Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNQ3_LEIBR

TriTrypDb:

LbrM.35.0540 , LBRM2903_350010900

Length:

538

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNQ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNQ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.823
CLV_C14_Caspase3-7	320	324	PF00656	0.752
CLV_C14_Caspase3-7	379	383	PF00656	0.661
CLV_C14_Caspase3-7	518	522	PF00656	0.691
CLV_NRD_NRD_1	17	19	PF00675	0.539
CLV_NRD_NRD_1	289	291	PF00675	0.715
CLV_NRD_NRD_1	389	391	PF00675	0.732
CLV_PCSK_KEX2_1	17	19	PF00082	0.539
CLV_PCSK_KEX2_1	289	291	PF00082	0.710
CLV_PCSK_KEX2_1	389	391	PF00082	0.732
CLV_PCSK_SKI1_1	81	85	PF00082	0.478
DEG_APCC_DBOX_1	80	88	PF00400	0.524
DEG_SPOP_SBC_1	246	250	PF00917	0.710
DEG_SPOP_SBC_1	305	309	PF00917	0.799
DEG_SPOP_SBC_1	409	413	PF00917	0.667
DOC_MAPK_gen_1	120	130	PF00069	0.474
DOC_MAPK_gen_1	78	86	PF00069	0.634
DOC_MAPK_MEF2A_6	123	130	PF00069	0.493
DOC_MAPK_MEF2A_6	78	86	PF00069	0.634
DOC_USP7_MATH_1	153	157	PF00917	0.725
DOC_USP7_MATH_1	215	219	PF00917	0.698
DOC_USP7_MATH_1	275	279	PF00917	0.591
DOC_USP7_MATH_1	28	32	PF00917	0.695
DOC_USP7_MATH_1	331	335	PF00917	0.807
DOC_USP7_MATH_1	371	375	PF00917	0.740
DOC_USP7_MATH_1	420	424	PF00917	0.699
DOC_USP7_MATH_1	442	446	PF00917	0.820
DOC_USP7_MATH_1	467	471	PF00917	0.669
DOC_USP7_MATH_1	480	484	PF00917	0.745
DOC_WW_Pin1_4	176	181	PF00397	0.799
DOC_WW_Pin1_4	224	229	PF00397	0.717
DOC_WW_Pin1_4	360	365	PF00397	0.717
DOC_WW_Pin1_4	416	421	PF00397	0.701
DOC_WW_Pin1_4	66	71	PF00397	0.797
LIG_14-3-3_CanoR_1	111	116	PF00244	0.464
LIG_14-3-3_CanoR_1	120	126	PF00244	0.567
LIG_14-3-3_CanoR_1	155	163	PF00244	0.724
LIG_14-3-3_CanoR_1	279	287	PF00244	0.722
LIG_14-3-3_CanoR_1	474	481	PF00244	0.673
LIG_DLG_GKlike_1	111	118	PF00625	0.619
LIG_FHA_1	129	135	PF00498	0.659
LIG_FHA_1	142	148	PF00498	0.585
LIG_FHA_1	282	288	PF00498	0.719
LIG_FHA_2	338	344	PF00498	0.828
LIG_FHA_2	377	383	PF00498	0.707
LIG_FHA_2	69	75	PF00498	0.696
LIG_FHA_2	98	104	PF00498	0.529
LIG_Integrin_isoDGR_2	455	457	PF01839	0.597
LIG_LIR_Nem_3	311	316	PF02991	0.567
LIG_LIR_Nem_3	520	526	PF02991	0.650
LIG_NRBOX	82	88	PF00104	0.523
LIG_SH2_NCK_1	378	382	PF00017	0.757
LIG_SH2_STAP1	526	530	PF00017	0.574
LIG_SH2_STAT3	200	203	PF00017	0.825
LIG_SH2_STAT3	88	91	PF00017	0.519
LIG_SH2_STAT5	23	26	PF00017	0.592
LIG_SH2_STAT5	378	381	PF00017	0.716
LIG_SH2_STAT5	39	42	PF00017	0.758
LIG_SH3_1	389	395	PF00018	0.674
LIG_SH3_2	12	17	PF14604	0.492
LIG_SH3_3	16	22	PF00018	0.672
LIG_SH3_3	257	263	PF00018	0.712
LIG_SH3_3	358	364	PF00018	0.694
LIG_SH3_3	365	371	PF00018	0.700
LIG_SH3_3	381	387	PF00018	0.647
LIG_SH3_3	389	395	PF00018	0.597
LIG_SH3_3	9	15	PF00018	0.742
LIG_SUMO_SIM_par_1	143	148	PF11976	0.555
MOD_CK1_1	132	138	PF00069	0.682
MOD_CK1_1	143	149	PF00069	0.701
MOD_CK1_1	230	236	PF00069	0.732
MOD_CK1_1	252	258	PF00069	0.710
MOD_CK1_1	267	273	PF00069	0.737
MOD_CK1_1	278	284	PF00069	0.725
MOD_CK1_1	296	302	PF00069	0.793
MOD_CK1_1	325	331	PF00069	0.799
MOD_CK1_1	334	340	PF00069	0.719
MOD_CK1_1	341	347	PF00069	0.729
MOD_CK1_1	363	369	PF00069	0.747
MOD_CK1_1	37	43	PF00069	0.669
MOD_CK1_1	376	382	PF00069	0.602
MOD_CK1_1	411	417	PF00069	0.741
MOD_CK1_1	422	428	PF00069	0.770
MOD_CK1_1	445	451	PF00069	0.742
MOD_CK1_1	488	494	PF00069	0.650
MOD_CK1_1	525	531	PF00069	0.578
MOD_CK1_1	65	71	PF00069	0.796
MOD_CK2_1	155	161	PF00069	0.813
MOD_CK2_1	215	221	PF00069	0.659
MOD_CK2_1	5	11	PF00069	0.756
MOD_CK2_1	66	72	PF00069	0.794
MOD_CK2_1	97	103	PF00069	0.531
MOD_Cter_Amidation	287	290	PF01082	0.720
MOD_GlcNHglycan	123	126	PF01048	0.554
MOD_GlcNHglycan	136	139	PF01048	0.636
MOD_GlcNHglycan	147	150	PF01048	0.790
MOD_GlcNHglycan	155	158	PF01048	0.680
MOD_GlcNHglycan	193	196	PF01048	0.699
MOD_GlcNHglycan	211	214	PF01048	0.560
MOD_GlcNHglycan	254	257	PF01048	0.730
MOD_GlcNHglycan	269	272	PF01048	0.744
MOD_GlcNHglycan	284	287	PF01048	0.719
MOD_GlcNHglycan	30	33	PF01048	0.648
MOD_GlcNHglycan	327	330	PF01048	0.716
MOD_GlcNHglycan	336	339	PF01048	0.754
MOD_GlcNHglycan	379	382	PF01048	0.757
MOD_GlcNHglycan	46	49	PF01048	0.694
MOD_GlcNHglycan	477	480	PF01048	0.696
MOD_GlcNHglycan	486	490	PF01048	0.675
MOD_GlcNHglycan	64	67	PF01048	0.518
MOD_GlcNHglycan	7	10	PF01048	0.704
MOD_GSK3_1	128	135	PF00069	0.681
MOD_GSK3_1	141	148	PF00069	0.584
MOD_GSK3_1	151	158	PF00069	0.757
MOD_GSK3_1	176	183	PF00069	0.705
MOD_GSK3_1	191	198	PF00069	0.488
MOD_GSK3_1	215	222	PF00069	0.751
MOD_GSK3_1	23	30	PF00069	0.723
MOD_GSK3_1	230	237	PF00069	0.733
MOD_GSK3_1	241	248	PF00069	0.630
MOD_GSK3_1	263	270	PF00069	0.727
MOD_GSK3_1	275	282	PF00069	0.729
MOD_GSK3_1	295	302	PF00069	0.707
MOD_GSK3_1	304	311	PF00069	0.691
MOD_GSK3_1	327	334	PF00069	0.813
MOD_GSK3_1	337	344	PF00069	0.727
MOD_GSK3_1	37	44	PF00069	0.598
MOD_GSK3_1	372	379	PF00069	0.767
MOD_GSK3_1	405	412	PF00069	0.770
MOD_GSK3_1	416	423	PF00069	0.667
MOD_GSK3_1	442	449	PF00069	0.601
MOD_GSK3_1	494	501	PF00069	0.726
MOD_GSK3_1	511	518	PF00069	0.722
MOD_GSK3_1	62	69	PF00069	0.790
MOD_LATS_1	277	283	PF00433	0.728
MOD_N-GLC_1	264	269	PF02516	0.728
MOD_N-GLC_1	443	448	PF02516	0.773
MOD_NEK2_1	134	139	PF00069	0.768
MOD_NEK2_1	145	150	PF00069	0.613
MOD_NEK2_1	175	180	PF00069	0.793
MOD_NEK2_1	220	225	PF00069	0.689
MOD_NEK2_1	247	252	PF00069	0.564
MOD_NEK2_1	294	299	PF00069	0.714
MOD_NEK2_1	322	327	PF00069	0.752
MOD_NEK2_1	35	40	PF00069	0.674
MOD_NEK2_1	410	415	PF00069	0.602
MOD_NEK2_1	447	452	PF00069	0.638
MOD_NEK2_2	180	185	PF00069	0.570
MOD_NEK2_2	373	378	PF00069	0.548
MOD_PIKK_1	341	347	PF00454	0.795
MOD_PKA_2	278	284	PF00069	0.725
MOD_PKA_2	473	479	PF00069	0.813
MOD_PKB_1	457	465	PF00069	0.842
MOD_Plk_1	264	270	PF00069	0.831
MOD_Plk_1	322	328	PF00069	0.807
MOD_Plk_1	443	449	PF00069	0.706
MOD_Plk_1	505	511	PF00069	0.755
MOD_Plk_1	515	521	PF00069	0.692
MOD_Plk_4	195	201	PF00069	0.823
MOD_Plk_4	215	221	PF00069	0.464
MOD_Plk_4	242	248	PF00069	0.572
MOD_Plk_4	296	302	PF00069	0.567
MOD_Plk_4	373	379	PF00069	0.729
MOD_Plk_4	405	411	PF00069	0.623
MOD_ProDKin_1	176	182	PF00069	0.803
MOD_ProDKin_1	224	230	PF00069	0.718
MOD_ProDKin_1	360	366	PF00069	0.717
MOD_ProDKin_1	416	422	PF00069	0.702
MOD_ProDKin_1	66	72	PF00069	0.794
MOD_SUMO_rev_2	309	319	PF00179	0.813
TRG_DiLeu_BaEn_1	79	84	PF01217	0.528
TRG_DiLeu_BaLyEn_6	290	295	PF01217	0.708
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.523
TRG_ENDOCYTIC_2	388	391	PF00928	0.705
TRG_ER_diArg_1	16	18	PF00400	0.509
TRG_ER_diArg_1	388	390	PF00400	0.736
TRG_Pf-PMV_PEXEL_1	85	90	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCL9	Leptomonas seymouri	49%	100%
A0A3Q8INA6	Leishmania donovani	78%	100%
A4ICU2	Leishmania infantum	78%	100%
E9ASG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%