Putative DNAJ domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR-repeat-containing chaperone protein DNAJ, putative

Species:

Leishmania braziliensis

UniProt:

A4HNQ8_LEIBR

TriTrypDb:

LbrM.35.0590 , LBRM2903_350011400

Length:

510

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNQ8

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	186	190	PF00656	0.256
CLV_C14_Caspase3-7	256	260	PF00656	0.482
CLV_NRD_NRD_1	331	333	PF00675	0.361
CLV_NRD_NRD_1	374	376	PF00675	0.372
CLV_NRD_NRD_1	501	503	PF00675	0.592
CLV_PCSK_FUR_1	369	373	PF00082	0.416
CLV_PCSK_KEX2_1	249	251	PF00082	0.541
CLV_PCSK_KEX2_1	331	333	PF00082	0.361
CLV_PCSK_KEX2_1	371	373	PF00082	0.411
CLV_PCSK_KEX2_1	374	376	PF00082	0.384
CLV_PCSK_KEX2_1	395	397	PF00082	0.250
CLV_PCSK_KEX2_1	441	443	PF00082	0.277
CLV_PCSK_KEX2_1	500	502	PF00082	0.610
CLV_PCSK_KEX2_1	63	65	PF00082	0.515
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.541
CLV_PCSK_PC1ET2_1	371	373	PF00082	0.411
CLV_PCSK_PC1ET2_1	374	376	PF00082	0.384
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.250
CLV_PCSK_PC1ET2_1	441	443	PF00082	0.267
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.515
CLV_PCSK_PC7_1	245	251	PF00082	0.413
CLV_PCSK_SKI1_1	245	249	PF00082	0.428
CLV_PCSK_SKI1_1	268	272	PF00082	0.453
CLV_PCSK_SKI1_1	309	313	PF00082	0.428
CLV_PCSK_SKI1_1	364	368	PF00082	0.417
CLV_PCSK_SKI1_1	371	375	PF00082	0.378
DEG_APCC_DBOX_1	244	252	PF00400	0.429
DEG_SPOP_SBC_1	114	118	PF00917	0.416
DEG_SPOP_SBC_1	170	174	PF00917	0.381
DOC_CYCLIN_RxL_1	374	388	PF00134	0.267
DOC_MAPK_gen_1	295	305	PF00069	0.469
DOC_USP7_MATH_1	182	186	PF00917	0.300
DOC_USP7_MATH_1	253	257	PF00917	0.427
DOC_USP7_MATH_1	27	31	PF00917	0.234
DOC_USP7_MATH_1	330	334	PF00917	0.383
DOC_USP7_MATH_1	411	415	PF00917	0.324
DOC_USP7_MATH_1	8	12	PF00917	0.678
DOC_USP7_UBL2_3	367	371	PF12436	0.368
DOC_USP7_UBL2_3	376	380	PF12436	0.250
DOC_USP7_UBL2_3	395	399	PF12436	0.147
DOC_WW_Pin1_4	119	124	PF00397	0.471
DOC_WW_Pin1_4	184	189	PF00397	0.470
DOC_WW_Pin1_4	193	198	PF00397	0.489
LIG_14-3-3_CanoR_1	289	295	PF00244	0.347
LIG_14-3-3_CanoR_1	90	98	PF00244	0.491
LIG_Actin_WH2_2	105	122	PF00022	0.385
LIG_BRCT_BRCA1_1	29	33	PF00533	0.423
LIG_BRCT_BRCA1_1	489	493	PF00533	0.654
LIG_FHA_1	276	282	PF00498	0.389
LIG_FHA_2	120	126	PF00498	0.486
LIG_FHA_2	132	138	PF00498	0.385
LIG_FXI_DFP_1	166	170	PF00024	0.404
LIG_Integrin_isoDGR_2	498	500	PF01839	0.643
LIG_LIR_Gen_1	205	216	PF02991	0.281
LIG_LIR_Nem_3	204	210	PF02991	0.296
LIG_LIR_Nem_3	422	428	PF02991	0.250
LIG_LIR_Nem_3	430	435	PF02991	0.250
LIG_Pex14_2	489	493	PF04695	0.686
LIG_PTB_Apo_2	149	156	PF02174	0.252
LIG_PTB_Apo_2	473	480	PF02174	0.463
LIG_RPA_C_Fungi	52	64	PF08784	0.463
LIG_SH2_CRK	379	383	PF00017	0.285
LIG_SH2_CRK	88	92	PF00017	0.300
LIG_SH2_GRB2like	54	57	PF00017	0.456
LIG_SH2_SRC	179	182	PF00017	0.441
LIG_SH2_SRC	67	70	PF00017	0.432
LIG_SH2_STAP1	277	281	PF00017	0.325
LIG_SH2_STAP1	40	44	PF00017	0.322
LIG_SH2_STAT3	218	221	PF00017	0.315
LIG_SH2_STAT5	200	203	PF00017	0.385
LIG_SH2_STAT5	208	211	PF00017	0.233
LIG_SH2_STAT5	277	280	PF00017	0.408
LIG_SH2_STAT5	61	64	PF00017	0.378
LIG_SH3_3	191	197	PF00018	0.507
LIG_SH3_3	45	51	PF00018	0.493
LIG_SUMO_SIM_anti_2	469	476	PF11976	0.541
LIG_SUMO_SIM_par_1	111	118	PF11976	0.367
LIG_TRAF2_1	352	355	PF00917	0.430
LIG_TRAF2_1	413	416	PF00917	0.266
LIG_TRAF2_1	466	469	PF00917	0.655
MOD_CK1_1	118	124	PF00069	0.321
MOD_CK1_1	457	463	PF00069	0.604
MOD_CK1_1	55	61	PF00069	0.322
MOD_CK2_1	131	137	PF00069	0.299
MOD_CK2_1	382	388	PF00069	0.224
MOD_CK2_1	411	417	PF00069	0.259
MOD_CK2_1	463	469	PF00069	0.444
MOD_Cter_Amidation	498	501	PF01082	0.632
MOD_GlcNHglycan	11	14	PF01048	0.614
MOD_GlcNHglycan	134	137	PF01048	0.442
MOD_GlcNHglycan	225	228	PF01048	0.444
MOD_GlcNHglycan	324	327	PF01048	0.476
MOD_GlcNHglycan	4	9	PF01048	0.651
MOD_GlcNHglycan	40	43	PF01048	0.389
MOD_GlcNHglycan	445	448	PF01048	0.493
MOD_GlcNHglycan	459	462	PF01048	0.540
MOD_GlcNHglycan	489	492	PF01048	0.534
MOD_GlcNHglycan	495	498	PF01048	0.472
MOD_GlcNHglycan	57	60	PF01048	0.205
MOD_GlcNHglycan	92	95	PF01048	0.355
MOD_GSK3_1	114	121	PF00069	0.404
MOD_GSK3_1	189	196	PF00069	0.448
MOD_GSK3_1	27	34	PF00069	0.491
MOD_GSK3_1	4	11	PF00069	0.508
MOD_GSK3_1	453	460	PF00069	0.544
MOD_GSK3_1	483	490	PF00069	0.448
MOD_GSK3_1	86	93	PF00069	0.420
MOD_N-GLC_1	290	295	PF02516	0.483
MOD_N-GLC_1	55	60	PF02516	0.306
MOD_NEK2_1	198	203	PF00069	0.482
MOD_NEK2_1	231	236	PF00069	0.442
MOD_NEK2_1	275	280	PF00069	0.345
MOD_NEK2_1	290	295	PF00069	0.382
MOD_NEK2_1	382	387	PF00069	0.390
MOD_NEK2_1	443	448	PF00069	0.515
MOD_NEK2_1	489	494	PF00069	0.547
MOD_NEK2_1	80	85	PF00069	0.521
MOD_PIKK_1	275	281	PF00454	0.437
MOD_PIKK_1	382	388	PF00454	0.169
MOD_PKA_2	102	108	PF00069	0.462
MOD_PKA_2	231	237	PF00069	0.411
MOD_PKA_2	330	336	PF00069	0.378
MOD_Plk_1	290	296	PF00069	0.397
MOD_Plk_1	80	86	PF00069	0.342
MOD_Plk_4	470	476	PF00069	0.534
MOD_ProDKin_1	119	125	PF00069	0.467
MOD_ProDKin_1	184	190	PF00069	0.471
MOD_ProDKin_1	193	199	PF00069	0.487
MOD_SUMO_rev_2	121	129	PF00179	0.389
MOD_SUMO_rev_2	304	311	PF00179	0.344
MOD_SUMO_rev_2	354	359	PF00179	0.292
MOD_SUMO_rev_2	414	419	PF00179	0.288
TRG_ENDOCYTIC_2	166	169	PF00928	0.421
TRG_ENDOCYTIC_2	208	211	PF00928	0.266
TRG_ENDOCYTIC_2	378	381	PF00928	0.250
TRG_ENDOCYTIC_2	88	91	PF00928	0.288
TRG_ER_diArg_1	144	147	PF00400	0.445
TRG_ER_diArg_1	331	334	PF00400	0.366
TRG_ER_diArg_1	500	502	PF00400	0.640
TRG_ER_FFAT_2	34	45	PF00635	0.240
TRG_NLS_MonoCore_2	438	443	PF00514	0.344
TRG_NLS_MonoExtC_3	370	375	PF00514	0.389
TRG_NLS_MonoExtC_3	439	445	PF00514	0.266
TRG_NLS_MonoExtN_4	369	375	PF00514	0.467
TRG_NLS_MonoExtN_4	438	444	PF00514	0.251
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.198

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0D1E2P6	Ustilago maydis (strain 521 / FGSC 9021)	24%	88%
A0A0D2XVZ5	Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936)	26%	98%
A0A0N1PF59	Leptomonas seymouri	76%	97%
A0A0S4JLZ7	Bodo saltans	53%	100%
A0A1X0P8B2	Trypanosomatidae	55%	100%
A0A1X0P9Z7	Trypanosomatidae	31%	74%
A0A3S7XAC9	Leishmania donovani	91%	100%
A0A422P0G2	Trypanosoma rangeli	30%	73%
A0A422P289	Trypanosoma rangeli	52%	100%
A4H7V3	Leishmania braziliensis	26%	100%
A4ICT7	Leishmania infantum	90%	100%
C9ZML0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	72%
C9ZST7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	97%
D0A2L6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9ASG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
F4IXE4	Arabidopsis thaliana	27%	70%
J9VKM5	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	25%	98%
Q13217	Homo sapiens	24%	100%
Q27968	Bos taurus	24%	100%
Q4Q228	Leishmania major	89%	100%
Q54IP0	Dictyostelium discoideum	35%	95%
Q54M21	Dictyostelium discoideum	24%	100%
Q5R8D8	Pongo abelii	33%	100%
Q5ZI13	Gallus gallus	24%	100%
Q84JR9	Arabidopsis thaliana	26%	75%
Q91YW3	Mus musculus	25%	100%
Q99615	Homo sapiens	33%	100%
Q9HGM9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
Q9MAH1	Arabidopsis thaliana	24%	73%
Q9QYI3	Mus musculus	34%	100%
Q9R0T3	Rattus norvegicus	24%	100%
Q9SIN1	Arabidopsis thaliana	24%	74%
V5BKG1	Trypanosoma cruzi	31%	73%
V5BRG9	Trypanosoma cruzi	22%	80%
V5BZY4	Trypanosoma cruzi	52%	100%
V5DRP2	Trypanosoma cruzi	23%	69%