TFIIS central domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNN6_LEIBR

TriTrypDb:

LbrM.35.0360 , LBRM2903_350009000

Length:

201

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNN6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNN6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006351	DNA-templated transcription	7	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009058	biosynthetic process	2	3
GO:0009059	macromolecule biosynthetic process	4	3
GO:0009987	cellular process	1	3
GO:0016070	RNA metabolic process	5	3
GO:0018130	heterocycle biosynthetic process	4	3
GO:0019438	aromatic compound biosynthetic process	4	3
GO:0032774	RNA biosynthetic process	5	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0034654	nucleobase-containing compound biosynthetic process	4	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044249	cellular biosynthetic process	3	3
GO:0044271	cellular nitrogen compound biosynthetic process	4	3
GO:0046483	heterocycle metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0090304	nucleic acid metabolic process	4	3
GO:0097659	nucleic acid-templated transcription	6	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:1901362	organic cyclic compound biosynthetic process	4	3
GO:1901576	organic substance biosynthetic process	3	3

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.512
CLV_PCSK_KEX2_1	105	107	PF00082	0.478
CLV_PCSK_KEX2_1	114	116	PF00082	0.439
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.498
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.424
DEG_SPOP_SBC_1	2	6	PF00917	0.587
DOC_CYCLIN_yClb5_NLxxxL_5	69	75	PF00134	0.462
DOC_MAPK_gen_1	11	21	PF00069	0.355
DOC_MAPK_MEF2A_6	14	23	PF00069	0.437
DOC_USP7_MATH_1	146	150	PF00917	0.532
DOC_USP7_MATH_1	151	155	PF00917	0.520
DOC_USP7_MATH_1	185	189	PF00917	0.645
DOC_USP7_MATH_1	195	199	PF00917	0.633
DOC_USP7_MATH_1	2	6	PF00917	0.587
DOC_USP7_MATH_1	98	102	PF00917	0.639
DOC_WW_Pin1_4	50	55	PF00397	0.364
LIG_BIR_II_1	1	5	PF00653	0.586
LIG_FHA_1	18	24	PF00498	0.306
LIG_FHA_2	118	124	PF00498	0.552
LIG_FHA_2	192	198	PF00498	0.717
LIG_FHA_2	51	57	PF00498	0.459
LIG_GBD_Chelix_1	15	23	PF00786	0.430
LIG_Pex14_2	156	160	PF04695	0.505
LIG_SH2_STAP1	39	43	PF00017	0.400
LIG_SH2_STAT3	39	42	PF00017	0.447
LIG_TRAF2_1	170	173	PF00917	0.621
LIG_TRAF2_1	53	56	PF00917	0.553
LIG_UBA3_1	61	69	PF00899	0.467
MOD_CK1_1	149	155	PF00069	0.559
MOD_CK1_1	167	173	PF00069	0.560
MOD_CK1_1	3	9	PF00069	0.678
MOD_CK2_1	166	172	PF00069	0.599
MOD_CK2_1	174	180	PF00069	0.678
MOD_CK2_1	50	56	PF00069	0.470
MOD_CK2_1	84	90	PF00069	0.511
MOD_GlcNHglycan	100	103	PF01048	0.571
MOD_GlcNHglycan	150	154	PF01048	0.608
MOD_GlcNHglycan	180	186	PF01048	0.727
MOD_GlcNHglycan	190	194	PF01048	0.515
MOD_GlcNHglycan	31	35	PF01048	0.579
MOD_GlcNHglycan	8	11	PF01048	0.567
MOD_GlcNHglycan	86	89	PF01048	0.565
MOD_GSK3_1	118	125	PF00069	0.487
MOD_GSK3_1	160	167	PF00069	0.630
MOD_GSK3_1	181	188	PF00069	0.645
MOD_GSK3_1	191	198	PF00069	0.598
MOD_GSK3_1	2	9	PF00069	0.670
MOD_N-GLC_1	50	55	PF02516	0.548
MOD_N-GLC_2	162	164	PF02516	0.462
MOD_NEK2_1	1	6	PF00069	0.685
MOD_NEK2_1	160	165	PF00069	0.543
MOD_PKA_2	173	179	PF00069	0.709
MOD_PKB_1	115	123	PF00069	0.550
MOD_Plk_1	117	123	PF00069	0.519
MOD_Plk_2-3	118	124	PF00069	0.505
MOD_Plk_2-3	90	96	PF00069	0.578
MOD_ProDKin_1	50	56	PF00069	0.363
MOD_SUMO_rev_2	7	16	PF00179	0.571
MOD_SUMO_rev_2	79	84	PF00179	0.727
TRG_ER_diArg_1	112	115	PF00400	0.481
TRG_NLS_MonoExtC_3	112	117	PF00514	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7E0	Leptomonas seymouri	65%	100%
A0A0S4JM83	Bodo saltans	29%	100%
A0A1X0P8N4	Trypanosomatidae	45%	100%
A0A3Q8IVQ2	Leishmania donovani	78%	70%
A0A422P2F0	Trypanosoma rangeli	45%	100%
A4ICV9	Leishmania infantum	79%	100%
D0A2I9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9ASE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q250	Leishmania major	79%	100%
V5DRU1	Trypanosoma cruzi	47%	100%