Transcription initiation factor TFIID subunit 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transcription factor IIa, putative

Species:

Leishmania braziliensis

UniProt:

A4HNQ1_LEIBR

TriTrypDb:

LbrM.35.0520 , LBRM2903_350010700

Length:

179

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 6
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005667	transcription regulator complex	2	4
GO:0005672	transcription factor TFIIA complex	4	4
GO:0032991	protein-containing complex	1	4
GO:0090575	RNA polymerase II transcription regulator complex	3	4
GO:0140513	nuclear protein-containing complex	2	4

Expansion

Sequence features

A4HNQ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNQ1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	4
GO:0006352	DNA-templated transcription initiation	6	4
GO:0006367	transcription initiation at RNA polymerase II promoter	7	4
GO:0006725	cellular aromatic compound metabolic process	3	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0009058	biosynthetic process	2	4
GO:0009059	macromolecule biosynthetic process	4	4
GO:0009987	cellular process	1	4
GO:0016070	RNA metabolic process	5	4
GO:0018130	heterocycle biosynthetic process	4	4
GO:0019438	aromatic compound biosynthetic process	4	4
GO:0032774	RNA biosynthetic process	5	4
GO:0034641	cellular nitrogen compound metabolic process	3	4
GO:0034654	nucleobase-containing compound biosynthetic process	4	4
GO:0043170	macromolecule metabolic process	3	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044249	cellular biosynthetic process	3	4
GO:0044271	cellular nitrogen compound biosynthetic process	4	4
GO:0046483	heterocycle metabolic process	3	4
GO:0071704	organic substance metabolic process	2	4
GO:0090304	nucleic acid metabolic process	4	4
GO:1901360	organic cyclic compound metabolic process	3	4
GO:1901362	organic cyclic compound biosynthetic process	4	4
GO:1901576	organic substance biosynthetic process	3	4

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_APCC_DBOX_1	152	160	PF00400	0.726
DEG_Nend_Nbox_1	1	3	PF02207	0.531
DEG_SCF_FBW7_1	53	59	PF00400	0.732
DEG_SCF_FBW7_2	20	27	PF00400	0.695
DOC_CKS1_1	53	58	PF01111	0.733
DOC_CYCLIN_yCln2_LP_2	76	82	PF00134	0.733
DOC_PP2B_LxvP_1	76	79	PF13499	0.675
DOC_USP7_MATH_1	46	50	PF00917	0.599
DOC_USP7_MATH_1	68	72	PF00917	0.683
DOC_WW_Pin1_4	20	25	PF00397	0.652
DOC_WW_Pin1_4	52	57	PF00397	0.674
LIG_14-3-3_CterR_2	175	179	PF00244	0.606
LIG_deltaCOP1_diTrp_1	27	34	PF00928	0.563
LIG_FHA_1	125	131	PF00498	0.571
LIG_FHA_1	132	138	PF00498	0.580
LIG_FHA_1	71	77	PF00498	0.638
LIG_LIR_Gen_1	123	133	PF02991	0.559
LIG_LIR_Gen_1	150	159	PF02991	0.582
LIG_LIR_Nem_3	123	129	PF02991	0.587
LIG_LIR_Nem_3	150	154	PF02991	0.580
LIG_LIR_Nem_3	28	34	PF02991	0.556
LIG_MYND_1	20	24	PF01753	0.696
LIG_SH2_CRK	66	70	PF00017	0.729
LIG_SH2_NCK_1	66	70	PF00017	0.729
LIG_SH2_SRC	77	80	PF00017	0.681
LIG_SH2_STAT5	151	154	PF00017	0.543
LIG_SH2_STAT5	77	80	PF00017	0.649
LIG_SH3_3	50	56	PF00018	0.633
LIG_SUMO_SIM_par_1	123	132	PF11976	0.574
LIG_TRAF2_1	101	104	PF00917	0.534
LIG_TRAF2_1	24	27	PF00917	0.646
LIG_TYR_ITIM	149	154	PF00017	0.553
MOD_CDK_SPK_2	20	25	PF00069	0.698
MOD_CK1_1	49	55	PF00069	0.647
MOD_CK1_1	71	77	PF00069	0.681
MOD_GSK3_1	52	59	PF00069	0.628
MOD_GSK3_1	67	74	PF00069	0.516
MOD_NEK2_1	109	114	PF00069	0.671
MOD_PIKK_1	163	169	PF00454	0.722
MOD_PKA_2	2	8	PF00069	0.490
MOD_Plk_1	109	115	PF00069	0.678
MOD_Plk_1	124	130	PF00069	0.670
MOD_Plk_4	131	137	PF00069	0.632
MOD_ProDKin_1	20	26	PF00069	0.649
MOD_ProDKin_1	52	58	PF00069	0.668
TRG_DiLeu_BaEn_1	125	130	PF01217	0.719
TRG_ENDOCYTIC_2	119	122	PF00928	0.698
TRG_ENDOCYTIC_2	151	154	PF00928	0.568
TRG_ENDOCYTIC_2	66	69	PF00928	0.730
TRG_ER_diArg_1	152	155	PF00400	0.720

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILR4	Leptomonas seymouri	55%	96%
A0A0S4JM71	Bodo saltans	29%	100%
A0A1X0P9A1	Trypanosomatidae	35%	92%
A0A3R7N2M9	Trypanosoma rangeli	34%	100%
D0A2L0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	99%
E9ASG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%