Elongation factor 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Elongation factor 2

Gene product:

elongation factor 2

Species:

Leishmania braziliensis

UniProt:

A4HNM6_LEIBR

TriTrypDb:

LbrM.35.0260 , LBRM2903_350008100

Length:

237

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNM6

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	2
GO:0003924	GTPase activity	7	2
GO:0005488	binding	1	2
GO:0005525	GTP binding	5	2
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0017076	purine nucleotide binding	4	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	34	38	PF00656	0.700
CLV_PCSK_KEX2_1	235	237	PF00082	0.792
CLV_PCSK_KEX2_1	54	56	PF00082	0.500
CLV_PCSK_KEX2_1	93	95	PF00082	0.500
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.500
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.500
CLV_PCSK_SKI1_1	142	146	PF00082	0.500
CLV_PCSK_SKI1_1	160	164	PF00082	0.274
CLV_PCSK_SKI1_1	66	70	PF00082	0.500
CLV_PCSK_SKI1_1	94	98	PF00082	0.500

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0B7D5	METTP	44%	32%
A0KZN4	SHESA	41%	40%
A0L631	MAGMM	39%	40%
A0LI00	SYNFM	42%	40%
A0LRL7	ACIC1	40%	34%
A0M6M2	GRAFK	40%	40%
A0Q1R8	CLONN	41%	39%
A0RQX4	CAMFF	39%	40%
A0RW30	CENSY	45%	32%
A1A0T0	BIFAA	43%	33%

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