ER membrane protein complex subunit 3

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Integral membrane protein DUF106, putative

Species:

Leishmania braziliensis

UniProt:

A4HNP4_LEIBR

TriTrypDb:

LbrM.35.0450 , LBRM2903_350009900

Length:

259

Annotations

LeishMANIAdb annotations

A very conserved component of the ER translocon. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0032991	protein-containing complex	1	1
GO:0072546	EMC complex	3	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1

Expansion

Sequence features

A4HNP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNP4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	249	251	PF00082	0.588
CLV_PCSK_KEX2_1	257	259	PF00082	0.674
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.588
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.674
CLV_PCSK_SKI1_1	214	218	PF00082	0.474
CLV_PCSK_SKI1_1	249	253	PF00082	0.565
CLV_PCSK_SKI1_1	60	64	PF00082	0.420
DOC_CYCLIN_RxL_1	57	64	PF00134	0.234
DOC_CYCLIN_yClb5_NLxxxL_5	99	108	PF00134	0.151
DOC_MAPK_DCC_7	14	24	PF00069	0.306
DOC_MAPK_FxFP_2	138	141	PF00069	0.463
DOC_MAPK_MEF2A_6	14	23	PF00069	0.340
DOC_PP2B_PxIxI_1	19	25	PF00149	0.280
DOC_PP4_FxxP_1	138	141	PF00568	0.463
DOC_WW_Pin1_4	67	72	PF00397	0.234
LIG_BIR_II_1	1	5	PF00653	0.548
LIG_BRCT_BRCA1_1	126	130	PF00533	0.246
LIG_BRCT_BRCA1_1	142	146	PF00533	0.409
LIG_BRCT_BRCA1_1	167	171	PF00533	0.246
LIG_LIR_Gen_1	15	24	PF02991	0.246
LIG_LIR_Gen_1	211	220	PF02991	0.313
LIG_LIR_Nem_3	127	133	PF02991	0.247
LIG_LIR_Nem_3	15	19	PF02991	0.252
LIG_LIR_Nem_3	168	173	PF02991	0.265
LIG_LIR_Nem_3	211	215	PF02991	0.281
LIG_LYPXL_SIV_4	233	241	PF13949	0.231
LIG_MLH1_MIPbox_1	126	130	PF16413	0.246
LIG_MLH1_MIPbox_1	167	171	PF16413	0.246
LIG_NRBOX	179	185	PF00104	0.249
LIG_NRP_CendR_1	257	259	PF00754	0.633
LIG_PCNA_PIPBox_1	122	131	PF02747	0.246
LIG_Pex14_2	129	133	PF04695	0.246
LIG_Pex14_2	212	216	PF04695	0.374
LIG_PTB_Apo_2	157	164	PF02174	0.511
LIG_PTB_Phospho_1	157	163	PF10480	0.511
LIG_SH2_CRK	34	38	PF00017	0.167
LIG_SH2_CRK	58	62	PF00017	0.220
LIG_SH2_STAT5	128	131	PF00017	0.246
LIG_SH2_STAT5	163	166	PF00017	0.246
LIG_SH2_STAT5	170	173	PF00017	0.246
LIG_SH3_1	89	95	PF00018	0.151
LIG_SH3_3	14	20	PF00018	0.268
LIG_SH3_3	200	206	PF00018	0.329
LIG_SH3_3	65	71	PF00018	0.151
LIG_SH3_3	89	95	PF00018	0.316
LIG_SUMO_SIM_anti_2	155	160	PF11976	0.511
LIG_TRAF2_2	206	211	PF00917	0.281
LIG_UBA3_1	104	110	PF00899	0.231
LIG_UBA3_1	81	89	PF00899	0.263
MOD_CK1_1	70	76	PF00069	0.220
MOD_GlcNHglycan	105	108	PF01048	0.351
MOD_GlcNHglycan	130	133	PF01048	0.246
MOD_GlcNHglycan	174	177	PF01048	0.399
MOD_GlcNHglycan	252	255	PF01048	0.547
MOD_GlcNHglycan	63	66	PF01048	0.489
MOD_GSK3_1	124	131	PF00069	0.256
MOD_N-GLC_1	39	44	PF02516	0.351
MOD_NEK2_1	124	129	PF00069	0.277
MOD_NEK2_1	172	177	PF00069	0.278
MOD_NEK2_1	38	43	PF00069	0.153
MOD_NEK2_1	61	66	PF00069	0.289
MOD_PIKK_1	244	250	PF00454	0.349
MOD_Plk_4	124	130	PF00069	0.266
MOD_Plk_4	165	171	PF00069	0.260
MOD_ProDKin_1	67	73	PF00069	0.234
TRG_DiLeu_BaEn_1	4	9	PF01217	0.511
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.266
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.171
TRG_ENDOCYTIC_2	170	173	PF00928	0.246
TRG_ENDOCYTIC_2	34	37	PF00928	0.251
TRG_ENDOCYTIC_2	58	61	PF00928	0.220
TRG_ER_diArg_1	229	232	PF00400	0.236
TRG_NES_CRM1_1	46	56	PF08389	0.151
TRG_NLS_MonoExtN_4	246	253	PF00514	0.406
TRG_Pf-PMV_PEXEL_1	152	157	PF00026	0.284

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P702	Leptomonas seymouri	77%	100%
A0A0S4JI82	Bodo saltans	53%	100%
A0A1X0P9P9	Trypanosomatidae	64%	100%
A0A3S7XAB1	Leishmania donovani	89%	100%
A0A422P2C0	Trypanosoma rangeli	62%	100%
A4ICV1	Leishmania infantum	89%	100%
A7A082	Saccharomyces cerevisiae (strain YJM789)	30%	100%
B3LQQ2	Saccharomyces cerevisiae (strain RM11-1a)	28%	100%
B5VLV9	Saccharomyces cerevisiae (strain AWRI1631)	28%	100%
D0A2K0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9ASF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
P36039	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
Q3ZCB8	Bos taurus	33%	99%
Q4Q242	Leishmania major	88%	100%
Q54YN3	Dictyostelium discoideum	30%	82%
Q5R7C1	Pongo abelii	33%	99%
Q5U2V8	Rattus norvegicus	33%	99%
Q7SXW4	Danio rerio	34%	99%
Q99KI3	Mus musculus	33%	99%
Q9P0I2	Homo sapiens	33%	99%
Q9P787	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
V5DRR4	Trypanosoma cruzi	63%	100%