Dihydrouridine synthase domain protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dihydrouridine synthase domain protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HNQ5_LEIBR

TriTrypDb:

LbrM.35.0560 , LBRM2903_350011100

Length:

440

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4HNQ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNQ5

Function

Biological processes
Term	Name	Level	Count
GO:0002943	tRNA dihydrouridine synthesis	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006400	tRNA modification	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008033	tRNA processing	8	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	11
GO:0017150	tRNA dihydrouridine synthase activity	5	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0050660	flavin adenine dinucleotide binding	4	11
GO:0097159	organic cyclic compound binding	2	11
GO:0106413	dihydrouridine synthase activity	4	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140101	catalytic activity, acting on a tRNA	4	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.375
CLV_C14_Caspase3-7	268	272	PF00656	0.541
CLV_NRD_NRD_1	182	184	PF00675	0.183
CLV_NRD_NRD_1	51	53	PF00675	0.364
CLV_PCSK_KEX2_1	154	156	PF00082	0.360
CLV_PCSK_KEX2_1	182	184	PF00082	0.271
CLV_PCSK_KEX2_1	410	412	PF00082	0.679
CLV_PCSK_KEX2_1	51	53	PF00082	0.331
CLV_PCSK_KEX2_1	78	80	PF00082	0.386
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.360
CLV_PCSK_PC1ET2_1	410	412	PF00082	0.679
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.388
CLV_PCSK_SKI1_1	105	109	PF00082	0.332
CLV_PCSK_SKI1_1	11	15	PF00082	0.312
CLV_PCSK_SKI1_1	204	208	PF00082	0.335
CLV_PCSK_SKI1_1	275	279	PF00082	0.346
CLV_PCSK_SKI1_1	288	292	PF00082	0.285
CLV_PCSK_SKI1_1	330	334	PF00082	0.382
CLV_PCSK_SKI1_1	340	344	PF00082	0.373
CLV_PCSK_SKI1_1	358	362	PF00082	0.530
CLV_PCSK_SKI1_1	411	415	PF00082	0.558
CLV_PCSK_SKI1_1	46	50	PF00082	0.445
CLV_PCSK_SKI1_1	88	92	PF00082	0.553
CLV_PCSK_SKI1_1	99	103	PF00082	0.605
CLV_Separin_Metazoa	201	205	PF03568	0.476
CLV_Separin_Metazoa	244	248	PF03568	0.560
DEG_Nend_UBRbox_1	1	4	PF02207	0.453
DEG_SCF_FBW7_2	60	66	PF00400	0.518
DOC_CKS1_1	60	65	PF01111	0.523
DOC_CYCLIN_RxL_1	327	336	PF00134	0.421
DOC_MAPK_gen_1	179	188	PF00069	0.459
DOC_MAPK_gen_1	358	366	PF00069	0.249
DOC_MAPK_gen_1	78	85	PF00069	0.343
DOC_MAPK_HePTP_8	176	188	PF00069	0.526
DOC_MAPK_MEF2A_6	11	20	PF00069	0.324
DOC_MAPK_MEF2A_6	179	188	PF00069	0.439
DOC_MAPK_MEF2A_6	352	359	PF00069	0.397
DOC_MAPK_MEF2A_6	78	87	PF00069	0.511
DOC_MAPK_MEF2A_6	99	108	PF00069	0.497
DOC_MAPK_NFAT4_5	105	113	PF00069	0.541
DOC_PP1_RVXF_1	328	335	PF00149	0.479
DOC_PP2B_LxvP_1	83	86	PF13499	0.251
DOC_USP7_MATH_1	169	173	PF00917	0.547
DOC_USP7_MATH_1	305	309	PF00917	0.510
DOC_USP7_MATH_1	402	406	PF00917	0.438
DOC_USP7_MATH_1	416	420	PF00917	0.676
DOC_USP7_MATH_1	436	440	PF00917	0.451
DOC_USP7_UBL2_3	189	193	PF12436	0.499
DOC_USP7_UBL2_3	361	365	PF12436	0.409
DOC_USP7_UBL2_3	74	78	PF12436	0.424
DOC_WW_Pin1_4	100	105	PF00397	0.467
DOC_WW_Pin1_4	19	24	PF00397	0.494
DOC_WW_Pin1_4	210	215	PF00397	0.534
DOC_WW_Pin1_4	225	230	PF00397	0.410
DOC_WW_Pin1_4	411	416	PF00397	0.483
DOC_WW_Pin1_4	59	64	PF00397	0.514
LIG_14-3-3_CanoR_1	183	189	PF00244	0.462
LIG_14-3-3_CanoR_1	204	214	PF00244	0.463
LIG_14-3-3_CanoR_1	247	255	PF00244	0.416
LIG_14-3-3_CanoR_1	338	343	PF00244	0.472
LIG_14-3-3_CanoR_1	382	386	PF00244	0.441
LIG_14-3-3_CanoR_1	88	94	PF00244	0.597
LIG_BRCT_BRCA1_1	21	25	PF00533	0.474
LIG_FHA_1	213	219	PF00498	0.567
LIG_FHA_1	37	43	PF00498	0.418
LIG_FHA_1	395	401	PF00498	0.628
LIG_FHA_2	193	199	PF00498	0.413
LIG_FHA_2	251	257	PF00498	0.379
LIG_GBD_Chelix_1	184	192	PF00786	0.341
LIG_LIR_Apic_2	91	96	PF02991	0.554
LIG_LIR_Gen_1	341	350	PF02991	0.410
LIG_LIR_Gen_1	376	385	PF02991	0.488
LIG_LIR_Gen_1	69	77	PF02991	0.386
LIG_LIR_Nem_3	22	28	PF02991	0.452
LIG_LIR_Nem_3	252	258	PF02991	0.537
LIG_LIR_Nem_3	331	337	PF02991	0.374
LIG_LIR_Nem_3	341	346	PF02991	0.371
LIG_LIR_Nem_3	351	357	PF02991	0.435
LIG_LIR_Nem_3	376	381	PF02991	0.446
LIG_LIR_Nem_3	419	425	PF02991	0.625
LIG_LIR_Nem_3	66	70	PF02991	0.353
LIG_LYPXL_yS_3	57	60	PF13949	0.521
LIG_PCNA_PIPBox_1	326	335	PF02747	0.458
LIG_PTB_Apo_2	342	349	PF02174	0.466
LIG_PTB_Phospho_1	342	348	PF10480	0.470
LIG_REV1ctd_RIR_1	378	386	PF16727	0.426
LIG_SH2_CRK	339	343	PF00017	0.383
LIG_SH2_CRK	93	97	PF00017	0.637
LIG_SH2_NCK_1	239	243	PF00017	0.466
LIG_SH2_STAP1	239	243	PF00017	0.466
LIG_SH2_STAP1	324	328	PF00017	0.479
LIG_SH2_STAP1	335	339	PF00017	0.468
LIG_SH2_STAP1	374	378	PF00017	0.371
LIG_SH2_STAT5	67	70	PF00017	0.416
LIG_SH3_3	17	23	PF00018	0.464
LIG_SH3_3	211	217	PF00018	0.539
LIG_SH3_3	356	362	PF00018	0.398
LIG_SH3_3	52	58	PF00018	0.523
LIG_SH3_4	361	368	PF00018	0.266
LIG_TRAF2_1	384	387	PF00917	0.390
LIG_TYR_ITIM	337	342	PF00017	0.470
LIG_TYR_ITIM	55	60	PF00017	0.524
MOD_CDK_SPK_2	100	105	PF00069	0.347
MOD_CDK_SPxxK_3	19	26	PF00069	0.481
MOD_CDK_SPxxK_3	225	232	PF00069	0.541
MOD_CK1_1	172	178	PF00069	0.379
MOD_CK1_1	187	193	PF00069	0.471
MOD_CK1_1	265	271	PF00069	0.466
MOD_CK2_1	250	256	PF00069	0.528
MOD_CK2_1	381	387	PF00069	0.458
MOD_Cter_Amidation	180	183	PF01082	0.297
MOD_DYRK1A_RPxSP_1	19	23	PF00069	0.487
MOD_DYRK1A_RPxSP_1	411	415	PF00069	0.455
MOD_GlcNHglycan	307	310	PF01048	0.338
MOD_GSK3_1	192	199	PF00069	0.457
MOD_GSK3_1	390	397	PF00069	0.545
MOD_GSK3_1	73	80	PF00069	0.456
MOD_N-GLC_1	172	177	PF02516	0.179
MOD_N-GLC_1	262	267	PF02516	0.255
MOD_NEK2_1	262	267	PF00069	0.464
MOD_NEK2_1	333	338	PF00069	0.467
MOD_NEK2_1	390	395	PF00069	0.446
MOD_NEK2_1	73	78	PF00069	0.552
MOD_PK_1	140	146	PF00069	0.455
MOD_PKA_1	140	146	PF00069	0.455
MOD_PKA_2	381	387	PF00069	0.429
MOD_Plk_1	172	178	PF00069	0.496
MOD_Plk_1	196	202	PF00069	0.541
MOD_Plk_1	3	9	PF00069	0.482
MOD_Plk_2-3	370	376	PF00069	0.488
MOD_Plk_2-3	66	72	PF00069	0.428
MOD_Plk_4	262	268	PF00069	0.508
MOD_Plk_4	3	9	PF00069	0.412
MOD_Plk_4	324	330	PF00069	0.274
MOD_ProDKin_1	100	106	PF00069	0.451
MOD_ProDKin_1	19	25	PF00069	0.491
MOD_ProDKin_1	210	216	PF00069	0.534
MOD_ProDKin_1	225	231	PF00069	0.410
MOD_ProDKin_1	411	417	PF00069	0.484
MOD_ProDKin_1	59	65	PF00069	0.506
MOD_SUMO_rev_2	268	277	PF00179	0.515
TRG_DiLeu_BaEn_1	386	391	PF01217	0.420
TRG_DiLeu_BaEn_2	255	261	PF01217	0.476
TRG_ENDOCYTIC_2	339	342	PF00928	0.395
TRG_ENDOCYTIC_2	378	381	PF00928	0.387
TRG_ENDOCYTIC_2	422	425	PF00928	0.430
TRG_ENDOCYTIC_2	57	60	PF00928	0.521
TRG_ENDOCYTIC_2	70	73	PF00928	0.431
TRG_ER_diArg_1	182	184	PF00400	0.389
TRG_Pf-PMV_PEXEL_1	388	392	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Z1	Leptomonas seymouri	67%	100%
A0A0N1PBT7	Leptomonas seymouri	23%	86%
A0A0S4JLG1	Bodo saltans	38%	88%
A0A0S4JUA9	Bodo saltans	24%	96%
A0A1X0P8K8	Trypanosomatidae	45%	100%
A0A3Q8IJ00	Leishmania donovani	79%	100%
A0A3Q8IN46	Leishmania donovani	24%	89%
A0A3R7KZP3	Trypanosoma rangeli	27%	100%
A0A422P287	Trypanosoma rangeli	46%	100%
A3LUK5	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	25%	72%
A4HAN2	Leishmania braziliensis	22%	86%
A4I9S4	Leishmania infantum	24%	89%
A4ICU0	Leishmania infantum	79%	100%
D0A2L3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9ASG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E9B4T5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	89%
O74553	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
O74731	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	92%
P37567	Bacillus subtilis (strain 168)	24%	100%
P53720	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P53759	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	100%
Q28BT8	Xenopus tropicalis	23%	69%
Q3KRC5	Rattus norvegicus	26%	69%
Q4Q231	Leishmania major	79%	100%
Q4Q391	Leishmania major	24%	89%
Q50049	Mycobacterium leprae (strain TN)	26%	100%
Q5HKD5	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	26%	100%
Q6BS64	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	23%	71%
Q8CU07	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	26%	100%
Q91XI1	Mus musculus	25%	69%
Q96G46	Homo sapiens	25%	68%
Q9D7B1	Mus musculus	28%	89%
Q9NX74	Homo sapiens	29%	89%
V5DJT2	Trypanosoma cruzi	27%	100%
V5DRQ6	Trypanosoma cruzi	49%	100%