Cytochrome c oxidase subunit Vb

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNQ6_LEIBR

TriTrypDb:

LbrM.35.0570 , LBRM2903_350011200

Length:

225

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005751	mitochondrial respiratory chain complex IV	4	11
GO:0032991	protein-containing complex	1	11
GO:0045277	respiratory chain complex IV	4	11
GO:0070069	cytochrome complex	3	11
GO:0098796	membrane protein complex	2	11
GO:0098798	mitochondrial protein-containing complex	2	11
GO:0098800	inner mitochondrial membrane protein complex	3	11
GO:0098803	respiratory chain complex	3	11
GO:1902494	catalytic complex	2	11
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNQ6

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	11
GO:0006123	mitochondrial electron transport, cytochrome c to oxygen	7	11
GO:0008152	metabolic process	1	11
GO:0009060	aerobic respiration	6	11
GO:0009987	cellular process	1	11
GO:0015980	energy derivation by oxidation of organic compounds	4	11
GO:0019646	aerobic electron transport chain	6	11
GO:0022900	electron transport chain	4	11
GO:0022904	respiratory electron transport chain	5	11
GO:0044237	cellular metabolic process	2	11
GO:0045333	cellular respiration	5	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016491	oxidoreductase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.528
CLV_NRD_NRD_1	50	52	PF00675	0.514
DEG_Nend_Nbox_1	1	3	PF02207	0.533
DOC_PP1_RVXF_1	74	80	PF00149	0.438
DOC_USP7_MATH_1	120	124	PF00917	0.453
DOC_USP7_MATH_1	54	58	PF00917	0.504
DOC_USP7_UBL2_3	162	166	PF12436	0.382
DOC_WW_Pin1_4	50	55	PF00397	0.493
LIG_14-3-3_CanoR_1	3	10	PF00244	0.453
LIG_APCC_ABBA_1	184	189	PF00400	0.481
LIG_APCC_ABBA_1	64	69	PF00400	0.508
LIG_FHA_1	92	98	PF00498	0.502
LIG_FHA_2	201	207	PF00498	0.517
LIG_LIR_Gen_1	107	117	PF02991	0.488
LIG_LIR_Gen_1	155	164	PF02991	0.397
LIG_LIR_Gen_1	203	211	PF02991	0.509
LIG_LIR_Gen_1	212	222	PF02991	0.580
LIG_LIR_Nem_3	107	113	PF02991	0.481
LIG_LIR_Nem_3	203	207	PF02991	0.542
LIG_LIR_Nem_3	212	218	PF02991	0.550
LIG_Pex14_2	211	215	PF04695	0.477
LIG_SH2_GRB2like	221	224	PF00017	0.495
LIG_SH2_PTP2	110	113	PF00017	0.472
LIG_SH2_SRC	117	120	PF00017	0.501
LIG_SH2_SRC	221	224	PF00017	0.495
LIG_SH2_SRC	67	70	PF00017	0.477
LIG_SH2_STAP1	67	71	PF00017	0.468
LIG_SH2_STAT3	33	36	PF00017	0.555
LIG_SH2_STAT5	110	113	PF00017	0.472
LIG_SH2_STAT5	177	180	PF00017	0.406
LIG_SH2_STAT5	202	205	PF00017	0.524
LIG_SH2_STAT5	221	224	PF00017	0.495
LIG_SH3_1	31	37	PF00018	0.537
LIG_SH3_3	147	153	PF00018	0.547
LIG_SH3_3	182	188	PF00018	0.485
LIG_SH3_3	31	37	PF00018	0.539
LIG_SUMO_SIM_par_1	92	99	PF11976	0.504
MOD_CK1_1	18	24	PF00069	0.614
MOD_CK2_1	200	206	PF00069	0.524
MOD_GlcNHglycan	17	20	PF01048	0.566
MOD_GSK3_1	15	22	PF00069	0.586
MOD_GSK3_1	46	53	PF00069	0.511
MOD_NEK2_1	10	15	PF00069	0.534
MOD_NEK2_1	2	7	PF00069	0.547
MOD_NEK2_1	60	65	PF00069	0.552
MOD_PIKK_1	2	8	PF00454	0.421
MOD_PKA_2	2	8	PF00069	0.537
MOD_Plk_1	29	35	PF00069	0.699
MOD_Plk_1	60	66	PF00069	0.528
MOD_Plk_1	91	97	PF00069	0.490
MOD_Plk_4	91	97	PF00069	0.490
MOD_ProDKin_1	50	56	PF00069	0.492
TRG_ENDOCYTIC_2	110	113	PF00928	0.472
TRG_ENDOCYTIC_2	157	160	PF00928	0.401
TRG_ENDOCYTIC_2	67	70	PF00928	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILG0	Leptomonas seymouri	94%	100%
A0A0S4JMS0	Bodo saltans	76%	100%
A0A1X0P8B6	Trypanosomatidae	87%	100%
A0A3S7XAI6	Leishmania donovani	98%	100%
A0A422P2A1	Trypanosoma rangeli	87%	100%
A4ICT9	Leishmania infantum	98%	100%
D0A2L4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	87%	100%
E9ASG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q230	Leishmania major	97%	100%
V5BA06	Trypanosoma cruzi	85%	76%