Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNP3_LEIBR

TriTrypDb:

LbrM.35.0440 , LBRM2903_350009800

Length:

503

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNP3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.430
CLV_NRD_NRD_1	163	165	PF00675	0.534
CLV_NRD_NRD_1	249	251	PF00675	0.544
CLV_NRD_NRD_1	291	293	PF00675	0.429
CLV_NRD_NRD_1	305	307	PF00675	0.378
CLV_NRD_NRD_1	309	311	PF00675	0.388
CLV_NRD_NRD_1	4	6	PF00675	0.574
CLV_NRD_NRD_1	412	414	PF00675	0.423
CLV_NRD_NRD_1	430	432	PF00675	0.588
CLV_NRD_NRD_1	437	439	PF00675	0.595
CLV_NRD_NRD_1	453	455	PF00675	0.451
CLV_NRD_NRD_1	75	77	PF00675	0.621
CLV_PCSK_FUR_1	428	432	PF00082	0.527
CLV_PCSK_KEX2_1	163	165	PF00082	0.534
CLV_PCSK_KEX2_1	249	251	PF00082	0.535
CLV_PCSK_KEX2_1	291	293	PF00082	0.427
CLV_PCSK_KEX2_1	3	5	PF00082	0.577
CLV_PCSK_KEX2_1	309	311	PF00082	0.397
CLV_PCSK_KEX2_1	412	414	PF00082	0.423
CLV_PCSK_KEX2_1	430	432	PF00082	0.588
CLV_PCSK_KEX2_1	453	455	PF00082	0.453
CLV_PCSK_KEX2_1	75	77	PF00082	0.600
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.554
CLV_PCSK_SKI1_1	215	219	PF00082	0.444
CLV_PCSK_SKI1_1	59	63	PF00082	0.681
DEG_Nend_UBRbox_3	1	3	PF02207	0.706
DOC_CYCLIN_RxL_1	168	179	PF00134	0.561
DOC_PP1_RVXF_1	213	219	PF00149	0.524
DOC_PP1_RVXF_1	269	275	PF00149	0.375
DOC_PP2B_LxvP_1	217	220	PF13499	0.440
DOC_PP2B_LxvP_1	265	268	PF13499	0.576
DOC_PP2B_LxvP_1	51	54	PF13499	0.613
DOC_PP4_FxxP_1	62	65	PF00568	0.668
DOC_USP7_MATH_1	108	112	PF00917	0.593
DOC_USP7_MATH_1	369	373	PF00917	0.628
DOC_USP7_MATH_1	429	433	PF00917	0.439
DOC_WW_Pin1_4	189	194	PF00397	0.549
DOC_WW_Pin1_4	364	369	PF00397	0.529
DOC_WW_Pin1_4	370	375	PF00397	0.495
LIG_14-3-3_CanoR_1	163	173	PF00244	0.551
LIG_14-3-3_CanoR_1	250	258	PF00244	0.666
LIG_14-3-3_CanoR_1	32	37	PF00244	0.776
LIG_14-3-3_CanoR_1	4	13	PF00244	0.697
LIG_14-3-3_CanoR_1	412	420	PF00244	0.498
LIG_14-3-3_CanoR_1	428	437	PF00244	0.445
LIG_14-3-3_CanoR_1	47	52	PF00244	0.613
LIG_14-3-3_CanoR_1	59	65	PF00244	0.595
LIG_14-3-3_CanoR_1	75	81	PF00244	0.494
LIG_BRCT_BRCA1_1	404	408	PF00533	0.390
LIG_CaM_IQ_9	283	298	PF13499	0.495
LIG_Clathr_ClatBox_1	398	402	PF01394	0.465
LIG_CSL_BTD_1	156	159	PF09270	0.507
LIG_eIF4E_1	211	217	PF01652	0.449
LIG_FHA_1	177	183	PF00498	0.555
LIG_FHA_1	195	201	PF00498	0.515
LIG_FHA_1	211	217	PF00498	0.393
LIG_FHA_1	232	238	PF00498	0.465
LIG_FHA_1	279	285	PF00498	0.364
LIG_FHA_1	361	367	PF00498	0.671
LIG_FHA_1	402	408	PF00498	0.383
LIG_LIR_Gen_1	314	322	PF02991	0.489
LIG_LIR_Gen_1	384	394	PF02991	0.417
LIG_LIR_Gen_1	405	416	PF02991	0.420
LIG_LIR_Gen_1	466	473	PF02991	0.377
LIG_LIR_Nem_3	302	308	PF02991	0.384
LIG_LIR_Nem_3	314	320	PF02991	0.407
LIG_LIR_Nem_3	384	389	PF02991	0.430
LIG_LIR_Nem_3	405	411	PF02991	0.404
LIG_LIR_Nem_3	466	472	PF02991	0.382
LIG_LIR_Nem_3	78	84	PF02991	0.541
LIG_Pex14_1	274	278	PF04695	0.353
LIG_Pex14_2	218	222	PF04695	0.522
LIG_PTB_Apo_2	472	479	PF02174	0.363
LIG_PTB_Phospho_1	472	478	PF10480	0.357
LIG_Rb_pABgroove_1	139	147	PF01858	0.515
LIG_SH2_CRK	211	215	PF00017	0.447
LIG_SH2_CRK	305	309	PF00017	0.379
LIG_SH2_PTP2	469	472	PF00017	0.278
LIG_SH2_SRC	241	244	PF00017	0.405
LIG_SH2_STAP1	381	385	PF00017	0.509
LIG_SH2_STAT5	277	280	PF00017	0.344
LIG_SH2_STAT5	469	472	PF00017	0.334
LIG_SH3_2	159	164	PF14604	0.606
LIG_SH3_3	13	19	PF00018	0.731
LIG_SH3_3	152	158	PF00018	0.615
LIG_SH3_3	496	502	PF00018	0.425
LIG_SUMO_SIM_par_1	195	203	PF11976	0.452
LIG_TRAF2_1	181	184	PF00917	0.459
LIG_TRAF2_1	433	436	PF00917	0.468
LIG_TYR_ITIM	303	308	PF00017	0.381
LIG_UBA3_1	216	223	PF00899	0.441
LIG_WW_3	52	56	PF00397	0.590
MOD_CK1_1	150	156	PF00069	0.611
MOD_CK1_1	189	195	PF00069	0.664
MOD_CK1_1	24	30	PF00069	0.568
MOD_CK1_1	349	355	PF00069	0.536
MOD_CK2_1	108	114	PF00069	0.535
MOD_CK2_1	189	195	PF00069	0.513
MOD_CK2_1	429	435	PF00069	0.535
MOD_GlcNHglycan	106	109	PF01048	0.805
MOD_GlcNHglycan	110	113	PF01048	0.693
MOD_GlcNHglycan	23	26	PF01048	0.562
MOD_GlcNHglycan	287	290	PF01048	0.335
MOD_GlcNHglycan	347	351	PF01048	0.477
MOD_GlcNHglycan	404	407	PF01048	0.384
MOD_GlcNHglycan	413	416	PF01048	0.423
MOD_GlcNHglycan	431	434	PF01048	0.441
MOD_GlcNHglycan	7	10	PF01048	0.684
MOD_GSK3_1	104	111	PF00069	0.577
MOD_GSK3_1	194	201	PF00069	0.525
MOD_GSK3_1	3	10	PF00069	0.684
MOD_GSK3_1	349	356	PF00069	0.572
MOD_GSK3_1	360	367	PF00069	0.598
MOD_GSK3_1	369	376	PF00069	0.566
MOD_GSK3_1	37	44	PF00069	0.555
MOD_GSK3_1	473	480	PF00069	0.447
MOD_GSK3_1	60	67	PF00069	0.648
MOD_GSK3_1	70	77	PF00069	0.533
MOD_GSK3_1	80	87	PF00069	0.480
MOD_N-GLC_1	370	375	PF02516	0.597
MOD_N-GLC_1	38	43	PF02516	0.553
MOD_N-GLC_1	473	478	PF02516	0.439
MOD_N-GLC_2	475	477	PF02516	0.353
MOD_NEK2_1	103	108	PF00069	0.698
MOD_NEK2_1	149	154	PF00069	0.671
MOD_NEK2_1	169	174	PF00069	0.690
MOD_NEK2_1	186	191	PF00069	0.607
MOD_NEK2_1	194	199	PF00069	0.724
MOD_NEK2_1	200	205	PF00069	0.426
MOD_NEK2_1	23	28	PF00069	0.708
MOD_NEK2_1	231	236	PF00069	0.375
MOD_NEK2_1	278	283	PF00069	0.331
MOD_NEK2_1	401	406	PF00069	0.389
MOD_NEK2_1	411	416	PF00069	0.424
MOD_NEK2_1	424	429	PF00069	0.551
MOD_NEK2_1	473	478	PF00069	0.439
MOD_NEK2_2	210	215	PF00069	0.414
MOD_NEK2_2	70	75	PF00069	0.537
MOD_PIKK_1	164	170	PF00454	0.571
MOD_PIKK_1	200	206	PF00454	0.431
MOD_PIKK_1	278	284	PF00454	0.332
MOD_PIKK_1	326	332	PF00454	0.469
MOD_PKA_1	128	134	PF00069	0.734
MOD_PKA_1	163	169	PF00069	0.515
MOD_PKA_1	3	9	PF00069	0.569
MOD_PKA_2	163	169	PF00069	0.567
MOD_PKA_2	251	257	PF00069	0.718
MOD_PKA_2	3	9	PF00069	0.575
MOD_PKA_2	411	417	PF00069	0.489
MOD_PKA_2	429	435	PF00069	0.476
MOD_PKA_2	74	80	PF00069	0.498
MOD_PKB_1	45	53	PF00069	0.673
MOD_Plk_1	136	142	PF00069	0.623
MOD_Plk_1	194	200	PF00069	0.483
MOD_Plk_1	473	479	PF00069	0.446
MOD_Plk_2-3	377	383	PF00069	0.495
MOD_Plk_4	150	156	PF00069	0.516
MOD_Plk_4	257	263	PF00069	0.518
MOD_Plk_4	316	322	PF00069	0.314
MOD_Plk_4	394	400	PF00069	0.387
MOD_Plk_4	464	470	PF00069	0.401
MOD_Plk_4	478	484	PF00069	0.372
MOD_Plk_4	7	13	PF00069	0.539
MOD_ProDKin_1	189	195	PF00069	0.549
MOD_ProDKin_1	364	370	PF00069	0.530
MOD_SUMO_rev_2	111	118	PF00179	0.508
MOD_SUMO_rev_2	347	354	PF00179	0.496
TRG_DiLeu_BaLyEn_6	212	217	PF01217	0.447
TRG_ENDOCYTIC_2	211	214	PF00928	0.449
TRG_ENDOCYTIC_2	305	308	PF00928	0.380
TRG_ENDOCYTIC_2	386	389	PF00928	0.362
TRG_ENDOCYTIC_2	469	472	PF00928	0.361
TRG_ER_diArg_1	162	164	PF00400	0.571
TRG_ER_diArg_1	249	252	PF00400	0.555
TRG_ER_diArg_1	290	292	PF00400	0.600
TRG_ER_diArg_1	308	310	PF00400	0.279
TRG_ER_diArg_1	31	34	PF00400	0.589
TRG_ER_diArg_1	411	413	PF00400	0.422
TRG_ER_diArg_1	428	431	PF00400	0.545
TRG_ER_diArg_1	74	76	PF00400	0.511
TRG_NLS_Bipartite_1	291	310	PF00514	0.402
TRG_NLS_MonoExtC_3	305	310	PF00514	0.389
TRG_Pf-PMV_PEXEL_1	163	168	PF00026	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYX2	Leptomonas seymouri	47%	100%
A0A3Q8IJS5	Leishmania donovani	62%	100%
A4ICV2	Leishmania infantum	63%	100%
E9ASF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
Q4Q243	Leishmania major	61%	100%