Ribonuclease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Ribonuclease

Gene product:

ribonuclease HII, putative

Species:

Leishmania braziliensis

UniProt:

A4HNP1_LEIBR

TriTrypDb:

LbrM.35.0420 , LBRM2903_350009600

Length:

474

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0032299	ribonuclease H2 complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4HNP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNP1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006298	mismatch repair	6	1
GO:0006401	RNA catabolic process	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0043137	DNA replication, removal of RNA primer	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0004518	nuclease activity	4	12
GO:0004519	endonuclease activity	5	12
GO:0004521	RNA endonuclease activity	5	12
GO:0004523	RNA-DNA hybrid ribonuclease activity	7	12
GO:0004540	RNA nuclease activity	4	12
GO:0005488	binding	1	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	12
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.603
CLV_NRD_NRD_1	12	14	PF00675	0.630
CLV_NRD_NRD_1	126	128	PF00675	0.612
CLV_NRD_NRD_1	456	458	PF00675	0.277
CLV_PCSK_FUR_1	124	128	PF00082	0.678
CLV_PCSK_FUR_1	29	33	PF00082	0.769
CLV_PCSK_KEX2_1	104	106	PF00082	0.640
CLV_PCSK_KEX2_1	12	14	PF00082	0.642
CLV_PCSK_KEX2_1	126	128	PF00082	0.557
CLV_PCSK_KEX2_1	210	212	PF00082	0.353
CLV_PCSK_KEX2_1	31	33	PF00082	0.705
CLV_PCSK_KEX2_1	340	342	PF00082	0.601
CLV_PCSK_KEX2_1	400	402	PF00082	0.287
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.353
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.767
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.608
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.287
CLV_PCSK_SKI1_1	127	131	PF00082	0.575
CLV_PCSK_SKI1_1	244	248	PF00082	0.395
CLV_PCSK_SKI1_1	31	35	PF00082	0.518
CLV_PCSK_SKI1_1	352	356	PF00082	0.668
CLV_PCSK_SKI1_1	464	468	PF00082	0.517
DEG_Nend_Nbox_1	1	3	PF02207	0.657
DEG_SPOP_SBC_1	317	321	PF00917	0.598
DOC_CKS1_1	249	254	PF01111	0.416
DOC_CYCLIN_RxL_1	240	251	PF00134	0.434
DOC_MAPK_gen_1	119	125	PF00069	0.497
DOC_MAPK_gen_1	126	136	PF00069	0.522
DOC_MAPK_gen_1	230	238	PF00069	0.587
DOC_MAPK_gen_1	26	35	PF00069	0.513
DOC_MAPK_RevD_3	113	127	PF00069	0.684
DOC_PP1_RVXF_1	188	195	PF00149	0.454
DOC_PP1_RVXF_1	29	36	PF00149	0.707
DOC_PP2B_LxvP_1	91	94	PF13499	0.709
DOC_PP4_FxxP_1	38	41	PF00568	0.723
DOC_SPAK_OSR1_1	211	215	PF12202	0.328
DOC_USP7_MATH_1	153	157	PF00917	0.413
DOC_USP7_MATH_1	159	163	PF00917	0.417
DOC_USP7_MATH_1	16	20	PF00917	0.715
DOC_USP7_MATH_1	317	321	PF00917	0.598
DOC_USP7_MATH_1	376	380	PF00917	0.537
DOC_USP7_MATH_1	406	410	PF00917	0.484
DOC_USP7_UBL2_3	240	244	PF12436	0.483
DOC_USP7_UBL2_3	445	449	PF12436	0.562
DOC_USP7_UBL2_3	469	473	PF12436	0.524
DOC_WW_Pin1_4	248	253	PF00397	0.424
LIG_14-3-3_CanoR_1	12	21	PF00244	0.689
LIG_14-3-3_CanoR_1	157	167	PF00244	0.472
LIG_14-3-3_CanoR_1	308	315	PF00244	0.530
LIG_14-3-3_CanoR_1	316	326	PF00244	0.470
LIG_14-3-3_CanoR_1	32	36	PF00244	0.592
LIG_14-3-3_CanoR_1	457	461	PF00244	0.476
LIG_BRCT_BRCA1_1	228	232	PF00533	0.625
LIG_Clathr_ClatBox_1	367	371	PF01394	0.476
LIG_FHA_1	12	18	PF00498	0.704
LIG_FHA_1	196	202	PF00498	0.477
LIG_FHA_1	249	255	PF00498	0.398
LIG_FHA_1	65	71	PF00498	0.583
LIG_FHA_1	94	100	PF00498	0.655
LIG_FHA_2	276	282	PF00498	0.404
LIG_FHA_2	413	419	PF00498	0.537
LIG_LIR_Apic_2	168	174	PF02991	0.659
LIG_LIR_Apic_2	339	345	PF02991	0.700
LIG_LIR_Gen_1	166	174	PF02991	0.593
LIG_LIR_Gen_1	175	185	PF02991	0.445
LIG_LIR_Gen_1	191	201	PF02991	0.360
LIG_LIR_Gen_1	202	212	PF02991	0.376
LIG_LIR_Gen_1	299	309	PF02991	0.548
LIG_LIR_Gen_1	379	388	PF02991	0.525
LIG_LIR_Gen_1	43	52	PF02991	0.691
LIG_LIR_Nem_3	166	170	PF02991	0.584
LIG_LIR_Nem_3	175	180	PF02991	0.458
LIG_LIR_Nem_3	191	197	PF02991	0.360
LIG_LIR_Nem_3	202	207	PF02991	0.345
LIG_LIR_Nem_3	256	260	PF02991	0.469
LIG_LIR_Nem_3	281	286	PF02991	0.523
LIG_LIR_Nem_3	299	304	PF02991	0.344
LIG_LIR_Nem_3	34	38	PF02991	0.678
LIG_LIR_Nem_3	355	360	PF02991	0.560
LIG_LIR_Nem_3	379	383	PF02991	0.509
LIG_LIR_Nem_3	43	47	PF02991	0.701
LIG_Pex14_2	163	167	PF04695	0.606
LIG_PTB_Apo_2	273	280	PF02174	0.374
LIG_PTB_Phospho_1	273	279	PF10480	0.374
LIG_SH2_CRK	342	346	PF00017	0.665
LIG_SH2_NCK_1	171	175	PF00017	0.651
LIG_SH2_NCK_1	260	264	PF00017	0.530
LIG_SH2_STAT5	253	256	PF00017	0.382
LIG_SH2_STAT5	266	269	PF00017	0.386
LIG_SH2_STAT5	279	282	PF00017	0.395
LIG_SH2_STAT5	325	328	PF00017	0.441
LIG_SH2_STAT5	357	360	PF00017	0.549
LIG_SH2_STAT5	382	385	PF00017	0.562
LIG_SH2_STAT5	422	425	PF00017	0.487
LIG_SH2_STAT5	446	449	PF00017	0.562
LIG_SH3_3	34	40	PF00018	0.720
LIG_SH3_3	359	365	PF00018	0.476
LIG_SH3_3	372	378	PF00018	0.474
LIG_SH3_5	378	382	PF00018	0.562
LIG_SUMO_SIM_anti_2	67	72	PF11976	0.605
LIG_SUMO_SIM_par_1	365	371	PF11976	0.476
LIG_WRC_WIRS_1	160	165	PF05994	0.514
MOD_CK1_1	100	106	PF00069	0.694
MOD_CK1_1	248	254	PF00069	0.432
MOD_CK1_1	289	295	PF00069	0.377
MOD_CK1_1	296	302	PF00069	0.389
MOD_CK1_1	310	316	PF00069	0.593
MOD_CK1_1	87	93	PF00069	0.545
MOD_CK2_1	125	131	PF00069	0.591
MOD_CK2_1	181	187	PF00069	0.462
MOD_CK2_1	412	418	PF00069	0.537
MOD_GlcNHglycan	14	17	PF01048	0.732
MOD_GlcNHglycan	18	21	PF01048	0.722
MOD_GlcNHglycan	261	264	PF01048	0.497
MOD_GlcNHglycan	295	298	PF01048	0.448
MOD_GlcNHglycan	86	89	PF01048	0.707
MOD_GlcNHglycan	99	102	PF01048	0.467
MOD_GSK3_1	12	19	PF00069	0.728
MOD_GSK3_1	125	132	PF00069	0.553
MOD_GSK3_1	179	186	PF00069	0.486
MOD_GSK3_1	222	229	PF00069	0.690
MOD_GSK3_1	289	296	PF00069	0.405
MOD_GSK3_1	325	332	PF00069	0.603
MOD_GSK3_1	56	63	PF00069	0.587
MOD_GSK3_1	93	100	PF00069	0.640
MOD_N-GLC_1	275	280	PF02516	0.427
MOD_N-GLC_1	286	291	PF02516	0.445
MOD_N-GLC_1	84	89	PF02516	0.490
MOD_NEK2_1	125	130	PF00069	0.584
MOD_NEK2_1	236	241	PF00069	0.502
MOD_NEK2_1	293	298	PF00069	0.403
MOD_NEK2_1	467	472	PF00069	0.552
MOD_PIKK_1	467	473	PF00454	0.560
MOD_PK_1	318	324	PF00069	0.480
MOD_PK_1	401	407	PF00069	0.537
MOD_PKA_1	12	18	PF00069	0.685
MOD_PKA_1	31	37	PF00069	0.475
MOD_PKA_2	11	17	PF00069	0.703
MOD_PKA_2	125	131	PF00069	0.550
MOD_PKA_2	307	313	PF00069	0.518
MOD_PKA_2	31	37	PF00069	0.435
MOD_PKA_2	317	323	PF00069	0.471
MOD_PKA_2	456	462	PF00069	0.476
MOD_PKA_2	54	60	PF00069	0.656
MOD_PKB_1	316	324	PF00069	0.574
MOD_Plk_1	275	281	PF00069	0.411
MOD_Plk_1	286	292	PF00069	0.441
MOD_Plk_2-3	181	187	PF00069	0.482
MOD_Plk_4	222	228	PF00069	0.687
MOD_Plk_4	275	281	PF00069	0.411
MOD_Plk_4	296	302	PF00069	0.509
MOD_Plk_4	318	324	PF00069	0.340
MOD_ProDKin_1	248	254	PF00069	0.418
MOD_SUMO_rev_2	175	185	PF00179	0.502
TRG_ENDOCYTIC_2	266	269	PF00928	0.386
TRG_ENDOCYTIC_2	357	360	PF00928	0.581
TRG_ENDOCYTIC_2	380	383	PF00928	0.540
TRG_ER_diArg_1	11	13	PF00400	0.631
TRG_ER_diArg_1	123	126	PF00400	0.607
TRG_ER_diArg_1	315	318	PF00400	0.628
TRG_Pf-PMV_PEXEL_1	105	110	PF00026	0.652
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	26	30	PF00026	0.761

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILG3	Leptomonas seymouri	83%	100%
A0A0S4JMV0	Bodo saltans	36%	82%
A0A1X0P978	Trypanosomatidae	55%	100%
A0A3Q8IFS0	Leishmania donovani	90%	100%
A0A3R7P2T0	Trypanosoma rangeli	60%	99%
A4ICV4	Leishmania infantum	90%	100%
D0A2J6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	99%
E9ASF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q8WSZ0	Leishmania major	90%	100%
V5BQJ3	Trypanosoma cruzi	60%	99%