Proteasome subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome subunit beta type-2, putative

Species:

Leishmania braziliensis

UniProt:

A4HNP0_LEIBR

TriTrypDb:

LbrM.35.0400 , LBRM2903_350009400

Length:

206

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0005737	cytoplasm	2	12
GO:0005839	proteasome core complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0140535	intracellular protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:0019774	proteasome core complex, beta-subunit complex	2	1
GO:0016020	membrane	2	2

Expansion

Sequence features

A4HNP0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNP0

PDB structure(s): 6qm7_K , 6qm7_Y , 6qm8_K , 6qm8_Y

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0010498	proteasomal protein catabolic process	5	12
GO:0019538	protein metabolic process	3	12
GO:0030163	protein catabolic process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0051603	proteolysis involved in protein catabolic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901565	organonitrogen compound catabolic process	4	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016787	hydrolase activity	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.328
CLV_PCSK_KEX2_1	179	181	PF00082	0.263
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.275
CLV_PCSK_SKI1_1	192	196	PF00082	0.329
DOC_PP1_RVXF_1	52	58	PF00149	0.486
DOC_USP7_MATH_1	93	97	PF00917	0.523
DOC_USP7_UBL2_3	192	196	PF12436	0.351
LIG_14-3-3_CanoR_1	87	91	PF00244	0.432
LIG_BIR_II_1	1	5	PF00653	0.297
LIG_Clathr_ClatBox_1	126	130	PF01394	0.529
LIG_eIF4E_1	101	107	PF01652	0.486
LIG_FHA_1	149	155	PF00498	0.481
LIG_FHA_1	39	45	PF00498	0.592
LIG_FHA_1	56	62	PF00498	0.542
LIG_FHA_2	161	167	PF00498	0.462
LIG_FHA_2	28	34	PF00498	0.473
LIG_FHA_2	35	41	PF00498	0.448
LIG_PTB_Apo_2	183	190	PF02174	0.462
LIG_REV1ctd_RIR_1	187	196	PF16727	0.590
LIG_SH2_CRK	110	114	PF00017	0.504
LIG_SH2_PTP2	13	16	PF00017	0.510
LIG_SH2_PTP2	26	29	PF00017	0.462
LIG_SH2_STAT5	13	16	PF00017	0.510
LIG_SH2_STAT5	131	134	PF00017	0.475
LIG_SH2_STAT5	26	29	PF00017	0.494
LIG_SH2_STAT5	60	63	PF00017	0.478
LIG_SUMO_SIM_anti_2	166	172	PF11976	0.472
LIG_TRAF2_1	163	166	PF00917	0.472
LIG_TRAF2_1	30	33	PF00917	0.482
MOD_CK1_1	148	154	PF00069	0.443
MOD_CK1_1	78	84	PF00069	0.614
MOD_CK1_1	89	95	PF00069	0.576
MOD_CK2_1	160	166	PF00069	0.462
MOD_CK2_1	27	33	PF00069	0.504
MOD_CK2_1	74	80	PF00069	0.420
MOD_GlcNHglycan	202	205	PF01048	0.315
MOD_GlcNHglycan	91	94	PF01048	0.377
MOD_GSK3_1	145	152	PF00069	0.485
MOD_GSK3_1	34	41	PF00069	0.472
MOD_GSK3_1	74	81	PF00069	0.495
MOD_GSK3_1	89	96	PF00069	0.471
MOD_LATS_1	73	79	PF00433	0.504
MOD_N-GLC_1	55	60	PF02516	0.385
MOD_NEK2_1	1	6	PF00069	0.336
MOD_NEK2_1	149	154	PF00069	0.415
MOD_NEK2_1	86	91	PF00069	0.412
MOD_PIKK_1	34	40	PF00454	0.486
MOD_PKA_2	74	80	PF00069	0.496
MOD_PKA_2	86	92	PF00069	0.508
MOD_Plk_4	145	151	PF00069	0.430
MOD_SUMO_rev_2	31	37	PF00179	0.462
TRG_DiLeu_BaEn_1	166	171	PF01217	0.462
TRG_ENDOCYTIC_2	13	16	PF00928	0.607
TRG_ENDOCYTIC_2	26	29	PF00928	0.494
TRG_ER_diArg_1	180	182	PF00400	0.531
TRG_ER_diArg_1	94	97	PF00400	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILR7	Leptomonas seymouri	89%	100%
A0A0S4J7A1	Bodo saltans	26%	83%
A0A0S4JIF5	Bodo saltans	61%	100%
A0A1X0P8B0	Trypanosomatidae	65%	94%
A0A3S5ISK6	Trypanosoma rangeli	70%	100%
A0A3S7XA80	Leishmania donovani	90%	100%
A4ICV5	Leishmania infantum	90%	100%
A5DB52	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	39%	100%
A5UM14	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	23%	100%
B1L6X8	Korarchaeum cryptofilum (strain OPF8)	22%	100%
C9REN7	Methanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7)	24%	92%
D0A2J4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9ASE9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O23714	Arabidopsis thaliana	41%	100%
O24633	Arabidopsis thaliana	41%	100%
O50110	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	26%	100%
P0CQ12	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	33%	92%
P0CQ13	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	33%	92%
P22141	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	100%
P40307	Rattus norvegicus	38%	100%
P49721	Homo sapiens	39%	100%
P91477	Caenorhabditis elegans	33%	100%
Q09720	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
Q4Q246	Leishmania major	89%	100%
Q55DY7	Dictyostelium discoideum	41%	100%
Q5E9K0	Bos taurus	38%	100%
Q8SRF1	Encephalitozoon cuniculi (strain GB-M1)	27%	100%
Q8U125	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	26%	100%
Q9LST6	Oryza sativa subsp. japonica	42%	97%
Q9NHC6	Trypanosoma brucei brucei	69%	100%
Q9P6U7	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	41%	100%
Q9R1P3	Mus musculus	38%	100%
Q9V0N9	Pyrococcus abyssi (strain GE5 / Orsay)	26%	100%
Q9VQE5	Drosophila melanogaster	33%	98%
V5C017	Trypanosoma cruzi	72%	100%