PDZ domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNP8_LEIBR

TriTrypDb:

LbrM.35.0490 , LBRM2903_350010400

Length:

445

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNP8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	282	286	PF00656	0.480
CLV_NRD_NRD_1	7	9	PF00675	0.444
CLV_NRD_NRD_1	88	90	PF00675	0.586
CLV_PCSK_KEX2_1	7	9	PF00082	0.536
CLV_PCSK_KEX2_1	88	90	PF00082	0.586
CLV_PCSK_SKI1_1	438	442	PF00082	0.466
CLV_Separin_Metazoa	175	179	PF03568	0.412
DEG_SPOP_SBC_1	347	351	PF00917	0.530
DEG_SPOP_SBC_1	63	67	PF00917	0.631
DOC_CKS1_1	407	412	PF01111	0.502
DOC_MAPK_gen_1	169	176	PF00069	0.399
DOC_MAPK_MEF2A_6	418	427	PF00069	0.312
DOC_PP2B_LxvP_1	302	305	PF13499	0.482
DOC_SPAK_OSR1_1	8	12	PF12202	0.461
DOC_USP7_MATH_1	118	122	PF00917	0.410
DOC_USP7_MATH_1	281	285	PF00917	0.489
DOC_USP7_MATH_1	63	67	PF00917	0.675
DOC_USP7_UBL2_3	257	261	PF12436	0.391
DOC_WW_Pin1_4	319	324	PF00397	0.709
DOC_WW_Pin1_4	326	331	PF00397	0.674
DOC_WW_Pin1_4	380	385	PF00397	0.374
DOC_WW_Pin1_4	406	411	PF00397	0.447
LIG_14-3-3_CanoR_1	108	116	PF00244	0.479
LIG_14-3-3_CanoR_1	120	126	PF00244	0.354
LIG_14-3-3_CanoR_1	324	330	PF00244	0.621
LIG_14-3-3_CanoR_1	365	371	PF00244	0.393
LIG_14-3-3_CanoR_1	438	445	PF00244	0.502
LIG_14-3-3_CanoR_1	62	69	PF00244	0.528
LIG_AP2alpha_2	431	433	PF02296	0.435
LIG_APCC_ABBA_1	155	160	PF00400	0.327
LIG_BIR_II_1	1	5	PF00653	0.456
LIG_BIR_III_3	1	5	PF00653	0.349
LIG_FHA_1	111	117	PF00498	0.581
LIG_FHA_1	180	186	PF00498	0.321
LIG_FHA_1	213	219	PF00498	0.480
LIG_FHA_2	122	128	PF00498	0.513
LIG_FHA_2	168	174	PF00498	0.463
LIG_FHA_2	359	365	PF00498	0.556
LIG_FHA_2	426	432	PF00498	0.373
LIG_Integrin_isoDGR_2	434	436	PF01839	0.464
LIG_LIR_Gen_1	211	221	PF02991	0.470
LIG_LIR_Gen_1	232	242	PF02991	0.607
LIG_LIR_LC3C_4	420	425	PF02991	0.315
LIG_LIR_Nem_3	211	217	PF02991	0.392
LIG_LIR_Nem_3	232	237	PF02991	0.481
LIG_LIR_Nem_3	428	433	PF02991	0.421
LIG_RPA_C_Fungi	387	399	PF08784	0.435
LIG_SH2_STAP1	125	129	PF00017	0.416
LIG_SH2_STAP1	214	218	PF00017	0.449
LIG_SH2_STAT5	214	217	PF00017	0.454
LIG_SH3_3	297	303	PF00018	0.690
LIG_SH3_3	404	410	PF00018	0.512
LIG_SUMO_SIM_anti_2	172	180	PF11976	0.466
LIG_SUMO_SIM_anti_2	24	30	PF11976	0.401
LIG_SUMO_SIM_anti_2	374	381	PF11976	0.303
LIG_SUMO_SIM_par_1	20	27	PF11976	0.422
LIG_TRAF2_1	170	173	PF00917	0.447
LIG_TRAF2_1	262	265	PF00917	0.475
LIG_TRAF2_1	412	415	PF00917	0.414
MOD_CDK_SPK_2	319	324	PF00069	0.660
MOD_CDK_SPxxK_3	319	326	PF00069	0.532
MOD_CK1_1	110	116	PF00069	0.469
MOD_CK1_1	121	127	PF00069	0.471
MOD_CK1_1	179	185	PF00069	0.390
MOD_CK1_1	200	206	PF00069	0.603
MOD_CK1_1	212	218	PF00069	0.277
MOD_CK1_1	292	298	PF00069	0.716
MOD_CK1_1	311	317	PF00069	0.773
MOD_CK1_1	322	328	PF00069	0.752
MOD_CK1_1	383	389	PF00069	0.444
MOD_CK2_1	121	127	PF00069	0.513
MOD_CK2_1	167	173	PF00069	0.482
MOD_CK2_1	358	364	PF00069	0.665
MOD_GlcNHglycan	139	142	PF01048	0.486
MOD_GlcNHglycan	14	17	PF01048	0.480
MOD_GlcNHglycan	339	342	PF01048	0.662
MOD_GlcNHglycan	385	388	PF01048	0.462
MOD_GlcNHglycan	419	422	PF01048	0.362
MOD_GSK3_1	208	215	PF00069	0.533
MOD_GSK3_1	304	311	PF00069	0.628
MOD_GSK3_1	322	329	PF00069	0.755
MOD_GSK3_1	335	342	PF00069	0.532
MOD_GSK3_1	347	354	PF00069	0.726
MOD_GSK3_1	402	409	PF00069	0.573
MOD_GSK3_1	53	60	PF00069	0.691
MOD_N-GLC_1	314	319	PF02516	0.658
MOD_N-GLC_1	33	38	PF02516	0.407
MOD_N-GLC_1	70	75	PF02516	0.497
MOD_NEK2_1	12	17	PF00069	0.404
MOD_NEK2_1	137	142	PF00069	0.387
MOD_NEK2_1	181	186	PF00069	0.464
MOD_NEK2_1	210	215	PF00069	0.522
MOD_NEK2_1	250	255	PF00069	0.568
MOD_NEK2_1	270	275	PF00069	0.474
MOD_NEK2_1	348	353	PF00069	0.560
MOD_NEK2_1	417	422	PF00069	0.380
MOD_NEK2_2	57	62	PF00069	0.557
MOD_PIKK_1	148	154	PF00454	0.526
MOD_PIKK_1	200	206	PF00454	0.463
MOD_PIKK_1	304	310	PF00454	0.638
MOD_PIKK_1	335	341	PF00454	0.546
MOD_PKA_2	107	113	PF00069	0.535
MOD_PKA_2	292	298	PF00069	0.602
MOD_PKA_2	417	423	PF00069	0.565
MOD_PKA_2	61	67	PF00069	0.774
MOD_PKB_1	436	444	PF00069	0.500
MOD_Plk_1	118	124	PF00069	0.398
MOD_Plk_1	250	256	PF00069	0.392
MOD_Plk_1	270	276	PF00069	0.638
MOD_Plk_4	110	116	PF00069	0.520
MOD_Plk_4	24	30	PF00069	0.421
MOD_ProDKin_1	319	325	PF00069	0.709
MOD_ProDKin_1	326	332	PF00069	0.674
MOD_ProDKin_1	380	386	PF00069	0.367
MOD_ProDKin_1	406	412	PF00069	0.445
MOD_SUMO_for_1	39	42	PF00179	0.457
MOD_SUMO_rev_2	127	132	PF00179	0.601
MOD_SUMO_rev_2	256	263	PF00179	0.379
TRG_ENDOCYTIC_2	214	217	PF00928	0.538
TRG_ENDOCYTIC_2	234	237	PF00928	0.368
TRG_ENDOCYTIC_2	430	433	PF00928	0.435
TRG_ER_diArg_1	436	439	PF00400	0.510
TRG_ER_diArg_1	7	9	PF00400	0.538
TRG_ER_diArg_1	88	90	PF00400	0.392
TRG_NES_CRM1_1	191	205	PF08389	0.347
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	261	265	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	360	364	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	438	443	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0I6	Leptomonas seymouri	53%	94%
A0A1X0P8C3	Trypanosomatidae	32%	100%
A0A3S5H814	Leishmania donovani	76%	100%
A4ICU7	Leishmania infantum	76%	100%
D0A2K8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9ASF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q238	Leishmania major	78%	100%
V5DRR0	Trypanosoma cruzi	32%	100%