GAF domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNR0_LEIBR

TriTrypDb:

LbrM.35.0610 , LBRM2903_350011600

Length:

442

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNR0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNR0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	433	437	PF00656	0.554
CLV_NRD_NRD_1	197	199	PF00675	0.646
CLV_NRD_NRD_1	227	229	PF00675	0.641
CLV_NRD_NRD_1	319	321	PF00675	0.564
CLV_NRD_NRD_1	332	334	PF00675	0.554
CLV_NRD_NRD_1	400	402	PF00675	0.504
CLV_NRD_NRD_1	94	96	PF00675	0.771
CLV_PCSK_KEX2_1	148	150	PF00082	0.605
CLV_PCSK_KEX2_1	199	201	PF00082	0.305
CLV_PCSK_KEX2_1	227	229	PF00082	0.648
CLV_PCSK_KEX2_1	312	314	PF00082	0.419
CLV_PCSK_KEX2_1	332	334	PF00082	0.535
CLV_PCSK_KEX2_1	35	37	PF00082	0.510
CLV_PCSK_KEX2_1	400	402	PF00082	0.508
CLV_PCSK_KEX2_1	94	96	PF00082	0.517
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.605
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.305
CLV_PCSK_PC1ET2_1	312	314	PF00082	0.394
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.483
CLV_PCSK_SKI1_1	200	204	PF00082	0.266
CLV_PCSK_SKI1_1	370	374	PF00082	0.630
DEG_Nend_UBRbox_2	1	3	PF02207	0.675
DEG_ODPH_VHL_1	275	286	PF01847	0.619
DOC_CYCLIN_yCln2_LP_2	285	288	PF00134	0.449
DOC_MAPK_gen_1	198	205	PF00069	0.560
DOC_MAPK_gen_1	332	338	PF00069	0.602
DOC_PIKK_1	22	30	PF02985	0.392
DOC_PP1_RVXF_1	159	166	PF00149	0.531
DOC_PP2B_LxvP_1	285	288	PF13499	0.449
DOC_PP2B_LxvP_1	349	352	PF13499	0.429
DOC_PP2B_LxvP_1	81	84	PF13499	0.769
DOC_PP2B_PxIxI_1	326	332	PF00149	0.707
DOC_PP4_FxxP_1	165	168	PF00568	0.601
DOC_PP4_FxxP_1	266	269	PF00568	0.485
DOC_USP7_MATH_1	157	161	PF00917	0.588
DOC_USP7_MATH_1	21	25	PF00917	0.665
DOC_USP7_MATH_1	216	220	PF00917	0.426
DOC_USP7_MATH_1	280	284	PF00917	0.447
DOC_USP7_MATH_1	39	43	PF00917	0.419
DOC_USP7_MATH_1	426	430	PF00917	0.587
DOC_WW_Pin1_4	323	328	PF00397	0.694
DOC_WW_Pin1_4	55	60	PF00397	0.736
DOC_WW_Pin1_4	94	99	PF00397	0.639
LIG_14-3-3_CanoR_1	313	322	PF00244	0.652
LIG_14-3-3_CanoR_1	38	47	PF00244	0.466
LIG_14-3-3_CanoR_1	99	104	PF00244	0.691
LIG_Actin_WH2_2	374	392	PF00022	0.627
LIG_BRCT_BRCA1_1	231	235	PF00533	0.415
LIG_Clathr_ClatBox_1	378	382	PF01394	0.632
LIG_FHA_1	133	139	PF00498	0.475
LIG_FHA_1	220	226	PF00498	0.562
LIG_FHA_1	269	275	PF00498	0.515
LIG_FHA_1	317	323	PF00498	0.558
LIG_FHA_1	32	38	PF00498	0.501
LIG_FHA_2	294	300	PF00498	0.534
LIG_FHA_2	383	389	PF00498	0.592
LIG_FHA_2	431	437	PF00498	0.336
LIG_GBD_Chelix_1	10	18	PF00786	0.590
LIG_Integrin_RGD_1	149	151	PF01839	0.346
LIG_LIR_Apic_2	162	168	PF02991	0.381
LIG_LIR_Apic_2	264	269	PF02991	0.557
LIG_LIR_Gen_1	126	134	PF02991	0.426
LIG_LIR_Gen_1	242	253	PF02991	0.520
LIG_LIR_Nem_3	126	131	PF02991	0.426
LIG_LIR_Nem_3	242	248	PF02991	0.469
LIG_NRBOX	126	132	PF00104	0.552
LIG_Pex14_2	245	249	PF04695	0.521
LIG_Pex14_2	262	266	PF04695	0.423
LIG_Rb_LxCxE_1	247	265	PF01857	0.587
LIG_SH2_CRK	208	212	PF00017	0.358
LIG_SH2_SRC	267	270	PF00017	0.515
LIG_SH2_STAP1	310	314	PF00017	0.600
LIG_SH2_STAT5	244	247	PF00017	0.513
LIG_SH2_STAT5	360	363	PF00017	0.509
LIG_SH3_3	161	167	PF00018	0.383
LIG_SH3_3	228	234	PF00018	0.601
LIG_SH3_3	274	280	PF00018	0.531
LIG_SH3_3	281	287	PF00018	0.576
LIG_SH3_3	340	346	PF00018	0.717
LIG_SH3_3	53	59	PF00018	0.671
LIG_SUMO_SIM_anti_2	374	380	PF11976	0.632
LIG_SUMO_SIM_par_1	293	299	PF11976	0.503
LIG_SUMO_SIM_par_1	377	382	PF11976	0.632
LIG_WRC_WIRS_1	263	268	PF05994	0.596
MOD_CDK_SPK_2	94	99	PF00069	0.515
MOD_CDK_SPxxK_3	55	62	PF00069	0.669
MOD_CK1_1	113	119	PF00069	0.604
MOD_CK1_1	219	225	PF00069	0.298
MOD_CK1_1	316	322	PF00069	0.573
MOD_CK1_1	42	48	PF00069	0.503
MOD_CK1_1	429	435	PF00069	0.332
MOD_CK2_1	293	299	PF00069	0.558
MOD_CK2_1	350	356	PF00069	0.538
MOD_Cter_Amidation	196	199	PF01082	0.658
MOD_GlcNHglycan	176	179	PF01048	0.468
MOD_GlcNHglycan	231	234	PF01048	0.434
MOD_GSK3_1	113	120	PF00069	0.406
MOD_GSK3_1	229	236	PF00069	0.581
MOD_GSK3_1	39	46	PF00069	0.465
MOD_GSK3_1	426	433	PF00069	0.323
MOD_GSK3_1	99	106	PF00069	0.738
MOD_N-GLC_1	157	162	PF02516	0.559
MOD_N-GLC_1	21	26	PF02516	0.664
MOD_NEK2_1	103	108	PF00069	0.596
MOD_NEK2_1	138	143	PF00069	0.467
MOD_NEK2_1	183	188	PF00069	0.564
MOD_NEK2_1	262	267	PF00069	0.609
MOD_NEK2_1	396	401	PF00069	0.607
MOD_NEK2_2	21	26	PF00069	0.664
MOD_NEK2_2	244	249	PF00069	0.535
MOD_PIKK_1	117	123	PF00454	0.608
MOD_PIKK_1	268	274	PF00454	0.494
MOD_PIKK_1	313	319	PF00454	0.545
MOD_PIKK_1	382	388	PF00454	0.578
MOD_PIKK_1	46	52	PF00454	0.581
MOD_PKA_2	382	388	PF00069	0.517
MOD_Plk_1	21	27	PF00069	0.395
MOD_Plk_1	239	245	PF00069	0.558
MOD_Plk_1	42	48	PF00069	0.671
MOD_Plk_1	429	435	PF00069	0.332
MOD_Plk_2-3	414	420	PF00069	0.322
MOD_Plk_2-3	430	436	PF00069	0.337
MOD_Plk_4	123	129	PF00069	0.427
MOD_Plk_4	239	245	PF00069	0.518
MOD_Plk_4	262	268	PF00069	0.602
MOD_Plk_4	280	286	PF00069	0.674
MOD_Plk_4	350	356	PF00069	0.615
MOD_Plk_4	430	436	PF00069	0.382
MOD_ProDKin_1	323	329	PF00069	0.696
MOD_ProDKin_1	55	61	PF00069	0.733
MOD_ProDKin_1	94	100	PF00069	0.637
MOD_SUMO_for_1	427	430	PF00179	0.475
MOD_SUMO_rev_2	414	422	PF00179	0.509
TRG_DiLeu_BaLyEn_6	133	138	PF01217	0.468
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.591
TRG_ENDOCYTIC_2	128	131	PF00928	0.428
TRG_ENDOCYTIC_2	424	427	PF00928	0.538
TRG_ER_diArg_1	331	333	PF00400	0.573
TRG_NLS_MonoExtN_4	32	39	PF00514	0.470
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.345
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JPJ4	Bodo saltans	31%	86%
A0A1X0P9M8	Trypanosomatidae	36%	99%
A0A3Q8IFS3	Leishmania donovani	73%	100%
A0A422P297	Trypanosoma rangeli	36%	99%
A4ICT5	Leishmania infantum	74%	100%
D0A2L8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	99%
E9ASG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q226	Leishmania major	72%	100%