Nucleolar protein 10

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear protein family a (nop10p), putative

Species:

Leishmania braziliensis

UniProt:

A4HNP2_LEIBR

TriTrypDb:

LbrM.35.0430 , LBRM2903_350009700

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	8
GO:1990904	ribonucleoprotein complex	2	8
GO:0005732	sno(s)RNA-containing ribonucleoprotein complex	3	1
GO:0031429	box H/ACA snoRNP complex	3	1
GO:0072588	box H/ACA RNP complex	4	1
GO:0090661	box H/ACA telomerase RNP complex	3	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4HNP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNP2

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	8
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006364	rRNA processing	8	8
GO:0006396	RNA processing	6	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009451	RNA modification	5	8
GO:0009987	cellular process	1	8
GO:0016070	RNA metabolic process	5	8
GO:0016072	rRNA metabolic process	7	8
GO:0034470	ncRNA processing	7	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0034660	ncRNA metabolic process	6	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0046483	heterocycle metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8
GO:0000154	rRNA modification	6	1
GO:0016073	snRNA metabolic process	7	1
GO:0031118	rRNA pseudouridine synthesis	7	1
GO:0031120	snRNA pseudouridine synthesis	7	1
GO:0040031	snRNA modification	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0005488	binding	1	8
GO:0030515	snoRNA binding	5	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0034513	box H/ACA snoRNA binding	6	1
GO:0070034	telomerase RNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	49	51	PF00675	0.340
CLV_NRD_NRD_1	58	60	PF00675	0.633
CLV_PCSK_KEX2_1	11	13	PF00082	0.354
CLV_PCSK_KEX2_1	48	50	PF00082	0.342
CLV_PCSK_KEX2_1	58	60	PF00082	0.545
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.354
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.375
CLV_PCSK_PC7_1	44	50	PF00082	0.375
CLV_PCSK_SKI1_1	49	53	PF00082	0.375
DOC_MAPK_gen_1	39	47	PF00069	0.375
DOC_SPAK_OSR1_1	50	54	PF12202	0.638
DOC_USP7_UBL2_3	48	52	PF12436	0.375
DOC_WW_Pin1_4	32	37	PF00397	0.375
LIG_14-3-3_CanoR_1	12	17	PF00244	0.375
LIG_MAD2	52	60	PF02301	0.415
LIG_SH2_STAT5	14	17	PF00017	0.412
MOD_CDK_SPxxK_3	32	39	PF00069	0.375
MOD_Cter_Amidation	9	12	PF01082	0.375
MOD_GlcNHglycan	27	30	PF01048	0.342
MOD_PKA_2	43	49	PF00069	0.375
MOD_ProDKin_1	32	38	PF00069	0.375
MOD_SUMO_rev_2	20	26	PF00179	0.375
MOD_SUMO_rev_2	35	41	PF00179	0.367
TRG_ER_diArg_1	42	45	PF00400	0.351
TRG_ER_diArg_1	49	51	PF00400	0.326
TRG_ER_diArg_1	58	60	PF00400	0.633
TRG_NLS_MonoExtC_3	47	52	PF00514	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IK52	Leishmania donovani	92%	100%
A4ICV3	Leishmania infantum	92%	100%
D0A2J7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	84%	100%
E9ASF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q244	Leishmania major	90%	100%
Q54J26	Dictyostelium discoideum	56%	98%
Q6BQP3	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	60%	100%
Q6CSZ0	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	66%	100%
Q6DRH5	Danio rerio	62%	98%
Q6FNL3	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	68%	100%
Q6JZK2	Trypanosoma cruzi	81%	100%
Q6Q547	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	59%	100%
Q74Z52	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	67%	100%
Q93XX8	Arabidopsis thaliana	52%	98%
Q9CQS2	Mus musculus	61%	98%
Q9NPE3	Homo sapiens	61%	98%
Q9P7M5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	60%	98%
Q9V5P6	Drosophila melanogaster	62%	98%
Q9XVR8	Caenorhabditis elegans	49%	98%
V5BQL3	Trypanosoma cruzi	81%	100%