Protein phosphatase 1 regulatory subunit 21

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Afadin- and alpha -actinin-Binding, putative

Species:

Leishmania braziliensis

UniProt:

A4HNN2_LEIBR

TriTrypDb:

LbrM.35.0320 , LBRM2903_350008600

Length:

224

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNN2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	138	140	PF00675	0.427
CLV_NRD_NRD_1	183	185	PF00675	0.419
CLV_NRD_NRD_1	187	189	PF00675	0.403
CLV_NRD_NRD_1	59	61	PF00675	0.575
CLV_PCSK_FUR_1	57	61	PF00082	0.497
CLV_PCSK_KEX2_1	138	140	PF00082	0.394
CLV_PCSK_KEX2_1	183	185	PF00082	0.413
CLV_PCSK_KEX2_1	57	59	PF00082	0.585
CLV_PCSK_PC7_1	54	60	PF00082	0.495
CLV_PCSK_SKI1_1	189	193	PF00082	0.411
DEG_COP1_1	4	16	PF00400	0.512
DEG_Nend_Nbox_1	1	3	PF02207	0.585
DOC_CYCLIN_RxL_1	183	196	PF00134	0.407
DOC_PP2B_LxvP_1	91	94	PF13499	0.324
DOC_USP7_MATH_1	113	117	PF00917	0.556
DOC_USP7_MATH_2	70	76	PF00917	0.432
DOC_USP7_UBL2_3	163	167	PF12436	0.351
DOC_WW_Pin1_4	19	24	PF00397	0.488
DOC_WW_Pin1_4	63	68	PF00397	0.650
DOC_WW_Pin1_4	94	99	PF00397	0.419
LIG_14-3-3_CanoR_1	124	128	PF00244	0.559
LIG_14-3-3_CanoR_1	17	25	PF00244	0.694
LIG_14-3-3_CanoR_1	57	67	PF00244	0.582
LIG_Actin_WH2_2	152	169	PF00022	0.436
LIG_BRCT_BRCA1_1	96	100	PF00533	0.408
LIG_eIF4E_1	104	110	PF01652	0.419
LIG_eIF4E_1	87	93	PF01652	0.420
LIG_FHA_1	105	111	PF00498	0.379
LIG_FHA_1	20	26	PF00498	0.539
LIG_FHA_2	124	130	PF00498	0.559
LIG_FHA_2	194	200	PF00498	0.483
LIG_FHA_2	42	48	PF00498	0.419
LIG_LIR_Nem_3	83	89	PF02991	0.477
LIG_MYND_1	94	98	PF01753	0.414
LIG_NRP_CendR_1	222	224	PF00754	0.520
LIG_SH2_STAP1	104	108	PF00017	0.405
LIG_SH2_STAP1	87	91	PF00017	0.333
LIG_SH3_2	64	69	PF14604	0.511
LIG_SH3_3	61	67	PF00018	0.622
LIG_SH3_3	8	14	PF00018	0.572
LIG_SUMO_SIM_anti_2	105	112	PF11976	0.426
LIG_TRAF2_1	168	171	PF00917	0.329
MOD_CDC14_SPxK_1	66	69	PF00782	0.536
MOD_CDK_SPK_2	94	99	PF00069	0.342
MOD_CDK_SPxK_1	63	69	PF00069	0.650
MOD_CK1_1	173	179	PF00069	0.459
MOD_CK1_1	19	25	PF00069	0.460
MOD_CK2_1	193	199	PF00069	0.461
MOD_CK2_1	41	47	PF00069	0.696
MOD_CK2_1	6	12	PF00069	0.451
MOD_DYRK1A_RPxSP_1	63	67	PF00069	0.736
MOD_GlcNHglycan	115	118	PF01048	0.547
MOD_GlcNHglycan	120	123	PF01048	0.566
MOD_GlcNHglycan	177	180	PF01048	0.342
MOD_GlcNHglycan	47	51	PF01048	0.564
MOD_GSK3_1	12	19	PF00069	0.466
MOD_GSK3_1	2	9	PF00069	0.524
MOD_GSK3_1	41	48	PF00069	0.539
MOD_GSK3_1	59	66	PF00069	0.546
MOD_GSK3_1	94	101	PF00069	0.506
MOD_NEK2_1	100	105	PF00069	0.459
MOD_NEK2_1	193	198	PF00069	0.390
MOD_NEK2_1	24	29	PF00069	0.487
MOD_PKA_1	58	64	PF00069	0.577
MOD_PKA_2	123	129	PF00069	0.518
MOD_PKA_2	16	22	PF00069	0.533
MOD_PKA_2	41	47	PF00069	0.669
MOD_PKA_2	58	64	PF00069	0.481
MOD_PKB_1	57	65	PF00069	0.493
MOD_Plk_1	193	199	PF00069	0.337
MOD_Plk_1	6	12	PF00069	0.451
MOD_Plk_2-3	6	12	PF00069	0.529
MOD_Plk_4	104	110	PF00069	0.476
MOD_ProDKin_1	19	25	PF00069	0.486
MOD_ProDKin_1	63	69	PF00069	0.649
MOD_ProDKin_1	94	100	PF00069	0.415
MOD_SUMO_for_1	155	158	PF00179	0.540
MOD_SUMO_rev_2	153	157	PF00179	0.351
MOD_SUMO_rev_2	171	176	PF00179	0.355
TRG_DiLeu_BaEn_1	88	93	PF01217	0.417
TRG_DiLeu_BaLyEn_6	20	25	PF01217	0.575
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.311
TRG_ER_diArg_1	57	60	PF00400	0.598
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5U6	Leptomonas seymouri	61%	98%
A0A1X0P8P1	Trypanosomatidae	38%	97%
A0A3Q8IQF0	Leishmania donovani	82%	100%
A4ICW3	Leishmania infantum	82%	100%
D0A2I6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9ASE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q254	Leishmania major	80%	100%