Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNN7_LEIBR

TriTrypDb:

LbrM.35.0370 , LBRM2903_350009100

Length:

316

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HNN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNN7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.593
CLV_NRD_NRD_1	205	207	PF00675	0.629
CLV_NRD_NRD_1	3	5	PF00675	0.463
CLV_NRD_NRD_1	54	56	PF00675	0.580
CLV_PCSK_KEX2_1	102	104	PF00082	0.615
CLV_PCSK_KEX2_1	2	4	PF00082	0.515
CLV_PCSK_KEX2_1	204	206	PF00082	0.633
CLV_PCSK_KEX2_1	54	56	PF00082	0.580
CLV_PCSK_PC7_1	98	104	PF00082	0.675
DEG_Nend_UBRbox_1	1	4	PF02207	0.721
DOC_CYCLIN_yCln2_LP_2	251	254	PF00134	0.579
DOC_MAPK_gen_1	102	111	PF00069	0.448
DOC_MAPK_MEF2A_6	166	173	PF00069	0.403
DOC_PP2B_LxvP_1	251	254	PF13499	0.579
DOC_PP4_FxxP_1	35	38	PF00568	0.543
DOC_USP7_MATH_1	194	198	PF00917	0.451
DOC_WW_Pin1_4	214	219	PF00397	0.489
LIG_14-3-3_CanoR_1	126	130	PF00244	0.287
LIG_14-3-3_CanoR_1	236	241	PF00244	0.396
LIG_14-3-3_CanoR_1	54	60	PF00244	0.292
LIG_AP2alpha_2	242	244	PF02296	0.489
LIG_APCC_ABBA_1	216	221	PF00400	0.601
LIG_eIF4E_1	13	19	PF01652	0.514
LIG_FHA_1	13	19	PF00498	0.256
LIG_FHA_1	254	260	PF00498	0.541
LIG_FHA_1	286	292	PF00498	0.411
LIG_FHA_1	307	313	PF00498	0.471
LIG_FHA_2	158	164	PF00498	0.492
LIG_FHA_2	66	72	PF00498	0.453
LIG_LIR_Apic_2	135	140	PF02991	0.503
LIG_LIR_Apic_2	239	243	PF02991	0.413
LIG_LIR_Apic_2	72	78	PF02991	0.314
LIG_LIR_Gen_1	271	280	PF02991	0.526
LIG_LIR_Gen_1	288	297	PF02991	0.292
LIG_LIR_Nem_3	241	247	PF02991	0.573
LIG_LIR_Nem_3	271	277	PF02991	0.470
LIG_LIR_Nem_3	288	292	PF02991	0.376
LIG_LIR_Nem_3	309	313	PF02991	0.684
LIG_LIR_Nem_3	31	35	PF02991	0.454
LIG_MYND_1	249	253	PF01753	0.586
LIG_NRBOX	20	26	PF00104	0.481
LIG_Pex14_1	240	244	PF04695	0.491
LIG_Pex14_1	311	315	PF04695	0.643
LIG_Pex14_2	22	26	PF04695	0.303
LIG_Pex14_2	300	304	PF04695	0.412
LIG_PTB_Apo_2	258	265	PF02174	0.484
LIG_PTB_Phospho_1	258	264	PF10480	0.488
LIG_RPA_C_Fungi	193	205	PF08784	0.501
LIG_SH2_CRK	274	278	PF00017	0.678
LIG_SH2_NCK_1	127	131	PF00017	0.591
LIG_SH2_SRC	113	116	PF00017	0.609
LIG_SH2_SRC	75	78	PF00017	0.328
LIG_SH2_STAP1	155	159	PF00017	0.495
LIG_SH2_STAT5	127	130	PF00017	0.326
LIG_SH2_STAT5	172	175	PF00017	0.471
LIG_SH2_STAT5	264	267	PF00017	0.598
LIG_SH2_STAT5	75	78	PF00017	0.492
LIG_SH3_3	225	231	PF00018	0.685
LIG_SH3_3	240	246	PF00018	0.696
LIG_SH3_3	256	262	PF00018	0.614
LIG_TYR_ITIM	272	277	PF00017	0.681
LIG_UBA3_1	34	40	PF00899	0.409
LIG_WRC_WIRS_1	286	291	PF05994	0.343
LIG_WW_3	252	256	PF00397	0.631
MOD_CDK_SPxK_1	214	220	PF00069	0.680
MOD_CK1_1	157	163	PF00069	0.519
MOD_CK1_1	285	291	PF00069	0.495
MOD_CK1_1	65	71	PF00069	0.595
MOD_CK2_1	157	163	PF00069	0.444
MOD_CK2_1	194	200	PF00069	0.506
MOD_Cter_Amidation	52	55	PF01082	0.468
MOD_GlcNHglycan	301	304	PF01048	0.256
MOD_GlcNHglycan	65	68	PF01048	0.385
MOD_GlcNHglycan	7	10	PF01048	0.665
MOD_GSK3_1	219	226	PF00069	0.724
MOD_GSK3_1	24	31	PF00069	0.381
MOD_GSK3_1	281	288	PF00069	0.512
MOD_GSK3_1	55	62	PF00069	0.499
MOD_GSK3_1	65	72	PF00069	0.342
MOD_NEK2_1	12	17	PF00069	0.324
MOD_NEK2_1	24	29	PF00069	0.378
MOD_NEK2_1	299	304	PF00069	0.334
MOD_NEK2_1	59	64	PF00069	0.503
MOD_NEK2_2	231	236	PF00069	0.660
MOD_PK_1	105	111	PF00069	0.334
MOD_PKA_1	54	60	PF00069	0.336
MOD_PKA_2	125	131	PF00069	0.341
MOD_PKA_2	219	225	PF00069	0.679
MOD_PKA_2	54	60	PF00069	0.336
MOD_PKB_1	103	111	PF00069	0.330
MOD_Plk_1	270	276	PF00069	0.416
MOD_Plk_2-3	87	93	PF00069	0.663
MOD_Plk_4	264	270	PF00069	0.624
MOD_Plk_4	306	312	PF00069	0.588
MOD_Plk_4	55	61	PF00069	0.540
MOD_ProDKin_1	214	220	PF00069	0.618
MOD_SUMO_for_1	144	147	PF00179	0.457
TRG_DiLeu_BaEn_3	91	97	PF01217	0.627
TRG_ENDOCYTIC_2	274	277	PF00928	0.577
TRG_ENDOCYTIC_2	310	313	PF00928	0.650
TRG_ER_diArg_1	1	4	PF00400	0.656
TRG_ER_diArg_1	102	104	PF00400	0.478
TRG_ER_diArg_1	181	184	PF00400	0.535
TRG_ER_diArg_1	203	206	PF00400	0.526
TRG_ER_diArg_1	54	56	PF00400	0.459
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Z7	Leptomonas seymouri	46%	99%
A0A3S7XAG8	Leishmania donovani	76%	100%
A4ICV8	Leishmania infantum	76%	100%
E9ASE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q249	Leishmania major	77%	100%