LeishMANIAdb
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Mitochondrial RNA binding complex 1 subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mitochondrial RNA binding complex 1 subunit
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HNQ2_LEIBR
TriTrypDb:
LbrM.35.0530 , LBRM2903_350010800
Length:
482

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 17
NetGPI no yes: 0, no: 17
Cellular components
Term Name Level Count
GO:0005759 mitochondrial matrix 5 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0035770 ribonucleoprotein granule 3 1
GO:0043226 organelle 2 2
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 2
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0099080 supramolecular complex 2 1
GO:0110165 cellular anatomical entity 1 2
GO:0005739 mitochondrion 5 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A4HNQ2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNQ2

Function

Biological processes
Term Name Level Count
GO:0000959 mitochondrial RNA metabolic process 6 2
GO:0000963 mitochondrial RNA processing 6 1
GO:0006139 nucleobase-containing compound metabolic process 3 2
GO:0006396 RNA processing 6 2
GO:0006725 cellular aromatic compound metabolic process 3 2
GO:0006807 nitrogen compound metabolic process 2 2
GO:0008152 metabolic process 1 2
GO:0009894 regulation of catabolic process 4 1
GO:0009987 cellular process 1 2
GO:0010467 gene expression 4 1
GO:0010468 regulation of gene expression 5 1
GO:0010608 post-transcriptional regulation of gene expression 6 1
GO:0016070 RNA metabolic process 5 2
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031329 regulation of cellular catabolic process 5 1
GO:0034641 cellular nitrogen compound metabolic process 3 2
GO:0043170 macromolecule metabolic process 3 2
GO:0043487 regulation of RNA stability 3 1
GO:0043488 regulation of mRNA stability 4 1
GO:0044237 cellular metabolic process 2 2
GO:0044238 primary metabolic process 2 2
GO:0044528 regulation of mitochondrial mRNA stability 5 1
GO:0046483 heterocycle metabolic process 3 2
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0061013 regulation of mRNA catabolic process 6 1
GO:0065007 biological regulation 1 1
GO:0065008 regulation of biological quality 2 1
GO:0071704 organic substance metabolic process 2 2
GO:0080090 regulation of primary metabolic process 4 1
GO:0090304 nucleic acid metabolic process 4 2
GO:0140053 mitochondrial gene expression 5 1
GO:1901360 organic cyclic compound metabolic process 3 2
GO:1903311 regulation of mRNA metabolic process 6 1
GO:0009451 RNA modification 5 1
GO:0043412 macromolecule modification 4 1
GO:1900864 mitochondrial RNA modification 6 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 2
GO:0003723 RNA binding 4 2
GO:0005488 binding 1 2
GO:0097159 organic cyclic compound binding 2 2
GO:1901363 heterocyclic compound binding 2 2
GO:0003729 mRNA binding 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 372 376 PF00656 0.430
CLV_NRD_NRD_1 2 4 PF00675 0.592
CLV_NRD_NRD_1 214 216 PF00675 0.497
CLV_NRD_NRD_1 41 43 PF00675 0.442
CLV_PCSK_KEX2_1 2 4 PF00082 0.595
CLV_PCSK_KEX2_1 41 43 PF00082 0.543
CLV_PCSK_SKI1_1 17 21 PF00082 0.489
CLV_PCSK_SKI1_1 182 186 PF00082 0.430
CLV_PCSK_SKI1_1 2 6 PF00082 0.520
CLV_Separin_Metazoa 44 48 PF03568 0.529
DEG_APCC_DBOX_1 181 189 PF00400 0.493
DEG_Nend_UBRbox_1 1 4 PF02207 0.648
DEG_SPOP_SBC_1 477 481 PF00917 0.413
DOC_CDC14_PxL_1 131 139 PF14671 0.467
DOC_CYCLIN_yClb5_NLxxxL_5 121 130 PF00134 0.252
DOC_CYCLIN_yCln2_LP_2 257 263 PF00134 0.358
DOC_MAPK_gen_1 47 57 PF00069 0.403
DOC_MAPK_MEF2A_6 199 207 PF00069 0.557
DOC_MAPK_MEF2A_6 439 446 PF00069 0.433
DOC_PP1_RVXF_1 195 201 PF00149 0.444
DOC_PP2B_LxvP_1 257 260 PF13499 0.372
DOC_PP4_FxxP_1 200 203 PF00568 0.399
DOC_USP7_MATH_1 342 346 PF00917 0.268
DOC_USP7_MATH_1 420 424 PF00917 0.452
DOC_USP7_MATH_1 440 444 PF00917 0.272
DOC_USP7_MATH_1 477 481 PF00917 0.553
DOC_USP7_MATH_1 68 72 PF00917 0.438
DOC_USP7_UBL2_3 458 462 PF12436 0.312
DOC_WW_Pin1_4 218 223 PF00397 0.567
DOC_WW_Pin1_4 438 443 PF00397 0.559
DOC_WW_Pin1_4 63 68 PF00397 0.381
LIG_14-3-3_CanoR_1 113 121 PF00244 0.398
LIG_14-3-3_CanoR_1 17 25 PF00244 0.438
LIG_14-3-3_CanoR_1 286 294 PF00244 0.321
LIG_14-3-3_CanoR_1 41 48 PF00244 0.595
LIG_Actin_WH2_2 107 124 PF00022 0.480
LIG_Actin_WH2_2 202 217 PF00022 0.486
LIG_Actin_WH2_2 221 238 PF00022 0.482
LIG_Actin_WH2_2 48 64 PF00022 0.410
LIG_APCC_ABBA_1 424 429 PF00400 0.521
LIG_eIF4E_1 395 401 PF01652 0.478
LIG_FHA_1 146 152 PF00498 0.468
LIG_FHA_1 202 208 PF00498 0.452
LIG_FHA_1 285 291 PF00498 0.476
LIG_FHA_1 41 47 PF00498 0.307
LIG_FHA_1 430 436 PF00498 0.514
LIG_FHA_1 439 445 PF00498 0.590
LIG_FHA_1 64 70 PF00498 0.372
LIG_FHA_1 89 95 PF00498 0.497
LIG_FHA_2 206 212 PF00498 0.434
LIG_FHA_2 225 231 PF00498 0.299
LIG_FHA_2 35 41 PF00498 0.581
LIG_FHA_2 458 464 PF00498 0.486
LIG_HP1_1 181 185 PF01393 0.268
LIG_LIR_Gen_1 128 137 PF02991 0.338
LIG_LIR_Gen_1 230 238 PF02991 0.343
LIG_LIR_Gen_1 344 354 PF02991 0.364
LIG_LIR_Gen_1 381 388 PF02991 0.350
LIG_LIR_Nem_3 128 134 PF02991 0.335
LIG_LIR_Nem_3 230 235 PF02991 0.326
LIG_LIR_Nem_3 240 246 PF02991 0.334
LIG_LIR_Nem_3 344 349 PF02991 0.380
LIG_LIR_Nem_3 352 357 PF02991 0.363
LIG_LIR_Nem_3 381 386 PF02991 0.353
LIG_LIR_Nem_3 398 404 PF02991 0.536
LIG_LYPXL_yS_3 404 407 PF13949 0.438
LIG_PTB_Apo_2 187 194 PF02174 0.466
LIG_PTB_Apo_2 301 308 PF02174 0.377
LIG_PTB_Phospho_1 187 193 PF10480 0.468
LIG_PTB_Phospho_1 301 307 PF10480 0.372
LIG_SH2_CRK 167 171 PF00017 0.382
LIG_SH2_PTP2 370 373 PF00017 0.373
LIG_SH2_SRC 370 373 PF00017 0.496
LIG_SH2_STAP1 246 250 PF00017 0.448
LIG_SH2_STAP1 307 311 PF00017 0.405
LIG_SH2_STAP1 53 57 PF00017 0.395
LIG_SH2_STAT3 48 51 PF00017 0.514
LIG_SH2_STAT5 370 373 PF00017 0.373
LIG_SH2_STAT5 395 398 PF00017 0.430
LIG_SH2_STAT5 65 68 PF00017 0.493
LIG_SH2_STAT5 75 78 PF00017 0.473
LIG_SH3_3 158 164 PF00018 0.512
LIG_SUMO_SIM_anti_2 225 230 PF11976 0.367
LIG_SUMO_SIM_anti_2 54 60 PF11976 0.353
LIG_SUMO_SIM_par_1 203 208 PF11976 0.482
LIG_SUMO_SIM_par_1 221 227 PF11976 0.257
LIG_TRAF2_1 385 388 PF00917 0.404
LIG_WRC_WIRS_1 130 135 PF05994 0.479
LIG_WRC_WIRS_1 343 348 PF05994 0.271
LIG_WRC_WIRS_1 380 385 PF05994 0.323
MOD_CK1_1 264 270 PF00069 0.420
MOD_CK2_1 224 230 PF00069 0.402
MOD_CK2_1 241 247 PF00069 0.296
MOD_CK2_1 446 452 PF00069 0.467
MOD_CK2_1 457 463 PF00069 0.476
MOD_GlcNHglycan 122 125 PF01048 0.506
MOD_GlcNHglycan 158 161 PF01048 0.463
MOD_GSK3_1 15 22 PF00069 0.434
MOD_GSK3_1 201 208 PF00069 0.289
MOD_GSK3_1 218 225 PF00069 0.497
MOD_GSK3_1 462 469 PF00069 0.477
MOD_GSK3_1 472 479 PF00069 0.569
MOD_NEK2_1 19 24 PF00069 0.340
MOD_NEK2_1 205 210 PF00069 0.423
MOD_NEK2_1 261 266 PF00069 0.317
MOD_NEK2_1 356 361 PF00069 0.356
MOD_NEK2_1 400 405 PF00069 0.345
MOD_NEK2_1 446 451 PF00069 0.624
MOD_NEK2_1 94 99 PF00069 0.391
MOD_PIKK_1 395 401 PF00454 0.355
MOD_PIKK_1 462 468 PF00454 0.536
MOD_PIKK_1 75 81 PF00454 0.370
MOD_PKA_2 285 291 PF00069 0.324
MOD_PKA_2 40 46 PF00069 0.314
MOD_Plk_1 462 468 PF00069 0.422
MOD_Plk_1 94 100 PF00069 0.409
MOD_Plk_2-3 310 316 PF00069 0.418
MOD_Plk_4 173 179 PF00069 0.388
MOD_Plk_4 20 26 PF00069 0.394
MOD_Plk_4 201 207 PF00069 0.275
MOD_Plk_4 224 230 PF00069 0.328
MOD_Plk_4 261 267 PF00069 0.312
MOD_Plk_4 335 341 PF00069 0.460
MOD_Plk_4 440 446 PF00069 0.499
MOD_ProDKin_1 218 224 PF00069 0.563
MOD_ProDKin_1 438 444 PF00069 0.552
MOD_ProDKin_1 63 69 PF00069 0.376
MOD_SUMO_rev_2 443 451 PF00179 0.585
MOD_SUMO_rev_2 54 64 PF00179 0.434
TRG_DiLeu_BaEn_2 462 468 PF01217 0.411
TRG_DiLeu_BaLyEn_6 246 251 PF01217 0.417
TRG_DiLeu_LyEn_5 352 357 PF01217 0.356
TRG_ENDOCYTIC_2 167 170 PF00928 0.352
TRG_ENDOCYTIC_2 370 373 PF00928 0.510
TRG_ENDOCYTIC_2 404 407 PF00928 0.579
TRG_ER_diArg_1 1 3 PF00400 0.600
TRG_Pf-PMV_PEXEL_1 236 240 PF00026 0.512
TRG_Pf-PMV_PEXEL_1 249 253 PF00026 0.321
TRG_Pf-PMV_PEXEL_1 50 54 PF00026 0.363

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6Z9 Leptomonas seymouri 75% 100%
A0A0S4JM31 Bodo saltans 40% 100%
A0A1X0P8G7 Trypanosomatidae 54% 100%
A0A3Q8IIP3 Leishmania donovani 90% 100%
A0A3S5H691 Leishmania donovani 24% 100%
A0A422P283 Trypanosoma rangeli 52% 100%
A4H5F5 Leishmania braziliensis 23% 100%
A4HTQ0 Leishmania infantum 24% 100%
A4ICU3 Leishmania infantum 90% 100%
C9ZPF4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 93%
D0A2L1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 100%
E9AMI7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9ASG1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4Q234 Leishmania major 89% 100%
Q4QI52 Leishmania major 25% 100%
V5BQI6 Trypanosoma cruzi 52% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS