Amino acid permease-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amino acid permease-like protein

Species:

Leishmania braziliensis

UniProt:

A4HNQ0_LEIBR

TriTrypDb:

LbrM.35.0510 , LBRM2903_350010600

Length:

483

Annotations

LeishMANIAdb annotations

An enormously expanded group of various amino acid transporters.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 6
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 45

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 102
NetGPI	no	yes: 0, no: 103

Show entries

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	94
GO:0020016	ciliary pocket	2	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Previous1 2Next

Expansion

Sequence features

A4HNQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNQ0

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0003333	amino acid transmembrane transport	5	10
GO:0006810	transport	3	10
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006820	monoatomic anion transport	5	1
GO:0006865	amino acid transport	5	10
GO:0009987	cellular process	1	10
GO:0015711	organic anion transport	5	1
GO:0015802	basic amino acid transport	6	1
GO:0015819	lysine transport	6	1

Previous1 2Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	10
GO:0005342	organic acid transmembrane transporter activity	3	10
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0008509	monoatomic anion transmembrane transporter activity	4	1
GO:0008514	organic anion transmembrane transporter activity	5	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015171	amino acid transmembrane transporter activity	5	10
GO:0015174	basic amino acid transmembrane transporter activity	6	1
GO:0015179	L-amino acid transmembrane transporter activity	6	10
GO:0015189	L-lysine transmembrane transporter activity	5	1

Previous1 2Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	344	348	PF00656	0.277
CLV_NRD_NRD_1	18	20	PF00675	0.518
CLV_NRD_NRD_1	194	196	PF00675	0.268
CLV_NRD_NRD_1	45	47	PF00675	0.494
CLV_NRD_NRD_1	55	57	PF00675	0.439
CLV_PCSK_KEX2_1	18	20	PF00082	0.515
CLV_PCSK_KEX2_1	194	196	PF00082	0.247
CLV_PCSK_KEX2_1	302	304	PF00082	0.197
CLV_PCSK_KEX2_1	44	46	PF00082	0.503
CLV_PCSK_KEX2_1	55	57	PF00082	0.434

Previous1 2 3 4 5…16Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P285	Leptomonas seymouri	22%	98%
A0A0N0P5D2	Leptomonas seymouri	29%	100%
A0A0N0P613	Leptomonas seymouri	25%	100%
A0A0N0P6F5	Leptomonas seymouri	27%	100%
A0A0N0P6F6	Leptomonas seymouri	29%	100%
A0A0N0P8T9	Leptomonas seymouri	28%	97%
A0A0N0P955	Leptomonas seymouri	29%	100%
A0A0N1I2L5	Leptomonas seymouri	26%	100%
A0A0N1I3F8	Leptomonas seymouri	30%	91%
A0A0N1I3H4	Leptomonas seymouri	31%	88%

Previous1 2 3 4 5…28Next