Phosphatidylinositol-4-phosphate 5-kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylinositol-4-phosphate 5-kinase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HNP5_LEIBR

TriTrypDb:

LbrM.35.0460 , LBRM2903_350010000

Length:

456

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNP5

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0044237	cellular metabolic process	2	12
GO:0006629	lipid metabolic process	3	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0006661	phosphatidylinositol biosynthetic process	6	1
GO:0008610	lipid biosynthetic process	4	1
GO:0008654	phospholipid biosynthetic process	5	1
GO:0009058	biosynthetic process	2	1
GO:0019637	organophosphate metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046474	glycerophospholipid biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0046488	phosphatidylinositol metabolic process	6	1
GO:0046854	phosphatidylinositol phosphate biosynthetic process	7	1
GO:0071704	organic substance metabolic process	2	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016307	phosphatidylinositol phosphate kinase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	182	184	PF00675	0.271
CLV_NRD_NRD_1	226	228	PF00675	0.277
CLV_NRD_NRD_1	292	294	PF00675	0.350
CLV_NRD_NRD_1	436	438	PF00675	0.255
CLV_PCSK_KEX2_1	226	228	PF00082	0.259
CLV_PCSK_KEX2_1	241	243	PF00082	0.336
CLV_PCSK_KEX2_1	294	296	PF00082	0.383
CLV_PCSK_KEX2_1	436	438	PF00082	0.305
CLV_PCSK_KEX2_1	79	81	PF00082	0.429
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.219
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.387
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.441
CLV_PCSK_SKI1_1	12	16	PF00082	0.420
CLV_PCSK_SKI1_1	150	154	PF00082	0.399
CLV_PCSK_SKI1_1	247	251	PF00082	0.206
CLV_PCSK_SKI1_1	266	270	PF00082	0.238
CLV_PCSK_SKI1_1	280	284	PF00082	0.244
CLV_PCSK_SKI1_1	294	298	PF00082	0.242
CLV_PCSK_SKI1_1	417	421	PF00082	0.278
CLV_PCSK_SKI1_1	436	440	PF00082	0.403
CLV_PCSK_SKI1_1	56	60	PF00082	0.477
CLV_PCSK_SKI1_1	79	83	PF00082	0.472
DEG_APCC_DBOX_1	149	157	PF00400	0.230
DOC_CYCLIN_RxL_1	291	298	PF00134	0.275
DOC_MAPK_gen_1	183	192	PF00069	0.175
DOC_MAPK_gen_1	226	233	PF00069	0.280
DOC_MAPK_gen_1	77	85	PF00069	0.539
DOC_MAPK_HePTP_8	170	182	PF00069	0.276
DOC_MAPK_MEF2A_6	173	182	PF00069	0.251
DOC_MAPK_MEF2A_6	226	235	PF00069	0.165
DOC_MAPK_MEF2A_6	77	85	PF00069	0.560
DOC_MAPK_NFAT4_5	173	181	PF00069	0.247
DOC_PP2B_LxvP_1	14	17	PF13499	0.283
DOC_PP2B_LxvP_1	69	72	PF13499	0.385
DOC_PP4_FxxP_1	286	289	PF00568	0.418
DOC_USP7_MATH_1	197	201	PF00917	0.165
DOC_USP7_MATH_1	215	219	PF00917	0.182
DOC_USP7_MATH_1	349	353	PF00917	0.324
DOC_USP7_MATH_1	363	367	PF00917	0.229
DOC_USP7_MATH_1	37	41	PF00917	0.522
DOC_USP7_MATH_1	447	451	PF00917	0.325
DOC_USP7_MATH_1	52	56	PF00917	0.358
DOC_USP7_UBL2_3	205	209	PF12436	0.257
DOC_WW_Pin1_4	270	275	PF00397	0.165
DOC_WW_Pin1_4	375	380	PF00397	0.246
LIG_14-3-3_CanoR_1	12	17	PF00244	0.609
LIG_14-3-3_CanoR_1	24	28	PF00244	0.446
LIG_14-3-3_CanoR_1	436	442	PF00244	0.388
LIG_14-3-3_CanoR_1	48	52	PF00244	0.293
LIG_14-3-3_CanoR_1	68	72	PF00244	0.374
LIG_Actin_WH2_2	16	34	PF00022	0.364
LIG_AP2alpha_1	192	196	PF02296	0.233
LIG_BRCT_BRCA1_1	126	130	PF00533	0.391
LIG_DLG_GKlike_1	437	444	PF00625	0.387
LIG_FHA_1	141	147	PF00498	0.395
LIG_FHA_1	440	446	PF00498	0.257
LIG_FHA_2	274	280	PF00498	0.242
LIG_FHA_2	320	326	PF00498	0.271
LIG_FHA_2	376	382	PF00498	0.387
LIG_LIR_Apic_2	109	114	PF02991	0.335
LIG_LIR_Apic_2	283	289	PF02991	0.387
LIG_LIR_Gen_1	303	312	PF02991	0.278
LIG_LIR_Gen_1	314	323	PF02991	0.242
LIG_LIR_Gen_1	352	362	PF02991	0.165
LIG_LIR_Gen_1	439	449	PF02991	0.375
LIG_LIR_Nem_3	303	307	PF02991	0.292
LIG_LIR_Nem_3	314	318	PF02991	0.259
LIG_LIR_Nem_3	352	357	PF02991	0.165
LIG_LIR_Nem_3	393	399	PF02991	0.257
LIG_LIR_Nem_3	439	444	PF02991	0.301
LIG_NRBOX	296	302	PF00104	0.165
LIG_NRP_CendR_1	454	456	PF00754	0.467
LIG_Pex14_2	107	111	PF04695	0.306
LIG_Pex14_2	192	196	PF04695	0.245
LIG_Pex14_2	415	419	PF04695	0.166
LIG_PTB_Apo_2	218	225	PF02174	0.165
LIG_REV1ctd_RIR_1	128	137	PF16727	0.230
LIG_REV1ctd_RIR_1	413	421	PF16727	0.301
LIG_SH2_CRK	175	179	PF00017	0.389
LIG_SH2_CRK	304	308	PF00017	0.336
LIG_SH2_CRK	315	319	PF00017	0.242
LIG_SH2_PTP2	396	399	PF00017	0.242
LIG_SH2_STAP1	315	319	PF00017	0.242
LIG_SH2_STAP1	434	438	PF00017	0.303
LIG_SH2_STAT5	188	191	PF00017	0.269
LIG_SH2_STAT5	396	399	PF00017	0.242
LIG_SH2_STAT5	406	409	PF00017	0.242
LIG_SH3_3	374	380	PF00018	0.165
LIG_SUMO_SIM_par_1	142	148	PF11976	0.285
LIG_SUMO_SIM_par_1	398	404	PF11976	0.387
LIG_TRAF2_1	145	148	PF00917	0.336
LIG_TRAF2_1	449	452	PF00917	0.373
LIG_TYR_ITIM	394	399	PF00017	0.229
LIG_WRC_WIRS_1	416	421	PF05994	0.191
LIG_WRC_WIRS_1	438	443	PF05994	0.387
LIG_WRC_WIRS_1	92	97	PF05994	0.416
LIG_WW_1	430	433	PF00397	0.165
MOD_CK1_1	273	279	PF00069	0.165
MOD_CK1_1	350	356	PF00069	0.170
MOD_CK1_1	366	372	PF00069	0.180
MOD_CK1_1	450	456	PF00069	0.482
MOD_CK1_1	73	79	PF00069	0.446
MOD_CK2_1	109	115	PF00069	0.406
MOD_CK2_1	142	148	PF00069	0.283
MOD_CK2_1	319	325	PF00069	0.271
MOD_CK2_1	350	356	PF00069	0.411
MOD_CK2_1	375	381	PF00069	0.422
MOD_CK2_1	385	391	PF00069	0.329
MOD_CK2_1	437	443	PF00069	0.349
MOD_CK2_1	47	53	PF00069	0.495
MOD_Cter_Amidation	77	80	PF01082	0.339
MOD_GlcNHglycan	308	311	PF01048	0.357
MOD_GlcNHglycan	330	333	PF01048	0.257
MOD_GlcNHglycan	342	345	PF01048	0.338
MOD_GlcNHglycan	349	352	PF01048	0.439
MOD_GlcNHglycan	9	12	PF01048	0.437
MOD_GSK3_1	334	341	PF00069	0.306
MOD_GSK3_1	366	373	PF00069	0.404
MOD_GSK3_1	38	45	PF00069	0.562
MOD_GSK3_1	67	74	PF00069	0.507
MOD_LATS_1	278	284	PF00433	0.387
MOD_NEK2_1	131	136	PF00069	0.242
MOD_NEK2_1	140	145	PF00069	0.242
MOD_NEK2_1	178	183	PF00069	0.306
MOD_NEK2_1	306	311	PF00069	0.326
MOD_NEK2_1	313	318	PF00069	0.288
MOD_NEK2_1	340	345	PF00069	0.186
MOD_NEK2_1	415	420	PF00069	0.283
MOD_NEK2_1	425	430	PF00069	0.257
MOD_NEK2_2	215	220	PF00069	0.165
MOD_NMyristoyl	1	7	PF02799	0.536
MOD_PIKK_1	124	130	PF00454	0.387
MOD_PIKK_1	38	44	PF00454	0.556
MOD_PK_1	142	148	PF00069	0.285
MOD_PKA_1	226	232	PF00069	0.290
MOD_PKA_1	371	377	PF00069	0.285
MOD_PKA_1	436	442	PF00069	0.247
MOD_PKA_2	226	232	PF00069	0.222
MOD_PKA_2	23	29	PF00069	0.493
MOD_PKA_2	338	344	PF00069	0.208
MOD_PKA_2	436	442	PF00069	0.275
MOD_PKA_2	47	53	PF00069	0.312
MOD_PKA_2	67	73	PF00069	0.434
MOD_Plk_1	109	115	PF00069	0.388
MOD_Plk_1	280	286	PF00069	0.241
MOD_Plk_1	313	319	PF00069	0.257
MOD_Plk_2-3	109	115	PF00069	0.399
MOD_Plk_4	166	172	PF00069	0.267
MOD_Plk_4	197	203	PF00069	0.379
MOD_Plk_4	313	319	PF00069	0.254
MOD_Plk_4	415	421	PF00069	0.257
MOD_ProDKin_1	270	276	PF00069	0.165
MOD_ProDKin_1	375	381	PF00069	0.246
MOD_SUMO_rev_2	261	271	PF00179	0.165
MOD_SUMO_rev_2	365	374	PF00179	0.430
TRG_DiLeu_BaEn_1	148	153	PF01217	0.242
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.271
TRG_ENDOCYTIC_2	175	178	PF00928	0.347
TRG_ENDOCYTIC_2	304	307	PF00928	0.306
TRG_ENDOCYTIC_2	315	318	PF00928	0.262
TRG_ENDOCYTIC_2	396	399	PF00928	0.242
TRG_ER_diArg_1	225	227	PF00400	0.233
TRG_ER_diArg_1	293	296	PF00400	0.387
TRG_ER_diArg_1	436	438	PF00400	0.255
TRG_NLS_Bipartite_1	226	244	PF00514	0.165
TRG_NLS_MonoExtC_3	292	298	PF00514	0.307
TRG_NLS_MonoExtN_4	77	83	PF00514	0.304
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.165
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT9	Leptomonas seymouri	23%	83%
A0A0N1PE70	Leptomonas seymouri	55%	100%
A0A0S4IZA7	Bodo saltans	24%	99%
A0A0S4JRR3	Bodo saltans	41%	98%
A0A1X0P9B0	Trypanosomatidae	47%	100%
A0A1X0PB79	Trypanosomatidae	23%	96%
A0A381MTN1	Leishmania infantum	22%	84%
A0A3Q8ILB5	Leishmania donovani	22%	84%
A0A3R7KQW9	Trypanosoma rangeli	45%	100%
A0A3S7XA92	Leishmania donovani	68%	100%
A0A422N247	Trypanosoma rangeli	23%	96%
A4HB28	Leishmania braziliensis	22%	100%
A4ICV0	Leishmania infantum	68%	100%
C9ZM20	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	95%
D0A2K2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D3ZSI8	Rattus norvegicus	24%	84%
E9ASF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
E9B598	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	84%
O13010	Sus scrofa	25%	100%
O60331	Homo sapiens	25%	68%
O70161	Mus musculus	24%	69%
O70172	Mus musculus	25%	100%
O88377	Rattus norvegicus	24%	100%
P48426	Homo sapiens	25%	100%
P70182	Mus musculus	25%	84%
P78356	Homo sapiens	24%	100%
Q0P5F7	Bos taurus	26%	100%
Q17QS4	Bos taurus	25%	100%
Q4Q241	Leishmania major	66%	100%
Q4Q2N5	Leishmania major	22%	84%
Q5F356	Gallus gallus	25%	100%
Q5I6B8	Rattus norvegicus	24%	66%
Q5PQ01	Xenopus laevis	26%	100%
Q5T9C9	Homo sapiens	26%	100%
Q6GL14	Xenopus tropicalis	26%	100%
Q6IQE1	Danio rerio	24%	100%
Q80XI4	Mus musculus	24%	100%
Q8TBX8	Homo sapiens	26%	100%
Q91XU3	Mus musculus	25%	100%
Q99755	Homo sapiens	25%	81%
Q9R0I8	Rattus norvegicus	25%	100%
V5BA13	Trypanosoma cruzi	47%	100%
V5BV28	Trypanosoma cruzi	24%	96%