Eukaryotic translation initiation factor 3 subunit L

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor 3 subunit l

Species:

Leishmania braziliensis

UniProt:

A4HNN3_LEIBR

TriTrypDb:

LbrM.35.0330 , LBRM2903_350008700

Length:

467

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005852	eukaryotic translation initiation factor 3 complex	2	12
GO:0016282	eukaryotic 43S preinitiation complex	4	6
GO:0032991	protein-containing complex	1	12
GO:0033290	eukaryotic 48S preinitiation complex	4	6
GO:0070993	translation preinitiation complex	3	6
GO:1990904	ribonucleoprotein complex	2	6
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HNN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNN3

Function

Biological processes
Term	Name	Level	Count
GO:0001732	formation of cytoplasmic translation initiation complex	7	6
GO:0009987	cellular process	1	6
GO:0016043	cellular component organization	3	6
GO:0022607	cellular component assembly	4	6
GO:0022618	ribonucleoprotein complex assembly	6	6
GO:0043933	protein-containing complex organization	4	6
GO:0065003	protein-containing complex assembly	5	6
GO:0071826	ribonucleoprotein complex subunit organization	5	6
GO:0071840	cellular component organization or biogenesis	2	6
GO:0006413	translational initiation	3	1
GO:0008152	metabolic process	1	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003743	translation initiation factor activity	4	12
GO:0005488	binding	1	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	162	166	PF00656	0.608
CLV_C14_Caspase3-7	27	31	PF00656	0.595
CLV_C14_Caspase3-7	302	306	PF00656	0.601
CLV_MEL_PAP_1	229	235	PF00089	0.408
CLV_NRD_NRD_1	262	264	PF00675	0.336
CLV_NRD_NRD_1	272	274	PF00675	0.390
CLV_NRD_NRD_1	28	30	PF00675	0.596
CLV_NRD_NRD_1	306	308	PF00675	0.316
CLV_NRD_NRD_1	363	365	PF00675	0.329
CLV_PCSK_KEX2_1	262	264	PF00082	0.336
CLV_PCSK_KEX2_1	272	274	PF00082	0.390
CLV_PCSK_KEX2_1	28	30	PF00082	0.596
CLV_PCSK_KEX2_1	363	365	PF00082	0.329
CLV_PCSK_PC7_1	24	30	PF00082	0.569
CLV_PCSK_SKI1_1	227	231	PF00082	0.315
CLV_PCSK_SKI1_1	263	267	PF00082	0.408
CLV_PCSK_SKI1_1	328	332	PF00082	0.352
CLV_PCSK_SKI1_1	337	341	PF00082	0.304
CLV_PCSK_SKI1_1	88	92	PF00082	0.396
DEG_APCC_DBOX_1	226	234	PF00400	0.529
DEG_COP1_1	147	156	PF00400	0.417
DEG_SPOP_SBC_1	426	430	PF00917	0.608
DOC_CYCLIN_RxL_1	85	93	PF00134	0.412
DOC_CYCLIN_yClb5_NLxxxL_5	295	304	PF00134	0.608
DOC_CYCLIN_yClb5_NLxxxL_5	386	393	PF00134	0.608
DOC_MAPK_gen_1	262	269	PF00069	0.565
DOC_MAPK_MEF2A_6	262	269	PF00069	0.608
DOC_MAPK_MEF2A_6	58	65	PF00069	0.464
DOC_PP2B_LxvP_1	339	342	PF13499	0.515
DOC_USP7_MATH_1	154	158	PF00917	0.602
DOC_USP7_UBL2_3	456	460	PF12436	0.668
DOC_WW_Pin1_4	231	236	PF00397	0.597
DOC_WW_Pin1_4	332	337	PF00397	0.504
LIG_14-3-3_CanoR_1	107	116	PF00244	0.525
LIG_14-3-3_CanoR_1	262	268	PF00244	0.529
LIG_Actin_WH2_2	446	461	PF00022	0.694
LIG_AP2alpha_1	327	331	PF02296	0.559
LIG_BIR_II_1	1	5	PF00653	0.663
LIG_BIR_III_4	101	105	PF00653	0.530
LIG_BRCT_BRCA1_1	109	113	PF00533	0.468
LIG_BRCT_BRCA1_1	166	170	PF00533	0.417
LIG_BRCT_BRCA1_1	257	261	PF00533	0.515
LIG_BRCT_BRCA1_1	334	338	PF00533	0.504
LIG_BRCT_BRCA1_1	429	433	PF00533	0.572
LIG_BRCT_BRCA1_1	446	450	PF00533	0.476
LIG_BRCT_BRCA1_1	68	72	PF00533	0.489
LIG_BRCT_BRCA1_1	82	86	PF00533	0.318
LIG_BRCT_BRCA1_2	82	88	PF00533	0.501
LIG_Clathr_ClatBox_1	393	397	PF01394	0.590
LIG_deltaCOP1_diTrp_1	103	113	PF00928	0.366
LIG_FHA_1	148	154	PF00498	0.520
LIG_FHA_1	186	192	PF00498	0.580
LIG_FHA_1	264	270	PF00498	0.590
LIG_FHA_1	299	305	PF00498	0.608
LIG_FHA_1	417	423	PF00498	0.580
LIG_FHA_2	1	7	PF00498	0.632
LIG_FHA_2	106	112	PF00498	0.617
LIG_FHA_2	213	219	PF00498	0.608
LIG_FHA_2	319	325	PF00498	0.565
LIG_FHA_2	390	396	PF00498	0.535
LIG_Integrin_isoDGR_2	270	272	PF01839	0.390
LIG_LIR_Apic_2	118	122	PF02991	0.590
LIG_LIR_Apic_2	148	154	PF02991	0.590
LIG_LIR_Gen_1	108	116	PF02991	0.538
LIG_LIR_Gen_1	128	137	PF02991	0.506
LIG_LIR_Gen_1	138	146	PF02991	0.508
LIG_LIR_Gen_1	14	22	PF02991	0.437
LIG_LIR_Gen_1	167	178	PF02991	0.417
LIG_LIR_Gen_1	192	203	PF02991	0.617
LIG_LIR_Gen_1	209	219	PF02991	0.497
LIG_LIR_Gen_1	247	254	PF02991	0.515
LIG_LIR_Gen_1	281	292	PF02991	0.515
LIG_LIR_Gen_1	335	343	PF02991	0.504
LIG_LIR_Gen_1	39	50	PF02991	0.528
LIG_LIR_Gen_1	430	437	PF02991	0.590
LIG_LIR_Gen_1	79	90	PF02991	0.399
LIG_LIR_Nem_3	103	109	PF02991	0.376
LIG_LIR_Nem_3	110	116	PF02991	0.511
LIG_LIR_Nem_3	128	133	PF02991	0.506
LIG_LIR_Nem_3	138	144	PF02991	0.501
LIG_LIR_Nem_3	14	19	PF02991	0.431
LIG_LIR_Nem_3	192	198	PF02991	0.586
LIG_LIR_Nem_3	209	214	PF02991	0.489
LIG_LIR_Nem_3	239	244	PF02991	0.523
LIG_LIR_Nem_3	247	251	PF02991	0.481
LIG_LIR_Nem_3	281	287	PF02991	0.515
LIG_LIR_Nem_3	324	330	PF02991	0.510
LIG_LIR_Nem_3	335	341	PF02991	0.503
LIG_LIR_Nem_3	39	45	PF02991	0.444
LIG_LIR_Nem_3	397	403	PF02991	0.565
LIG_LIR_Nem_3	430	436	PF02991	0.587
LIG_LIR_Nem_3	447	453	PF02991	0.461
LIG_LIR_Nem_3	59	63	PF02991	0.533
LIG_LIR_Nem_3	79	85	PF02991	0.380
LIG_NRBOX	202	208	PF00104	0.565
LIG_NRBOX	389	395	PF00104	0.590
LIG_PCNA_yPIPBox_3	166	174	PF02747	0.608
LIG_PCNA_yPIPBox_3	202	211	PF02747	0.535
LIG_Pex14_2	327	331	PF04695	0.512
LIG_REV1ctd_RIR_1	16	24	PF16727	0.455
LIG_SH2_CRK	141	145	PF00017	0.590
LIG_SH2_CRK	195	199	PF00017	0.616
LIG_SH2_CRK	211	215	PF00017	0.515
LIG_SH2_CRK	284	288	PF00017	0.565
LIG_SH2_CRK	400	404	PF00017	0.605
LIG_SH2_CRK	82	86	PF00017	0.374
LIG_SH2_GRB2like	382	385	PF00017	0.590
LIG_SH2_NCK_1	119	123	PF00017	0.583
LIG_SH2_NCK_1	195	199	PF00017	0.590
LIG_SH2_SRC	195	198	PF00017	0.608
LIG_SH2_SRC	303	306	PF00017	0.608
LIG_SH2_STAP1	109	113	PF00017	0.590
LIG_SH2_STAP1	38	42	PF00017	0.445
LIG_SH2_STAP1	82	86	PF00017	0.495
LIG_SH2_STAT3	38	41	PF00017	0.472
LIG_SH2_STAT5	248	251	PF00017	0.513
LIG_SH2_STAT5	286	289	PF00017	0.590
LIG_SH2_STAT5	303	306	PF00017	0.590
LIG_SH2_STAT5	378	381	PF00017	0.529
LIG_SH3_3	94	100	PF00018	0.623
LIG_SUMO_SIM_anti_2	439	447	PF11976	0.547
LIG_SUMO_SIM_par_1	391	398	PF11976	0.512
LIG_TYR_ITIM	139	144	PF00017	0.590
LIG_TYR_ITIM	80	85	PF00017	0.457
LIG_UBA3_1	112	117	PF00899	0.608
LIG_UBA3_1	169	174	PF00899	0.577
LIG_UBA3_1	372	380	PF00899	0.590
LIG_UBA3_1	403	407	PF00899	0.529
LIG_UBA3_1	457	462	PF00899	0.681
LIG_WRC_WIRS_1	81	86	PF05994	0.389
MOD_CDK_SPK_2	332	337	PF00069	0.504
MOD_CK1_1	147	153	PF00069	0.556
MOD_CK1_1	212	218	PF00069	0.582
MOD_CK1_1	231	237	PF00069	0.590
MOD_CK1_1	298	304	PF00069	0.574
MOD_CK1_1	318	324	PF00069	0.574
MOD_CK2_1	212	218	PF00069	0.590
MOD_CK2_1	318	324	PF00069	0.539
MOD_CK2_1	389	395	PF00069	0.535
MOD_CK2_1	426	432	PF00069	0.608
MOD_CMANNOS	124	127	PF00535	0.315
MOD_Cter_Amidation	270	273	PF01082	0.390
MOD_GlcNHglycan	191	194	PF01048	0.375
MOD_GlcNHglycan	211	214	PF01048	0.173
MOD_GSK3_1	185	192	PF00069	0.590
MOD_GSK3_1	295	302	PF00069	0.585
MOD_GSK3_1	337	344	PF00069	0.590
MOD_N-GLC_1	298	303	PF02516	0.315
MOD_N-GLC_1	93	98	PF02516	0.602
MOD_NEK2_1	37	42	PF00069	0.534
MOD_NEK2_1	389	394	PF00069	0.505
MOD_NEK2_1	80	85	PF00069	0.492
MOD_NEK2_2	236	241	PF00069	0.565
MOD_PIKK_1	37	43	PF00454	0.482
MOD_PIKK_1	461	467	PF00454	0.637
MOD_PKA_1	272	278	PF00069	0.515
MOD_PKA_2	272	278	PF00069	0.548
MOD_PKA_2	315	321	PF00069	0.590
MOD_Plk_1	154	160	PF00069	0.554
MOD_Plk_1	164	170	PF00069	0.565
MOD_Plk_1	298	304	PF00069	0.527
MOD_Plk_1	93	99	PF00069	0.577
MOD_Plk_4	135	141	PF00069	0.521
MOD_Plk_4	236	242	PF00069	0.511
MOD_Plk_4	299	305	PF00069	0.529
MOD_Plk_4	389	395	PF00069	0.515
MOD_Plk_4	80	86	PF00069	0.389
MOD_ProDKin_1	231	237	PF00069	0.597
MOD_ProDKin_1	332	338	PF00069	0.504
TRG_DiLeu_BaEn_1	155	160	PF01217	0.545
TRG_DiLeu_BaLyEn_6	111	116	PF01217	0.417
TRG_DiLeu_LyEn_5	155	160	PF01217	0.590
TRG_ENDOCYTIC_2	109	112	PF00928	0.574
TRG_ENDOCYTIC_2	141	144	PF00928	0.590
TRG_ENDOCYTIC_2	16	19	PF00928	0.443
TRG_ENDOCYTIC_2	195	198	PF00928	0.616
TRG_ENDOCYTIC_2	211	214	PF00928	0.515
TRG_ENDOCYTIC_2	248	251	PF00928	0.517
TRG_ENDOCYTIC_2	284	287	PF00928	0.529
TRG_ENDOCYTIC_2	378	381	PF00928	0.529
TRG_ENDOCYTIC_2	400	403	PF00928	0.605
TRG_ENDOCYTIC_2	82	85	PF00928	0.372
TRG_ENDOCYTIC_2	87	90	PF00928	0.388
TRG_ER_diArg_1	261	263	PF00400	0.536
TRG_ER_diArg_1	272	274	PF00400	0.551
TRG_ER_diArg_1	362	364	PF00400	0.529
TRG_ER_diArg_1	408	411	PF00400	0.547
TRG_NES_CRM1_1	128	142	PF08389	0.515
TRG_NES_CRM1_1	371	383	PF08389	0.531
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	411	416	PF00026	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDA7	Leptomonas seymouri	81%	87%
A0A0S4KNQ8	Bodo saltans	34%	100%
A0A1X0P8D7	Trypanosomatidae	53%	95%
A0A3Q8IIN0	Leishmania donovani	97%	86%
A0A3R7KQY4	Trypanosoma rangeli	53%	96%
A1C690	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	23%	98%
A1DGW6	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	23%	98%
A2R7S7	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	23%	98%
A4ICW2	Leishmania infantum	97%	86%
A5A6M4	Pan troglodytes	24%	83%
A6S1A3	Botryotinia fuckeliana (strain B05.10)	24%	98%
A7E5J5	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	24%	98%
A7SDW5	Nematostella vectensis	24%	89%
A8PHP4	Brugia malayi	23%	85%
A8X419	Caenorhabditis briggsae	24%	87%
A9VCY6	Monosiga brevicollis	25%	91%
B0WR18	Culex quinquefasciatus	23%	87%
B0XS74	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	23%	98%
B3M7W0	Drosophila ananassae	24%	87%
B3NH71	Drosophila erecta	25%	87%
B4GR63	Drosophila persimilis	25%	86%
B4HFJ3	Drosophila sechellia	25%	87%
B4IWN1	Drosophila grimshawi	24%	86%
B4KZ45	Drosophila mojavensis	24%	87%
B4LEJ0	Drosophila virilis	24%	87%
B4MX71	Drosophila willistoni	24%	87%
B4PG99	Drosophila yakuba	25%	87%
B4QR64	Drosophila simulans	25%	87%
D0A2I7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	96%
E9ASE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	86%
L7HXG6	Magnaporthe oryzae (strain Y34)	23%	99%
P0CN56	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	23%	74%
P0CN57	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	23%	74%
P0CT08	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	23%	99%
Q0CPA8	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	23%	98%
Q0UIU6	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	23%	96%
Q16FL6	Aedes aegypti	23%	87%
Q1DZB0	Coccidioides immitis (strain RS)	22%	97%
Q2H9N4	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	22%	99%
Q2M0S3	Drosophila pseudoobscura pseudoobscura	25%	86%
Q2U041	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	23%	98%
Q3ZCK1	Bos taurus	25%	83%
Q4PF85	Ustilago maydis (strain 521 / FGSC 9021)	22%	70%
Q4Q253	Leishmania major	96%	100%
Q4X1D2	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	23%	98%
Q5B0H6	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	23%	98%
Q5F428	Gallus gallus	25%	83%
Q6CAE9	Yarrowia lipolytica (strain CLIB 122 / E 150)	25%	90%
Q6P878	Xenopus tropicalis	24%	83%
Q7Q5Y8	Anopheles gambiae	23%	87%
Q7SB62	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	23%	99%
Q7T2A5	Danio rerio	25%	81%
Q86LA2	Dictyostelium discoideum	26%	76%
Q8AVJ0	Xenopus laevis	24%	83%
Q8QZY1	Mus musculus	25%	83%
Q95QW0	Caenorhabditis elegans	23%	87%
Q9VTU4	Drosophila melanogaster	25%	87%
Q9Y262	Homo sapiens	25%	83%
V5BV76	Trypanosoma cruzi	53%	96%