Putative vacuolar protein sorting-associated protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vacuolar protein sorting-associated protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HNQ4_LEIBR

TriTrypDb:

LbrM.35.0550 , LBRM2903_350011000

Length:

617

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	2
GO:0016020	membrane	2	2
GO:0031090	organelle membrane	3	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HNQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNQ4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	19
GO:0016192	vesicle-mediated transport	4	19
GO:0051179	localization	1	19
GO:0051234	establishment of localization	2	19
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	274	278	PF00656	0.301
CLV_NRD_NRD_1	13	15	PF00675	0.487
CLV_NRD_NRD_1	195	197	PF00675	0.273
CLV_NRD_NRD_1	240	242	PF00675	0.394
CLV_NRD_NRD_1	343	345	PF00675	0.282
CLV_NRD_NRD_1	574	576	PF00675	0.261
CLV_PCSK_FUR_1	11	15	PF00082	0.539
CLV_PCSK_KEX2_1	13	15	PF00082	0.487
CLV_PCSK_KEX2_1	195	197	PF00082	0.283
CLV_PCSK_SKI1_1	35	39	PF00082	0.302
CLV_PCSK_SKI1_1	367	371	PF00082	0.304
CLV_PCSK_SKI1_1	390	394	PF00082	0.356
CLV_PCSK_SKI1_1	515	519	PF00082	0.378
CLV_PCSK_SKI1_1	571	575	PF00082	0.186
DEG_APCC_DBOX_1	389	397	PF00400	0.395
DEG_Nend_Nbox_1	1	3	PF02207	0.566
DOC_CKS1_1	245	250	PF01111	0.313
DOC_CKS1_1	286	291	PF01111	0.359
DOC_CYCLIN_yCln2_LP_2	249	255	PF00134	0.286
DOC_CYCLIN_yCln2_LP_2	518	524	PF00134	0.165
DOC_MAPK_DCC_7	241	251	PF00069	0.395
DOC_MAPK_gen_1	322	330	PF00069	0.282
DOC_MAPK_gen_1	531	540	PF00069	0.224
DOC_MAPK_MEF2A_6	206	215	PF00069	0.442
DOC_MAPK_MEF2A_6	230	239	PF00069	0.290
DOC_MAPK_MEF2A_6	531	540	PF00069	0.281
DOC_PP2B_LxvP_1	249	252	PF13499	0.307
DOC_USP7_MATH_1	231	235	PF00917	0.282
DOC_USP7_MATH_1	27	31	PF00917	0.232
DOC_USP7_MATH_1	355	359	PF00917	0.370
DOC_USP7_MATH_1	596	600	PF00917	0.410
DOC_USP7_UBL2_3	206	210	PF12436	0.282
DOC_USP7_UBL2_3	318	322	PF12436	0.179
DOC_USP7_UBL2_3	471	475	PF12436	0.282
DOC_WW_Pin1_4	153	158	PF00397	0.363
DOC_WW_Pin1_4	244	249	PF00397	0.310
DOC_WW_Pin1_4	285	290	PF00397	0.357
LIG_14-3-3_CanoR_1	181	189	PF00244	0.283
LIG_14-3-3_CanoR_1	218	223	PF00244	0.398
LIG_14-3-3_CanoR_1	299	306	PF00244	0.224
LIG_14-3-3_CanoR_1	325	331	PF00244	0.282
LIG_14-3-3_CanoR_1	371	375	PF00244	0.307
LIG_14-3-3_CanoR_1	463	470	PF00244	0.312
LIG_Actin_WH2_2	141	156	PF00022	0.282
LIG_Actin_WH2_2	215	232	PF00022	0.368
LIG_BIR_III_2	277	281	PF00653	0.301
LIG_BRCT_BRCA1_1	607	611	PF00533	0.228
LIG_Clathr_ClatBox_1	236	240	PF01394	0.293
LIG_deltaCOP1_diTrp_1	18	28	PF00928	0.448
LIG_eIF4E_1	51	57	PF01652	0.263
LIG_FHA_1	109	115	PF00498	0.342
LIG_FHA_1	143	149	PF00498	0.295
LIG_FHA_1	164	170	PF00498	0.346
LIG_FHA_1	230	236	PF00498	0.336
LIG_FHA_1	245	251	PF00498	0.211
LIG_FHA_1	29	35	PF00498	0.364
LIG_FHA_1	325	331	PF00498	0.355
LIG_FHA_1	355	361	PF00498	0.426
LIG_FHA_1	487	493	PF00498	0.282
LIG_FHA_1	504	510	PF00498	0.282
LIG_FHA_1	572	578	PF00498	0.249
LIG_FHA_1	589	595	PF00498	0.260
LIG_FHA_1	601	607	PF00498	0.205
LIG_FHA_2	223	229	PF00498	0.395
LIG_FHA_2	314	320	PF00498	0.351
LIG_FHA_2	399	405	PF00498	0.321
LIG_FHA_2	542	548	PF00498	0.292
LIG_FHA_2	583	589	PF00498	0.165
LIG_Integrin_isoDGR_2	365	367	PF01839	0.282
LIG_LIR_Gen_1	107	118	PF02991	0.375
LIG_LIR_Gen_1	145	155	PF02991	0.290
LIG_LIR_Gen_1	18	28	PF02991	0.315
LIG_LIR_Gen_1	254	263	PF02991	0.282
LIG_LIR_Gen_1	93	103	PF02991	0.295
LIG_LIR_Nem_3	100	106	PF02991	0.318
LIG_LIR_Nem_3	107	112	PF02991	0.333
LIG_LIR_Nem_3	145	150	PF02991	0.290
LIG_LIR_Nem_3	18	24	PF02991	0.318
LIG_LIR_Nem_3	225	229	PF02991	0.282
LIG_LIR_Nem_3	301	306	PF02991	0.282
LIG_LIR_Nem_3	93	98	PF02991	0.315
LIG_MYND_1	248	252	PF01753	0.365
LIG_NRBOX	33	39	PF00104	0.281
LIG_PCNA_yPIPBox_3	60	72	PF02747	0.282
LIG_Pex14_2	336	340	PF04695	0.263
LIG_PTB_Apo_2	22	29	PF02174	0.452
LIG_PTB_Apo_2	497	504	PF02174	0.263
LIG_PTB_Phospho_1	497	503	PF10480	0.263
LIG_REV1ctd_RIR_1	292	301	PF16727	0.165
LIG_SH2_GRB2like	138	141	PF00017	0.423
LIG_SH2_GRB2like	23	26	PF00017	0.466
LIG_SH2_NCK_1	417	421	PF00017	0.309
LIG_SH2_SRC	138	141	PF00017	0.292
LIG_SH2_STAP1	106	110	PF00017	0.268
LIG_SH2_STAP1	255	259	PF00017	0.263
LIG_SH2_STAP1	417	421	PF00017	0.285
LIG_SH2_STAT3	451	454	PF00017	0.395
LIG_SH2_STAT5	109	112	PF00017	0.311
LIG_SH2_STAT5	138	141	PF00017	0.282
LIG_SH2_STAT5	23	26	PF00017	0.295
LIG_SH2_STAT5	539	542	PF00017	0.368
LIG_SH2_STAT5	543	546	PF00017	0.363
LIG_SH3_1	242	248	PF00018	0.395
LIG_SH3_3	242	248	PF00018	0.342
LIG_SH3_3	283	289	PF00018	0.347
LIG_SH3_3	393	399	PF00018	0.276
LIG_SH3_3	80	86	PF00018	0.395
LIG_SUMO_SIM_anti_2	232	240	PF11976	0.285
LIG_SUMO_SIM_anti_2	370	376	PF11976	0.295
LIG_SUMO_SIM_anti_2	534	539	PF11976	0.274
LIG_SUMO_SIM_par_1	232	240	PF11976	0.283
LIG_SUMO_SIM_par_1	326	332	PF11976	0.395
LIG_SUMO_SIM_par_1	505	510	PF11976	0.395
LIG_SUMO_SIM_par_1	60	65	PF11976	0.277
LIG_TRAF2_1	68	71	PF00917	0.261
LIG_UBA3_1	150	154	PF00899	0.261
LIG_UBA3_1	411	419	PF00899	0.263
LIG_UBA3_1	424	429	PF00899	0.313
MOD_CDK_SPxxK_3	153	160	PF00069	0.355
MOD_CK1_1	156	162	PF00069	0.326
MOD_CK1_1	163	169	PF00069	0.377
MOD_CK1_1	205	211	PF00069	0.424
MOD_CK1_1	4	10	PF00069	0.671
MOD_CK1_1	599	605	PF00069	0.397
MOD_CK1_1	87	93	PF00069	0.382
MOD_CK2_1	313	319	PF00069	0.314
MOD_CK2_1	326	332	PF00069	0.282
MOD_CK2_1	370	376	PF00069	0.307
MOD_CK2_1	541	547	PF00069	0.282
MOD_CK2_1	582	588	PF00069	0.165
MOD_Cter_Amidation	11	14	PF01082	0.427
MOD_GlcNHglycan	346	349	PF01048	0.355
MOD_GlcNHglycan	4	7	PF01048	0.647
MOD_GlcNHglycan	86	89	PF01048	0.336
MOD_GSK3_1	114	121	PF00069	0.355
MOD_GSK3_1	138	145	PF00069	0.287
MOD_GSK3_1	156	163	PF00069	0.367
MOD_GSK3_1	185	192	PF00069	0.357
MOD_GSK3_1	218	225	PF00069	0.316
MOD_GSK3_1	23	30	PF00069	0.329
MOD_GSK3_1	344	351	PF00069	0.286
MOD_GSK3_1	45	52	PF00069	0.250
MOD_GSK3_1	576	583	PF00069	0.352
MOD_GSK3_1	584	591	PF00069	0.252
MOD_GSK3_1	596	603	PF00069	0.269
MOD_N-GLC_1	367	372	PF02516	0.291
MOD_N-GLC_1	383	388	PF02516	0.172
MOD_N-GLC_1	503	508	PF02516	0.263
MOD_NEK2_1	1	6	PF00069	0.588
MOD_NEK2_1	113	118	PF00069	0.322
MOD_NEK2_1	189	194	PF00069	0.293
MOD_NEK2_1	313	318	PF00069	0.320
MOD_NEK2_1	462	467	PF00069	0.276
MOD_NEK2_1	582	587	PF00069	0.405
MOD_NEK2_1	600	605	PF00069	0.228
MOD_NEK2_1	611	616	PF00069	0.233
MOD_PIKK_1	169	175	PF00454	0.299
MOD_PIKK_1	486	492	PF00454	0.286
MOD_PIKK_1	49	55	PF00454	0.293
MOD_PK_1	218	224	PF00069	0.386
MOD_PKA_1	344	350	PF00069	0.263
MOD_PKA_2	180	186	PF00069	0.302
MOD_PKA_2	298	304	PF00069	0.224
MOD_PKA_2	324	330	PF00069	0.309
MOD_PKA_2	370	376	PF00069	0.335
MOD_PKA_2	462	468	PF00069	0.291
MOD_PKA_2	84	90	PF00069	0.358
MOD_PKB_1	200	208	PF00069	0.395
MOD_Plk_1	114	120	PF00069	0.429
MOD_Plk_1	367	373	PF00069	0.311
MOD_Plk_1	386	392	PF00069	0.456
MOD_Plk_2-3	175	181	PF00069	0.307
MOD_Plk_2-3	398	404	PF00069	0.282
MOD_Plk_4	114	120	PF00069	0.436
MOD_Plk_4	231	237	PF00069	0.288
MOD_Plk_4	370	376	PF00069	0.261
MOD_Plk_4	596	602	PF00069	0.276
MOD_Plk_4	90	96	PF00069	0.205
MOD_ProDKin_1	153	159	PF00069	0.363
MOD_ProDKin_1	244	250	PF00069	0.310
MOD_ProDKin_1	285	291	PF00069	0.357
MOD_SUMO_for_1	278	281	PF00179	0.307
MOD_SUMO_for_1	428	431	PF00179	0.355
MOD_SUMO_for_1	592	595	PF00179	0.395
MOD_SUMO_rev_2	274	280	PF00179	0.261
MOD_SUMO_rev_2	394	401	PF00179	0.282
TRG_DiLeu_BaEn_1	146	151	PF01217	0.261
TRG_DiLeu_BaEn_1	387	392	PF01217	0.395
TRG_DiLeu_BaEn_1	440	445	PF01217	0.342
TRG_DiLeu_BaEn_2	331	337	PF01217	0.263
TRG_DiLeu_BaLyEn_6	245	250	PF01217	0.323
TRG_DiLeu_BaLyEn_6	444	449	PF01217	0.342
TRG_ENDOCYTIC_2	255	258	PF00928	0.282
TRG_ENDOCYTIC_2	317	320	PF00928	0.355
TRG_ENDOCYTIC_2	95	98	PF00928	0.321
TRG_ER_diArg_1	11	14	PF00400	0.430
TRG_ER_diArg_1	195	197	PF00400	0.188
TRG_ER_diArg_1	199	202	PF00400	0.167
TRG_Pf-PMV_PEXEL_1	575	580	PF00026	0.261

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7D5	Leptomonas seymouri	83%	100%
A0A0N0P7P1	Leptomonas seymouri	31%	100%
A0A0S4JI94	Bodo saltans	50%	94%
A0A1X0P7Y3	Trypanosomatidae	29%	100%
A0A1X0P895	Trypanosomatidae	66%	100%
A0A3Q8IG36	Leishmania donovani	33%	100%
A0A3R7MWF2	Trypanosoma rangeli	21%	93%
A0A3S7XAA1	Leishmania donovani	90%	100%
A0A422P2E3	Trypanosoma rangeli	65%	100%
A4HP92	Leishmania braziliensis	32%	100%
A4ICU1	Leishmania infantum	91%	100%
A4IDJ7	Leishmania infantum	33%	100%
D0A395	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ASG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9AT00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
O08700	Rattus norvegicus	30%	100%
O18637	Drosophila virilis	20%	94%
O49048	Arabidopsis thaliana	30%	100%
O74534	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	97%
P22213	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	93%
P38932	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
P97390	Mus musculus	30%	100%
Q09805	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q24179	Drosophila melanogaster	21%	97%
Q4Q1J8	Leishmania major	33%	100%
Q4Q232	Leishmania major	90%	100%
Q54GE3	Dictyostelium discoideum	28%	100%
Q54QC8	Dictyostelium discoideum	20%	100%
Q5VNU3	Oryza sativa subsp. japonica	21%	94%
Q60770	Mus musculus	22%	100%
Q62991	Rattus norvegicus	21%	97%
Q64324	Mus musculus	21%	100%
Q7XWP3	Oryza sativa subsp. japonica	21%	93%
Q851W1	Oryza sativa subsp. japonica	21%	99%
Q8BRF7	Mus musculus	21%	97%
Q8WVM8	Homo sapiens	21%	96%
Q9C5P7	Arabidopsis thaliana	22%	92%
Q9C5X3	Arabidopsis thaliana	20%	93%
Q9NRW7	Homo sapiens	29%	100%
Q9SZ77	Arabidopsis thaliana	21%	93%
V5BV59	Trypanosoma cruzi	65%	100%
V5DCK0	Trypanosoma cruzi	31%	100%