6ING9 Xenopus laevis 29% 80%
Q6L4R7 Oryza sativa subsp. japonica 31% 67%
Q6L5H6 Oryza sativa subsp. japonica 31% 77%
Q6NKS1 Arabidopsis thaliana 33% 78%
Q6YTI2 Oryza sativa subsp. japonica 28% 67%
Q7XCJ7 Oryza sativa subsp. japonica 27% 76%
Q7XHN8 Oryza sativa subsp. japonica 29% 79%
Q7XJ53 Arabidopsis thaliana 24% 86%
Q7XQU7 Oryza sativa subsp. japonica 31% 100%
Q7XR06 Oryza sativa subsp. japonica 30% 100%
Q7XU84 Oryza sativa subsp. japonica 32% 85%
Q7XUC5 Oryza sativa subsp. japonica 28% 77%
Q7Y138 Oryza sativa subsp. japonica 28% 77%
Q84JD5 Arabidopsis thaliana 25% 76%
Q84JI0 Oryza sativa subsp. japonica 35% 74%
Q8BGL1 Mus musculus 34% 74%
Q8BHN0 Mus musculus 31% 83%
Q8BXN7 Mus musculus 30% 80%
Q8H063 Oryza sativa subsp. japonica 26% 76%
Q8H4S6 Oryza sativa subsp. japonica 28% 70%
Q8L7I4 Arabidopsis thaliana 31% 100%
Q8LAY8 Arabidopsis thaliana 35% 84%
Q8N3J5 Homo sapiens 29% 80%
Q8N819 Homo sapiens 33% 69%
Q8R0F6 Mus musculus 30% 76%
Q8RX37 Arabidopsis thaliana 29% 78%
Q8RXV3 Arabidopsis thaliana 35% 96%
Q8VZN9 Arabidopsis thaliana 34% 80%
Q93YW5 Arabidopsis thaliana 33% 100%
Q94AT1 Arabidopsis thaliana 29% 71%
Q94CL8 Arabidopsis thaliana 28% 78%
Q9FG61 Arabidopsis thaliana 29% 67%
Q9FIF5 Arabidopsis thaliana 33% 72%
Q9FKX4 Arabidopsis thaliana 29% 77%
Q9FLI3 Arabidopsis thaliana 30% 72%
Q9FX08 Arabidopsis thaliana 26% 70%
Q9FXE4 Arabidopsis thaliana 35% 67%
Q9FYN7 Oryza sativa subsp. japonica 33% 78%
Q9H0C8 Homo sapiens 29% 76%
Q9LDA7 Arabidopsis thaliana 30% 100%
Q9LHJ9 Arabidopsis thaliana 29% 77%
Q9LME4 Arabidopsis thaliana 31% 100%
Q9LMT1 Arabidopsis thaliana 31% 85%
Q9LNF4 Arabidopsis thaliana 32% 78%
Q9LNW3 Arabidopsis thaliana 36% 67%
Q9LRZ4 Arabidopsis thaliana 29% 85%
Q9LUU7 Arabidopsis thaliana 30% 71%
Q9M1V8 Arabidopsis thaliana 23% 70%
Q9M9C6 Arabidopsis thaliana 26% 68%
Q9M9W9 Arabidopsis thaliana 31% 83%
Q9S9Z7 Arabidopsis thaliana 29% 100%
Q9SD02 Arabidopsis thaliana 33% 83%
Q9SD12 Arabidopsis thaliana 27% 79%
Q9SIU8 Arabidopsis thaliana 32% 100%
Q9SLA1 Arabidopsis thaliana 34% 76%
Q9SUF4 Arabidopsis thaliana 30% 100%
Q9SZ53 Arabidopsis thaliana 35% 83%
Q9WVR7 Rattus norvegicus 29% 66%
Q9XEE8 Arabidopsis thaliana 32% 76%
Q9XGZ9 Arabidopsis thaliana 30% 90%
Q9Z1Z6 Rattus norvegicus 30% 76%
Q9ZW21 Arabidopsis thaliana 31% 82%
V5AZJ4 Trypanosoma cruzi 41% 75%
V5BA03 Trypanosoma cruzi 55% 100%
V5BCX6 Trypanosoma cruzi 40% 99%
V5BH00 Trypanosoma cruzi 34% 84%
V5BSS7 Trypanosoma cruzi 33% 73%
V5DCR6 Trypanosoma cruzi 37% 72%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS