LeishMANIAdb
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Putative mitochondrial carrier protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative mitochondrial carrier protein
Gene product:
mitochondrial carrier protein, putative
Species:
Leishmania braziliensis
UniProt:
A4HNQ9_LEIBR
TriTrypDb:
LbrM.35.0600 , LBRM2903_350011500
Length:
755

Annotations

LeishMANIAdb annotations

Appears to fold into two separate 6TM-6TM transporter domains. Each is homologous to an individual mitochondrial CoA transporter. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005743 mitochondrial inner membrane 5 10
GO:0016020 membrane 2 12
GO:0019866 organelle inner membrane 4 10
GO:0031090 organelle membrane 3 10
GO:0031966 mitochondrial membrane 4 10
GO:0110165 cellular anatomical entity 1 12

Expansion

Sequence features

A4HNQ9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNQ9

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 12
GO:0009987 cellular process 1 12
GO:0051179 localization 1 12
GO:0051234 establishment of localization 2 12
GO:0055085 transmembrane transport 2 12
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 240 244 PF00656 0.421
CLV_C14_Caspase3-7 41 45 PF00656 0.383
CLV_NRD_NRD_1 181 183 PF00675 0.244
CLV_NRD_NRD_1 196 198 PF00675 0.266
CLV_NRD_NRD_1 379 381 PF00675 0.231
CLV_NRD_NRD_1 435 437 PF00675 0.442
CLV_NRD_NRD_1 599 601 PF00675 0.337
CLV_NRD_NRD_1 697 699 PF00675 0.249
CLV_PCSK_KEX2_1 181 183 PF00082 0.229
CLV_PCSK_KEX2_1 288 290 PF00082 0.339
CLV_PCSK_KEX2_1 378 380 PF00082 0.231
CLV_PCSK_KEX2_1 434 436 PF00082 0.442
CLV_PCSK_KEX2_1 599 601 PF00082 0.318
CLV_PCSK_KEX2_1 665 667 PF00082 0.231
CLV_PCSK_PC1ET2_1 288 290 PF00082 0.339
CLV_PCSK_PC1ET2_1 434 436 PF00082 0.456
CLV_PCSK_PC1ET2_1 665 667 PF00082 0.273
CLV_PCSK_PC7_1 595 601 PF00082 0.278
CLV_PCSK_SKI1_1 172 176 PF00082 0.244
CLV_PCSK_SKI1_1 234 238 PF00082 0.608
CLV_PCSK_SKI1_1 250 254 PF00082 0.598
CLV_PCSK_SKI1_1 578 582 PF00082 0.193
CLV_PCSK_SKI1_1 734 738 PF00082 0.426
CLV_PCSK_SKI1_1 746 750 PF00082 0.443
DEG_APCC_DBOX_1 577 585 PF00400 0.376
DEG_ODPH_VHL_1 165 177 PF01847 0.266
DEG_SPOP_SBC_1 264 268 PF00917 0.411
DEG_SPOP_SBC_1 282 286 PF00917 0.535
DEG_SPOP_SBC_1 4 8 PF00917 0.452
DOC_AGCK_PIF_2 625 630 PF00069 0.281
DOC_ANK_TNKS_1 238 245 PF00023 0.419
DOC_ANK_TNKS_1 598 605 PF00023 0.478
DOC_CKS1_1 382 387 PF01111 0.474
DOC_CKS1_1 548 553 PF01111 0.400
DOC_CYCLIN_yCln2_LP_2 737 740 PF00134 0.534
DOC_MAPK_MEF2A_6 186 193 PF00069 0.468
DOC_MAPK_MEF2A_6 46 54 PF00069 0.433
DOC_PP1_RVXF_1 170 176 PF00149 0.431
DOC_PP2B_LxvP_1 50 53 PF13499 0.464
DOC_PP2B_LxvP_1 737 740 PF13499 0.635
DOC_PP2B_LxvP_1 9 12 PF13499 0.398
DOC_PP4_FxxP_1 473 476 PF00568 0.276
DOC_USP7_MATH_1 16 20 PF00917 0.563
DOC_USP7_MATH_1 25 29 PF00917 0.550
DOC_USP7_MATH_1 281 285 PF00917 0.459
DOC_USP7_MATH_1 325 329 PF00917 0.266
DOC_USP7_MATH_1 4 8 PF00917 0.477
DOC_USP7_MATH_1 40 44 PF00917 0.490
DOC_USP7_MATH_1 489 493 PF00917 0.376
DOC_USP7_MATH_1 560 564 PF00917 0.322
DOC_USP7_MATH_1 583 587 PF00917 0.556
DOC_USP7_MATH_2 690 696 PF00917 0.376
DOC_USP7_UBL2_3 491 495 PF12436 0.478
DOC_WW_Pin1_4 242 247 PF00397 0.453
DOC_WW_Pin1_4 381 386 PF00397 0.456
DOC_WW_Pin1_4 505 510 PF00397 0.498
DOC_WW_Pin1_4 547 552 PF00397 0.314
DOC_WW_Pin1_4 686 691 PF00397 0.478
LIG_14-3-3_CanoR_1 100 110 PF00244 0.447
LIG_14-3-3_CanoR_1 250 255 PF00244 0.387
LIG_14-3-3_CanoR_1 33 40 PF00244 0.588
LIG_14-3-3_CanoR_1 387 392 PF00244 0.513
LIG_14-3-3_CanoR_1 542 552 PF00244 0.309
LIG_14-3-3_CanoR_1 681 687 PF00244 0.474
LIG_Actin_WH2_1 170 188 PF00022 0.474
LIG_Actin_WH2_2 730 748 PF00022 0.523
LIG_AP2alpha_1 532 536 PF02296 0.274
LIG_BRCT_BRCA1_1 179 183 PF00533 0.452
LIG_BRCT_BRCA1_1 224 228 PF00533 0.347
LIG_BRCT_BRCA1_1 311 315 PF00533 0.193
LIG_BRCT_BRCA1_1 473 477 PF00533 0.331
LIG_BRCT_BRCA1_1 707 711 PF00533 0.533
LIG_CaM_IQ_9 392 408 PF13499 0.376
LIG_Clathr_ClatBox_1 110 114 PF01394 0.436
LIG_deltaCOP1_diTrp_1 89 95 PF00928 0.347
LIG_EH1_1 426 434 PF00400 0.281
LIG_FHA_1 139 145 PF00498 0.438
LIG_FHA_1 268 274 PF00498 0.323
LIG_FHA_1 369 375 PF00498 0.266
LIG_FHA_1 441 447 PF00498 0.407
LIG_FHA_1 47 53 PF00498 0.344
LIG_FHA_1 564 570 PF00498 0.314
LIG_FHA_1 651 657 PF00498 0.301
LIG_FHA_1 678 684 PF00498 0.478
LIG_FHA_1 708 714 PF00498 0.436
LIG_FHA_1 79 85 PF00498 0.444
LIG_FHA_2 238 244 PF00498 0.363
LIG_FHA_2 426 432 PF00498 0.266
LIG_FHA_2 453 459 PF00498 0.274
LIG_FHA_2 54 60 PF00498 0.458
LIG_FHA_2 726 732 PF00498 0.633
LIG_FXI_DFP_1 110 114 PF00024 0.636
LIG_LIR_Gen_1 102 111 PF02991 0.370
LIG_LIR_Gen_1 116 124 PF02991 0.473
LIG_LIR_Gen_1 222 229 PF02991 0.263
LIG_LIR_Gen_1 328 335 PF02991 0.267
LIG_LIR_Gen_1 353 362 PF02991 0.306
LIG_LIR_Gen_1 474 484 PF02991 0.293
LIG_LIR_Gen_1 529 538 PF02991 0.281
LIG_LIR_Gen_1 550 560 PF02991 0.335
LIG_LIR_Gen_1 627 635 PF02991 0.177
LIG_LIR_Gen_1 89 98 PF02991 0.366
LIG_LIR_LC3C_4 120 124 PF02991 0.453
LIG_LIR_Nem_3 102 106 PF02991 0.350
LIG_LIR_Nem_3 116 122 PF02991 0.418
LIG_LIR_Nem_3 187 193 PF02991 0.471
LIG_LIR_Nem_3 222 226 PF02991 0.263
LIG_LIR_Nem_3 309 314 PF02991 0.321
LIG_LIR_Nem_3 328 332 PF02991 0.245
LIG_LIR_Nem_3 353 357 PF02991 0.346
LIG_LIR_Nem_3 469 475 PF02991 0.350
LIG_LIR_Nem_3 529 533 PF02991 0.333
LIG_LIR_Nem_3 534 539 PF02991 0.280
LIG_LIR_Nem_3 550 555 PF02991 0.298
LIG_LIR_Nem_3 586 590 PF02991 0.482
LIG_LIR_Nem_3 627 631 PF02991 0.232
LIG_LIR_Nem_3 639 643 PF02991 0.289
LIG_LIR_Nem_3 89 95 PF02991 0.364
LIG_LRP6_Inhibitor_1 412 418 PF00058 0.266
LIG_PCNA_yPIPBox_3 665 674 PF02747 0.376
LIG_PCNA_yPIPBox_3 729 737 PF02747 0.610
LIG_Pex14_1 607 611 PF04695 0.411
LIG_Pex14_2 147 151 PF04695 0.231
LIG_Pex14_2 201 205 PF04695 0.391
LIG_Pex14_2 473 477 PF04695 0.276
LIG_Pex14_2 532 536 PF04695 0.273
LIG_Pex14_2 587 591 PF04695 0.535
LIG_Pex14_2 711 715 PF04695 0.473
LIG_Rb_LxCxE_1 89 112 PF01857 0.459
LIG_SH2_CRK 119 123 PF00017 0.455
LIG_SH2_CRK 218 222 PF00017 0.266
LIG_SH2_CRK 311 315 PF00017 0.313
LIG_SH2_CRK 354 358 PF00017 0.335
LIG_SH2_CRK 388 392 PF00017 0.425
LIG_SH2_CRK 409 413 PF00017 0.431
LIG_SH2_CRK 525 529 PF00017 0.266
LIG_SH2_CRK 675 679 PF00017 0.471
LIG_SH2_GRB2like 552 555 PF00017 0.278
LIG_SH2_NCK_1 218 222 PF00017 0.288
LIG_SH2_NCK_1 545 549 PF00017 0.417
LIG_SH2_STAP1 119 123 PF00017 0.494
LIG_SH2_STAP1 388 392 PF00017 0.462
LIG_SH2_STAP1 441 445 PF00017 0.421
LIG_SH2_STAP1 545 549 PF00017 0.417
LIG_SH2_STAP1 552 556 PF00017 0.335
LIG_SH2_STAT5 190 193 PF00017 0.533
LIG_SH2_STAT5 338 341 PF00017 0.291
LIG_SH2_STAT5 530 533 PF00017 0.349
LIG_SH2_STAT5 552 555 PF00017 0.335
LIG_SH2_STAT5 590 593 PF00017 0.530
LIG_SH2_STAT5 611 614 PF00017 0.428
LIG_SH2_STAT5 630 633 PF00017 0.308
LIG_SH3_3 161 167 PF00018 0.281
LIG_SH3_3 19 25 PF00018 0.561
LIG_SH3_3 451 457 PF00018 0.358
LIG_SH3_3 545 551 PF00018 0.420
LIG_SUMO_SIM_anti_2 120 125 PF11976 0.523
LIG_SUMO_SIM_par_1 306 312 PF11976 0.376
LIG_SUMO_SIM_par_1 452 458 PF11976 0.339
LIG_TRAF2_1 68 71 PF00917 0.277
LIG_TYR_ITIM 216 221 PF00017 0.266
LIG_TYR_ITIM 500 505 PF00017 0.331
LIG_TYR_ITIM 523 528 PF00017 0.266
LIG_TYR_ITIM 543 548 PF00017 0.266
LIG_TYR_ITIM 673 678 PF00017 0.325
LIG_WRC_WIRS_1 148 153 PF05994 0.411
LIG_WRC_WIRS_1 223 228 PF05994 0.298
LIG_WRC_WIRS_1 584 589 PF05994 0.360
MOD_CDK_SPK_2 686 691 PF00069 0.331
MOD_CDK_SPxK_1 381 387 PF00069 0.300
MOD_CK1_1 20 26 PF00069 0.605
MOD_CK1_1 309 315 PF00069 0.314
MOD_CK1_1 563 569 PF00069 0.460
MOD_CK1_1 586 592 PF00069 0.356
MOD_CK1_1 650 656 PF00069 0.416
MOD_CK1_1 682 688 PF00069 0.331
MOD_CK1_1 707 713 PF00069 0.261
MOD_CK2_1 102 108 PF00069 0.538
MOD_CK2_1 242 248 PF00069 0.567
MOD_CK2_1 452 458 PF00069 0.436
MOD_CK2_1 53 59 PF00069 0.508
MOD_CK2_1 65 71 PF00069 0.532
MOD_CK2_1 686 692 PF00069 0.189
MOD_Cter_Amidation 286 289 PF01082 0.411
MOD_GlcNHglycan 114 118 PF01048 0.646
MOD_GlcNHglycan 129 134 PF01048 0.545
MOD_GlcNHglycan 22 25 PF01048 0.684
MOD_GlcNHglycan 257 260 PF01048 0.306
MOD_GlcNHglycan 28 31 PF01048 0.656
MOD_GlcNHglycan 285 288 PF01048 0.411
MOD_GlcNHglycan 311 314 PF01048 0.225
MOD_GlcNHglycan 35 38 PF01048 0.655
MOD_GlcNHglycan 368 371 PF01048 0.276
MOD_GlcNHglycan 39 43 PF01048 0.636
MOD_GlcNHglycan 492 495 PF01048 0.373
MOD_GlcNHglycan 513 516 PF01048 0.284
MOD_GlcNHglycan 649 652 PF01048 0.411
MOD_GlcNHglycan 741 744 PF01048 0.489
MOD_GSK3_1 113 120 PF00069 0.623
MOD_GSK3_1 16 23 PF00069 0.700
MOD_GSK3_1 263 270 PF00069 0.373
MOD_GSK3_1 340 347 PF00069 0.540
MOD_GSK3_1 38 45 PF00069 0.591
MOD_GSK3_1 441 448 PF00069 0.521
MOD_GSK3_1 511 518 PF00069 0.344
MOD_GSK3_1 543 550 PF00069 0.382
MOD_GSK3_1 655 662 PF00069 0.295
MOD_GSK3_1 682 689 PF00069 0.460
MOD_GSK3_1 700 707 PF00069 0.270
MOD_GSK3_1 747 754 PF00069 0.489
MOD_N-GLC_1 25 30 PF02516 0.727
MOD_NEK2_1 147 152 PF00069 0.379
MOD_NEK2_1 199 204 PF00069 0.371
MOD_NEK2_1 228 233 PF00069 0.352
MOD_NEK2_1 237 242 PF00069 0.472
MOD_NEK2_1 3 8 PF00069 0.664
MOD_NEK2_1 366 371 PF00069 0.416
MOD_NEK2_1 511 516 PF00069 0.321
MOD_NEK2_1 543 548 PF00069 0.416
MOD_NEK2_1 574 579 PF00069 0.271
MOD_NEK2_1 593 598 PF00069 0.145
MOD_NEK2_1 652 657 PF00069 0.411
MOD_NEK2_1 702 707 PF00069 0.320
MOD_NEK2_1 711 716 PF00069 0.354
MOD_NEK2_1 749 754 PF00069 0.597
MOD_NEK2_2 192 197 PF00069 0.209
MOD_NEK2_2 306 311 PF00069 0.300
MOD_NEK2_2 331 336 PF00069 0.360
MOD_NEK2_2 394 399 PF00069 0.360
MOD_NEK2_2 90 95 PF00069 0.474
MOD_PK_1 387 393 PF00069 0.331
MOD_PKA_1 434 440 PF00069 0.411
MOD_PKA_2 386 392 PF00069 0.366
MOD_PKA_2 434 440 PF00069 0.415
MOD_PKA_2 99 105 PF00069 0.445
MOD_Plk_1 117 123 PF00069 0.605
MOD_Plk_1 17 23 PF00069 0.654
MOD_Plk_1 441 447 PF00069 0.592
MOD_Plk_4 117 123 PF00069 0.633
MOD_Plk_4 160 166 PF00069 0.300
MOD_Plk_4 17 23 PF00069 0.618
MOD_Plk_4 314 320 PF00069 0.249
MOD_Plk_4 387 393 PF00069 0.473
MOD_Plk_4 394 400 PF00069 0.358
MOD_Plk_4 441 447 PF00069 0.596
MOD_Plk_4 46 52 PF00069 0.590
MOD_Plk_4 5 11 PF00069 0.474
MOD_Plk_4 515 521 PF00069 0.411
MOD_Plk_4 53 59 PF00069 0.494
MOD_Plk_4 586 592 PF00069 0.284
MOD_Plk_4 610 616 PF00069 0.249
MOD_Plk_4 652 658 PF00069 0.321
MOD_Plk_4 659 665 PF00069 0.342
MOD_Plk_4 682 688 PF00069 0.366
MOD_Plk_4 692 698 PF00069 0.266
MOD_ProDKin_1 242 248 PF00069 0.576
MOD_ProDKin_1 381 387 PF00069 0.300
MOD_ProDKin_1 505 511 PF00069 0.360
MOD_ProDKin_1 547 553 PF00069 0.372
MOD_ProDKin_1 686 692 PF00069 0.331
TRG_DiLeu_BaEn_1 118 123 PF01217 0.682
TRG_DiLeu_BaEn_1 71 76 PF01217 0.518
TRG_ENDOCYTIC_2 119 122 PF00928 0.608
TRG_ENDOCYTIC_2 190 193 PF00928 0.408
TRG_ENDOCYTIC_2 218 221 PF00928 0.266
TRG_ENDOCYTIC_2 223 226 PF00928 0.266
TRG_ENDOCYTIC_2 311 314 PF00928 0.313
TRG_ENDOCYTIC_2 354 357 PF00928 0.420
TRG_ENDOCYTIC_2 388 391 PF00928 0.266
TRG_ENDOCYTIC_2 409 412 PF00928 0.266
TRG_ENDOCYTIC_2 502 505 PF00928 0.411
TRG_ENDOCYTIC_2 525 528 PF00928 0.304
TRG_ENDOCYTIC_2 530 533 PF00928 0.326
TRG_ENDOCYTIC_2 545 548 PF00928 0.301
TRG_ENDOCYTIC_2 552 555 PF00928 0.411
TRG_ENDOCYTIC_2 590 593 PF00928 0.304
TRG_ENDOCYTIC_2 611 614 PF00928 0.411
TRG_ENDOCYTIC_2 628 631 PF00928 0.266
TRG_ENDOCYTIC_2 675 678 PF00928 0.296
TRG_ENDOCYTIC_2 697 700 PF00928 0.281
TRG_ER_diArg_1 181 183 PF00400 0.271
TRG_ER_diArg_1 276 279 PF00400 0.281
TRG_ER_diArg_1 377 380 PF00400 0.266
TRG_ER_diArg_1 435 438 PF00400 0.320
TRG_ER_diArg_1 575 578 PF00400 0.411
TRG_NES_CRM1_1 478 490 PF08389 0.325
TRG_NLS_MonoExtC_3 433 438 PF00514 0.325

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I5T6 Leptomonas seymouri 72% 100%
A0A0S4JI73 Bodo saltans 45% 100%
A0A1X0P8K0 Trypanosomatidae 55% 100%
A0A3Q8IVR2 Leishmania donovani 86% 100%
A0A422P2C2 Trypanosoma rangeli 55% 100%
A4ICT6 Leishmania infantum 86% 100%
D0A2L7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9ASG8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4Q227 Leishmania major 85% 100%
V5BV54 Trypanosoma cruzi 56% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS