Conserved NUDIX hydrolase protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mutt-Nudix-related hydrolase 5, putative

Species:

Leishmania braziliensis

UniProt:

A4HNN8_LEIBR

TriTrypDb:

LbrM.35.0380 , LBRM2903_350009200

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNN8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006195	purine nucleotide catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009154	purine ribonucleotide catabolic process	6	1
GO:0009166	nucleotide catabolic process	6	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009261	ribonucleotide catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0015936	coenzyme A metabolic process	6	1
GO:0015938	coenzyme A catabolic process	7	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0033865	nucleoside bisphosphate metabolic process	5	1
GO:0033869	nucleoside bisphosphate catabolic process	6	1
GO:0033875	ribonucleoside bisphosphate metabolic process	6	1
GO:0034031	ribonucleoside bisphosphate catabolic process	7	1
GO:0034032	purine nucleoside bisphosphate metabolic process	5	1
GO:0034034	purine nucleoside bisphosphate catabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046434	organophosphate catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:0072523	purine-containing compound catabolic process	5	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901136	carbohydrate derivative catabolic process	4	1
GO:1901292	nucleoside phosphate catabolic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0010945	CoA pyrophosphatase activity	6	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0003986	acetyl-CoA hydrolase activity	6	1
GO:0016289	CoA hydrolase activity	5	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016790	thiolester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	174	178	PF00656	0.300
CLV_C14_Caspase3-7	43	47	PF00656	0.344
CLV_NRD_NRD_1	229	231	PF00675	0.289
CLV_PCSK_KEX2_1	207	209	PF00082	0.466
CLV_PCSK_KEX2_1	229	231	PF00082	0.289
CLV_PCSK_KEX2_1	93	95	PF00082	0.286
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.456
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.286
CLV_PCSK_SKI1_1	124	128	PF00082	0.374
CLV_PCSK_SKI1_1	197	201	PF00082	0.290
CLV_PCSK_SKI1_1	270	274	PF00082	0.363
DEG_APCC_DBOX_1	123	131	PF00400	0.415
DEG_Nend_Nbox_1	1	3	PF02207	0.475
DEG_SCF_FBW7_1	143	148	PF00400	0.297
DOC_CKS1_1	57	62	PF01111	0.480
DOC_CKS1_1	63	68	PF01111	0.377
DOC_MAPK_MEF2A_6	67	75	PF00069	0.353
DOC_PP2B_LxvP_1	290	293	PF13499	0.461
DOC_PP4_FxxP_1	216	219	PF00568	0.452
DOC_USP7_MATH_1	191	195	PF00917	0.410
DOC_USP7_MATH_1	29	33	PF00917	0.429
DOC_USP7_MATH_1	34	38	PF00917	0.358
DOC_USP7_MATH_2	173	179	PF00917	0.286
DOC_USP7_UBL2_3	58	62	PF12436	0.418
DOC_WW_Pin1_4	114	119	PF00397	0.389
DOC_WW_Pin1_4	141	146	PF00397	0.343
DOC_WW_Pin1_4	153	158	PF00397	0.325
DOC_WW_Pin1_4	169	174	PF00397	0.273
DOC_WW_Pin1_4	215	220	PF00397	0.439
DOC_WW_Pin1_4	222	227	PF00397	0.485
DOC_WW_Pin1_4	228	233	PF00397	0.434
DOC_WW_Pin1_4	52	57	PF00397	0.532
DOC_WW_Pin1_4	62	67	PF00397	0.447
DOC_WW_Pin1_4	73	78	PF00397	0.304
LIG_14-3-3_CanoR_1	10	20	PF00244	0.405
LIG_Actin_WH2_2	175	192	PF00022	0.285
LIG_BRCT_BRCA1_1	31	35	PF00533	0.410
LIG_FHA_1	154	160	PF00498	0.338
LIG_FHA_1	161	167	PF00498	0.259
LIG_FHA_1	184	190	PF00498	0.262
LIG_FHA_1	262	268	PF00498	0.350
LIG_FHA_1	93	99	PF00498	0.193
LIG_FHA_2	41	47	PF00498	0.605
LIG_GBD_Chelix_1	255	263	PF00786	0.225
LIG_LIR_Gen_1	135	145	PF02991	0.252
LIG_LIR_Gen_1	156	166	PF02991	0.415
LIG_LIR_Gen_1	178	189	PF02991	0.271
LIG_LIR_Gen_1	82	91	PF02991	0.287
LIG_LIR_Nem_3	135	140	PF02991	0.288
LIG_LIR_Nem_3	156	161	PF02991	0.363
LIG_LIR_Nem_3	178	184	PF02991	0.192
LIG_NRBOX	183	189	PF00104	0.203
LIG_Pex14_2	211	215	PF04695	0.321
LIG_Pex14_2	35	39	PF04695	0.401
LIG_SH2_CRK	201	205	PF00017	0.496
LIG_SH2_NCK_1	137	141	PF00017	0.398
LIG_SH2_SRC	137	140	PF00017	0.398
LIG_SH2_STAT5	181	184	PF00017	0.301
LIG_SH3_2	165	170	PF14604	0.343
LIG_SH3_3	162	168	PF00018	0.331
LIG_SH3_3	242	248	PF00018	0.425
LIG_SH3_3	273	279	PF00018	0.265
LIG_SH3_3	30	36	PF00018	0.426
LIG_SUMO_SIM_par_1	70	76	PF11976	0.321
LIG_TRAF2_1	126	129	PF00917	0.286
LIG_TRAF2_1	172	175	PF00917	0.288
LIG_TYR_ITIM	179	184	PF00017	0.186
LIG_TYR_ITIM	199	204	PF00017	0.318
LIG_WRC_WIRS_1	41	46	PF05994	0.304
MOD_CDC14_SPxK_1	55	58	PF00782	0.615
MOD_CDK_SPK_2	114	119	PF00069	0.192
MOD_CDK_SPK_2	228	233	PF00069	0.425
MOD_CDK_SPK_2	62	67	PF00069	0.357
MOD_CDK_SPxK_1	52	58	PF00069	0.607
MOD_CDK_SPxxK_3	222	229	PF00069	0.290
MOD_CK1_1	100	106	PF00069	0.423
MOD_CK1_1	147	153	PF00069	0.230
MOD_CK1_1	203	209	PF00069	0.451
MOD_CK1_1	261	267	PF00069	0.379
MOD_CK1_1	45	51	PF00069	0.487
MOD_CK2_1	132	138	PF00069	0.316
MOD_CK2_1	169	175	PF00069	0.317
MOD_CK2_1	280	286	PF00069	0.295
MOD_GlcNHglycan	13	16	PF01048	0.378
MOD_GlcNHglycan	282	285	PF01048	0.477
MOD_GSK3_1	141	148	PF00069	0.333
MOD_GSK3_1	257	264	PF00069	0.353
MOD_GSK3_1	42	49	PF00069	0.503
MOD_GSK3_1	52	59	PF00069	0.508
MOD_GSK3_1	73	80	PF00069	0.570
MOD_GSK3_1	92	99	PF00069	0.285
MOD_NEK2_1	1	6	PF00069	0.434
MOD_NEK2_1	182	187	PF00069	0.280
MOD_NEK2_1	189	194	PF00069	0.260
MOD_NEK2_1	302	307	PF00069	0.569
MOD_NEK2_1	87	92	PF00069	0.304
MOD_PIKK_1	147	153	PF00454	0.192
MOD_Plk_1	103	109	PF00069	0.415
MOD_Plk_4	183	189	PF00069	0.406
MOD_Plk_4	258	264	PF00069	0.453
MOD_ProDKin_1	114	120	PF00069	0.389
MOD_ProDKin_1	141	147	PF00069	0.343
MOD_ProDKin_1	153	159	PF00069	0.325
MOD_ProDKin_1	169	175	PF00069	0.273
MOD_ProDKin_1	215	221	PF00069	0.439
MOD_ProDKin_1	222	228	PF00069	0.479
MOD_ProDKin_1	52	58	PF00069	0.538
MOD_ProDKin_1	62	68	PF00069	0.437
MOD_ProDKin_1	73	79	PF00069	0.318
TRG_DiLeu_BaEn_1	128	133	PF01217	0.336
TRG_DiLeu_BaEn_1	286	291	PF01217	0.256
TRG_DiLeu_BaEn_4	128	134	PF01217	0.336
TRG_DiLeu_BaEn_4	174	180	PF01217	0.192
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.523
TRG_ENDOCYTIC_2	137	140	PF00928	0.271
TRG_ENDOCYTIC_2	181	184	PF00928	0.271
TRG_ENDOCYTIC_2	201	204	PF00928	0.505
TRG_ER_diArg_1	228	230	PF00400	0.318
TRG_NES_CRM1_1	266	280	PF08389	0.350

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I791	Leptomonas seymouri	58%	97%
A0A0S4JMA9	Bodo saltans	34%	97%
A0A1X0P9B8	Trypanosomatidae	42%	100%
A0A3R7N2P2	Trypanosoma rangeli	46%	100%
A0A3S7XAB7	Leishmania donovani	80%	92%
A4ICV7	Leishmania infantum	79%	92%
D0A2J1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9ASE7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q248	Leishmania major	78%	100%
V5BZZ8	Trypanosoma cruzi	46%	100%