Retinoblastoma-like protein 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNP7_LEIBR

TriTrypDb:

LbrM.35.0480 , LBRM2903_350010200

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNP7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.676
CLV_C14_Caspase3-7	59	63	PF00656	0.685
CLV_NRD_NRD_1	277	279	PF00675	0.384
CLV_NRD_NRD_1	468	470	PF00675	0.348
CLV_NRD_NRD_1	513	515	PF00675	0.557
CLV_NRD_NRD_1	565	567	PF00675	0.692
CLV_PCSK_KEX2_1	139	141	PF00082	0.454
CLV_PCSK_KEX2_1	277	279	PF00082	0.384
CLV_PCSK_KEX2_1	396	398	PF00082	0.467
CLV_PCSK_KEX2_1	468	470	PF00082	0.333
CLV_PCSK_KEX2_1	513	515	PF00082	0.508
CLV_PCSK_KEX2_1	531	533	PF00082	0.493
CLV_PCSK_KEX2_1	563	565	PF00082	0.596
CLV_PCSK_KEX2_1	624	626	PF00082	0.507
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.494
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.354
CLV_PCSK_PC1ET2_1	531	533	PF00082	0.604
CLV_PCSK_PC1ET2_1	563	565	PF00082	0.594
CLV_PCSK_PC1ET2_1	624	626	PF00082	0.539
CLV_PCSK_SKI1_1	129	133	PF00082	0.535
CLV_PCSK_SKI1_1	277	281	PF00082	0.414
CLV_PCSK_SKI1_1	396	400	PF00082	0.559
CLV_PCSK_SKI1_1	545	549	PF00082	0.424
DEG_APCC_DBOX_1	635	643	PF00400	0.527
DEG_SPOP_SBC_1	28	32	PF00917	0.665
DEG_SPOP_SBC_1	298	302	PF00917	0.545
DEG_SPOP_SBC_1	448	452	PF00917	0.442
DOC_ANK_TNKS_1	563	570	PF00023	0.488
DOC_CDC14_PxL_1	421	429	PF14671	0.549
DOC_CKS1_1	548	553	PF01111	0.404
DOC_CYCLIN_RxL_1	126	137	PF00134	0.475
DOC_MAPK_DCC_7	586	594	PF00069	0.666
DOC_MAPK_gen_1	396	403	PF00069	0.333
DOC_MAPK_gen_1	513	521	PF00069	0.474
DOC_MAPK_HePTP_8	184	196	PF00069	0.256
DOC_MAPK_MEF2A_6	187	196	PF00069	0.350
DOC_MAPK_MEF2A_6	356	363	PF00069	0.803
DOC_MAPK_MEF2A_6	586	594	PF00069	0.666
DOC_MAPK_MEF2A_6	599	606	PF00069	0.629
DOC_PP1_RVXF_1	127	134	PF00149	0.474
DOC_PP1_RVXF_1	181	187	PF00149	0.434
DOC_PP1_RVXF_1	394	401	PF00149	0.464
DOC_PP1_RVXF_1	492	499	PF00149	0.291
DOC_PP1_RVXF_1	514	521	PF00149	0.528
DOC_PP2B_LxvP_1	604	607	PF13499	0.517
DOC_PP4_FxxP_1	108	111	PF00568	0.507
DOC_PP4_FxxP_1	548	551	PF00568	0.610
DOC_USP7_MATH_1	174	178	PF00917	0.443
DOC_USP7_MATH_1	448	452	PF00917	0.498
DOC_USP7_MATH_1	497	501	PF00917	0.443
DOC_USP7_MATH_1	652	656	PF00917	0.512
DOC_USP7_UBL2_3	360	364	PF12436	0.637
DOC_WW_Pin1_4	310	315	PF00397	0.556
DOC_WW_Pin1_4	547	552	PF00397	0.496
DOC_WW_Pin1_4	65	70	PF00397	0.801
DOC_WW_Pin1_4	667	672	PF00397	0.633
LIG_14-3-3_CanoR_1	145	150	PF00244	0.509
LIG_14-3-3_CanoR_1	183	187	PF00244	0.455
LIG_14-3-3_CanoR_1	382	391	PF00244	0.465
LIG_Actin_WH2_2	272	288	PF00022	0.290
LIG_BIR_II_1	1	5	PF00653	0.736
LIG_BRCT_BRCA1_1	412	416	PF00533	0.525
LIG_BRCT_BRCA1_1	54	58	PF00533	0.531
LIG_CaM_IQ_9	628	643	PF13499	0.417
LIG_Clathr_ClatBox_1	539	543	PF01394	0.490
LIG_CtBP_PxDLS_1	601	605	PF00389	0.619
LIG_eIF4E_1	660	666	PF01652	0.483
LIG_FHA_1	243	249	PF00498	0.284
LIG_FHA_1	339	345	PF00498	0.591
LIG_FHA_1	513	519	PF00498	0.540
LIG_FHA_1	521	527	PF00498	0.460
LIG_FHA_2	29	35	PF00498	0.760
LIG_FHA_2	37	43	PF00498	0.696
LIG_FHA_2	454	460	PF00498	0.435
LIG_FHA_2	609	615	PF00498	0.643
LIG_LIR_Apic_2	105	111	PF02991	0.531
LIG_LIR_Apic_2	112	118	PF02991	0.517
LIG_LIR_Gen_1	456	465	PF02991	0.477
LIG_LIR_Gen_1	661	671	PF02991	0.475
LIG_LIR_Nem_3	456	461	PF02991	0.490
LIG_LIR_Nem_3	466	470	PF02991	0.460
LIG_LIR_Nem_3	661	666	PF02991	0.489
LIG_NRBOX	460	466	PF00104	0.496
LIG_PCNA_yPIPBox_3	581	591	PF02747	0.615
LIG_Pex14_1	659	663	PF04695	0.477
LIG_Pex14_2	470	474	PF04695	0.409
LIG_Rb_pABgroove_1	201	209	PF01858	0.345
LIG_RPA_C_Fungi	464	476	PF08784	0.477
LIG_SH2_CRK	207	211	PF00017	0.390
LIG_SH2_CRK	663	667	PF00017	0.539
LIG_SH2_GRB2like	207	210	PF00017	0.262
LIG_SH2_PTP2	115	118	PF00017	0.632
LIG_SH2_SRC	115	118	PF00017	0.351
LIG_SH2_SRC	573	576	PF00017	0.475
LIG_SH2_STAP1	627	631	PF00017	0.523
LIG_SH2_STAT3	167	170	PF00017	0.408
LIG_SH2_STAT5	115	118	PF00017	0.579
LIG_SH2_STAT5	151	154	PF00017	0.344
LIG_SH2_STAT5	284	287	PF00017	0.379
LIG_SH2_STAT5	546	549	PF00017	0.413
LIG_SH2_STAT5	573	576	PF00017	0.754
LIG_SH3_1	522	528	PF00018	0.513
LIG_SH3_2	117	122	PF14604	0.544
LIG_SH3_2	355	360	PF14604	0.672
LIG_SH3_3	114	120	PF00018	0.592
LIG_SH3_3	211	217	PF00018	0.457
LIG_SH3_3	266	272	PF00018	0.410
LIG_SH3_3	311	317	PF00018	0.604
LIG_SH3_3	341	347	PF00018	0.604
LIG_SH3_3	349	355	PF00018	0.578
LIG_SH3_3	522	528	PF00018	0.465
LIG_SH3_3	63	69	PF00018	0.724
LIG_SH3_3	644	650	PF00018	0.540
LIG_SH3_3	651	657	PF00018	0.490
LIG_SH3_3	665	671	PF00018	0.496
LIG_SUMO_SIM_par_1	228	234	PF11976	0.490
LIG_SUMO_SIM_par_1	537	543	PF11976	0.471
LIG_SUMO_SIM_par_1	664	670	PF11976	0.601
LIG_TYR_ITIM	205	210	PF00017	0.372
LIG_UBA3_1	131	139	PF00899	0.473
LIG_WRC_WIRS_1	464	469	PF05994	0.472
MOD_CDK_SPK_2	310	315	PF00069	0.483
MOD_CDK_SPK_2	547	552	PF00069	0.374
MOD_CK1_1	19	25	PF00069	0.608
MOD_CK1_1	242	248	PF00069	0.460
MOD_CK1_1	26	32	PF00069	0.640
MOD_CK1_1	302	308	PF00069	0.536
MOD_CK1_1	38	44	PF00069	0.638
MOD_CK1_1	45	51	PF00069	0.574
MOD_CK1_1	450	456	PF00069	0.291
MOD_CK1_1	52	58	PF00069	0.561
MOD_CK1_1	60	66	PF00069	0.555
MOD_CK1_1	667	673	PF00069	0.616
MOD_CK2_1	29	35	PF00069	0.737
MOD_CK2_1	453	459	PF00069	0.485
MOD_CK2_1	53	59	PF00069	0.686
MOD_CK2_1	608	614	PF00069	0.528
MOD_DYRK1A_RPxSP_1	65	69	PF00069	0.599
MOD_GlcNHglycan	176	179	PF01048	0.559
MOD_GlcNHglycan	188	191	PF01048	0.444
MOD_GlcNHglycan	22	25	PF01048	0.731
MOD_GlcNHglycan	263	267	PF01048	0.411
MOD_GlcNHglycan	272	275	PF01048	0.336
MOD_GlcNHglycan	286	289	PF01048	0.483
MOD_GlcNHglycan	301	304	PF01048	0.573
MOD_GlcNHglycan	366	369	PF01048	0.623
MOD_GlcNHglycan	55	58	PF01048	0.665
MOD_GlcNHglycan	570	573	PF01048	0.588
MOD_GlcNHglycan	595	598	PF01048	0.624
MOD_GlcNHglycan	643	646	PF01048	0.549
MOD_GSK3_1	15	22	PF00069	0.668
MOD_GSK3_1	182	189	PF00069	0.531
MOD_GSK3_1	23	30	PF00069	0.610
MOD_GSK3_1	280	287	PF00069	0.363
MOD_GSK3_1	298	305	PF00069	0.474
MOD_GSK3_1	34	41	PF00069	0.744
MOD_GSK3_1	42	49	PF00069	0.508
MOD_GSK3_1	449	456	PF00069	0.495
MOD_GSK3_1	53	60	PF00069	0.616
MOD_N-GLC_1	26	31	PF02516	0.713
MOD_NEK2_1	240	245	PF00069	0.460
MOD_NEK2_1	383	388	PF00069	0.711
MOD_NEK2_1	399	404	PF00069	0.537
MOD_NEK2_1	40	45	PF00069	0.523
MOD_NEK2_1	447	452	PF00069	0.411
MOD_NEK2_1	620	625	PF00069	0.511
MOD_NEK2_2	463	468	PF00069	0.432
MOD_PIKK_1	240	246	PF00454	0.514
MOD_PIKK_1	499	505	PF00454	0.423
MOD_PIKK_1	81	87	PF00454	0.693
MOD_PKA_2	182	188	PF00069	0.450
MOD_PKA_2	512	518	PF00069	0.577
MOD_PKA_2	64	70	PF00069	0.733
MOD_Plk_1	614	620	PF00069	0.614
MOD_Plk_4	280	286	PF00069	0.362
MOD_Plk_4	399	405	PF00069	0.512
MOD_Plk_4	453	459	PF00069	0.501
MOD_ProDKin_1	310	316	PF00069	0.551
MOD_ProDKin_1	547	553	PF00069	0.505
MOD_ProDKin_1	65	71	PF00069	0.804
MOD_ProDKin_1	667	673	PF00069	0.638
MOD_SUMO_for_1	279	282	PF00179	0.407
TRG_DiLeu_BaEn_1	439	444	PF01217	0.482
TRG_DiLeu_BaLyEn_6	522	527	PF01217	0.512
TRG_ENDOCYTIC_2	207	210	PF00928	0.361
TRG_ENDOCYTIC_2	663	666	PF00928	0.473
TRG_ER_diArg_1	277	279	PF00400	0.429
TRG_ER_diArg_1	467	469	PF00400	0.346
TRG_ER_diArg_1	513	516	PF00400	0.562
TRG_ER_diArg_1	564	566	PF00400	0.676
TRG_NES_CRM1_1	517	529	PF08389	0.411
TRG_NLS_MonoCore_2	562	567	PF00514	0.664
TRG_NLS_MonoExtC_3	562	567	PF00514	0.638
TRG_NLS_MonoExtN_4	561	567	PF00514	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Z4	Leptomonas seymouri	67%	100%
A0A0S4JPG4	Bodo saltans	31%	100%
A0A1X0P8L9	Trypanosomatidae	41%	100%
A0A3S7XAH7	Leishmania donovani	85%	100%
A0A422P299	Trypanosoma rangeli	38%	100%
A4ICU8	Leishmania infantum	85%	100%
D0A2K5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ASF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q239	Leishmania major	87%	100%
V5BZZ1	Trypanosoma cruzi	40%	100%