Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNP9_LEIBR

TriTrypDb:

LbrM.35.0500 , LBRM2903_350010500

Length:

198

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNP9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	21	23	PF00675	0.544
CLV_NRD_NRD_1	6	8	PF00675	0.552
CLV_NRD_NRD_1	99	101	PF00675	0.495
CLV_PCSK_KEX2_1	142	144	PF00082	0.548
CLV_PCSK_KEX2_1	164	166	PF00082	0.533
CLV_PCSK_KEX2_1	21	23	PF00082	0.468
CLV_PCSK_KEX2_1	62	64	PF00082	0.338
CLV_PCSK_KEX2_1	99	101	PF00082	0.452
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.287
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.539
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.338
CLV_PCSK_SKI1_1	164	168	PF00082	0.444
CLV_PCSK_SKI1_1	35	39	PF00082	0.566
CLV_PCSK_SKI1_1	62	66	PF00082	0.466
CLV_PCSK_SKI1_1	99	103	PF00082	0.299
CLV_Separin_Metazoa	174	178	PF03568	0.326
DEG_Nend_Nbox_1	1	3	PF02207	0.613
DOC_CDC14_PxL_1	78	86	PF14671	0.469
DOC_CYCLIN_RxL_1	161	170	PF00134	0.460
DOC_MAPK_gen_1	139	147	PF00069	0.276
DOC_MAPK_gen_1	62	70	PF00069	0.513
DOC_MAPK_MEF2A_6	62	70	PF00069	0.538
DOC_MAPK_RevD_3	176	191	PF00069	0.518
DOC_USP7_UBL2_3	36	40	PF12436	0.535
DOC_WW_Pin1_4	121	126	PF00397	0.345
DOC_WW_Pin1_4	154	159	PF00397	0.484
LIG_14-3-3_CanoR_1	179	184	PF00244	0.508
LIG_14-3-3_CanoR_1	7	11	PF00244	0.550
LIG_14-3-3_CanoR_1	99	109	PF00244	0.501
LIG_Actin_WH2_2	106	124	PF00022	0.309
LIG_FHA_1	171	177	PF00498	0.335
LIG_FHA_2	18	24	PF00498	0.604
LIG_FHA_2	184	190	PF00498	0.499
LIG_FHA_2	56	62	PF00498	0.470
LIG_FHA_2	7	13	PF00498	0.522
LIG_Integrin_isoDGR_2	92	94	PF01839	0.558
LIG_LIR_Gen_1	111	121	PF02991	0.486
LIG_LIR_Gen_1	131	140	PF02991	0.190
LIG_LIR_Gen_1	157	167	PF02991	0.418
LIG_LIR_Nem_3	111	117	PF02991	0.491
LIG_LIR_Nem_3	131	135	PF02991	0.190
LIG_LIR_Nem_3	157	162	PF02991	0.399
LIG_LIR_Nem_3	46	52	PF02991	0.486
LIG_NRBOX	64	70	PF00104	0.583
LIG_PCNA_PIPBox_1	42	51	PF02747	0.563
LIG_PCNA_yPIPBox_3	35	49	PF02747	0.483
LIG_REV1ctd_RIR_1	49	58	PF16727	0.567
LIG_SH2_CRK	180	184	PF00017	0.486
LIG_SH3_3	67	73	PF00018	0.510
LIG_SH3_3	79	85	PF00018	0.354
LIG_TRAF2_1	58	61	PF00917	0.441
LIG_TYR_ITIM	178	183	PF00017	0.307
LIG_UBA3_1	183	191	PF00899	0.535
MOD_CK1_1	170	176	PF00069	0.593
MOD_CK1_1	182	188	PF00069	0.505
MOD_CK2_1	17	23	PF00069	0.596
MOD_CK2_1	55	61	PF00069	0.487
MOD_CK2_1	6	12	PF00069	0.531
MOD_GlcNHglycan	134	138	PF01048	0.410
MOD_GSK3_1	117	124	PF00069	0.330
MOD_GSK3_1	179	186	PF00069	0.492
MOD_NEK2_1	109	114	PF00069	0.494
MOD_NEK2_1	117	122	PF00069	0.449
MOD_NEK2_1	183	188	PF00069	0.433
MOD_NEK2_1	68	73	PF00069	0.556
MOD_PIKK_1	167	173	PF00454	0.370
MOD_PIKK_1	38	44	PF00454	0.563
MOD_PKA_1	35	41	PF00069	0.581
MOD_PKA_2	138	144	PF00069	0.400
MOD_PKA_2	6	12	PF00069	0.547
MOD_PKA_2	93	99	PF00069	0.531
MOD_PKB_1	177	185	PF00069	0.533
MOD_Plk_1	109	115	PF00069	0.423
MOD_Plk_2-3	55	61	PF00069	0.563
MOD_Plk_2-3	6	12	PF00069	0.566
MOD_Plk_4	109	115	PF00069	0.333
MOD_Plk_4	179	185	PF00069	0.474
MOD_ProDKin_1	121	127	PF00069	0.339
MOD_ProDKin_1	154	160	PF00069	0.481
MOD_SUMO_rev_2	3	10	PF00179	0.600
MOD_SUMO_rev_2	55	64	PF00179	0.564
TRG_DiLeu_BaEn_1	61	66	PF01217	0.520
TRG_DiLeu_BaEn_3	59	65	PF01217	0.415
TRG_DiLeu_BaEn_4	26	32	PF01217	0.508
TRG_DiLeu_BaLyEn_6	162	167	PF01217	0.441
TRG_ENDOCYTIC_2	180	183	PF00928	0.489
TRG_ER_diArg_1	176	179	PF00400	0.544
TRG_ER_diArg_1	99	101	PF00400	0.472
TRG_Pf-PMV_PEXEL_1	165	169	PF00026	0.351
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I786	Leptomonas seymouri	81%	100%
A0A0S4JIF8	Bodo saltans	25%	96%
A0A1X0P8L2	Trypanosomatidae	44%	100%
A0A3S7XA94	Leishmania donovani	85%	100%
A0A422P2B0	Trypanosoma rangeli	40%	99%
A4ICU6	Leishmania infantum	85%	100%
D0A2K9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	99%
E9ASF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q237	Leishmania major	85%	100%
V5BA10	Trypanosoma cruzi	49%	100%