Putative mitochondrial inner membrane signal peptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine peptidase clan SF, family S26B, putative

Species:

Leishmania braziliensis

UniProt:

A4HNM8_LEIBR

TriTrypDb:

LbrM.35.0280 , LBRM2903_350008200

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0032991	protein-containing complex	1	1
GO:0042720	mitochondrial inner membrane peptidase complex	3	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:1902494	catalytic complex	2	1
GO:0005743	mitochondrial inner membrane	5	1
GO:0019866	organelle inner membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1

Expansion

Sequence features

A4HNM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNM8

Function

Biological processes
Term	Name	Level	Count
GO:0006465	signal peptide processing	5	12
GO:0006508	proteolysis	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0016485	protein processing	5	12
GO:0019538	protein metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0051604	protein maturation	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0006627	protein processing involved in protein targeting to mitochondrion	7	1
GO:0034982	mitochondrial protein processing	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004175	endopeptidase activity	4	12
GO:0004252	serine-type endopeptidase activity	5	12
GO:0008233	peptidase activity	3	12
GO:0008236	serine-type peptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0017171	serine hydrolase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.173
CLV_C14_Caspase3-7	135	139	PF00656	0.250
CLV_NRD_NRD_1	186	188	PF00675	0.380
CLV_NRD_NRD_1	63	65	PF00675	0.380
CLV_PCSK_KEX2_1	186	188	PF00082	0.380
CLV_PCSK_KEX2_1	63	65	PF00082	0.414
CLV_PCSK_KEX2_1	89	91	PF00082	0.234
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.234
DEG_SCF_FBW7_2	116	123	PF00400	0.173
DOC_CKS1_1	117	122	PF01111	0.173
DOC_CYCLIN_RxL_1	194	203	PF00134	0.321
DOC_CYCLIN_yCln2_LP_2	53	59	PF00134	0.223
DOC_MAPK_DCC_7	14	23	PF00069	0.531
DOC_MAPK_gen_1	11	20	PF00069	0.573
DOC_MAPK_gen_1	186	193	PF00069	0.349
DOC_MAPK_MEF2A_6	14	23	PF00069	0.454
DOC_MAPK_MEF2A_6	64	73	PF00069	0.372
DOC_PP1_RVXF_1	2	8	PF00149	0.367
DOC_PP2B_LxvP_1	53	56	PF13499	0.213
DOC_PP4_FxxP_1	66	69	PF00568	0.380
DOC_USP7_MATH_1	166	170	PF00917	0.313
DOC_USP7_MATH_1	216	220	PF00917	0.690
DOC_WW_Pin1_4	116	121	PF00397	0.403
DOC_WW_Pin1_4	204	209	PF00397	0.653
LIG_14-3-3_CanoR_1	150	154	PF00244	0.264
LIG_FHA_2	123	129	PF00498	0.476
LIG_FHA_2	130	136	PF00498	0.378
LIG_LIR_Apic_2	203	208	PF02991	0.551
LIG_LIR_Gen_1	107	117	PF02991	0.289
LIG_LIR_Gen_1	169	177	PF02991	0.248
LIG_LIR_Gen_1	17	27	PF02991	0.460
LIG_LIR_Gen_1	50	59	PF02991	0.246
LIG_LIR_Nem_3	107	112	PF02991	0.272
LIG_LIR_Nem_3	12	18	PF02991	0.465
LIG_LIR_Nem_3	141	147	PF02991	0.380
LIG_LIR_Nem_3	169	174	PF02991	0.248
LIG_LIR_Nem_3	50	54	PF02991	0.261
LIG_MYND_1	44	48	PF01753	0.234
LIG_SH2_CRK	117	121	PF00017	0.264
LIG_SH2_CRK	57	61	PF00017	0.263
LIG_SH2_PTP2	109	112	PF00017	0.338
LIG_SH2_SRC	109	112	PF00017	0.338
LIG_SH2_STAT5	109	112	PF00017	0.338
LIG_SH2_STAT5	144	147	PF00017	0.336
LIG_SH2_STAT5	51	54	PF00017	0.246
LIG_SH2_STAT5	57	60	PF00017	0.246
LIG_SH3_3	110	116	PF00018	0.345
LIG_SUMO_SIM_anti_2	74	80	PF11976	0.264
LIG_TYR_ITIM	55	60	PF00017	0.286
MOD_CK1_1	149	155	PF00069	0.258
MOD_CK1_1	182	188	PF00069	0.244
MOD_CK1_1	207	213	PF00069	0.474
MOD_CK2_1	128	134	PF00069	0.348
MOD_CK2_1	214	220	PF00069	0.465
MOD_GSK3_1	200	207	PF00069	0.264
MOD_GSK3_1	38	45	PF00069	0.246
MOD_GSK3_1	5	12	PF00069	0.373
MOD_GSK3_1	79	86	PF00069	0.315
MOD_N-GLC_1	71	76	PF02516	0.380
MOD_NEK2_1	5	10	PF00069	0.401
MOD_NEK2_2	6	11	PF00069	0.374
MOD_PIKK_1	166	172	PF00454	0.380
MOD_PKA_2	10	16	PF00069	0.561
MOD_PKA_2	149	155	PF00069	0.396
MOD_PKA_2	92	98	PF00069	0.176
MOD_Plk_1	179	185	PF00069	0.239
MOD_Plk_1	83	89	PF00069	0.257
MOD_Plk_4	200	206	PF00069	0.380
MOD_Plk_4	38	44	PF00069	0.268
MOD_Plk_4	55	61	PF00069	0.191
MOD_ProDKin_1	116	122	PF00069	0.403
MOD_ProDKin_1	204	210	PF00069	0.656
TRG_DiLeu_BaEn_2	49	55	PF01217	0.380
TRG_ENDOCYTIC_2	109	112	PF00928	0.341
TRG_ENDOCYTIC_2	15	18	PF00928	0.467
TRG_ENDOCYTIC_2	51	54	PF00928	0.252
TRG_ENDOCYTIC_2	57	60	PF00928	0.255
TRG_ER_diArg_1	62	64	PF00400	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5U2	Leptomonas seymouri	68%	100%
A0A0S4KL01	Bodo saltans	36%	100%
A0A1X0P9C8	Trypanosomatidae	47%	100%
A0A3Q8IK39	Leishmania donovani	83%	98%
A0A3R7N3L4	Trypanosoma rangeli	41%	100%
A4ICW7	Leishmania infantum	83%	98%
D0A2I2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9ASD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	98%
Q4Q258	Leishmania major	83%	100%
V5BA41	Trypanosoma cruzi	46%	100%