Putative SET domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HNM9_LEIBR

TriTrypDb:

LbrM.35.0290 , LBRM2903_350008300

Length:

473

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNM9

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0016740	transferase activity	2	12
GO:0000166	nucleotide binding	3	3
GO:0005488	binding	1	3
GO:0005524	ATP binding	5	3
GO:0008716	D-alanine-D-alanine ligase activity	5	3
GO:0016874	ligase activity	2	3
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	3
GO:0016881	acid-amino acid ligase activity	4	3
GO:0017076	purine nucleotide binding	4	3
GO:0030554	adenyl nucleotide binding	5	3
GO:0032553	ribonucleotide binding	3	3
GO:0032555	purine ribonucleotide binding	4	3
GO:0032559	adenyl ribonucleotide binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0036094	small molecule binding	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3
GO:0097159	organic cyclic compound binding	2	3
GO:0097367	carbohydrate derivative binding	2	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3
GO:0008168	methyltransferase activity	4	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.533
CLV_NRD_NRD_1	225	227	PF00675	0.448
CLV_NRD_NRD_1	314	316	PF00675	0.568
CLV_NRD_NRD_1	326	328	PF00675	0.447
CLV_NRD_NRD_1	461	463	PF00675	0.457
CLV_PCSK_KEX2_1	225	227	PF00082	0.473
CLV_PCSK_KEX2_1	24	26	PF00082	0.459
CLV_PCSK_KEX2_1	358	360	PF00082	0.502
CLV_PCSK_PC1ET2_1	24	26	PF00082	0.459
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.502
CLV_PCSK_SKI1_1	233	237	PF00082	0.414
CLV_PCSK_SKI1_1	358	362	PF00082	0.478
CLV_PCSK_SKI1_1	469	473	PF00082	0.603
DOC_CYCLIN_yCln2_LP_2	136	142	PF00134	0.388
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.391
DOC_MAPK_gen_1	135	142	PF00069	0.524
DOC_MAPK_gen_1	185	193	PF00069	0.454
DOC_MAPK_gen_1	324	333	PF00069	0.428
DOC_MAPK_MEF2A_6	185	193	PF00069	0.438
DOC_PP1_RVXF_1	173	180	PF00149	0.405
DOC_PP2B_LxvP_1	136	139	PF13499	0.463
DOC_PP4_FxxP_1	397	400	PF00568	0.562
DOC_USP7_MATH_1	194	198	PF00917	0.505
DOC_USP7_MATH_1	206	210	PF00917	0.565
DOC_USP7_MATH_1	212	216	PF00917	0.584
DOC_USP7_MATH_1	229	233	PF00917	0.451
DOC_USP7_MATH_1	366	370	PF00917	0.486
DOC_USP7_MATH_1	52	56	PF00917	0.559
DOC_USP7_MATH_1	65	69	PF00917	0.595
DOC_USP7_UBL2_3	324	328	PF12436	0.536
DOC_WW_Pin1_4	13	18	PF00397	0.591
DOC_WW_Pin1_4	300	305	PF00397	0.430
DOC_WW_Pin1_4	50	55	PF00397	0.512
LIG_14-3-3_CanoR_1	143	151	PF00244	0.534
LIG_14-3-3_CanoR_1	359	367	PF00244	0.504
LIG_14-3-3_CanoR_1	442	452	PF00244	0.497
LIG_14-3-3_CanoR_1	95	100	PF00244	0.461
LIG_APCC_ABBA_1	149	154	PF00400	0.513
LIG_APCC_ABBA_1	308	313	PF00400	0.572
LIG_BRCT_BRCA1_1	29	33	PF00533	0.510
LIG_BRCT_BRCA1_1	302	306	PF00533	0.343
LIG_deltaCOP1_diTrp_1	254	258	PF00928	0.324
LIG_EH1_1	102	110	PF00400	0.486
LIG_FHA_1	143	149	PF00498	0.508
LIG_FHA_1	284	290	PF00498	0.566
LIG_FHA_1	303	309	PF00498	0.569
LIG_FHA_1	74	80	PF00498	0.517
LIG_FHA_2	13	19	PF00498	0.552
LIG_FHA_2	167	173	PF00498	0.447
LIG_FHA_2	246	252	PF00498	0.537
LIG_FHA_2	421	427	PF00498	0.391
LIG_LIR_Apic_2	349	355	PF02991	0.517
LIG_LIR_Apic_2	361	366	PF02991	0.351
LIG_LIR_Gen_1	339	348	PF02991	0.433
LIG_LIR_Gen_1	418	429	PF02991	0.528
LIG_LIR_Nem_3	232	237	PF02991	0.440
LIG_LIR_Nem_3	30	36	PF02991	0.419
LIG_LIR_Nem_3	339	343	PF02991	0.445
LIG_LIR_Nem_3	418	424	PF02991	0.472
LIG_LIR_Nem_3	55	60	PF02991	0.490
LIG_NRBOX	78	84	PF00104	0.258
LIG_SH2_CRK	57	61	PF00017	0.464
LIG_SH2_NCK_1	112	116	PF00017	0.391
LIG_SH2_SRC	112	115	PF00017	0.416
LIG_SH2_STAT3	347	350	PF00017	0.302
LIG_SH2_STAT5	234	237	PF00017	0.492
LIG_SH2_STAT5	257	260	PF00017	0.463
LIG_SH2_STAT5	347	350	PF00017	0.424
LIG_SH2_STAT5	91	94	PF00017	0.415
LIG_SH3_3	112	118	PF00018	0.474
LIG_SH3_3	259	265	PF00018	0.499
LIG_SH3_3	340	346	PF00018	0.436
LIG_SH3_3	467	473	PF00018	0.513
LIG_Sin3_3	80	87	PF02671	0.272
LIG_SUMO_SIM_anti_2	104	109	PF11976	0.452
LIG_TRAF2_1	249	252	PF00917	0.357
LIG_TYR_ITIM	110	115	PF00017	0.501
LIG_WRC_WIRS_1	167	172	PF05994	0.284
LIG_WRC_WIRS_1	421	426	PF05994	0.372
MOD_CK1_1	53	59	PF00069	0.322
MOD_CK2_1	12	18	PF00069	0.517
MOD_CK2_1	166	172	PF00069	0.465
MOD_CK2_1	245	251	PF00069	0.526
MOD_CK2_1	282	288	PF00069	0.561
MOD_GlcNHglycan	465	468	PF01048	0.566
MOD_GlcNHglycan	66	70	PF01048	0.623
MOD_GlcNHglycan	76	79	PF01048	0.496
MOD_GSK3_1	162	169	PF00069	0.381
MOD_GSK3_1	242	249	PF00069	0.356
MOD_GSK3_1	278	285	PF00069	0.505
MOD_GSK3_1	444	451	PF00069	0.440
MOD_GSK3_1	74	81	PF00069	0.484
MOD_GSK3_1	85	92	PF00069	0.511
MOD_N-GLC_1	181	186	PF02516	0.514
MOD_N-GLC_1	246	251	PF02516	0.347
MOD_N-GLC_1	387	392	PF02516	0.261
MOD_N-GLC_2	144	146	PF02516	0.485
MOD_N-GLC_2	29	31	PF02516	0.387
MOD_N-GLC_2	62	64	PF02516	0.370
MOD_NEK2_1	162	167	PF00069	0.503
MOD_NEK2_1	289	294	PF00069	0.477
MOD_NEK2_2	194	199	PF00069	0.515
MOD_NEK2_2	322	327	PF00069	0.548
MOD_NEK2_2	425	430	PF00069	0.409
MOD_PKA_1	358	364	PF00069	0.313
MOD_PKA_2	142	148	PF00069	0.481
MOD_PKA_2	358	364	PF00069	0.517
MOD_PKA_2	94	100	PF00069	0.274
MOD_Plk_1	162	168	PF00069	0.524
MOD_Plk_1	415	421	PF00069	0.493
MOD_Plk_1	456	462	PF00069	0.465
MOD_Plk_2-3	415	421	PF00069	0.472
MOD_Plk_4	162	168	PF00069	0.486
MOD_Plk_4	289	295	PF00069	0.510
MOD_Plk_4	448	454	PF00069	0.540
MOD_Plk_4	456	462	PF00069	0.528
MOD_Plk_4	78	84	PF00069	0.399
MOD_ProDKin_1	13	19	PF00069	0.585
MOD_ProDKin_1	300	306	PF00069	0.424
MOD_ProDKin_1	50	56	PF00069	0.507
MOD_SUMO_rev_2	303	310	PF00179	0.333
TRG_DiLeu_BaLyEn_6	467	472	PF01217	0.586
TRG_ENDOCYTIC_2	112	115	PF00928	0.399
TRG_ENDOCYTIC_2	421	424	PF00928	0.372
TRG_ENDOCYTIC_2	57	60	PF00928	0.465
TRG_ER_diArg_1	225	227	PF00400	0.545
TRG_NLS_MonoExtC_3	356	362	PF00514	0.308
TRG_NLS_MonoExtN_4	355	361	PF00514	0.306

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILG6	Leptomonas seymouri	67%	100%
A0A0N1ILV0	Leptomonas seymouri	26%	92%
A0A0S4JLQ2	Bodo saltans	28%	100%
A0A0S4KKY2	Bodo saltans	41%	100%
A0A1X0P8J8	Trypanosomatidae	40%	100%
A0A3Q8IJR2	Leishmania donovani	84%	100%
A0A3R7P2U3	Trypanosoma rangeli	38%	100%
A4I1M6	Leishmania infantum	21%	89%
A4ICW6	Leishmania infantum	83%	100%
D0A2I3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9ASD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q257	Leishmania major	82%	100%
V5BQK1	Trypanosoma cruzi	39%	100%